folding structure and function is it a globular or an intrinsically disordered protein
Báo cáo khoa học: Structure and function of human a-lactalbumin made lethal to tumor cells (HAMLET)-type complexes pptx
... misfolding and aggregation have been associated with tissue toxicity and disease, partial protein unfolding is becoming recognized as a mechanism to generate beneficial functional diversity [2] It is ... exchange column conditioned with oleic acid [2] The complex was named HAMLET and was defined as a complex between partially unfolded a- lactalbumin and oleic acid Human a- lactalbumin is a globular ... Hospital Foundation, Royal Physiographic Society, Anna-Lisa, Sven-Erik Lundgren Foundation, Knut and Alice Wallenberg Foundation, Inga-Britt and Arne Lundbergs Foundation and the John and Augusta...
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Is it a preposition is it a conjunction or is it an adverb
... this: How are you progressing at work An opportunity has arisen for a Twitter correspondent at Sky News Board and the expected answers are: How are you getting on at work An opportunity ... because both of these phrasal verbs are followed by prepositions (at and for) The particles on and up are adverbs, so as far as I can see these are not prepositional verbs at all, but Type phrasal ... shopping later Where there's a will, there's a way Phrasal verbs - are the particles prepositions or adverbs? A phrasal verb consists of a verb and one or more particles, either prepositions or adverb...
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The small GTPASE ARF like protein 1 (ARL1) is a new regulator of golgi structure and function
... Arl5 human Arl5 human Arl8 human Arl8 human Arl4 human Arl4 human Arl7 human Arl7 human Arl4L human Arl4L human Arl6 human Arl2 human Arl3 human ARFR 155.4 140 120 100 80 60 Nucleotide Substitutions ... for most members at the moment 12 13 human ARF1 human ARF mouse ARF2 mouse ARF2 human ARF3 human ARF3 human ARF4 human ARF4 human ARF5 human ARF5 human ARF6 human ARF6 rat Arl1 rat Arl1 human ... plasma membrane (ARF1, ARF6 and ARFRP1) including focal adhesions (ARF1) and membrane ruffles (ARF1 and ARF6) (Schurmann et al., 1995; Moss and Vaughan, 1998; Huang et al., 1999; Chavrier and Goud,...
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Tài liệu The Decline in the U.S. Personal Saving Rate: Is It Real and Is It a Puzzle? pptx
... without any limits and this would raise the standard of living both in the United States and abroad Of course, in reality, international capital markets are segmented and far from frictionless, and ... when standard and generally accepted economic principles and theories fail to provide a quantitatively satisfactory explanation for a set of empirical regularities In this case, the empirical “stylized ... in Tanzi and Zee (1998) for saving rates and tax data for a panel of countries in the Organisation for Economic Co-operation and Development However, in quantitative terms, Parker (2000) also...
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Tài liệu Báo cáo khoa học: a-Conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes doc
... oocyte-expressed human nAChR subunit combinabrain [64] and has proven to be a powerful radioligand in tions and seems to have a similar selectivity and activity as numerous binding and autoradiography studies ... represented by PIA and MII (SNPV motif in the first loop and nanomolar activity on a3 /a6 containing nAChRs) and EpI and ImI (SDPR motif in the first loop and nanomolar activity on a7 nAChRs) It remains to ... candidates Initial pharmacological studies using the agonists nicotine and cytisine and the a3 selective antagonist n-BTX in striatal synaptosome preparations suggested an a4 b2* nAChR with a...
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Báo cáo khoa học: Evolutionary changes to transthyretin: structure and function of a transthyretin-like ancestral protein doc
... characteristics of transthyretins and TLPs are indicated above the alignment: motifs A –C’ are indicated with straight lines and are labelled; b-strands are indicated with arrows and are labelled ... 325–335 Ames BN, Cathcart R, Schwiers E & Hochstein P (1981) Uric acid provides an antioxidant defense in humans against oxidant- and radical-causing aging and cancer: a hypothesis Proc Natl Acad ... Betaproteobacteria Proteobacteria, Gammaproteobacteria Proteobacteria, Gammaproteobacteria Proteobacteria, Gammaproteobacteria Proteobacteria, Gammaproteobacteria Proteobacteria, Gammaproteobacteria 2 2...
