genes disc1 pacap trap1 and dysbindin in major psychiatric disorders such as schizophrenia depression and bipolar disease
Báo cáo khoa học: Temporal expression of heat shock genes during cold stress and recovery from chill coma in adult Drosophila melanogaster pdf
... by Chown and Terblanche [26] Within certain limits, these physiological injuries are reversible As previously noted in D melanogaster [27], when the cold stress period is increased, the associated ... role in cold tolerance Hsp22 is a key player in cell protection against oxidative injuries [42], a typical feature of chilling injury [43] In addition, sHsps are effective in preserving the integrity ... (Australian east coast, 1733ÂS) in May 2008 Flies were maintained in 250 mL bottles for 15 generations at 19 C and 70% relative humidity under continuous light on a medium that contained yeast (3.2%...
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Báo cáo khoa học: Transcript profiling reveals diverse roles of auxin-responsive genes during reproductive development and abiotic stress in rice pdf
... crosstalk between auxin and other plant hormones [21–24] Our study also shows that genes involved in cytokinin (e.g cytokinin-Oglucosyltransferase, cytokinin dehydrogenase, and response regulators), ... 1-aminocyclopropane-1-carboxy3150 late oxidase, and 1-aminocyclopropane-1-carboxylate synthase) and gibberellin (e.g gibberellin receptor, gibberellin-20-oxidase, and gibberellin-2b-dioxygenase) ... AFBs) as auxin receptors has been a milestone in our understanding of the molecular mechanisms of auxin signaling pathways These F-box proteins are components of E3 ligase and target Aux ⁄ IAAs, in...
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Báo cáo hóa học: " Functional polymorphisms in genes of the Angiotensin and Serotonin systems and risk of hypertrophic " ppt
... The beta-myosin heavy chain (MYH7), cardiac troponin T (TNNT2), alpha-tropomyosin (TPM1), cardiac troponin I (TNNI3), and myosin binding protein C3 (MYBPC3) genes were sequenced as reported [29,30] ... non-coding RNAs that bind to sequences in the 3' UTRs of mRNAs by complementary base-pairing, and repress mRNA post-transcriptionally The + 1166 C-allele determines the interruption of the base-pairing ... ONTARGET/TRANSCEND Investigators Effects of telmisartan, ramipril, and their combination on left ventricular hypertrophy in individuals at high vascular risk in the Ongoing Telmisartan Alone and in Combination...
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báo cáo hóa học:" Substitutions in the Reverse Transcriptase and Protease Genes of HIV-1 Subtype B in Untreated Individuals and Patients Treated With Antiretroviral Drugs" potx
... a uracil as a result of the deamination of a cytosine, leading to the inclusion of an adenosine instead of guanosine in positive-stranded cDNA This results in mutant viruses that contain several ... they appear alone, such as K20R and V32I in PR and D67N and G333A in RT Other mutations resulting from GA transitions may occur rarely, such as V82T (the preferred mutation in this position is ... of substitutions in RT and PR while excluding codons known to be associated with drug resistance Again, we observed a decrease in prevalence of GA transitions and even an increased prevalence...
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Báo cáo y học: "An open pilot study of zonisamide augmentation in major depressive patients not responding to a low dose trial with duloxetine: preliminary results on tolerability and clinical effects" ppsx
... N-methyl-D-aspartate glutamatergic transmission as well as changes in the activity of crucial neurotransmitters involved in the pathophysiology of depression, including dopamine and serotonin [11-13] ... Otani K, Fukushima Y: Carbamazepine and zonisamide increase extracellular dopamine and serotonin levels in vivo, and carbamazepine does not antagonize adenosine effect in vitro: mechanisms of blockade ... HAM-A, ASEX and YMRS from baseline to week 12 and to week 24 in final responders and final nonresponders ASEX = Arizona Sexual Experience Scale; HAM-A = Hamilton Anxiety Scale; HAM-D = Hamilton Depression...
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báo cáo khoa học: " Analysis of anther transcriptomes to identify genes contributing to meiosis and male gametophyte development in rice" pptx
... components included those involved in calcium-mediated signaling, e.g calcium dependent protein kinases, caleosins and other proteins containing C2 domain and EF hands Genes involved in secondary ... analysis involving comparison of adjacent stages revealed an interesting pattern showing a steady and significant increase in the number of genes activating in post-meiotic stages (i.e., in SCP and ... percentage in individual functional categories has been highlighted to facilitate better visual interpretation of the data (Table 2) Genes involved in protein metabolism, involving folding, sorting and...
