gsea using general biochemical and cell biological categories from kegg

CHARACTERIZATION OF MYCOBACTERIAL ESTRASES LIPASES USING COMBINED BIOCHEMICAL AND COMPUTATIONAL ENZYMOLOGY

... (LINCS) algorithm (Hess, Bekker et al 1997) and (Hess 2007) 2.3 Virtual Ligand Screening: Computational docking of ligands in protein 3D structure model was performed using Autodock Vina (Trott and ... using the Lamarckian genetic algorithm and local search method (Solis and Wets, 1981) The initial orientations, position, torsion angles of ligands were set randomly and during docking all rotatable ... tween80 (PBST) and cells were vortexed Bacterial cells were lysed using probe sonicator with the following parameters: 60% amplitude, mins, 10 seconds 41 pulse on seconds off and the lysed cells were...

Báo cáo khoa học: "Efﬁcient Unsupervised Discovery of Word Categories Using Symmetric Patterns and High Frequency Words" ppt

Danh mục: Báo cáo khoa học

... obtained as follows 20 of our categories were selected at random from the non-overlapping categories we have discovered, and three words were selected from each of these at random 10 triplets were selected ... order to discover hierarchical categories, and utilizes those categories in order to automatically discover additional patterns (Berland and Charniak, 1999) use hand crafted patterns to discover ... manner from the categories produced by k-means, and 10 triplets were generated by random selection of content words from the same window in the corpus In Part II, subjects were given the full categories...

báo cáo hóa học:" Development and evaluation of a clinical algorithm to monitor patients on antiretrovirals in resource-limited settings using adherence, clinical and CD4 cell count criteria" ppt

Danh mục: Hóa học - Dầu khí

... 2009, 12:3 CD4 cell count was measured by change in CD4 cell count from baseline, 30% fall and 50% fall from maximum achieved, persistent CD4 cell count of

Báo cáo khoa học: "Autologous somatic cell nuclear transfer in pigs using recipient oocytes and donor cells from the same animal" pdf

Danh mục: Báo cáo khoa học

... was obtained from autologous SCNT using oocytes and cumulus cells from the same pig than from SCNT using autologous follicular cells and heterologous skin fibroblasts (5 ± 2% and 10 ± 1%) There ... derived from autologous or heterologous donor cells (Experiment 3) For autologous somatic cell cloning, 1,243 immature oocytes were obtained from 40 pairs of ovaries (31.1 oocytes/pig) and cultured ... influence cell fusion in Table In vitro development of somatic cell nuclear transfer embryos derived from autologous or heterologous donor cells Type of donor cell Origin of donor cells Reconstruction...

Study of pharmacokinetics of prenylflavonoids and dynamics of estrogen action in sera following ingestion of epimedium using validated, ultra sensitive cell based bioassays

Danh mục: Cao đẳng - Đại học

... CA, USA) Illumina (San Diego, CA, USA) QIAGEN (Hilden, Germany) 52 2.2 Cell lines and cell culture HeLa cervical cancer cells and MCF-7 breast cancer cells were purchased and cultured as recommended ... ERα and ERβ cell- based bioassays 2.3.1 Establishment of ERα and ERβ stable cells (from Yap et al., 2005) Determination of LD90 of antibiotics in HeLa cells To successfully generate stable cell ... optimal cell plating density for ERα and ERβ cells was determined to be × 104 cells and 0.5 × 104 cells per well, respectively The optimal incubation period was 30 h for ERα or 24 h for ERβ cells...

Study of pharmacokinetics of prenylflavonoids and dynamics of estrogen action in sera following ingestion of epimedium using validated, ultra sensitive cell based bioassays 2

Danh mục: Cao đẳng - Đại học

... endpoint of estrogen action and also discrimination of agonists from antagonists Relative cell numbers were determined by Invitrogen’s CyQuant system and relative cell proliferation were expressed ... -13 -12 -11 -10 -9 -8 -7 -6 -5 -4 [ligand], M 98 3.1.6 Anti-estrogenic activities of SERMs and ER-antagonist in ERα and ERβ cell lines The ability of ERα and ERβ bioassays to detect anti-estrogenic ... steroid 89 3.1.3 Validation of ERα and ERβ cell- based bioassays The inter- and intra-assay variations of both ERα and ERβ bioassays, were determined by using 0.1 nM and 0.5 nM of estradiol, respectively...

Study of pharmacokinetics of prenylflavonoids and dynamics of estrogen action in sera following ingestion of epimedium using validated, ultra sensitive cell based bioassays 4

Danh mục: Cao đẳng - Đại học

... ERα and ERβ stable cell lines and MCF-7 breast cancer cells to detect estrogenic agonistic and antagonistic activities of mixtures was studied ERα and ERβ stable cells; and MCF-7 breast cancer cells ... MCF-7 cells Like ERα and ERβ cell- based bioassays, the MCF-7 cell proliferation assay also possesses the ability of being able to distinguish full agonists from partial agonists 191 Superagonism ... agonists Estriol and estrone are found to be full agonists like estradiol Interestingly, some compounds elicited superagonist effects Flavonoids like apigenin and genistein exhibited superagonist...

