foxp3−cd4 cd25 ccr4 t cells are proinflammatory and increased in ham tsp patients
Báo cáo y học: "CD4+CD25+ immunoregulatory T cells may not be involved in controlling autoimmune arthritis" ppsx
... compared with that in naïve mice, suggesting that T cells activated by immunization had become resting memory T cells To further evaluate the role of the CD4 +CD25+ cells in PGIA, an adoptive transfer ... regulatory T cells but are resistant to PGIA It has been shown that CD28–B7 interaction is essential for the homeostasis of the CD4 +CD25+ regulatory T cells that control autoimmune diabetes [6] ... [3H]thymidine incorporation, and expressed as stimulation index (SI; a ratio of incorporated [3H]thymidine [counts per minute] in antigen-stimulated cultures relative to counts per minute in nonstimulated...
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Báo cáo y học: "Indoleamine 2,3-dioxygenase-expressing dendritic cells are involved in the generation of CD4+CD25+ regulatory T cells in Peyer''''s patches in an orally tolerized, collagen-induced arthritis mouse model" ppt
... determining immunity or immune tolerance; this determination is based on the maturation or activation state and the subset of DCs, and cytokine profiles in the microenvironment at the time of antigen ... affect the T- cell response In the resting state, autoreactive T cells residing in the periphery are suppressed effectively by regulatory T cells, which are thought to prevent the development of ... PCR using IDO sense (5'-CACTGTACCAGTGCAGTAG-3') and antisense (5'-ACCATTCACACACT CGTTAT-3') primers, and using Foxp3 sense (5'-CAGCTGCCTACAGTGCCCCTAG-3') and antisense (5'CATTTGCCACGAGTGGGTAG-3')...
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Báo cáo y học: " Expansion of CD4+CD25+ helper T cells without regulatory function in smoking and COPD" potx
... subject recruitment, bronchoscopies and manuscript preparation All authors read and approved the final manuscript Competing interests The authors declare that they have no competing interests Received: ... lymphocyte numbers between the three groups; the difference was within the lymphocyte population, mainly related to the T lymphocyte subtypes In conclusion, we demonstrate that smoking subjects with ... to be inappropriate, which enables an uncontrolled progress of the immunoreaction, involving the activation of T cells into a cytotoxic phenotype This further supports a potential involvement...
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Báo cáo y học: "The relationship between CD4+CD25+CD127regulatory T cells and inflammatory response and outcome during shock states" potx
... different between patients and healthy volunteers throughout the study period, patients with shock presented with constantly decreased NK absolute To get further insight in to the role of Tregs during ... severity and cytokines plasma concentrations Considering the correlation between Tregs and outcome, at least in septic patients, we evaluated the relation between these cells and severity Indeed, there ... percentage of Tregs was higher in the septic patients than in the nonseptic patients and healthy volunteers, there were no differences in terms of absolute count, reflecting the persistence of the...
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Báo cáo y học: "Longitudinal increases in mitochondrial DNA levels in blood cells are associated with survival in critically ill patients" pdf
... Authors' contributions All authors participated in the interpretation of the results DH collected the study samples and the clinical data HC collected the mtDNA data and wrote the manuscript AD carried ... further demonstrates that the changes in mtDNA were not driven by changes in platelets Similar estimates were maintained after adjustment for platelets as well as white blood cell count and antioxidant ... antioxidants conducted at the Kingston General Hospital, Kingston, Canada, the details of which were recently published [19] Consecutive eligible adult patients admitted to ICU within the last...
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Báo cáo y học: "CD25brightCD4+ regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease" potx
... influence the inflammatory processes in the joint These features were apparent in the vast majority of the patients despite the different treatments they received, indicating that the anti-rheumatic ... at least in patients with JIA it has been reported that T cells in synovial fluid are not in active cell cycle [28] This study is the first to demonstrate that CD25brightCD4+ T cells from patients ... spondyloarthropathies Excluded are patients with reactive arthritis and gastrointestinal inflammation Table Cytokine production and proliferation of CD25- CD4+ T cells in in vitro cultures Patient IFN-γ(pg/ml)...
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Báo cáo y học: "Phenotypic and functional characterisation of CD4+ memory T cells homing to the joints in juvenile idiopathic arthritis" pps
... and with systemic JIA) were tested for CCL21 concentrations The clinical characteristics of patients with JIA and the ongoing treatment at the time of the study are reported in Tables and For ... role of CCR7 in the recruitment of CD4+ memory T cells into the inflamed joints of patients with JIA, and attempted the functional and anatomical dissection of these cells according to their expression ... follicular structures In contrast, CCR5+ cells were detected mainly in the lining layer and in the sublining zone of the superficial subintima and, to a smaller extent, in the perivascular infiltrates...