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Báo cáo y học: " Brain size and brain/intracranial volume ratio in major mental illness" doc
... illness As of the date of this writing, a Medline search combining CT, brain and schizophrenia retrieve 443 publications, and brain, schizophrenia, and MRI return 1152 publications In the case of bipolar ... difficulties estimating the volume of radiolucent CSF (e.g in the sulci) A review of 50 CT studies in schizophrenia reported inconsistency (and diminution) of findings over time, and the interesting observation ... bipolar disorder and manic depressive disorder, CT, and brain return 70 publications, and with MRI instead of CT, 228 Salient is the development of major data bases such as the ‘Internet Brain...
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Báo cáo y học: " Efficacy, safety and tolerability of escitalopram in doses up to 50 mg in Major Depressive Disorder (MDD): an open-label, pilot study" doc
... increasing interference from the R-enantiomer [4] Escitalopram, uniquely among the SSRIs, potentiates its own binding, raising the possibility of increasing effect with increasing doses [5] In ... ≤8 and staying at ≤8), sustained remission (reaching a MADRS score of ≤8 and staying at ≤12) and response (achieving a 50% decrease in MADRS from baseline MADRS score), mean changes in the MADRS ... supervising physician The investigation was conducted in accordance with the Declaration of Helsinki and Good Clinical Practice guidelines although a non-conformance in the medication packaging was...
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báo cáo khoa học: " PR genes of apple: identification and expression in response to elicitors and inoculation with Erwinia amylovora" doc
... PR-5 and PR-8 was not induced in either mock-inoculated or P syringae-inoculated apple shoots (Fig 4) PR-1a is not induced in response to inoculation with E amylovora In contrast to the robust induction ... PR-5 and PR8, PR-1a was not induced during the first 96 hours following inoculation of young apple shoots with E amylovora Ea273 In addition, PR-1a was not induced in tissues in Table 2: In- silico ... demonstrated resistance to fire blight in 2-year-old greenhouse-grown apple trees and increased chitinase and glucanase activity in apple seedlings following treatment with ASM at 200 mg AI per liter [14]...
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Báo cáo khoa học: "Tumor slices as a model to evaluate doxorubicin in vitro treatment and expression of trios of genes PRSS11, MTSS1, CLPTM1 and PRSS11, MTSS1, SMYD2 in canine mammary gland cancer" pptx
... Veterinaria Scandinavica 2008, 50:27 http://www.actavetscand.com/content/50/1/27 Patients were evaluated by clinical history and physical examination including mammary tumor measurement and inguinal ... Lip- and Palate-Associated Transmembrane Protein 1), which could correctly classify 95% of the samples, and another one, was PRSS11, MTSS1, and SMYD2 (Set and Mynd Domain-Containing Protein 2) ... Acta Veterinaria Scandinavica 2008, 50:27 Introduction Human and canine malignant mammary tumors share some epidemiological and clinicopathological features Incidence in both species increases with...
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Báo cáo khoa học: "Recombinant activated factor VIIa for the treatment of bleeding in major abdominal surgery including vascular and urological" doc
... indications are rather rare in abdominal and vascular surgery and in urology (hereinafter referred to as 'in the field of abdominal surgery') and are not meant to be further analyzed in this publication, ... indications of recombinant activated factor VII in patients undergoing abdominal surgery Registered indications Prophylaxis of bleeding related to surgical or invasive interventions as well as ... bleeding complications and factors with influence on bleeding in abdominal surgery Vascular lesion Congenital thrombocytopathy Storage pool diseases (release disorders) , Glanzmann thrombasthenia,...
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Báo cáo y học: "Background: Mood disorders including depression and bipolar disorders are a major cause of morbidity in childhood and adolescence, and hospitalizations for mood disorders are the leading diagnosis for all hospitalizations in general hospit
... of mood disorders, in 2003 they were 101 times as likely and in 2006 they were 122 times as likely The incidence of hospitalizations for mood disorders increased with age In 2006, the incidence ... cases in 2000, increasing to 45% in 2006, and, correspondingly, the proportion paid by private insurance decreased from 57% to 45% Over the same period, teaching hospitals accounted for an increasingly ... this analysis lie in the large database, the probability based sampling, and the standardized methodology of the tri-annual data As with other administrative measures of disease, hospital discharge...
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Evaluation of the impact of polymorphisms on candidate genes of allergic rhinitis and asthma on disease outcomes in the singapore population
... locations of the major genes regulating atopic diseases Candidate genes Positional candidate genes Identify candidate genes Determine functional relevance of polymorphisms in candidate genes Assess role ... pollens, including trees in spring, grasses in summer and weeds in fall As to perennial rhinitis (year-round), the triggers include indoor allergens such as mold, house dust mite, cockroach and animal ... SNPs in disease gene in interaction with the environment Two aspects of research in gene function (In vivo and in vitro) Useful for understanding, prevention and therapy for atopic diseases Figure...
