... contributor forthe clearance of NPs, thus the reducing rate of MPS uptake could be considered as the best strategy for prolonging the circulation of NPs (Li & Huang, 2008) Therefore, PA/EPI prepared in ... two groups, each with 10 mice The experimental group received a single intravenous (i.v.) dose of blank PANs (200 mg/kg); the other group was treated with a single i.v dose of normal saline All ... When the standard consists of intravenously administered drug, this is known as relative bioavailability (BAR) The BAR of PA/EPI after administration was calculated using the following formula...
... contains labels forthe front and back ofthe hinged label SH ADCLS-TFP2RUA Adhesive label for ADC’s 5RU TFP Fiber Panel Each label sheet contains labels forthe front and back ofthe hinged label ... for ADC’s 1RU TFP Fiber Panel Each label sheet contains labels forthe front and back ofthe hinged label SH ADCLS-TFP1RUA Adhesive label for ADC’s 2RU TFP Fiber Panel Each label sheet contains ... Labeling Sheets Ordering Information Description UOM Catalog Number ADCLS-CL4A SH ADCLS-CL10A Adhesive label for ADC’s patch cords or horizontal cable 1" x 1/4" Each label sheet contains 35 individual...
... uniformly in xII0 The remainder ofthe proof involves similar arguments as given above and as inthe proof of parts ii) v) of Theorem 2.3 and, hence, is omitted Next, we provide a time-varying ... needed for developing the main results of this monograph In a denition or when a word is dened inthe text, the concept dened is italicized Italics inthe running text is also used for emphasis The ... collection of interacting subsystems The behavior and properties ofthe aggregate large-scale system can then be deduced from the behaviors ofthe individual subsystems and their interconnections Often...
... traditional banking Another indicator ofthe decline inthe profitability of traditional banking is the fall inthe ratio of market value to book value of bank capital from the mid-1960s to the early ... conducted by the Bank for International Settlements (the “Promisel Report”), the Bank of England, the Group of Thirty, theOf ce ofthe U.S Comptroller ofthe Currency, the Commodity Futures Trading Commission, ... banking institutions Indeed, banks’ loan losses in these countries as a fraction of GNP exceeded losses in both the banking and the savings and loans industries inthe United States The International...
... sequences into a loop ofthe SH2 domain and screening for binding to the phosphotyrosyl ligand peptide [67] In principle, folded insertions should reduce the entropic penalty for inserting a long ... the B1 domain of IgG-binding protein G [42] Individual clones were examined for expression and grown inthe presence of a 15N source, allowing 1H-15N HSQC NMR analysis of crude lysate for well-dispersed ... but the C-terminus of helix has shifted away from the core to accommodate the overpacking (as indicated by the arrow) Interestingly, most ofthe core residues retained near-ideal rotameric conformations...
... determines the solution The conditions for predictability are then related to the behavior ofthe unique solution ofthe initial value problem on the boundary of this region Inthe following two ... natural starting point for studying the problem inthe nonlinear setting In fact, the method of this paper applies to a much wider class of initial data to be considered in a forthcoming paper We ... to the case where the inequalities (111) are not strict by noting the following continuity principle: Given a fixed metric satisfying the conditions ofthe theorem, the initial value problem for...
... with serines significantly affects both their thermodynamic and kinetic stability [10,12], suggesting the involvement ofthe cysteine pair inthe thermal stabilization of both enzymes Inthe present ... damage ofthe other disulfide bonds ofthe protein To demonstrate the active role of CXC motif inthe oxidative folding process, we carried out the unfolding of SsMTAPII, PfPNP and their CXClacking ... mutants by incubation for 22 h at 25 °C with m GdnCl in 20 mm Tris ⁄ HCl (pH 7.4), containing 30 mm dithiothreitol The reversibility ofthe GdnClinduced unfolding was then examined by assaying the catalytic...
... study the inuence of anking regions on the existence of quadruplexes, their stability and quadruplex duplex competition inthe presence ofthe complementary strand As the quadruplex-forming region ... equilibrium Inthe current study, we have explored the inuence of anking sequences inthe quadruplex-forming region ofthe c-kit proto-oncogene promoter [16] Conformational analysis of preformed quadruplexes ... 107 106 the binding enthalpy for duplex formation, which increased with the increase inthe number of anking bases from to 6, and deviation from the increasing DHITC trend was observed for c-kitG8...
... finding supports that charged interactions are of importance for governing TkMGMT hyperthermostability Other proteins In addition to the described groups of proteins, only a few other hyperthermostable ... combination ofthe two (Fig 1A) In vitro folding ⁄ unfolding experiments in solution often involve chemical (i.e urea or guanidine hydrochloride, GuHCl) or thermal perturbations ofthe protein; the ... Comparisons ofthe thermodynamics and kinetics ofthe folding of proteins from mesophilic and thermophilic ⁄ hyperthermophilic organisms can provide an insight into the mechanisms of stabilization...
