... the longer term prospectsofthe venture Additionally, it is often people working for such organizations that prioritize involving the recipients ofthetechnology in the process, by asking the ... synergistic results by combining the expertise and resources ofthe private partner withthe administrative and political power ofthe governmental partner They can take several forms, but are usually ... A further concern is the sustainability of such projects: if they not prove to be profitable forthe private partners, will they abandon the projects? Alternately, the projects provide for sufficient...
... generated where they are required bythe standards, and where they are necessary forthe control ofthe processes in the organization In addition to the requirements of ISO 9000, the code of GMP goes ... world-wide to standardize on their understanding ofthe implementation ofthe standards, and methods of assessing its implementation Therefore, the most cost effective and comprehensive solution for implementing ... assessment of suppliers capabilities to ensure the delivery of equipment or the design ofthe facilities in accordance withthe requirements ofthe code of GMP This may require the education of suppliers...
... Sciences, the National Academy of Engineering, andthe Institute of Medicine The members ofthe committee responsible forthe report were chosen for their special competences andwith regard for appropriate ... scientific and engineering research, dedicated to the furtherance of science andtechnologyand to their use forthe general welfare Upon the authority ofthe charter granted to it bythe Congress ... project and, when feasible, forthe development of hydropower under the auspices ofthe Bureau of Reclamation Merging the Plans ofthe Bureau andthe Corps The Pick–Sloan Plan was an amalgam of separate...
... summary feedback on the forecasts made by other experts, and then make a further forecast For a summary ofthe evidence on the accuracy of Delphi versus unstructured judgment, see Rowe and Wright (2001) ... amongst the decision makers (i.e New Zealand and foreign government trade officials), andthe effects ofthe outcomes of these negotiations could be large In this case, role playing or the use of ... investments andthe likelihood of large forecasting errors Forecasts are required at the different stages of product development to assist managers withthe go/no-go decisions and then in planning the...
... institutions and NHS Trusts in the North West of England The research team are responsible forthe content ofthe intervention and have worked with a design company to produce the toolkit and website The ... Page ofand their preferences for how this should be delivered, including format ofthe toolkit and type and amount of support required to use it Barriers and facilitators to using the toolkit and ... users informing them about the study and send them a copy ofthe relatives’ information sheet with a covering letter asking them to pass this to any relatives that they would be happy for us to...
... mutants, and performed experiments and contributed to the writing ofthe manuscript XJY designed, coordinated the study, and contributed to the writing ofthe manuscript All authors read and approved ... along with forward (5’-tac tga cgc tct cgc acc-3’) and reverse (5’-tct cga cgc agg act cg-3’) primers targeted to the 5’ end ofthe LTR and Gag region ofthe HIV-1 Bru genome [29] The optimized thermal ... and detected by WB withthe same antibody Protein bands in each fraction were further quantified withthe software Quantity One (Bio-Rad), andthe values are expressed as a percentage of chromatin-bound...
... in the proof-reading and formatting of this thesis as well as forthe IT support For friends like Angela, Andy, Jonathan, forthe special moments especially when the going gets tough Andfor ... exchange rates On the other hand, the potential for risk-sharing within a single currency area seem to remain In sum, despite the shortcomings ofthe early theory ofthe OCA, the theory has however ... discuss the new additions and perspectives to the original Theory ofthe OCA 2.3 ‘NEW’ THEORY OFTHE OPTIMUM CURRENCY AREAS This section clarifies the other motivations behind the emergence of real...
... hypothesis of Tytler et al [48], it may be that insertion ofthe inverted wedge shape formed bythe AP1 a-helix into membranes of E coli leads to the formation of nonbilayer structures and thereby ... that, in the absence of AP1, values for a and DH are negative for these model membranes, but, in the presence ofthe peptide, they are positive These results conrm that E coli membranes are thermodynamically ... pressure ofthe monolayer, and A represents the area per molecule in the monolayer The Gibbs free energy of mixing (DGMix) quanties the stability of monolayer mixtures, thereby providing information...
... investigated the substrate specificity of these Gaq Q209E-specific antibodies for other key members of Ga subunits, including Gas, Gai and Ga13 The antibodies recognized all the deamidated forms of Ga ... pathways by deamidating Gai2, Gai1 and Gaq Although the deamidation of Gai2 by PMT was identified by MS [16], that of Gai1 and Gaq was only supported by indirect evidence, such as the alteration of ... accordance withthe manufacturer’s instructions The cells were incubated at 37 °C for h after treatment withthe toxins, and lysed by incubation in 200 lLÆwell)1 of 0.1 m formic acid for 20 at...
... conversion andthe pK2 ofthe sulfonephthalein mediator It can be argued that at the reaction pH of 5.0, the lower the pK2 ofthe mediator, the easier it is for laccase to oxidize it, as the fraction of ... range of pK values forthe dissociation of their phenolic moiety, and that the oxidation potential of phenols is modulated by solution pH (at pH < pK) [29], led us to expand on the subject of phenol ... whether there was any pH dependence ofthe Ep of sulfonephthaleins, and, if any, whether it proceeded in the same direction as the pH dependence ofthe sulfonephthalein mediators in Table By...