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Báo cáo y học: "Defective CD4+CD25+ regulatory T cell functioning in collagen-induced arthritis: an important factor in pathogenesis, counter-regulated by endogenous IFN-γ" potx
... underlying the effect of IFN-γ on Treg cell activity is exerted in part via ACs Competing interests The author(s) declare that they have no competing interests Authors' contributions BDK, HK and TM ... experiments we tested the importance of Treg cells in the pathogenesis of CIA by rendering wild-type mice deficient in Treg cells by treating the mice with depleting anti -CD25 antibody Starting from ... of wild-type Treg cells against wild-type or IFN-γR KO (data not shown) Teff cells These data demonstrate that the defect in inhibiting CD4 +CD25- Teff cells acquired the presence of Treg cells...
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Báo cáo y học: "Peripheral blood but not synovial fluid natural killer T cells are biased towards a Th1-like phenotype in rheumatoid arthritis" pptx
... involved in the disease process of RA and that a strategy to boost the regulatory potential of NKT cells might be useful in the treatment of RA Materials and methods Patients and healthy control individuals ... aberrant presentation of the natural NKT cell antigen, but not decreased reactivity, might account for the NKT cell reduction in these responder patients In contrast, in 46.2% of the patients ('nonresponders') ... resulted in prevention or suppression of disease These studies indicate that NKT cells can play a role in the regulation of autoimmunity and that they are therefore an interesting subject for further...
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Báo cáo y học: "Reduced proportions of natural killer T cells are present in the relatives of lupus patients and are associated with autoimmunity" ppt
... number not for citation purposes) that are secreted by the NKT cells in the different lupus mouse models, with interleukin-4-secreting NKT cells inhibiting lupus and interferon-γ-secreting NKT cells ... to participate in the study In total 144 patients, 288 parents, and 79 siblings were investigated Population control individuals for the lupus patients were obtained by random digit dialing, which ... study, we found no correlation between the proportion of total NKT cells and disease activity or drug therapy in our lupus patients, which suggests that the reduction in NKT cells in these patients...
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Báo cáo y học: "β Transforming growth factor-β-induced regulatory T cells referee inflammatory and autoimmune diseases" potx
... on the target cell surface This small latent complex can be associated with the latent TGF-β1-binding protein, forming a large latent complex thought to serve as a tether for binding proteins and ... manipulated to orchestrate changes in aberrant immunity In mediating its suppressive effects, TGF-β signals through the type I and type II TGF-β serine–threonine kinase receptors, T RI and T RII Interaction ... Foxp3+CD4 +CD25+ T cells, suggesting that the treatment induced the emergence (enhancement) of T cells with the regulatory phenotype [71] In short, despite the complex picture of Treg in autoimmunity, it can...
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Báo cáo y học: " CD39+ Regulatory T cells suppress generation and differentiation of Th17 cells in human malignant pleural effusion via a LAP-dependent mechanism" pps
... expression and found that the purified CD39 + CD4 + CD25 high T cells were almost FOXP3 positive and were almost CD127 negative, indicating that these T cells were Tregs The most important finding in the ... Interestingly, we further noted that the numbers of CD39 + Tregs and Th17 cells are inversely correlated in MPE, and that the ratios of CD39+Tregs/Th17 cells were significantly lower in MPE than ... important role in regulating generation and differentiation of Th17 cells in human MPE It has been reported by the other groups [15,22-24] that Tregs can differentiate into Th17 cells In the animal...
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Báo cáo y học: " Expression of K2P5.1 potassium channels on CD4+ T lymphocytes correlates with disease activity in rheumatoid arthritis patients" potx
... RA patients T lymphocytes were isolated from the peripheral blood of 73 RA patients (cross-sectional-study: 58 patients, longitudinal study: 20 patients, included in both studies: patients) and ... months Note that the y-axis in D) is split for better clarity and that two patients are marked in red especially in the case of tocilizumab which inhibits the systemic acute phase reaction at ... observed in treated T cells compared to untreated controls (n = 5; see Table 2) In a next set of experiments a longitudinal follow-up study was initiated including patients who underwent therapy...
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báo cáo hóa học:" yuDetecting the percent of peripheral blood mononuclear cells displaying p-STAT-3 in malignant glioma patients" pot
... p-STAT-3 since patients both receiving and not receiving steroids within the same histology could not be compared due to the routine administration of intraoperative dexamethasone Furthermore, insufficient ... STAT-3 activity in only the immune cells results in marked antitumor effects in vivo, indicating that STAT-3 expression within the immune cells is what restrains antitumor eradication [15] Furthermore, ... displaying p-STAT-3 does not correlate with the percentage of p-STAT-3 positive tumor cells in the glioma To determine if the level of p-STAT-3 positive cells in the glioma correlated to the mean...
