general characteristics of the rab gtpase subfamily
Tài liệu Báo cáo khoa học: Receptor binding characteristics of the endocrine disruptor bisphenol A for the human nuclear estrogen-related receptor c pptx
... Given that the roles of these residues definitely confirm each other, the difference in their significance might be attributable to the importance and ⁄ or necessity of the receipt of the phenol-hydroxyl ... rationale for the major role of Arg316 in arresting the ligand When the amino acid sequences of the LBD of all the NRs were aligned to that of ERRc, it became noticeable that 26 receptors among the total ... ligand-binding pocket of the ERRc The proximity of each amino acid residue (within a ˚ distance of A) to BPA is shown in the boxes depicting the a-helices The portrait was originated from the X-ray crystal...
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Tài liệu Báo cáo khoa học: The structure and biological characteristics of the Spirochaeta aurantia outer membrane glycolipid LGLB pdf
... Fragments of HSQC and HMBC spectra of compound Labels illustrate assignment of the amide linkage between the amino group of Asp and the carboxyl group of GalA residue E Scheme The structures of oligosaccharides ... branching information [31] The charge state of a fragment ion is then identified by using the isotope profile, owing to the high resolution provided by the TOF mass analyser The product-ion spectrum ... 1436.42, owing to the loss of the branching xylose residues M and O, and of GlcA residue L The remaining linear sequence, consisting of K-B-F-I-D-N-Q, was confirmed by the observation of Ó FEBS 2004...
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Báo cáo " Characteristics of the voi mep massif’s altitudinal belt differentiation " doc
... Characteristics of the Voi Mep massif’s altitudinal belt differentiation 11 Topographic features of the Voi Mep massif Voi Mep massif with the highest peak (1739m) of the same name ... narrow water divide surfaces On the background of an old weathering crust also emerge granitic blocks of different sizes, rather well eroded, creating a peculiarity of the top surface Currently this ... process - Slopes on granites: there are many steep slopes on the west of the massive, developed along fissures, tectonic faults cutting into granites The origin of these surfaces are rapid gravity...
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Báo cáo khoa học: Phosphorylation of the Saccharomyces cerevisiae Grx4p glutaredoxin by the Bud32p kinase unveils a novel signaling pathway involving Sch9p, a yeast member of the Akt / PKB subfamily pot
... 1B) The partial phosphorylation of Grx4p still observed in the case of the two mutants (corresponding to 30–40% of that of the wild-type) could be explained either by the intervention of another ... in the phosphorylation of Bud32p at Ser258 In order to investigate the impact of Ser258 substitution in vivo, we compared the growth of the S258A mutant with that of the wild-type strain and of ... elongation We have then examined the effects of Ser258 phosphorylation of Bud32p on the transcriptional activity of the EKC ⁄ KEOPS complex by analyzing the activation rate of the galactoseinducible...
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Báo cáo khoa học: DNA-binding characteristics of the regulator SenR in response to phosphorylation by the sensor histidine autokinase SenS from Streptomyces reticuli doc
... together, these data confirm the specificity of the SenR-binding sites and corroborate the assumption that phosphorylation of SenR by SenSP alters its DNA-binding characteristics Discussion The ... released with the same solution in the presence of 250 mm imidazole The protein concentration of the samples was determined by a previously established method [42] The quality of the proteins ... addition of 12 pmol of SenR to the reaction mixture led to an 84% decrease of free up-furS1, whereas the same amount of SenRP provoked only a 10% reduction (Fig 5D) The presence of small...
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Gynecological Malignancies: Epidemiological Characteristics of the Patients in a Tertiary Care Hospital in India doc
... making the management of the disease easier Median value of PCI of family of the patients was Rs 400 and mean value was Rs 543 with a range of Rs 100 - 2500 The mean PCI of family of the patients ... depicts the reproductive characteristics mean of 48.1 years Ten out of 27 ovarian cancer cases of the patients Nearly two-third of the patients with (37.1%) were found between the ages of 35 and ... two-third of the monthly income (PCI) of family of the patients, which patients (78 out of 113 patients or 69.0%) were in the was Rs 400, the patients with gynecological malignancies age range of 35-64...
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Báo cáo khoa học: Enzymatic actions of Pasteurella multocida toxin detected by monoclonal antibodies recognizing the deamidated a subunit of the heterotrimeric GTPase Gq potx
... Fig Isolation of Gaq Q209E-specific antibodies (A) Alignment of amino acid sequences of the switch region in the a subunits of mouse heterotrimeric GTPases by CLUSTALW Sequences of synthetic oligopeptides ... encompassing the catalytic domain may be liberated into the cytoplasm, where the substrates, Ga proteins, reside Thus, the N-terminal region of PMT may hamper the action of the catalytic C-PMT (b) The ... detected by the Gaq Q209E-specific antibody Fig S4 Model of the activation of PMT by the breaking of the disulfide-bond between Cys1159 and Cys1165 Table S1 Primers for construction of plasmids in the...
