genetic basis of biological sexuality
Báo cáo y học: "Genetic polymorphism of p53, but not GSTP1, is association with susceptibility to esophageal cancer risk – A Meta-Analysis"
Ngày tải lên :
25/10/2012, 11:40
... reached a consensus on all
of the items. Data extracted from these articles in-
cluded the first author’s name, year of publication,
country of origin, ethnicity, number of cases and con-
trols, ... power of the selected studies by using
the DSTPLAN4.2 software, in order to assess the
probability of detecting an association between
RANTES polymorphisms and asthma at the 0.05 level
of significance, ... located in epithelial cell of the mouth
throat or lungs and adenocarcinoma is composed of
cells of glandular tissue. Over the past 5 decades,
many changes in the prevalence of esophageal cancer...
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The Emergence of Biological Value
Ngày tải lên :
01/11/2013, 08:20
... it is often claimed (e.g., Depew and Weber 1998) that the nor-
mativity of biological functions can be fully naturalized in terms of Wright’s
(1998) analysis, in which a function is a part of a ... sense.
Of course, science often looks to history to explain how the present state
of a system came into being, but the present causal powers of a system
must nevertheless be explicable in terms of ... stability of the oscillator.
This dynamical interpretation of semantic information provides us with a
new physical picture of the cognitive component of adaptive functional
action.
Most, if not all, of...
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Tài liệu Báo cáo khoa học: Molecular basis of glyphosate resistance – different approaches through protein engineering doc
Ngày tải lên :
14/02/2014, 14:20
... molecular mode of action of glypho-
sate and the molecular basis for glyphosate resistance.
Structure and function of EPSPS
EPSPS catalyzes the transfer of the enolpyruvyl moiety
of phosphoenolpyruvate ... 4% of the
total soluble protein content of the cell [48].
Fig. 3. Microbial mechanisms of glyphosate
degradation. (A) Two principal pathways of
glyphosate degradation are known.
Top: cleavage of ... however, was devoid of substrate or inhibitor,
and consequently did not reveal the nature of the
active site or the mode of action of glyphosate. A dec-
ade later, the crystal structure of EPSPS was...
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Tài liệu Handbook of Clinical Sexuality for Mental Health Professionals docx
Ngày tải lên :
15/02/2014, 02:20
... have a high prevalence of sexual dysfunction,
some of which is medication-induced, some of which is illness-induced, and some of which is
simply part of the difficulties of living.
4. El-Defrawi, ... my partner? How
Handbook of Clinical Sexuality for Mental Health
Professionals
Jeffrey W.Janata, PhD is Assistant Professor in the Department of Psychiatry and
Director of the Behavioral Medicine ... of the Department of Forensic
Medicine in the University of Ulm in Germany
S.Michael Plaut, PhD is Assistant Dean for Student Affairs and Associate Professor of
Psychiatry at the University of...
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Tài liệu Báo cáo khoa học: EGF receptor in relation to tumor development: molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors docx
Ngày tải lên :
16/02/2014, 09:20
... phos-
phorylation state of their proteins, thereby changing
the amount and localization of Bcl-2 family members.
However, each type of cancer has its own way of
disrupting the balance of the networks of signaling
cascades ... with stimulation of ERK1 ⁄ 2 and
Pak1 pathways, gefitinib might lead to inhibition of
invasiveness of human cancer cells through the inhibi-
tion of ERK1 ⁄ 2 and Pak1. The use of gefitinib in cells
with ... inhibi-
tion of Akt- and ERK1 ⁄ 2-dependent pathways eventu-
ally change the expression level of one or more of
these Bcl-2 family members.
Bad
Bad is one of the ‘death-promoting’ members of the
Bcl-2...
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Tài liệu Báo cáo khoa học: Basis of recognition between the NarJ chaperone and the N-terminus of the NarG subunit from Escherichia coli nitrate reductase pdf
Ngày tải lên :
16/02/2014, 14:20
... centre of geometry of the NarG(1–15) peptide. Only
the best structures of each of the 10 best clusters are depicted
(
HADDOCK score). Surface residues of NarJT in brown form the
bottom of the ... the
complex by 10-fold, as judged by k
off
. The physiological
chaperone cycle probably consists of the rapid binding
of the N-terminus of the partner, regardless of whether
it is a twin-arginine signal ... completion of the
maturation process of the partner. The nature of the
signal that may trigger dissociation of the complex
remains unclear; however, we propose that a local
perturbation of the hydrogen...
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Tài liệu The Basis of Early Christian Theism ppt
Ngày tải lên :
21/02/2014, 08:20
... not of certainty, but of mere opinion.