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Báo cáo khóa học: S-(2,3-Dichlorotriazinyl)glutathione A new affinity label for probing the structure and function of glutathione transferases potx
... the A and B chains are 26.67 A2 and 49.26 A2 , and the ˚ and 79.30 A2 , respect˚ B-factors of S atoms are 38.14 A ively It is therefore reasonable to propose that conformational changes and changes ... for inactivation (pH 6.5) was the same as that necessary for high GST activity This probably affords an enzyme conformation similar to that adopted during catalysis, thus creating more favourable ... catalytic reaction This finding strengthens the view that the SDTG acts as a true affinity label for the GSHbinding site and indicates that this new reagent may have wider applicability as an affinity...
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Báo cáo khoa học: Human haptoglobin structure and function – a molecular modelling study pptx
... Hb, acts as an antioxidant agent [37] An additional activity of HPT is related to its ability to suppress heat-induced and oxidative stress-induced unfolding and precipitation of a number of proteins, ... ionizable residue pKa values were calculated using propka [35] Acknowledgements This work was supported by a grant from the Italian Ministry of University and Research References Materials and ... PSI-Blast [38] iterations against the nonredundant protein database using the sequences coded GI 1212947 and GI 4826762 for HPT1 and HPT2 variants, respectively, as a bait The 18 N-terminal amino acids...
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Báo cáo khoa học: "Comparison between the structure and function of chloroplasts at different levels of willow canopy during a growing season" ppsx
... activity, chloroplast ultrastructure, and leaf characteristics of high- and low-light plants and of sun and shade leaves Photosynth Res 2, 115-141 light E.M (1986) Correlation of activity and amount ... ultrastructure was analyzed from the electron micrographs as described by Aro et aL, (1986) and Vapaavuori (1986) On an average, typi- cal chloroplasts were analyzed sample of the replicate plots ... the low rates of C0 A uptake recorded (Fig 2A) were possibly caused by decreased availability of excitation energy in the canopy and not by altered organization of thylakoid membranes Later in...
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Báo cáo y học: "Tibialis posterior in health and disease: a review of structure and function with specific reference to electromyographic studies" pot
... health and disease Tibialis Tibialis posterior EMG activity during walking in health and disease Tibialis posterior EMG activity during walking in health and disease – schematic estimates for ... foot and ankle – diagnosis, pathology, and treatment The relationship between foot and ankle deformity and disease duration in 50 patients Foot Ankle 1982, 2:318-324 Woodburn J, Cornwall M, Soames ... revised the manuscript All authors read and approved the final manuscript Additional material Additional file Posterior approach A video demonstration of the posterior approach of intramuscular electrode...
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Báo cáo y học: "A comparative approach for the investigation of biological information processing: An examination of the structure and function of computer hard drives and DNA" doc
... initial concept for comparative analysis between the DHD and CHD and and drafted the initial version of the manuscript GA drafted portions of the manuscript and revised it critically for important ... Nuclear Attachment Substrate (NAS) which is a physical structure analogous to the disk and track layout of the CHD The DNA organized within the CT’s is structurally anchored and may be spatially organized ... D’Onofrio and An: A comparative approach for the investigation of biological information processing: An examination of the structure and function of computer hard drives and DNA Theoretical Biology and...
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Structure and function of methyltransferases from antibiotic resistance bacteroides of human intestine and a study on nm ng with cam
... vector using the following primerBT_2972: Forward: 5’CTTTCATATGCATCATCATCATCATCATAGTAACAATAATACAT’3 Reverse: 5’ CTTTCTCGAGTCATCTTTTTTGTCCTATATAGAATACGTA’3 BVU_3255: Forward: 5’ CTTTCATATGCATCATCATCATCATCATAATAATGAC ... proteins were crystallized in the apo form and as complex with ligands such as SAM and SAH The sequence analysis suggests that both BT_2972 and BVU_3255 are small molecule methyltransferase and ... Veerendra Kumar and Sivaraman J: Structural and functional characterization a methyltransferase of ubiquinone biosynthesis pathway from antibiotic resistance pathogen Bacteroides vulgatus ATCC 8482...
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Trade and Poverty Is There a Connection
... been such a sharp deterioration in transport infrastructure that it is difficult for traders to reach areas that are more than a relatively short distance from a major route It is an open question ... pp.419-447 Harrison, A and Hanson, G H (1999) ‘Trade liberalization and wage inequality in Mexico' Industrial and Labor Relations Review, vol.52 pp.271-288 Harrison, A and Revenga, A (1998) ‘Labor markets, ... chamber), and can be used by unskilled labour They provide quality maize meal products to nearby customers in the poor communities in areas such as Mashonaland Central, Manicaland, Masvingo, and...
