geranylgeranylated rhob mediates the apoptotic and antineoplastic effects of farnesyltransferase inhibitors new insights into cancer cell suicide
Báo cáo Y học: A novel gain-of-function mutation of the integrin a2 VWFA domain docx
... noncollagenous ligands but does not form part of the ligand binding site In addition to the effects on ligand binding, the mutation also affected the use of cations by the ligand binding site Although the ... between the MIDAS and the JA208 epitope [9], while JA202 and Gi9 inhibited ligand binding The JA203 data further demonstrate the importance of the helix a3 region in a2 VWFA domain function The E318W ... shown that the ligand binding function of the aL and aM VWFA domains can be modulated by controlling the conformational state of the domain The majority of approaches have directly targeted the a7...
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Some aspects of American culture and society in the twentieth and twenty-first centuries through a number of selected short literary works
... the differences in the behaviors and attitudes of the grandmother, the father and the mother and the children at least cause discontent to one another The grandmother held the floor most of the ... with plot, theme, point of view, character and setting Technique has to with the structuring of the story into the plot so that the writer can convey the theme and the manipulating of the language ... is the outsider of the events and describes from the points of view of one character in the story.) - Theme is the message of the story that the author wants to send to readers The message is often...
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Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx
... identify individuals with mild disease, thereby providing the missing data The phenotype of XLA and the potential of BTK and ITK inhibitors The outcome of defective BTK signaling in humans has ... onethird of all mutations in the BTK gene are missense and some of these reduce the stability of the protein This is exemplified by mutations in the BTK motif of the Tec homology (TH) domain [18] ... transcription of the ITK gene and is key for the productive infection of HIV in these cells Accordingly, the inhibition of ITK activity compromises HIV infection, gene expression and replication...
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báo cáo khoa học: " pax1-1 partially suppresses gain-of-function mutations in Arabidopsis AXR3/IAA17" pdf
... from the F2 of the cross To verify that these plants were homozygous for the wild-type ER allele, they were backcrossed to shy2-2 (Ler) and the F1 generation was scored for the absence of the ... plates and then transferred after days, to new plates supplemented with IAA The position of each root tip was marked and after a further days, the amount of new root growth was measured To test the ... (ventral) surfaces, and the transition from the juvenile to the adult phase of vegetative development is marked by the onset of trichome production on the abaxial surfaces of the leaves [46] Under...
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Báo cáo khoa học: The transcription factor ZBP-89 suppresses p16 expression through a histone modification mechanism to affect cell senescence doc
... ZBP-89 expression in the human lung cancer cell line NCI-H460 Western blots verified the exogenous expression of the ZBP-89 vector (Fig 1A), and the efficiency of inhibition of ZBP-89 expression ... coexistence of HDAC3 and ZBP-89 in the same complex (Fig 4B) further supports this notion, and the data in Fig 5A,D show that knockdown of ZBP-89 failed to decrease the binding of HDAC4 to the p16 ... the details of the regulatory mechanisms of ZBP-89 Experimental procedures Cell culture, transfection, and luciferase reporter assay The human lung cancer cell line NCI-H460 and the human embryonic...
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Báo cáo hóa học: " Existence results for a class of nonlocal problems involving p-Laplacian" pot
... hypotheses (F3), (F4) and (F5) and (1.2) are clearly satisfied Proofs of the theorems Let us start by considering the functional J : W1,p(Ω) ® R given by J(u) = M p |∇u|p dx − F(x, u)dx Proof of ... W1,p(Ω), Therefore, problem (1.1) has at least three distinct solutions in W1,p(Ω) □ Proof of Theorem 2.2 We divide the proof into several lemmas Lemma 3.3 If condition (F3) and (F5) hold, then J|Wcis ... with the proof of Lemma 3.1, we know that J satisfied the (C) condition □ Sum up the above fact, from Lemma 2.4 and Remark 2.1, Theorem 2.2 follows from the Lemma 3.3 to 3.5 Acknowledgements The...
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CHARACTERIZATION OF INHIBITORS OF ALDEHYDE DEHYDROGENASE 2 IDENTIFIED THROUGH A HIGH-THROUGHPUT DOCKING APPROACH
... and activity of ALDH isozymes are found in many human cancers and are often associated with poor prognosis (95, 96) Therefore, the development of inhibitors of the different ALDH enzymes is of ... cyclophosphamide in cancer cells (6) The roles played by the different ALDH isozymes in disease states continue to develop and the need for the development of selective inhibitors of the individual ... describe the results of assays designed to characterize the site of interaction and the mode of inhibition for the unique compounds that function as inhibitors of aldehyde dehydrogenase and determine...
