generation of enantiomerically pure carboxylic acids with chiral centers in the α position
Báo cáo y học: " Randomized clinical trial of bedside ultrasound among patients with abdominal pain in the emergency " doc
Ngày tải lên :
13/08/2014, 23:21
... patient-provider interaction with a better explanation of the patient's problem with the help of the US examination results More subsequent examinations were performed in the group not receiving US at the ... surgery with the use of surgeon-performed US at the bedside when a patient presents with abdominal pain [7-10] The results shown in this study seem to support routine use of the method in the ED ... lower in the short term Therefore, taking into consideration other benefits, we believe that implementation of bedside US in the ED improves management of the patients Competing interests The authors...
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The generation of native human monoclonal antibodies with neutralising activity for dengue virus 2
Ngày tải lên :
11/09/2015, 09:56
... mAb binding to DV E protein 137 7.6 Binding activity and affinity determination on different genotypes of DV1 141 7.6.1Comparison of binding affinity of 14C10 mAb with hu4G2 141 7.6.2 Determination ... native gel of 14C10 mAb against DIII of E protein of DV 138 139 xiii Figure 7.11 Graph of binding affinities of 14C10 Fab, 14C10 mAb and Hu 4G2 140 Figure 7.12 PRNT of 14C10 Fab at increasing concentrations ... 116 Mutations in DNA sequence of the IgG heavy chain of Clone 20G6 118 Figure 5.3 Upregulation of AID in EBV-infected cells 119 Figure 5.4 Densitometry graph of AID with β – actin as internal control...
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The generation of native human monoclonal antibodies with neutralising activity for dengue virus 3
Ngày tải lên :
11/09/2015, 09:56
... FIG.1.2 Ribbon drawing of E protein Dengue E protein dimer with three defined domains within each monomer: Domain I in red, Domain II in yellow with fusion loop in green, and Domain III in blue (Modis, ... alter the spatial distances 33 between the glycans on the E proteins, thereby inhibiting the interaction of the virus with DC-SIGN (Pokidysheva, Zhang et al 2006) Another route may involve binding ... at the tip of Domain II (DII) of the E protein, (which is the location of the fusion peptide), the hinge region between Domain I (DI) and DII of E protein and between DI and Domain III (DIII) of...
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Generation of mouse graves ophthalmopathy model with full length TSH receptor plasmid and cytokine evaluation by real time PCR
Ngày tải lên :
07/10/2015, 09:55
... and Th2 cytokine profiles were present in their T cell lines [19] Other reports showed predominance of CD8+ T cells in the orbit with either inconsistent cytokine profiles, a mixture of Th1 and ... pmol/ml In measurement of TSBAB in sera, the higher the TSBAB activity level, the smaller the result in pmol/ml In TSAB activity measurement in sera, the higher the activity, the higher the result in ... TSBAB status in the strains of mice immunized with TSHR Table 21 52 Cross tabulation of TSAB status in the strains of mice immunized with TSHR Table 20 51 61 Summary of cytokine profile and immunological...
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Children security as part of the " living together with floods" strategy in the Mekong river delta, VietNam
Ngày tải lên :
18/10/2013, 12:15
... data showing high percentage of child deaths in the total the losses of life in the flood seasons in the MD Save the Children (2003) reported that the vast majority of the drowning deaths in recent ... but others were not trained There is no official swimming training in the school program in the Mekong River Delta It seems an irrational structure for children living in a floodplain as the Delta ... those living in the urban areas, children in the rural area are familiar with the water in rivers and canals Their daily lives are linked with the rice fields and flood plains Some of them learn...
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Tài liệu Guidelines for the appointment of General Practitioners with Special Interests in the Delivery of Clinical Services pdf
Ngày tải lên :
14/02/2014, 21:20
... arrangements, including links with others working in the same clinical area in primary care, at PCT level and in acute trusts The GPwSI will be accountable to the PCT Board with clinical responsibility ... aims In principle ,the main activities of the service will be based around education and improving standards of sexual health medicine within the primary care organisation as well as offering ... passed the Examination of the RCGP and who are current members of the College and Skilled at training health care professionals and Special interest Evidence of working under direct supervision with...
