... AccessHealth-Related Quality of Life in Parkinson disease: Correlation between Health UtilitiesIndex III and Unified Parkinson s Disease RatingScale (UPDRS) in U.S. male veteransGalit Kleiner-Fisman1*, Matthew ... article as: Kleiner-Fisman et al.: Health-Related Quality of Life in Parkinson disease: Correlation between Health Utilities Index III and Unified Parkinson s Disease Rating Scale (UPDRS) in U.S. male ... for inclusion.Review of the diagnosis of parkinsonism was furtherscrutinized and only individuals fulfilling United King-dom Brain Bank Criteria [18] for idiopathic PD (IPD)were included in...
... analysis and alanine scanning (as reviewed in 9, 15 and 16). Four distinct binding epitopes have been identified, within the L1, CR, L2 and Fn1 insert domains. Residues in the L1 and L2 domains of ... internalization of the acti-vated receptor/insulin complex,80which is important both in terminating theinsulin signal andin insulin degradation (this being the major mechanism bywhich insulin ... dimeric constructs, and the preferred model ofligand binding is one in which both α-subunits contribute asymmetrically tothe insulin binding site, and a single molecule of bound insulin contacts bothhalves...
... greater increase in protein breakdown results in netprotein catabolism. The increased splanchnic protein synthesis and preventionof decline in muscle protein synthesis during short term insulin ... synthesis and mitochondrial biogenesis when amino acids are provided. Insulin-induced fall in circulating amino acids blunts the stimulatory effect of insulin on synthesisof muscle proteins. Insulin’s ... in the muscle), intosarcoplasmic protein (protein present within the cytosol) and into myosin heavychain (a key structural and contractile protein). In addition, mitochondria areisolated and...
... the renin–angiotensin system (RAS), plasminogen activatorinhibitor-1 (PAI-1) and more recently omentin and visfatin.79TheroleofTNF-α,leptin, Il-6, resistin and adiponectin in linking obesity ... CNS, including leptin,insulin and free fatty acids, that may in uence glucose homeostasis independentof their effects on feeding behaviour.Insulin Resistance. Edited by Sudhesh Kumar and Stephen ... this in detail. One involves single-cell recordings in brain-slice preparations during exposure to varying concentrations of glucose,the other using implanted electrodes in animals and measuring...
... obesity and inversely correlated to diabetes and insulin resistance in the obese, and admin-istering adiponectin restores insulin sensitivity and assists weight reduction.9PPARγ and GlucoseHomeostasisRobert ... leptin, circulating levels ofadiponectin have been shown to correlate with insulin sensitivity in both genetic and dietary models of murine insulin resistance and obesity,65, 66while infusionof ... the insulin-sensitizing action of metformin.71 In conjunction with theobservation that PPARγ activation increases adiponectin expression and produc-tion both in vitro andin vivo, these findings...
... yearsBMI:Ethnicity: Chinese(Guangdong Province)MOSPAquestionnaireFasting serum insulin(Fasting insulinresistance index: ‘amultiplicationvalue of fastinginsulin and fastingglucose by 25’)Age, ... betweenactive and inactiveindividualsObese groups:significantly lowerfasting insulin in active comparedto inactiveindividuals(continues overleaf )FINDINGS FROM OBSERVATIONAL STUDIES IN CHILDREN ... tooccupationalactivity)Divided into 5categories ofactivity levelFasting insulin Age, BMI, SES,smoking, heavydrinking, existingCHDInverse associationbetween PA and fasting insulinfrom 94 to79 pmol/lp<0.001...
... orunfavorable, depending on the disease. As a case in point, formation of huntingtin-containing inclusionbodies in Huntington’s disease encourages cell survival,whereas monomers and small inclusion bodies ... antiapoptotic potential and decrease cell protection by Hsp25. In another example,Hsp27 and aB-crystallin appear inParkinson s disease Y. Sun and T. H. MacRae Small heat shock proteins and disease FEBS ... (ALS), and the prion disorders, are examples[93–102]. Deposits are fibrillar, enriched in b-pleatedsheet, and some contain neurofilament proteins as in desmin-related myopathy inclusions andParkinson sassociated...
... between nursing staff in nursing homes and home-based care with respect to pain intensity in the lumbarspine. In the cervical spine, pain intensity was lower forstaff in nursing homes. In both ... three-year training,nursing aides (including assistant nurses) with at least aone-year nursing training without examination, and nurs-ing auxiliaries with less or no formal nursing training.41 ... system. In the present study, serious findingsindicating disorders related to the intervertebral bodies(nerve pain in the SLR test and pain on stretching thefemur) were only made in 2% of...
... which can be found in haircare products for washing, dyeing, bleaching, styling, spraying and perming. This exposure can impair health and may be present as skin and respiratory diseases. Effects ... hairdressing and smoking and infertility and spontaneous abortion was examined in Norway [33]. The analysis was based on the datafrom a regional, cross-sectional study on cardiovasculardiseases and ... fertility disordersand preg-nancy complications in hairdressers fulfilled the inclu-sion criteria. Mainly women were included in theexaminations.One review, as well as 11 original studies,...
... techniqueproposed in [46] for its intentional application. In fact, weare just pointing out the inadequacy of this technique to an-alyze the incidence of wide-ranging set of single and multiple disturbances ... (UFJF), Juizde Fora, Brazil, in 1999, and the M.S. and Ph.D. degrees in electrical engineering fromthe University of Campinas (UNICAMP),Campinas, Brazil, in 2001 and 2005, respec-tively. Currently, ... proposed technique and the one proposed in [2], developed recently to classify sin-gle and multiple disturbancesin voltage signal by consid-ering the voltage disturbances defined in [2, 3], are...