he metabolic syndrome in hispanics the role of insulin resistance and inflammation
A study of bloating symptomatology, the role of gastrointestinal transit and the response to treatment with the 5 HT4 receptor agonist in patients with bloating predominant irritable bowel syndrome
... the midline of pons and upper brain stem While in the gut, the EC cells containing 5-HT are localized primarily in the Lieberekuhn’s crypts and at the base of villi of the small intestine The amount ... intestinal transit; and 2) tegaserod could improve bloating and intestine transit in these patients Therefore, the objective of this study is to investigate the symptomatology of bloating, the ... Outline of the biosynthetic and metabolic pathway of 5-HT (Adapt from Reiter, 1998, www.appi.org) In the central nervous system, 5-HT is synthesized within the nerve terminal The 5-HT produced in...
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WORKING PAPER SERIES NO. 398 / OCTOBER 2004: MERGERS AND ACQUISITIONS AND BANK PERFORMANCE IN EUROPE THE ROLE OF STRATEGIC SIMILARITIES potx
... tend to follow two main kinds of empirical methods On the one hand there are a number of studies comparing pre- and post-merger performance On the other hand, another strand of the empirical literature ... effect of changes on the capital levels on performance hinges on the recent theory of the banking firm, which is based on the ‘specialness’ of banks in a setting in which there are asymmetries of information ... Bollenbacher (1995) and McKinsey (2002) ECB Working Paper Series No 398 October 2004 (where SIni is the similarity index for the nth variable for the ith merger, and XBni and XTni are the scores of the...
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Báo cáo khoa học: The role of helix 8 and of the cytosolic C-termini in the internalization and signal transduction of B1 and B2 bradykinin receptors potx
... binding was determined in the presence of lm unlabeled agonist and subtracted from the total binding to calculate the specific binding Internalization of [3H]BK and [3H]DAK To determine the internalization ... in uences the formation of a helical structure These authors proposed that activation of the receptor, and subsequently of the G protein, leads to a change in the environment of helix resulting ... provide insight into the receptor specificity of the B2wt internalization motif The resulting data also hint at a receptor specific role of the putative helix in G protein activation and interaction...
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Báo cáo khoa học: The role of residues R97 and Y331 in modulating the pH optimum of an insect b-glycosidase of family 1 pdf
... the same is occurring in the mutant R97M, because there is no data on the interactions between the substrate and the arginine residue Finally, another aspect of the R97 and Y331 inuence on catalysis ... remained the same, but the pKa of E399 clearly increased Actually, the substitution of R97 by methionine or lysine resulted in the same increment in the pKa of E399 (Table 2) Therefore, M97 and ... 50 mM Bicine buffer 7.08.5) The pH stability of Sfbgly50 was checked by incubation in the same buffers for a time equal to the assay time and then determining the activity remaining at the optimum...
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Báo cáo khoa học: Dissecting the role of protein–protein and protein–nucleic acid interactions in MS2 bacteriophage stability potx
... verify the urea-induced and GdnHCl-induced changes in the secondary structure of the proteins, we analyzed the UV CD spectra of MS2 and VLPs in the absence and presence of 5.0 m and 9.0 m urea and ... in the hydrophobic interior of the protein emit fluorescence when excited at 280 nm When the protein unfolds in the presence of denaturing agents, the exposure of buried residues reflects the conformational ... other hand, when we incubated the coat protein with tRNA or the hairpin sequence, neither was able to protect the protein against denaturation (Fig 7A) After pressure release, the value of the...
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báo cáo sinh học:" Task-shifting HIV counselling and testing services in Zambia: the role of lay counsellors" pot
... component of the training includes instruction as well as role- plays and case studies to ensure that trainees understand the concepts and methods of HIV counselling and testing In the four-week ... gathered from the quality assurance portion of the evaluation were used to calculate error rates at the level of the facility and of the province Since these errors were also tallied according ... AS and CS conceived the study, participated in the design and helped draft the manuscript PK, LN, DK, MS, MK and CT participated in the design and helped draft the manuscript LN and MK did the...