... differences in the isoforms: DC/NK or NK/tumor cross-talk induces IL-10 withthe NKp30c isoform and IFNg with isoforms NKp30a and NKp30b Clustering ofthe NKp30 transcriptional profiles could be ... prepared the manuscript PK, VS, PC and EJ co-organized the meeting and critically reviewed the manuscript TG and FM reviewed the manuscript, are officers ofthe Society for Immunotherapy, and serve ... a new hypothesis in which the expression of IDO and PD-L1, andthe accumulation of Tregs, is dependent upon the infiltration of CD8+ T cells in the tumor site These might be induced by specific...
... psychologists (of who two are also co-authors of this paper) All ofthe panel members were working at the Eating Disorder Unit at the time ofthe study The expert carers (four mothers of daughters with ... subscale scores ofthe final version ofthe EDSIS andthe general aspects of caregiving (ECI), psychological distress (GHQ-12) andthe global severity ofthe illness perceived bythe carer (CGAS), ... between 0.74 and 0.91 [31]) The reliability ofthe ECI was also estimated in our study: Cronbach's alpha was 0.93 forthe total scale (66 items), 0.85 forthe Positive scale and 0.94 forthe Negative...
... differences in the isoforms: DC/NK or NK/tumor cross-talk induces IL-10 withthe NKp30c isoform and IFNg with isoforms NKp30a and NKp30b Clustering ofthe NKp30 transcriptional profiles could be ... prepared the manuscript PK, VS, PC and EJ co-organized the meeting and critically reviewed the manuscript TG and FM reviewed the manuscript, are officers ofthe Society for Immunotherapy, and serve ... a new hypothesis in which the expression of IDO and PD-L1, andthe accumulation of Tregs, is dependent upon the infiltration of CD8+ T cells in the tumor site These might be induced by specific...
... immunoreactivity of both iNOS and nNOS in the same lesion Materials and Methods Selection of cases Two cases of goats with natural listeriosis (6 months old and 2.5 years old) (Cases and 2) and two controls ... is the first study of NOS expression in the goat brain with listeriosis The involvement of iNOS in bovine and caprine listeriosis has been reported previously, andthe increased expression of ... found in the neuronal processes Both nNOS and iNOS immunoreactivity were found in a proportion ofthe neurons in the brainstem andthe staining pattern was similar to those of control brains with...
... responses to the influenza virus DNA vaccine withthe PMED approach [20] Another approach forthe delivery of DNA vaccines is the use of needle-free devices Needle-free injection of DNA Page of (page ... used in the manufacturing of certain alcoholic beverages The recovery process then requires lysis ofthe cells, in order to release the plasmid retained within the E coli cells DNA is then purified ... the brain of infected animals and humans Prior to approval of a vaccine, approximately one-third ofthe horses infected with WNV would die or be euthanized The WNV DNA vaccine, developed by Fort...
... 2004, and that recruitment in PROGRESS in many countries was largely completed bythe end of 2004 Therefore, the SSC guidelines existed for only a small portion ofthe study duration, and thus the ... ofthe PROGRESS Registry andthe US had twice the number of patients treated with DrotAA as the next highest country (Canada) Enrollment numbers did not correlate with DrotAA use The effect of ... chi-squared test Due to the nonrandomized nature ofthe study, baseline imbalances between patients withand without DrotAA therapy existed, therefore an adjusted mortality analysis was performed using...
... instructed, for example, the grammatical function, the unpredictable change of form in certain grammatical context, the regularity and irregularity, the singular and plural forms ofthe new word Therefore, ... graduated from universities of foreign languages and five of them have Master degree, andthe other five are taking MA courses Among them, there were males, and 17 females Half ofthe teachers have experienced ... Put the oil filler cap on Put back the dipstick Clean the spark plug Switch off the engine Take out the dipstick Clean the oil off the dipstick Replace the spark plug in the socket Take off the...
... being customised withthe names ofthe competing teams and decorated with colours and symbolism reflecting the culture ofthe host nation 12 Thejudgementof fitness for purpose ofthe most modern ... inflated with air and encased in a leather cover was in standard use The laws ofthe game specified the weight and size limits ofthe balls to be manufactured and used Although the nature ofthe game ... many ofthe problems associated with previous designs The spherical cover ofthe soccer ball was traditionally formed by hand stitching flat panels of leather together and inserting the bladder for...
... congestion costs is given by: where c is the elasticity of demand for trips and c is the private cost of travel For a discussion ofthe sources and effects of air and noise pollution by passenger cars, ... wealth for risk of serious injury to the marginal rate of substitution of wealth for risk of death ofthe value of 0.1 17 This ratio must be multiplied bythe value of statistical dcath (excl of ... level Furthermore they mention the possibility that the unit percentage of depreciation increases both withthe noise level andwiththe value ofthe house In this paper, a standardized value of BF...
... density contours forthe autoterms of chirplets are defined mathematically by ellipsoids The direction and length ofthe principle axes are functions ofthe chirp rate andthe time spread These axes ... required for optimization as well as improves the robustness ofthe estimation The number of components can also be set equal to the number of peaks found in the Radon transformation, and then adjusting ... Based on the superposition property, the Radon transform will show peaks at values of θ corresponding to the axes orientations of each ofthe ellipsoids In order to exclude the effect ofthe interference...