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The NR4A orphan nuclear receptors are target genes of the novel drug c1 in cancer cells and potential mediators of drug induced apoptosis
... myosin, gelsolin, filamin, spectrins, microtubular proteins including tubulins, microtubule associated proteins, and intermediate filament proteins including vimentin keratin and nuclear lamins ... (Degterev and Yuan, 2008) Also the plethora of caspases found in mammalian systems –activator caspases caspase 2, 4, 8, 9, 10, 12, executioner caspases caspase 3, 6, and inflammatory caspases caspase ... conformational change and activation of caspase making caspase capable of cleaving and activating downstream caspases including caspase 3, and which now carry out the execution phase of apoptosis...
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Tài liệu Báo cáo khoa học: Identification of two late acyltransferase genes responsible for lipid A biosynthesis in Moraxella catarrhalis doc
... O35E using primers b2E and b2B (Table 2, Fig 1B), and cloned into pCR2.1 using a TOPO TA cloning kit to obtain pCRlpxL The insertion was released by EcoRI–BamHI digestion, and then subcloned into ... containing 15 lgÆmL)1 spectinomycin Plasmids were extracted from the spectinomycinresistant colonies, identified by digestion with BamHI and SacI as well as by sequence analysis, and named pWlpxX and ... identification using primers b1X and b1B, and the inactivated lpxX mutant was verified by sequencing Cloning of lpxL and construction of the knockout mutant O35ElpxL A DNA sequence containing the lpxL was amplified...
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MALNUTRITION AND INFECTIOUS DISEASE MORBIDITY AMONG CHILDREN MISSED BY THE CHILDHOOD IMMUNIZATION PROGRAM IN INDONESIA pot
... 1Complete defined as receiving OPV-1, OPV-2, OPV-3, DPT-1, DPT-2, DPT-3, and measles vaccines; partial defined as receiving at least one of the seven vaccine doses, and no receipt as receiving none ... immunization card The NSS included questions regarding vaccination status beginning in 2000 Axillary temperature was recorded Hemoglobin was measured using a HemoCue© instrument (HemoCue AB, Angelholm, ... not only from missing the vaccines and having less protection against vaccine-preventable diseases, but from having a higher prevalence of malnutrition and morbidity These findings support the...
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OUTBREAK OF HAND, FOOT AND MOUTH DISEASE IN BHUBANESWAR, ODISHA: EPIDEMIOLOGY AND CLINICAL FEATURES doc
... observed in 11 cases The lesions were associated with itching in 24 cases which was more pronounced during the healing phase In the 46 cases having complete follow-up, average healing time was 8.6 ... three cases showing INDIAN PEDIATRICS JUNE 10, 2012 [E-PUB AHEAD OF PRINT] KAR, et al HAND, FOOT AND MOUTH DISEASE eosinophilia and two cases with neutrophilia Routine and microscopic examination ... Routine blood examinations including complete blood count, Erythrocyte sedimentation rate, urine routine and microscopy and stool routine and microscopy were done in all cases Histopathology was...
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Bacteria are often maligned as the causes of human and animal disease (like this one, Leptospira, which causes serious disease in livestock)
... Congo In these two instances the mortality rate was between 50 –90% Following those epidemics, Ebola hit Africa in many other instances the worst yet being in the year 2000 when it struck Uganda infecting ... methods, such as: wearing gloves isolating infected individuals practicing nurse barrier techniques proper sterilization and disposal of all equipment b Burials must be done correctly no washing or ... strains were isolated in animal carcasses and in the bodies of those who handled those carcasses - These outbreaks were preceded by an abnormally large death in wild Gorilla populations Clinical...
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Agency and Consciousness in Discourse: Self-other Dynamics as a Complex System ppt
... massively expanded in this stage and with it the capacity to think and reason in ways that are the prototypes of metaphorical thinking itself The expanding capacity to see things the way an increasing ... multi-levelled and intricate relations that ground us in our trajectories in space, in time, in society, and in culture, emphasizes the instantial nature of meaning-making and of consciousness itself The instantial ... viewpoints In this way, the child learns to interpret things from the point of view of the other, as well as to posit in language and in imagination alternative relations between other and world and...
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Urbanization and cardiovascular disease: Raising heart-healthy children in today’s cities pot
... prevalence of heart disease has been increasing in China, partly as a result of a worsening profile of risk factors including increased prevalence of hypertension, smoking and obesity levels [Wu, ... diseases (ischaemic heart disease and cerebrovascular disease) in São Paulo [de Padua Mansur, et al., 2009] Southeast region included foods associated with an increased risk for CVD: soft drinks ... in Mumbai (Bombay), India International Journal of Epidemiology, 37 pp.524–535 , Qian, J et al., 2010 Smoking and smoking cessation in China, 1993–2003 - Trends in smoking and quitting in China...
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