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báo cáo hóa học:" The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization" pptx
... examined and photographed the cells on a Zeiss Axioskop using 20× Tritiated thymidine incorporation into DNA At the conclusion of the 24 hour incubation, the culture medium was removed and the ... We then visualized the mineralizing cells with 2% Alizarin Red After rinsing in distilled water and air drying the samples, we mounted the coverslips on microscope slides using Fluoromount and ... released and start a new proliferation stage to heal the defect The increase in cell replication in a mineralizing cell likely represents a de-differentiation from the mineralizing phase to the growing...
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báo cáo hóa học:" The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization" pdf
... examined and photographed the cells on a Zeiss Axioskop using 20× Tritiated thymidine incorporation into DNA At the conclusion of the 24 hour incubation, the culture medium was removed and the ... We then visualized the mineralizing cells with 2% Alizarin Red After rinsing in distilled water and air drying the samples, we mounted the coverslips on microscope slides using Fluoromount and ... released and start a new proliferation stage to heal the defect The increase in cell replication in a mineralizing cell likely represents a de-differentiation from the mineralizing phase to the growing...
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Research for a Future in Space: The Role of Life and Physical Sciences ppt
... Engineering in providing services to the government, the public, and the scientific and engineering communities The Council is administered jointly by both Academies and the Institute of Medicine ... president of the National Academy of Engineering The Institute of Medicine was established in 1970 by the National Academy of Sciences to secure the services of eminent members of appropriate professions ... distinguished scholars engaged in scientific and engineering research, dedicated to the furtherance of science and technology and to their use for the general welfare Upon the authority of the...
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Báo cáo khoa học: "The role of Bcl-xL and nuclear factor-kB in the effect of taxol on the viability of dendritic cells" ppsx
... viability These findings provide a basic rationale for the use of taxol in DC immunotherapy and insights into the development of combinational DC therapies with other anticancer drugs that not harm the ... involved in the survival and maturation of DCs [11,17,20] To investigate further the mechanisms of taxol-induced changes, the viablity of TPCK, an inhibitor of the serine protease that inhibit NF-κB ... major cytokines involved in immune responses Importantly, taxol increased the expression of the anti-apoptotic protein Bcl-xL, and increased the mobilization of p65 subunit molecules into the DC nucleus...
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Báo cáo khoa học: " The role of marine salt and surfactants in the decline of Tyrrhenian coastal vegetation in Italy" ppt
... trees of P pinea, P tobira, Q ilex and A opalus growing When interpreting the results of the chemical analysis of rainwater and deposits it is necessary to bear in mind the interactions between the ... chemical, physical, etc) The ratio that is most probably the closest to the original ratio in the aerosol is that recorded in the rainwater gathered near the coastline, ie the one closest to the ... Finally, the comparison between the different behaviour of the species tested suggests that resistance to the action of aerosols is the result of the strength of the structures protecting the...
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Báo cáo y học: "The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis" pps
... IL-1 and TNF, rather than a 'cytokine cascade' with either of these cytokines controlling the production of the other (Figure 4a) Both Enbrel and the neutralising anti-IL-1β antibody decreased the ... by then, large quantities of these MMPs have already been produced, thus blurring the results In contrast, the PCR findings reflect the state of the cells days after addition of the Enbrel and/ or ... TNF-α and IL-1, the contribution of these two proinflammatory cytokines on the production of each other, on other proinflammatory mediators, on the expression and production of various MMPs and...
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Báo cáo khoa hoc:"Muscle-related traits in cattle: The role of the myostatin gene in the South Devon breed" pps
... structure Therefore, the key information required is the way in which the del11 allele affects traits of economic importance There is information available in the literature on the effects of double ... effects of the del11 allele on many traits of economic importance in the South Devon and quantifies the multivariate impact of the del11 alleles on the traits recorded in a random sample of the breed ... in uential than that of its dam in determining the difficulty of calving The objective of this study was to review the impact of the del11 allele for breeds in which it is segregating The MLC, which...
