fluid wall interactions in the lattice boltzmann simulations
Tài liệu Báo cáo khoa học: Cobalamin uptake and reactivation occurs through specific protein interactions in the methionine synthase–methionine synthase reductase complex docx
Ngày tải lên :
18/02/2014, 08:20
... domain or full-length MSR results in a quenching of the intrinsic flavin fluorescence, suggesting that the flavin chromophore is shielded from the solvent in the protein–protein complex [19] From the ... of MS During primary turnover, the homocysteine-binding domain (dotted barrel) and the CH3-H4-folate binding-domain (black barrel) form discrete complexes with the cobalamin-binding domain (dark ... footnote) in the reaction mixture may reduce a proportion of the FMN domain, converting some of the enzyme to the active form The 3-fold increase in activity may arise from the binding of the FMN...
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Tài liệu Báo cáo khoa học: The role of electrostatic interactions in the antitumor activity of dimeric RNases docx
Ngày tải lên :
19/02/2014, 06:20
... detected at the dimer interface of the models or in the surroundings of the mutated residues The models of RNase A covalent dimers in the exchanging conformation were prepared using the 7RSA structure ... Electrostatic interactions and antitumor RNases the dimer interface of the models or in the surroundings of the hinge loop residues Likewise, the models of nonexchanging and exchanging HHP-RNase ... through the exchange between subunits of either their N-terminal, or their C-terminal ends [33–35] We found that the behavior with the model membrane of the dimer in which the C-terminal ends...
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Managing Drug Interactions in the Treatment of HIV-Related Tuberculosis docx
Ngày tải lên :
06/03/2014, 04:20
... available The Role of Rifamycins in Tuberculosis Treatment Despite the complexity of these drug interactions, the key role of the rifamycins in the success of tuberculosis treatment mandates that the ... rifabutin dose was decreased in response to antiretroviral therapy then stops taking the interacting drug (e.g., ritonavir), the resulting rifabutin concentrations are likely to be sub-therapeutic These ... in drug-metabolizing enzymes Therefore, drug interactions and their relevance may not be the same in different populations Third, in the attempt to provide the most up-to-date information we include...
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Báo cáo Y học: Probing intermolecular protein–protein interactions in the calcium-sensing receptor homodimer using bioluminescence resonance energy transfer (BRET) potx
Ngày tải lên :
08/03/2014, 09:20
... agonist-induced alterations in BRET signal intensities reflecting 7TM dimer rearrangement as a result of the activating twist in the ATDs of the CaR homodimer Further investigations into the signal ... However, as these fusion proteins were retained in vesicles inside of the cells, we were not able to use them in the BRET studies It would have been interesting to tag Rluc and GFP molecules to the i2 ... agonist-induced BRET observed in this study is that the translation of agonist binding to the ATDs of the family C GPCR homodimer into G-protein coupling of the 7TM)7TM moiety is mediated by another...
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Báo cáo khoa học: Netropsin interactions in the minor groove of d(GGCCAATTGG) studied by a combination of resolution enhancement and ab initio calculations pot
Ngày tải lên :
16/03/2014, 22:20
... to the walls of the minor groove in their own region The terminal guanidinium group is nearly coplanar with pyrrole ring A, as they make a dihedral angle of 6.7° (9.7° for NETRSN) The terminal ... However, it is interesting that the guanine amino group may be in uenced by this contact We compared the interaction energies in both a planar and a nonplanar guanine G9 amino group The HF interaction ... in the planar guanine amino group was computed to be 55 kJÆmol)1 (40 kJÆmol)1 in the nonplanar guanine amino group), 25 kJÆmol)1 in total interaction energy (7 kJÆmol)1 in the nonplanar guanine...
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Báo cáo khoa học: Protein interactions in the sumoylation cascade – lessons from X-ray structures pdf
Ngày tải lên :
30/03/2014, 04:20
... with the adenylation domain at the base, and the UFD and cysteine domains on both sides The catalytic cysteine residue lies in a long loop between the cysteine domain and the adenylation domain ... Ala72 in Nedd8, and Arg72 in ubiquitin (highlighted in yellow in Fig 2C) Matching E1 residues are Thr149 in uba2, Arg190 in uba3 and Gln608 in uba1 (highlighted in purple in Fig 3E) Interestingly, ... and mechanism An intriguing question is how the individual components of the sumoylation machinery interact during the Interactions between sumoylation proteins various steps of the modification...