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General Explanations of the Administration’s Fiscal Year 2013 Revenue Proposals doc
... year of the date of acceptance of the application and must place the property in service within three years from the date of the issuance of the certification The change would be effective on the ... or as a head of household The width of the phase-in range and the beginning of the phase-out range are indexed for inflation Hence, the maximum amount of the credit and the end of the phase-out ... of the certification have been met within one year of the date of acceptance of the application and must place the property in service within three years from the date of the issuance of the...
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báo cáo hóa học:" The characteristics of the mechanoreceptors of the hip with arthrosis" doc
... the tissue was removed and the degree of arthrosis examined on the basis of Bombelli’s classification [21] This study was approved by Ethics Committee No 007.06.01 of the Federal University of ... increased number of vessels The acetabular labrum had thick and parallel collagen There was a reduction in the number of collagen fibers and vessels in the arthrosis group However, there were no ... the groups with arthrosis With regard to the total number of densities of the mechanoreceptors in the two groups, there was a significant reduction in the arthrosis group (P = 0.0082) Morisawa,...
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Chapter 3 - General Principles of the IMS Architecture pot
... establishment) the P-CSCF asserts the identity of the user to the rest of the nodes in the network This way, other nodes not need to further authenticate the user, because they trust the P-CSCF The rest of ... is GPRS, the location of the P-CSCF is subordinated to the location of the GGSN In roaming scenarios, GPRS allows location of the GGSN either in the home or in the visited network (the SGSN is ... interface to the HSS The main reasons to interface the HSS are as follows • To download the authentication vectors of the user who is trying to access the IMS from the HSS The S-CSCF uses these vectors...
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Báo cáo y học: " The characteristics of the synonymous codon usage in hepatitis B virus and the effects of host on the virus in codon usage pattern" ppsx
... usage bias The Figureure represented that the plots of HBV aggregated below the expected curve, suggesting other selections take part in the process of HBV evolution Comparative analysis of the RSCU ... GGG(G) 1.22 0.98 a the synonymous codon usage pattern of human cell was calculated based on the data of the synonymous codon usage frequencies of human cell The codon usage bias of HBV suggests ... on the subtypes of HBV, the plots for the subtype adw were generally divided into two groups, while the other three subtypes seem to have a similar genetic characteristic (Figure 2) Figure The...
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Báo cáo y học: " Complementation of diverse HIV-1 Env defects through cooperative subunit interactions: a general property of the functional trimer" potx
... approximately 15–20% of the total supernatant from the cells For each data point, the standard errors of the mean of duplicate samples are shown Results To test the ability of fusion-inactive Env ... information is not yet available for the native state of gp41, but the structure of the final post-fusion state has been determined to be a trimer of hairpins in the form of a six-helix coiled-coil bundle ... orchestrated series of conformational changes in both Env subunits that drive the fusion process The emerging understanding of the complexities of HIV Env/receptor interactions and the subsequent...
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Báo cáo y học: "On the general theory of the origins of retroviruses" pot
... to the formalism as I re-visualize it in the light of the existing literature in physics, mathematics and retrovirology Discussion The mathematical formalism of the theory of the origins of retroviruses ... the others, ensuring the constancy of Vm, Ha, Tt and As The unique advantage of this approach is that only a few of the components need to be known for a mathematical formalism of the theory of ... experiences: (1) an Xy- component of the SB denoted the Index of Origin or IO; (2) at Hs the index of entry or IE The path of such a retrovirus is analogous to the trajectory of an object cast from one...
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Characterisation of the rho GTPase target dishevelled associated activator of morphogenesis 1 (DAAM1
... maintained by the interaction of the GBD (DID) and the DAD Binding of an active GTPase to the GBD disrupts the DID-DAD interaction, thereby relieving the inhibition The formin then exists in ... Formins The focus of this thesis is on Dishevelled Associated Activator of Morphogenesis (DAAM1), a member of the formin family of proteins The name formin originated from the discovery of the limb ... the release of Rho GTPases from the GDIs and allow their translocation to the membrane for another round of activation Cycling between the “ON” and “OFF” states ensures that the Rho GTPases function...
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The role of the small GTPase rab31 in cancer
... Members of the Rab1 1 subfamily (Rab1 1A, Rab1 1B, and Rab2 5) are key regulators of endocytic recycling, including that of integrin, and their dysregulation are likely to affect aspects of cell ... invasion are linked largely to changes in expression levels of these Rabs, rather than their mutations Rab3 1, a member of the Rab5 subfamily, has recently emerged as a membrane traffic modulator ... and migration [56] Rab2 5 [57, 58], a member of the Rab1 1 subfamily that is highly expressed in the epithelial cells of the gastrointestinal tract, lungs and kidney, has in the past few years...
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A general form of the Second Main Theorem for hypersurfaces
... taken in to the account of counting functions) Motivated by the case of hyperplanes, in this paper we generalize Theorem B to the case of arbitrary hypersurfaces, and the multiplicities of intersections ... (1.1) where K is the set of all subsets K ⊂ {1, , q} such that the hypersurfaces {Dj , j ∈ K} are in general position in V The proof of our theorem consists of two parts: In the first parts ... where the positive integer M depends on , d, q, n, deg V This completes the proof of Theorem 1.1 References [1] G Dethloff and T V Tan and D D Thai, An extension of the CartanNochka second main theorem...
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