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THE BIOLOGY, PHYSIOLOGY AND SOCIOLOGY OF REPRODUCTION ALSO SEXUAL HYGIENE WITH SPECIAL REFERENCE TO THE MALE docx
Ngày tải lên :
06/03/2014, 13:20
... biological principle in the profound changes which the voice undergoes at the time of puberty These changes in the male subject consist in increasing the depth of the larynx, thereby increasing the length ... depletion of the mother's physical power, particularly manifest in the depletion of the blood During the period when the young child is developing within the body of the mother, she must make other ... lengthening of the thigh and leg bones In serial homology with the thigh and leg are the bones of the arm and we find that these are undergoing an increase in length commensurate with the increase...
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Báo cáo khoa học: Bacitracin inhibits the reductive activity of protein disulfide isomerase by disulfide bond formation with free cysteines in the substrate-binding domain pptx
Ngày tải lên :
14/03/2014, 23:20
... cysteines In conclusion, we show a mechanism of action of bacitracin on PDI that involves covalent binding of an open thiol form of bacitracin to free cysteines in the substrate-binding domain of ... Bacitracin A and B fulfill this requirement, making them the active antimicrobial compounds of the bacitracin mix The oxidation of the amino-thiazoline ring to the keto-thiazole ring to form bacitracin ... bacitracin A as ‘Bacitracin A’, and all other amino acids not involved in the crosslink by the single-letter code The PDI peptide side of the disulfide bond is named R1, and the bacitracin side...
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Báo cáo khoa học: Intermonomer cross-linking of F-actin alters the dynamics of its interaction with H-meromyosin in the weak-binding state ppt
Ngày tải lên :
16/03/2014, 13:20
... study, the interaction of ATP and S1 with actin during activation of myosin S1 ATPase using caged ATP did not produce an increase in rotational motion in the environment of the Cys374 site of actin ... subdomain 1, where the spin probe is attached, is not directly involved in the intermonomer cross-link, because one of the cross-linking sites is occupied by the spin probe, therefore, the rigidity ... complexes the motion of the probe is less restricted relative to the strong binding state and there is no difference between the two weak binding complexes In the case of cross-linked F-actin, the...
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Báo cáo khoa học: A pathway through interferon-c is the main pathway for induction of nitric oxide upon stimulation with bacterial lipopolysaccharide in mouse peritoneal cells pot
Ngày tải lên :
17/03/2014, 10:20
... (20 lL of the total volume) by incubating these probes ( 20 000 counts per minute) with nuclear extracts (5 lg of protein content) at room temperature for 30 in binding buffer The binding buffer ... which lacks the binding ability owing to substitution of two AA residues in the IRF-1 binding motif to GG, and also because the bands were supershifted out of the range by preincubation of the nuclear ... activation of NF-jB participates in the direct induction of NO by LPS (as seen in RAW264.7 cells), but not in the induction by IFN-c (as seen in both types of cells) or in the indirect induction...
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Báo cáo khoa học: Interactions of ultraspiracle with ecdysone receptor in the transduction of ecdysone- and juvenile hormone-signaling pdf
Ngày tải lên :
23/03/2014, 13:20
... receptors, including human RXR (which is the ortholog of USP) have shown that an area on the surface of the ligand binding domain involving the C-terminus of a-helix 3, a-helix 4, and the N-terminus of ... include: (a) binding the a-helix 12 of the receptor into its own hydrophobic groove [22]; (b) stabilization of the a-helix 12 near the hydrophobic groove in a position that the C-terminus of the a-helix ... bind to the DR1 motif (Fig 3, above) Thus, we tested the participation of USP in JH III activation of DR1JHECore by observing the effect of increasing the concentration of exogenous dUSP on the...
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A Study on the Effects of Argentine Tango as a Form of Partnered Dance for those with Parkinson Disease and the Healthy Elderly pptx
Ngày tải lên :
28/03/2014, 20:20
... trainer Subjects were instructed to continue their ordinary exercise routine, and not to begin anything new during the course of the study Subjects were assessed the week prior to initiation of ... get together with others like them because of the supportive and therapeutic aspects They requested that they have lunch together at the end of the sessions During the dance classes, they were very ... subjects lying supine Their results suggested that the basal ganglia, the area of neurological degeneration in those with PD, are specifically involved in the control of dance movements Increased...