Study of pharmacokinetics of prenylflavonoids and dynamics of estrogen action in sera following ingestion of epimedium using validated, ultra sensitive cell based bioassays 5

Danh mục: Cao đẳng - Đại học

... Serum samples were obtained and assayed ex-vivo for levels of estrone and estradiol by tandem mass spectrometry, for ERα and ERβ bioactivity and MCF-7 breast cancer cell proliferative effects ... track serum levels and bioactivities of the many compounds, known and unknown, that exert pharmacological effects in both animal models and humans The development of these cell- based assays enabled ... ligands, such as icaritin found in Epimedium, which have been reported to be able to initiate the degradation of the ER and suppress estrogen signaling and proliferation of breast cancer cells...

Study of pharmacokinetics of prenylflavonoids and dynamics of estrogen action in sera following ingestion of epimedium using validated, ultra sensitive cell based bioassays 6

Danh mục: Cao đẳng - Đại học

... 27008–27016 Mak, P., Cruz, F.D and Chen, S 1999 A yeast screen system for aromatase inhibitors and ligands for androgen receptor: yeast cells transformed with aromatase and androgen receptor Environ ... and Gray, L.E Jr 2004 Development and Characterization of a Cell Line that Stably Expresses an Estrogen-Responsive Luciferase Reporter for the Detection of Estrogen Receptor Agonist and Antagonists ... Clemons, P A., Wei, R., Carr, S A., Lander, E S and Golub, T R 2006 The connectivity map: using gene-expression signatures to connect small molecules, genes, and disease Science 313: 1929-1935...

Sirtuin2 in the CNS expression, functional roles, action mechanism and mutation induced alteration of molecular cell biological properties

Danh mục: Cao đẳng - Đại học

... axons and oligodendrocytes in CNS (or Schwann cells in PNS) These interactions between neurons and oligodendrocytes on one hand affect proper differentiation and myelination of oligodendrocytes, and ... diversity of cellular functions, ranging from cell cycle regulation, cell differentiation and survival, cell metabolism and calorie restriction (CR) related anti-aging (reviewed in Haigis and Guarente, ... regulate CR and aging, cell survival, cell differentiation and metabolism (Anastasiou and Krek, 2006) Firstly, SIRT1 is a positive master controlling cell growth and survival Luo et al and Vaziri...

Ebook General, organic, and biological chemistry (5th edition) Part 1

Danh mục: Hóa học - Dầu khí

... shown? a M2ϩ and X3Ϫ (M3X2) b M2ϩ and XϪ (MX2) c Mϩ and X3Ϫ (MX3) d M2ϩ and X2Ϫ (MX) 4.103 The correct chemical formula for the ionic compound formed between Mg and O is a MgO b Mg2O2 c MgO2 d Mg2O ... chemical formula for, and the name of the compound formed from, each of the following pairs of ions 4.95 4.96 4.97 4.98 b Kϩ and NO3Ϫ a Naϩ and N3Ϫ c Mg2ϩ and O2Ϫ d NH4ϩ and PO43Ϫ Name each compound ... charge? b Cu2O and CuO a Co2O3 and CoCl3 d MgS and NaI c K2O and Al2O3 Name each compound in the following pairs of polyatomicion-containing compounds b Pb3(PO4)2 and Pb3(PO4)4 a CuNO3 and Cu(NO3)2...

Báo cáo y học: " Rationale for one stage exchange of infected hip replacement using uncemented implants and antibiotic impregnated bone graft"

Danh mục: Y học thưởng thức

... (SCV) of staphylococci and other pathogens may survive5 and even replicate6 intracellularily, in osteoblasts, endothelial cells and even in polymorphonuclear leukocytes and macrophages Such populations ... tobramycin and vancomycin polymethylmethacrylate beads and spacers from Simplex and Palacos Am J Orthop 1998;27(3):201-5 26 Masri B, Duncan C, Beauchamp C Long-term elution of antibiotics from bone-cement: ... Bergh K Cancellous bone as an antibiotic carrier Acta Orthop Scand 2000;71(1):80-4 31 Witso E, Persen L, Loseth K, Bergh K Adsorption and release of antibiotics from morselized cancellous bone...

1 UNFIRED BRICK USING FLY ASH AND RED MUD BASED ON GEOPOLYMER TECHNOLOGY

Danh mục: Kiến trúc - Xây dựng

... than Portland, typically ranging in size between 10 and 100 micron Therefore, fly ash is also a good mineral filler in hot mix asphalt (HMA) and improves the fluidity of flowable fill and grout ... Samples were prepared using red mud from Tan Binh Chemistry Factory and fly ash from Nhon Trach Dong Nai Power Station with ratio of red mud:fly ash was 20:80, 30:70, 40:60; 50:50 and 60:40 Fly ash ... that using ml alkaline activator/100g solid mixture is 120 kG/cm2 while compressive strength of specimens that using using 8, 9, 10 ml alkaline activator/100g solid mixture is 156, 158 and 158...