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báo cáo khoa học: " Exploring the role of organizational policies and procedures in promoting research utilization in registered nurses" potx
... identify factors influencing the use of RBPs among staff nurses in the Canadian province of Newfoundland and Labrador with the specific aim of understanding the role of P&Ps in promoting research ... Table 3) The three RBPs that nurses were the most aware of were the same practices they were the most persuaded of and used the most: flushing peripheral locks, urinary catheter care, and using graduated ... placed nurses in this study in the persuasion stage of adoption, overall In other words, they were aware of and believed in the value of the practices but were not using them to make clinical decisions...
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Báo cáo y học: "The role of mast cells and fibre type in ischaemia reperfusion injury of murine skeletal muscles" pot
... compare because of the wide variety of IR models in use In particular, there is a great deal of variation in the period of ischaemia, the muscle temperature during ischaemia and the period of reperfusion ... was monitored and maintained at 36 ± 1°C After the ischemia period, the bands were removed and the mice allowed to recover After 24 h reperfusion the mice were re-anaesthetized and the gastrocnemius, ... though the latter contained twice the density of mast cells, indicate that there is also a genetic component to IR injury Our data would support the hypothesis that there is a base line level of...
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Báo cáo y học: "A systematic review of the role of vitamin insufficiencies and supplementation in COPD" docx
... assessment of vitamins has the disadvantage that they represent the more recent intake, and for some vitamins such as vitamin C, the levels in peripheral blood are not representative of intake and not ... COPD [106] Vitamin A and B Vitamin A (retinol and carotens) plays an important role in several functions of the human body including vision, bone and skin health, and further has an innate antioxidant ... protective role of vitamins against COPD but did not measure vitamins in serum or with a FFQ Therefore conclusions about the special role of any vitamin in COPD could not be obtained Vitamin D and COPD...
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Báo cáo y học: " The role of cyclin D2 and p21/waf1 in human T-cell leukemia virus type 1 infected cells" potx
... cyclin binding motifs, one at the N- and the other at the C- terminus [20] p21/waf1 (mut) is mutated at the N-terminus and is therefore still able to bind to cyclins through the C-terminus, making ... the nucleolus, whereas the lighter blue staining represents the nucleoplasm As expected, the intensity of staining for cyclin D2 and p21/ waf1 was increased in HTLV-1 infected T-cells When the ... scenario where the p21/cyclin D2 ratio has not changed, rather only the abundance of the complex has increased Another important consequence of the interaction of p21/ waf1 with cyclin D2 is the sequestration...
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ELUCIDATING THE ROLE OF REDOX EFFECTS AND THE KU80 C-TERMINAL REGION IN THE REGULATION OF THE HUMAN DNA REPAIR PROTEIN KU
... has the potential to influence the DNA binding activity of Ku (51) To further understand the role of the C-terminus of Ku80, we created two mutants The first mutant contains a truncated form of ... due to the lack of the linker region tethering together two molecules that are simply within range of the linker arm and possibly not involved in a genuine interaction (41) 10 Materials and Methods ... Preliminary work was performed to determine the elution volume of Ku70/80C and Ku80CTR independent of the other protein Individual proteins were pre-incubated in running buffer and applied to the...
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the role of il-33 and il-17 family cytokines in periodontal disease
... causing changes in biofilm physiology The metabolic activity of the aerobic species reduces the oxygen concentration and pH within the biofilm promoting colonisation of the intermediate and subsequent ... activity of these enzymes promotes the permeation of P gingivalis into the gingival epithelium and can provide a gateway for other organisms to invade In addition, these enzymes play a direct role in ... associated with an inflamed gingiva Therefore, these authors introduced the specific plaque hypothesis (Loesche, 1976) The introduction of this hypothesis led to the quest to find specific pathogenic...
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