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Báo cáo hóa học: " Atomic Force Microscopy Study of Protein– Protein Interactions in the Cytochrome CYP11A1 (P450scc)-Containing Steroid Hydroxylase System" docx
Ngày tải lên :
21/06/2014, 11:20
... and dried in airflow The binary complexes were obtained by mixing 10 μl of μM solutions of appropriate individual proteins in 50 KP, pH 7.4 Then, the mixture was incubated for 10 min, diluted ... higher hmax than the ones of individual AdR and Ad In the binary mixture, the share of these objects in the positive wing of the Δr = (r(h) AdR+Ad [r(h)AdR + r(h)Ad]) distribution with the height 1.8–2.6 ... r(h)AdR/Ad for binary mixtures (d) Arrows (1) indicate the images of protein monomers Arrows (2) indicate the images of the binary protein complexes Arrows (3) indicate the images of the ternary...
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THE IMPORTANCE OF BIOLOGICAL INTERACTIONS IN THE STUDY OF BIODIVERSITY pdf
Ngày tải lên :
28/06/2014, 08:20
... has been divided in three sections correponding to the three main kinds of biological interactions: interactions between living organisms (Section 1), interactions between living organisms and ... parameters as shown in Hawaii with the increase in the altitudinal range of Cx quinquefasciatus and the differences in vector competence to avian malaria after the second introduction of the vector (Fonseca ... states that the term biodiversity comprises all the variety of life, in all its manifestations, at all its levels of organization, and including their complex interactions The biological interactions...
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Motion and Gesture Interactions in the digital age
Ngày tải lên :
20/07/2014, 15:26
... Motion & Gestures interactions in the digital age From the first personal computing with Static interface and physical controls Motion & Gestures interactions in the digital age To an incredible new ... visualize the effect of a specific interaction in the digital space Motion & Gestures interactions in the digital age Introduction Motion Design & Digital products Web 1.0: Java & Gif At the beginning ... and motion interactions was the right answer to show a new kind of affordance Physical Motion patterns becomes virtual interactions Motion & Gestures interactions in the digital age Introduction...
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Báo cáo y học: "The role played by cell-substrate interactions in the pathogenesis of osteoclast-mediated peri-implant osteolysis" potx
Ngày tải lên :
09/08/2014, 07:20
... is indicated by the resorptive defect in osteoclast-mediated bone resorption in mice in which either of these genes has been deleted [36,37] In humans, inactivating mutations in the cathepsin ... examined for β3 integrin protein and CTR mRNA expression As shown in Figure 6a, b, β3 integrin immunohistochemical staining was detected in both the mononuclear and multinuclear cells in resorption ... different integrins, including the vitronectin receptor αvβ3 [2,3] Expression of this integrin has served as a useful marker to identify osteoclasts and to distinguish them from their colony forming...
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Báo cáo y học: "CXCR3/CXCL10 interactions in the development of hypersensitivity pneumonitis" pot
Ngày tải lên :
12/08/2014, 18:21
... divided into four groups based on the positioning of the cysteine residues in the mature protein [36], induce directional migration of immune cells through their interactions with G-protein coupled ... Figure scheme of the effect of the CXCR3/CXL10 interactions in the lung of hypersensitivity patients Putative Putative scheme of the effect of the CXCR3/CXL10 interactions in the lung of hypersensitivity ... demonstrated in the lung of HP patients with T cell alveolitis Whether the presence of the two chemokines is concomitant and there are common molecular mechanisms involved in the CC and CXC chemokine...
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Axisymmetric and three dimensional lattice boltzmann models and their applications in fluid flows
Ngày tải lên :
11/09/2015, 14:36
... the continuity assumption at macroscopic level, which means the macro variables are well defined in a infinite small point and vary continuously from one point to another On the other hand, the ... source terms into the 2D lattice Boltzmann equation (LBE) Through fully considering the lattice effects in our derivation, all these models can mimic the 2D Navier-Stokes equation in the cylindrical ... to the nearby lattice nodes according to a certain lattice velocity model Since all lattice velocity models are regular and defined in the Cartesian coordinates, the standard LBM is based on the...