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báo cáo hóa học:" Higher percentage of CD133+ cells is associated with poor prognosis in colon carcinoma patients with stage IIIB" pptx
Ngày tải lên :
18/06/2014, 15:20
... nest; (C) and (D): the staining of CD133 on the luminal surface and the basal surface of cancer cells; (E): the staining of CD133 on budding cancer nest; (F): the staining of CD133 on poor-differentiated ... 2003 in the Cancer Center of Sun Yat-Sen University, Guangzhou, China None of the patients had undergone either chemotherapy or radiotherapy before the collection of the samples All of them were ... Stage IIIB The association of overall survival with the percentage of CD133+ cells in colon carcinoma patients with Stage IIIB The patients with a lower percentage of CD133+ cells (
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Báo cáo hóa học: "Prognostic impact of clinical course-specific mRNA expression profiles in the serum of perioperative patients with esophageal cancer in the ICU: a case control study" potx
Ngày tải lên :
18/06/2014, 16:20
... prognostic indicator in fulminant hepatitis in patients without encephalopathy upon admission [10,11] In the present study, we examined 11 proinflammatory genes in patients receiving therapy in the ... of the diagnostic accuracy of CRP and mRNA levels (a) Change in circulating CRP mRNA expression during the clinical course in ICU Upregulation of CRP mRNA was induced at POD by the surgical intervention ... for the prognosis of fulminant hepatitis Hepatol Int 2008, 2:213-221 Wong FH, Huang CY, Su LJ, et al: Combination of microarray profiling and protein-protein interaction databases delineates the...
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báo cáo hóa học: "Measuring the impact of health problems among adults with limited mobility in Thailand: further validation of the Perceived Impact of Problem Profile" docx
Ngày tải lên :
18/06/2014, 22:20
... disability in Thailand Methods The study was conducted in urban, rural and remote areas of Khon Kaen Province in the Northeast Region (Isaan), the setting of the Thai arm of the RESILIENCE study The ... factors influence the use of instrumentation in other settings The results of this study support the psychometric properties of the PIPP Impact subscales in adults with locomotor disability in Thailand ... studies involving the pooling of data from multiple sites with the anchoring of scores on a common metric, would allow further explora- http://www.hqlo.com/content/6/1/6 tion of the stability of the...
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báo cáo hóa học: " Activation of retinal microglia rather than microglial cell density correlates with retinal neovascularization in the mouse model of oxygen-induced retinopathy" ppt
Ngày tải lên :
19/06/2014, 22:20
... directly involved in the formation of retinal NV in the later stages of the OIR model In this study, we investigated the temporal and spatial distribution of microglial cells during the different ... by their position above the inner retinal vascular layer (i e in the vitreous), their round cell body without any processes, their GFP expression under the control of the Cx3cr1 promoter, and their ... regression in hyperoxia During the hyperoxic phase, the kinetics of the disappearence of the retinal vessels is faster than the kinetics of microglia activation which peaks at P10 Accordingly, activated...
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báo cáo hóa học:" Measuring the impact of health problems among adults with limited mobility in Thailand: further validation of the Perceived Impact of Problem Profile" doc
Ngày tải lên :
20/06/2014, 16:20
... disability in Thailand Methods The study was conducted in urban, rural and remote areas of Khon Kaen Province in the Northeast Region (Isaan), the setting of the Thai arm of the RESILIENCE study The ... factors influence the use of instrumentation in other settings The results of this study support the psychometric properties of the PIPP Impact subscales in adults with locomotor disability in Thailand ... studies involving the pooling of data from multiple sites with the anchoring of scores on a common metric, would allow further explora- http://www.hqlo.com/content/6/1/6 tion of the stability of the...
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Báo cáo hóa học: "Integro-differential inequality and stability of BAM FCNNs with time delays in the leakage terms and distributed delays" doc
Ngày tải lên :
21/06/2014, 00:20
... show the effectiveness of the results obtained here in Section Finally, in Section 6, we give the conclusion Model description and preliminaries In this section, we will consider the model of impulsive ... ensuring the existence, uniqueness and global exponential stability of equilibrium point are obtained by the topological degree theory, properties of M-matrix, the integro-differential inequality ... performed all the steps of proof in this research and also wrote the paper KL participated in the design of the study and helped to draft and revise manuscript All authors read and approved the final...
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báo cáo hóa học: " Joint optimization of MIMO radar waveform and biased estimator with prior information in the presence of clutter" pot
Ngày tải lên :
21/06/2014, 02:20
... ST (17) The problem of main interest in this study is the joint optimization of the WCM and bias estimator to improve the performance of parameter estimation by minimizing the constrained biased ... on the following three cases: the CRB of two angles with exactly known initial parameters, the effect of the optimal biased estimator or prior information on the CRB, and the effect of the initial ... error of the clutter estimate is defined as the ratio of the estimation error of the initial total clutter power to the exact one Figure shows the CRB versus the estimation error of the initial...
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