... those ofthe WT form In other words, inthe mutant thrombin the binding of sodium is not intrinsically perturbed, but should be uncoupled from the specific conformational transitions occurring inthe ... simulation of DK9 thrombin in explicit water solvent supports the role ofthe A-chain in affecting the conformation and catalytic properties ofthe B-chain, particularly in some insertion loops ofthe ... sodium binding X-ray structures of human thrombin show that the A-chain closely follows the contour ofthe catalytic B-chain, hinging the two interacting six-stranded barrel-like domains ofthe B-chain...
... and formation of a compact transition state The temperature-dependence ofthe refolding rate provides thermodynamic insights into the nature ofthe TSE for folding Curvature inthe plot of 1/T ... determined protein stability, and their involvement inthe folding pathway from studies of refolding/unfolding kinetics While the single point mutation P37A is destabilizing by 4.5 kJÆmol)1, in ... WT* The single point S19P mutation leads to a F ¼ 0.37, which points to the stabilizing effect of this mutation not being realized inthe folding TSE, indicative ofthe loop between the N-terminal...
... in vivo with the intramolecular route dominating during periods of minimum synthesis and secretion ofthe cysteine protease The role of a heterologous intermolecular mechanism inthe processing ... transition remained unaffected (Fig 5C) Reduction ofthe intrinsic stability ofthe protein inthe presence of EDTA and the absence of detectable stabilization effect inthe presence of mM Ca2+ indicate ... Monitoring ofthe ellipticity at 205 nm during heating produced a sigmoidal biphasic transition curve indicative of cooperative unfolding for a multidomain protein (Fig 5D) Again, the midpoints for...
... authority can independently target either the nominal exchange rate or the interest rate, leaving the determination ofthe other to the interplay ofthe market forces The overwhelming evidence ... saving performance of 25 the public sector, and the abrupt financing demands ofthe government increases uncertainty and risk inthe financial markets It also increases the volatility ofthe money ... empirical findings for developing countries as a whole or forthe sub-group of “emerging markets” have shown that cumulative sums of each ofthe foregoing items for a few years or forthe full financial...
... proteins [38–40] These include tighter hydrophobic packing ofthe protein core [41–43], increased electrostatic interactions on the surface ofthe protein [44,45], more prolines and alanines ... by the SDS ⁄ BME treatment, and remain either in a monomeric or a tetrameric state, depending on the pH ofthe protein buffer In contrast, SDS ⁄ b-ME treatment alone dissociates a fraction ofthe ... within the TTR family in dark and light blue, and those within the TLP subgroup in dark and light gray The secondary structure elements are based on hTTR [12] Residues lining the substrate-binding...
... Kd values forthe binding ofthe cations onto the CRMP-2 protein surface are 15–20 mm forthe divalent cations and > 100 mm for potassium The detection of several isoforms of CRMP-2 in rat hippocampus ... inthe 3D structure of CRMP2 (Fig 6) The first concerns the main deamidation site and four ofthe main oxidation sites The second one contains the remaining two main oxidation sites and two minor ... identified inthe brain Our data, including the mapping of post-translational modifications onto the structure of CRMP-2, open up new possibilities for studying the function and interactions of CRMP-2,...
... the reaction ofthe current during the sag can help determine the source ofthe sag If the current doubles when the voltage sags 10%, then the cause ofthe sag is on the load side ofthe current ... capture the waveform if there is a significant deviation in any portion ofthe waveform Others capture waveforms if there is a significant change inthe rms value of successive waveforms Another method ... the current monitor point If the current increases or decreases 10–20% during a 10% voltage sag, then the cause ofthe sag is on the source side ofthe current monitoring point Sensitive equipment...
... all ofthe many topics encompassed by the field The chapters are written primarily forthe electric power engineering professional who is seeking factual information, and secondarily forthe professional ... particular topic of interest is not included in this list, please refer to the list of companion volumes seen at the beginning of this book In reading the individual chapters of this handbook, ... Outstanding Engineering Educator Award, the 1996 Birdsong Superior Teaching Award at Auburn University, and the IEEE Power Engineering Society Outstanding Power Engineering Educator Award in 2003 Professor...
... decrease the fuel supply to bring generation into equilibrium with load In this case, storage is inthe form of coal inthe pile or natural gas inthe well An excellent form of storage is water in ... They therefore must cut back part ofthe time because ofthe lack of water A combination hydro and wind plant can conserve water when the wind is blowing, and use the water later, when the wind ... justify a wind turbine, and had the effect of killing the small wind turbine business 1.1.3 Large, Non-Grid Connected These machines would be installed on islands or in native villages inthe far...
... ratio are in uenced by the utility’s load curve, and the price of off-peak power For example, the CAES plant in Germany requires h of compression per hour of generation On the other hand, the Alabama ... better candidate for combined cycle applications whereby the fuel cell exhaust can be used as input to the intake of a gas turbine or the boiler of a steam turbine The total thermal efficiency ... until early inthe 21st century 2.1.4.7 Zinc and Aluminum Air Batteries Zinc air batteries are currently being tested in postal trucks in Germany These batteries use either aluminum or zinc as a...