And this estimate of the function of philosophy with respect to theological truth, which the Fathers worked
out on the basis of the concrete example of the ... the truth, but each only from one point of view, and on the basis of only one
method of approach. The conclusions of each were the result of a process of more or less complete
abstraction, and ... scholar of the Church University Board of Regents from July, 1895, to the
present time.
End of the Project Gutenberg EBook of The Basis of Early Christian Theism, by Lawrence Thomas Cole
*** END OF...
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Tài liệu Mesoscopic Model for Mechanical Characterization of Biological Protein Materials docx
Ngày tải lên :
22/02/2014, 08:20
... may affect the
estimation of Young’s modulus of biological fibers.
10
Further, for validation of our
computational model for biological protein materials consisting of protein crystals, as
shown ... illustration of biological protein materials composed of protein
crystals. (a) cartoon of a fiber, made of protein crystals, under mechanical loading. (b)
protein crystal lattices constituting the biological ... degree -of- fold, Q, is responsible for high yield stress of biological protein
materials through breakage of hydrogen bond of β-sheet structural motif.
For deeper understanding the role of native...
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Molecular Basis of Pulmonary Disease Insights from Rare Lung Disorders pdf
Ngày tải lên :
05/03/2014, 23:20
... the
occurrence of an outcome of interest. This might be a study of time until disease pro-
gression or overall survival. In these types of study designs, it is the person-years of
follow-up that ... Panos
When you hear hoofbeats behind you, don’t expect to see a zebra.
Theodore E. Woodward, MD, University of Maryland, Circa 1950 (1)
Abstract The National Institutes of Health Of ce of Rare Diseases ... there are many different types of study designs; some of which require only
a fraction of the number of subjects required to the randomized controlled trial, which
is often considered the gold standard.
Alternate...
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GENOMIC DISORDERS The Genomic Basis of Disease doc
Ngày tải lên :
05/03/2014, 23:20
... started his PHD on genetics of Alzheimer
disease, but because the families were still being sampled, he initially spent a lot of effort in
22 Part II / Genomic Structure
0.1% of human genetic disease, ... typical integration
is then finished off by the formation of a second-strand nick and integration of the end of the
cDNA (Fig. 2A). However, significant portions of the events appear to complete ... genomic
rearrangements.
Most of the Alu–Alu recombination events are between nearby elements, generally spanning
distances of less than 50 kb and often only a few kb in length. There are also a number of cases
of chromosomal...
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Báo cáo khoa học: Protein–protein interactions and selection: generation of molecule-binding proteins on the basis of tertiary structural information potx
Ngày tải lên :
06/03/2014, 11:20
... different species [23–25]. The success of the series of
studies shows that the stable framework structure of
Fv enables the transfer of function by means of CDR
replacement.
Barbas et al. first ... the
CDR loop of the single variable heavy chain of a
heavy-chain camel antibody (VHH) (Fig. 1B) by com-
paring topologies between VHH and NCS (Fig. 2A);
grafting of the CDR 3 loop of antilysozyme ... sequence of charyb-
dotoxin with one of toxin a to express a new binding
function. Comparison of the X-ray crystal structures
between charybdotoxin and toxin a showed the struc-
tural resemblance of...
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GENETIC MANIPULATION OF DNA AND PROTEIN – EXAMPLES FROM CURRENT RESEARCH pptx
Ngày tải lên :
06/03/2014, 23:20
... characterizations
of the mutant forms of the Tus protein, many aspects of the mechanism of replication fork
arrest at Tus-Ter complexes have been determined. This and a brief description of the
current ... is a problem word in genetics for some people. This volume has another
purpose - to be accessible to those who fear the power of genetics. Those of us who
know modern genetics understand that ... complete understanding of genetics, humankind will reach an important new
stage. Humans will be able to change their own genes. Of course, evolution will
continue to be an agent of genetic change;...
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Báo cáo khoa học: Molecular basis of perinatal hypophosphatasia with tissue-nonspecific alkaline phosphatase bearing a conservative replacement of valine by alanine at position 406 Structural importance of the crown domain potx
Ngày tải lên :
07/03/2014, 05:20
... Left lane:
14
C-methylated protein markers of 200, 97.5, 66, 46 and 30 kDa, from the top of
the gel.
N. Numa et al. Molecular basis of perinatal form of hypophosphatasia
FEBS Journal 275 (2008) ... gel.
Molecular basis of perinatal form of hypophosphatasia N. Numa et al.
2730 FEBS Journal 275 (2008) 2727–2737 ª 2008 The Authors Journal compilation ª 2008 FEBS
Molecular basis of perinatal ... GPI-anchorless soluble
version of the mutant protein. The K
cat
⁄ K
m
value of
the mutant TNSALP was less than one-tenth of the
K
cat
⁄ K
m
value of the soluble form of the wild-type
enzyme, indicating...
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