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Báo cáo y học: "Gain of a 500-fold sensitivity on an intravital MR Contrast Agent based on an endohedral Gadolinium-Cluster-Fullerene-Conjugate: A new chance in cancer diagnostics"
... membranes and their use is restricted to the blood stream and the interstitial space The use of transfection agents facilitating the passage of Gd-containing endofullerenes across the cell membrane into ... appended to the C-termini of the NLS and the CPP peptides for disulfide bond formation between these modules This enables the intracellular enzymatic cleavage and dissociation of the CPP from the NLS ... NLS immediately after the passage into the cytoplasm For the reaction the SH-groups of the CPP-Cys and of the tetrazine-NLS-Cys address module 12 were oxidized in the range of mg × ml-1 in a 20%...
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Tài liệu Báo cáo khoa học: C-Terminal extension of a plant cysteine protease modulates proteolytic activity through a partial inhibitory mechanism doc
... [15] Sequencing of the cDNA (from mRNA) of Erv-C from the leaf of the plant in our laboratory [16], and comparison of the cDNA-derived amino acid sequence with other members of the family reveal ... used the clone of Erv-C which was constructed from the cDNA (mRNA) of the leaf of the plant [16] and the deletion mutant of that has been generated by eliminating the last 24 amino acids at the ... an isoform of ErvC which is present in the latex of the plant Materials and methods vector [16] A fragment of the original cDNA encoding the prodomain, the mature domain and CT-extension of Erv-C...
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Tài liệu Controlling Fine Particulate Matter Under the Clean Air Act: A Menu of Options pdf
... arsenic, mercury, and a host of others Furthermore, the Act divides responsibility for various types of sources and air pollutants between the states and localities on the one hand, and the federal ... Manufacturing The largest source of emissions in cement manufacturing— and the centerpiece of the process—is the kiln Cement kilns generate over 40 percent of the PM emissions and more than 80 percent of ... manufacturing Among other things, the rules require the enclosure of many parts of the cement manufacturing operation, and mandate the ventilation of enclosed areas to a control system Iron and Steel Coke...
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Tài liệu Báo cáo Y học: Enhancement by a-tocopheryl hemisuccinate of nitric oxide production induced by lypopolysaccharide and interferon-c through the upregulation of protein kinase C in rat vascular smooth muscle cells docx
... LPS, we examined the effects of inhibitors of PKA and PKC on TS-enhanced NO production As shown in Fig 5A, the PKA inhibitors KT-5720 and H8 and the PKC inhibitors Ro31-2880 and GF109203X did ... degrees of inhibition of NO production with Ro31-2880 and GF109203X were approximately 70 and 30%, respectively Effects of TS on the amount of PKCa We further examined the effects of TS on the amounts ... compared the effects of a-T and its derivatives TA and TN with that of TS on LPS/IFN-induced NO production The additions of a-T, TA and TN did not induce NO production in the absence of LPS/IFN,...
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Tài liệu Playing through: A Guide to the Unwritten Rules of Golf potx
... Matter 12 “You’re Out!” and Other Intricacies of Golf Attire 25 Respect the Course 36 Carts and Greens and Traps and Water 47 Where to Stand: The Theory of the “X” 57 The Biggest Frustration ... going to help them In this situation, we’ll wait until we’re on the tee and they’re on the green of the hole behind us, and then get their attention and explain the situation Typically, they’ll appreciate ... your children and grandchildren awareness of others The golfer whom others remember fondly is the golfer who is considerate of how his actions affect others’ enjoyment of the game and knows how...
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Đề tài " Approximating a bandlimited function using very coarsely quantized data: A family of stable sigma-delta modulators of arbitrary order " pptx
... DAUBECHIES AND RON DEVORE For j > we use Mj ≤ (2 − α)Mj and Mj−1 ≥ αMj−1 to upper bound the right-hand side of (40), and we replace the various κs and Ms by their definitions; then we see that the equation ... From the definition of ν one easily checks that this is indeed the case, completing the proof We are now ready to state and prove our general lemmas, used in the induction argument of the proof of ... before, that the proof of a uniform bound (J) for the |un | in the n > recursion simultaneously provides the same uniform (J) bound for the |un | in the n < recursion We then have the following...