Municipal solid waste disposal by using metallurgical technologies and equipments

Danh mục: Môi trường

... coming from flame furnace and EAF steelmaking All the three technologies and equipments involved are respectively from steel rolling, coking, and steel making process in metallurgical industry, and ... of WP from HW of Shijingshan District, Beijing, and BC from Shougang Group, China The BC, WP1, and WP2 were crushed into 90-mesh by a universal crusher to be used as experimental sample And its ... single WP1 and BC where synergism occurs because different radicals from BC and WP interact with each other Additionally, the synergism of co-coking of WP1 and BC can increase oil and reducing...

Exergoeconomic optimization and improvement of a cogeneration system modeled in a process simulator using direct search and evolutionary methods

Danh mục: Môi trường

... OF is the same, and the process steam and process hot water demands are assumed constant Here, the larger problem OP11 is considered for both mathematical optimization and exergoeconomic improvement ... transfer, subscripts F and P indicate system fuel and system product, respectively, NK is the number of system components, and NP and NF are the numbers of system products and fuels, respectively ... or modified, n-D Powell’s method, and the efficient combined DSC-Powell 1-D search algorithm The n-D and 1-D algorithms are schematically described in Figures and 3, respectively Powell’s method...

Using Variables, Statements, and Operators

Danh mục: Quản trị mạng

... Understand the special NULL data type ■ Read GET and POST form input, and store it in variables ■ Perform calculations and comparisons using operators ■ Use and override operator precedence rules Embedding ... within the call to echo(), and they have been rendered by the browser in its output TEAM LinG CHAPTER 3: Using Variables, Statements, and Operators 65 Assigning and Using Variable Values To assign ... character, string, and Boolean types, and more complex arrays and objects Table 3-1 lists the four basic types, with examples: TEAM LinG CHAPTER 3: Using Variables, Statements, and Operators Data...

Module 2: Using Web Parts and Digital Dashboard Components

Danh mục: Chứng chỉ quốc tế

... controlled, and displayed by using the other property groups The content properties are Content, ContentLink, and ContentType 8 Module 2: Using Web Parts and Digital Dashboard Components Using the ... includes any title bar and any standard buttons that a digital dashboard includes in that title bar 20 Module 2: Using Web Parts and Digital Dashboard Components Using the Height and Width Properties ... Module 2: Using Web Parts and Digital Dashboard Components Overview Slide Objective To provide an overview of the module topics and objectives ! Understanding Web Parts Lead-in ! Using Web Part...

Using Local Variables and Creating Functions that Return Results

Danh mục: Kỹ thuật lập trình

... idealCircumstances:Boolean = buyCD(19, "Friday"); if(idealCircumstances == true){ gotoAndPlay("Happiness"); }else{ gotoAndPlay("StayHome"); } Pay particular attention to the line that reads: var idealCircumstances:Boolean ... this lesson have not made use of this syntax (they still work properly), using this syntax is considered good practice and should improve the speed of ActionScript execution The speed increase ... "News", channelNames[2] = "Classics", and so on This is important to understand as we progress NOTE For more information on arrays, see Lesson 6, "Creating and Manipulating Data." Let's create...

Lecture of using english letters and emails

Danh mục: Kỹ năng viết tiếng Anh

... (e.g.Dr/Professor /General) Yours sincerely C ẤU TRÚC CƠ B ẢN C ỦA EMAIL  Introduction:Email (electronic mail) - means of sending messages between computers Advantages: personal and easy to use; ... form  LAYOUT Header information: incluse C.c: This stands for carbon copies, which means much the same as it does on a letter b.c.c:This stands for blind carbon copies, which,as in a letter,you ... information IOW in other words NRN no reply necessary OTOH on the other hand M ỘT S Ố M ẪU CÂU C ẦN NH Ớ MAKE YOUR MAIL/EMAIL BE FORMAL AND CONVINCING Starting (M đ ầu) - We are writing to inform/confirm/request/enquire...

Tài liệu Learning DebianGNU Linux-Chapter 8.:Using Linux Applications and Clients docx

Danh mục: Hệ điều hành

... transitions and animation, HTML export, and templates Its drawing tools let you draw lines, curves, and shapes, and perform other operations, such as rotations and fills Presents can also import and ... /download) and issue the following commands: tar xvf so501_01.tar cd so501_inst /setup If you saved your tar file using a name other than so501_01.tar, you'll need to adapt the first and second commands ... functions Spreadsheets can import and export a variety of document types, including Lotus 1-2-3 (WKS, WK1, WK3, and WK4 files) and Microsoft Excel 3.0, 4.0, 5.0, 7.0/95, and 97 Figure 8.5: The Spreadsheets...

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gsea using general biochemical and cell biological categories from kegg transpath go and transfac