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Báo cáo y học: " Phosphodiesterase 6 subunits are expressed and altered in idiopathic pulmonary fibrosis" pdf
... 5’-AAG AGT GGC TTT GGT TTG GTT-3’, PDE6D FP: 5’-AAT GGT TCT TCG AGT TTG GC-3’; RP: 5’-AAA GTC TCA CTC TGG ATG TGC T- 3’, PDE6G FP: 5’-TTT AAG CAG CGA CAG ACC AG-3’; RP: 5’-ATA TTG GGC CAG CTC GTG-3’, ... 5’-CAG GAT ACA GCA GGT TGA AGA CT-3’, PDE6C FP: 5’-AAG AAT GTT TTG TCC CTG CCT A-3’; RF: 5’-AAG AGT GGC TTT GGT TTG GTT-3’, PDE6D FP: 5’-GGA TGC TGA GAC AGG GAA GAT A-3’; RP: 5’-GCC AGG TAT TTG TGG ... regulated at the protein level in IPF lungs Several lines of evidence reported that the inhibitory PDE6G/H subunits of the PDE6 are expressed in non-retinal tissues [33] and are involved in the stimulation...
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Báo cáo y học: "Are CD4+CD25-Foxp3+ cells in untreated new-onset lupus patients regulatory T cells" doc
... explore the nature of this abnormally increased cell entity in UNOL patients Patients and healthy controls Twenty-two UNOL patients of Chinese ethnicity (19 women and men) were recruited in this study ... declare that they have no competing interests Authors' contributions HY and WZ developed the study, analyzed the data, and drafted the manuscript LZ and YL participated in the data collection, ... CD127 in a heterodimeric complex with TSLP receptor [15] TSLP-activated dendritic cells might participate in the homeostatic maintenance of CD4+ and development of Tregs in thymus [16] In this study,...
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Báo cáo y học: "Endogenous TGF-β activation by reactive oxygen species is key to Foxp3 induction in TCR-stimulated and HIV-1-infected human CD4+CD25- T cells" docx
... been implicated in the induction of Tregs in murine cells, we set out to investigate whether TGF-β has a role in the unexpected induction of Tregs by TCR stimulation in human T cells In the human ... present in the supernatants of TCR- and CD28stimulated cultures, and indeed active TGF-β is the functional molecule, the question remains as to how latent TGF-β is activated The finding that TGF-β ... replication in CD4 +CD25- T cells Our data demonstrate a novel connection of TGF-β and Tregs in HIV infection of T cells that may have implications in the Treg activity observed in vivo in infected patients...
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báo cáo hóa học:" Human T cells express CD25 and Foxp3 upon activation and exhibit effector/memory phenotypes without any regulatory/suppressor function" ppt
... (0.6%) These results suggest that activation-induced expression of Foxp3 in CD4 +CD25+ T cells is more stable than that in http://www.translational-medicine.com/content/7/1/89 CD8 +CD25+ T cells ... following T cell activation Foxp3 expression following T cell activation T cells were isolated from healthy volunteers and split into two groups Control group remained unactivated and cultured in the ... Foxp3 These results are consistent with our observation in Fig showing that expression of Foxp3 in CD4+ T cells is more stable than that in CD8+ T cells 6-8 days following T cell activation In previous...
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Báo cáo y học: "A paragon of self-tolerance: CD25+CD4+ regulatory T cells and the control of immune responses" pps
... Mason D: Regulatory T cells in the control of autoimmunity: the essential role of transforming growth factor beta and interleukin in the prevention of autoimmune thyroiditis in rats by peripheral ... distinctions still remain between the surface phenotype of TR and primed T cells, but they are more relative than absolute For example, although both primed T cells and TR cells express CD25, the latter ... (which start off apparently FOXP3–) after anti-CD3/anti-CD28 stimulation [36] It remains to be determined whether this simply represents an expansion to detectability of the tiny Foxp3+GITR +CD25 CD4+...
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Báo cáo y học: " Induction of IL-10-producing CD4+CD25+ T cells in animal model of collagen-induced arthritis by oral administration of type II collagen" pptx
... antiinflammatory cytokine secreted by Th2 lymphocytes, contributes to the process of peripheral tolerance [1,6] Our data suggest that the establishment of CII-mediated tolerance to arthritic inflammation ... very interesting to investigate the role of Th3 cells In order to further define the characteristics of cells that exert immunosuppressive functions, we are in the process of examining the expression ... R218 Our findings indicate that the serum levels of proinflammatory and anti-inflammatory IgG subtypes are differentially modulated in mice that have undergone repeated oral administration of CII...
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