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THE EFFECTS OF MEGAMERGERS ON EFFICIENCY AND PRICES: EVIDENCE FROM A BANK PROFIT FUNCTION docx
... small, The loan and deposit price changes tend to offset each other in their effects on profits, and the profit effects from price changes are almost immeasurably small relative to the profit effects ... about the data set IV The Profit Efficiency Effects of Megamer~ers The Level of Profit Efficiency We begin discussing the results with some information on the levels of profit efficiency of merging ... bank by assigning the most extreme 5% at the top and bottom of the distribution to the 95th and 5th percentage points, respectively, to further reduce the effects of random error The Me~amer~er...
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Báo cáo khoa học: Emergence of a subfamily of xylanase inhibitors within glycoside hydrolase family 18 pdf
... shown in Fig The increase of RU from the baseline represents the binding of the xylanase to the surface-bound inhibitor The plateau line represents the steadystate ⁄ equilibrium phase of the XYNC–inhibitor ... inhibition specificity [4,5] The presence of xylanase inhibitor in rice is not surprising as hemicellulose in the cell walls of rice cells is composed mainly of arabinoxylan [16] and the ability to degrade ... between the two proteins XIP-I a7 helix (232–245) interacts with the loops forming the xylanase groove; side chains emerging from the helix point into the heart of the cleft and occupy the four...
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Báo cáo khoa học: The oxidative effect of bacterial lipopolysaccharide on native and cross-linked human hemoglobin as a function of the structure of the lipopolysaccharide A comparison of the effects of smooth and rough lipopolysaccharide ppt
... comparison of the effects of rough and smooth LPSs of E coli, both in the presence and absence of EDTA (Fig 1) The rate of oxidation was increased in the presence of the LPSs of both the smooth and ... effects of the LPSs of rough and smooth E coli on the oxidation of Hb A0, both in the presence and absence of EDTA, is provided in Fig The rate of oxidation was increased in the presence of the ... measure of the rate of oxidation of oxyHb RESULTS The effect of pH on the auto-oxidation of cross-linked Hb was studied The rate of decrease of the concentration of oxyHb increased as the pH was...
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Báo cáo khoa học: Macrocypins, a family of cysteine protease inhibitors from the basidiomycete Macrolepiota procera pot
... coli, and the NH2-MGFE sequence of rMcp1 favours only partial cleavage The far-UV CD spectra of rMcp1 and rMcp4 confirmed the expectation from the sequences that the conformations of the inhibitors ... suggesting that they belong to the same family of cysteine protease inhibitors, the mycocypins, thus substantiating the establishment of the I48 family of protease inhibitors in the MEROPS classification ... NdeI and BamHI restriction sites to the 5¢ and 3¢ ends of the insert, respectively After resequencing the resulting product, and digesting the inserts and vectors with NdeI ⁄ BamHI (New England...
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Báo cáo khoa học: Efficient synthesis of a disulfide-containing protein through a batch cell-free system from wheat germ pdf
... PDI on the active fraction of the scFv The enzyme was added in the DTT-deficient synthesis solution after h translation, and the reaction was further continued for the same number of hours The soluble ... 3¢-untranslated region The initiation codon and the stop codon were introduced by the PCR primers (s1 and a1) (B) Incorporation of [14C]Leu into polypeptides during the cell- free translation of the scFvLH ... conditions for the cell- free synthesis of the active disulfide-containing scFv Materials and methods Materials The gene encoding the scFv fragment of the Se155–4 IgG antibody, in the orientation...
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synthesis and growth of hematite nanodiscs through a facile hydrothermal approach
... adsorption of CO and/ or O2 molecules and then reduce the catalytic ability On the other hand, the residues from PVP decomposition in the heating process might also affect the catalytic property of nanoparticles ... radius 1.8 A) and thereby stabilize the bonding within the surface plane The selective surface effect of Cl- anion could finally affect the morphology and size of particles Similar effects have ... discussed in the following context pH The hydrolysis of Fe3? ions is closely related to the pH of the solution The pH is normally adjusted by addition of acid or base Here the effect of pH on particle...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ mở máy động cơ lồng sóc hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25