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Tài liệu Báo cáo khoa học: Structure and function of active chromatin and DNase I hypersensitive sites pdf
... mammalian cells, then KDM 2A may suppress this pathway and maintain histone acetylation at transcribed CG islands It is becoming increasingly likely that CG islands remain free of DNA methylation ... nuclease hypersensitivity [85] Mast cells express GATA-2 as well as NFAT and AP-1, and GATA-2 initiates the formation of an additional discrete GATA-2 ⁄ AP-1 enhanceosome-like complex existing ... elongating Pol II In addition to yeast SAGA and NuA4, the mammalian HAT HBO1 is also potentially able to be recruited to and to acetylate H4 on K5, K8 and K12, as well as H3 throughout active...
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Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx
... immunocytochemistry and lgÆmL)1 for coimmunoprecipitation Materials and methods Animals Primary cultures, transfection and imaging of hippocampal and cerebellar neurons Hippocampal and cerebellar dissociated ... (Hamamatsu, Japan) and used in accordance with protocols approved by the Animal Care and Use Committee of RIKEN Immunoprecipitation was performed as described previously [20] Briefly, COS7 cells or ... immunocytochemical staining with anti-Flag or anti-HA sera Cell images were acquired by confocal microscopy (LSM510; Carl Zeiss, Inc., Oberkochen, Germany) Morphometric analysis of dendritic arborization patterns...
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Tài liệu Body Size: The Structure and Function of Aquatic Ecosystems pptx
... Corynactis californica1 Metridium senile Zoanthidea Palythoa variabilis Scleractinia (hard corals) Acropora millepora5 Alveopora spongiosa1 Balanophyllia elegans1 Montipora digitata5 Pocillopora ... californicus1 Octocorallia (soft corals & sea pens) Paracyanthus stearnsi1 Sansibia spp.1 Stylatula elongata1 Xenia spp.1 Actinaria (sea anemones) Anemonia viridis1 Anthopleura elegantissima ... feeding apparatus at a rate disproportionately more than that of the increase in body size (allometric scaling) For instance, colonial sea anemones, corals and gorgonians have a growth form that allows...
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Tài liệu Báo cáo khoa học: How disorder influences order and vice versa – mutual effects in fusion proteins containing an intrinsically disordered and a globular protein docx
... for NTAIL-GFP was a dened transition visible in the range 7585 C range, whereas PNT-GFP and SIC1-GFP did not display a classical two-state conformational transition We also monitored the mean ... (5Â-TAC CTGGCCAATGAATATGCATCATCATCATCATCATA CTCCGTCGACCCCACC-3Â) designed to introduce a hexahistidine tag and a ClaI restriction site at nucleotide position and a reverse primer (5Â-ATCGCCATGGTC ... in Marseille The authors wish to thank Antonino Natalello and Silvia Maria Doglia for their assistance with the uorescence spectroscopy, as well as for critically reading the manuscript We are...
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Tài liệu Báo cáo khoa học: Structure and function of plant aspartic proteinases pptx
... prosegment and the PSI domain, with a domain organization similar to that of mammalian or microbial APs An inactivation mechanism for plant APs has been proposed by Kervinen et al based on the ... aspartic proteinases TcAP1 and TcAP2 from Theobroma cacao seeds Planta 215, 754–762 12 Park, H., Yamanaka, N., Mikkonen, A. , Kusakabe, I & Kobayashi, H (2000) Purification and characterization of aspartic ... 105–120 An, C.I., Fukusaki, E & Kobayashi, A (2002) Aspartic proteinases are expressed in pitchers of the carnivorous plant Nepenthes alata Blanco Planta 214, 661–667 Asakura, T., Watanabe, H., Abe,...
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Tài liệu Báo cáo khoa học: Cold survival in freeze-intolerant insects The structure and function of b-helical antifreeze proteins pdf
... describe the structure and dynamics of each protein, and present a comparison of sbwAFP and TmAFP with each other and with proteins that have a similar fold Structure of sbwAFP and TmAFP The structure ... b-sheets that are found on one or more faces of the protein perpendicular to the helical axis The strands from ˚ the b-sheets are spaced 4.8 A apart and are relatively flat and untwisted compared to ... these proteins As with sbwAFP, TmAFP has fewer coils than the other right-handed b-helical proteins (Fig 4A) , and does not have extensions from the coils that can act as ligand binding sites An...
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