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Tài liệu In the Shadows of a Fallen Wall docx
Ngày tải lên :
22/02/2014, 06:20
... mother -in- law, Karin’s — then passed through the second floor of the house next door and landed in the third, killing the family hiding in the basement Karin’s family, having taken cover in their ... change.” Just as people once built, maintained, and patrolled the Wall, it remains people BREAKING DOWN THE WALL 19 who retain these walls in their heads, disavowing the shift that many call progress ... flouting my credentials I had put them in the byline to explain why I had been in eastern Germany,1 not to wave the award in the reader’s face The editor also altered the closing by cutting out the...
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Báo cáo khoa học: Studies on the role of the receptor protein motifs possibly involved in electrostatic interactions on the dopamine D1 and D2 receptor oligomerization pdf
Ngày tải lên :
07/03/2014, 03:20
... monitor the physical interactions between receptor proteins [51,52] Results Radioligand binding assay As shown in Table 1, the binding parameters obtained for dopamine D1 receptor and its mutant indicate ... phosphorylated serine residue in the C-terminus of the A2A receptor are involved in heterodimerization between the adenosine A2A receptor and the dopamine D2 receptor [43] A similar interaction has ... that the Kd values for these two receptors were similar; however, the density of the D1MUT (404AA405) was Table Binding parameters for the dopamine receptors For dopamine D2 receptor binding, the...
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Báo cáo khoa học: Identification, subcellular localization and functional interactions of PilMNOWQ and PilA4 involved in transformation competency and pilus biogenesis in the thermophilic bacterium Thermus thermophilus HB27 ppt
Ngày tải lên :
07/03/2014, 12:20
... implicated in retraction of the PilA4-comprising DNA translocator transporting the DNA through the periplasmic space Binding of the DNA to the DNA-binding protein ComEA on the surface of the inner ... proteins and on the effect of mutations in distinct competence proteins on the subcellular localization of other proteins Taken together, the data presented here provide the first insights into the ... acylation and, thereby, be involved in membrane anchoring of the pilin Since PilA4 is similar to the meningococcal pilin and contains several central serine residues, it is tempting to speculate...
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Báo cáo khoa học: Contributions to catalysis and potential interactions of the three catalytic domains in a contiguous trimeric creatine kinase doc
Ngày tải lên :
16/03/2014, 06:20
... closing of one active site is structurally linked to substrate binding in the second Stated another way, formation of the TSAC in one active site may act to stabilize the open state in the other, ... ligated into TOPO cloning vectors and mutated The mutated construct was then excised and re-ligated back into the original expression vector containing the two non-mutated domains The following restriction ... substrate binding are shown in blue, and the N-terminal ‘hinge’ proline is shown in pink The highly conserved reactive cysteine residues that were the mutagenic target of this study are shown in green...
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Báo cáo Y học: A polymer with a backbone of 3-deoxy-D-glycero -D-galacto -non-2ulopyranosonic acid, a teichuronic acid, and a b-glucosylated ribitol teichoic acid in the cell wall of plant pathogenic Streptomyces sp. VKM Ac-2124 pdf
Ngày tải lên :
17/03/2014, 10:20
... and the presence of an unidentified ninhydrin-positive component suggest that the cell wall contains other polymer(s) in addition to ribitol teichoic acid The polymers present in the cell wall ... 0.33 : 0.33 based on the integral intensities of the signals in the 1H NMR spectrum It is likely that the percentages of the teichuronic acid, the Kdn-containing polymer, and the ribitol teichoic ... (III) The percentage of the teichoic acid ( 10 % mass of the cell wall) was calculated from the content of the teichoic acidlinked phosphorus (0.8%) and taking into account the structure of the...
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Báo cáo khoa học: Interactions of ultraspiracle with ecdysone receptor in the transduction of ecdysone- and juvenile hormone-signaling pdf
Ngày tải lên :
23/03/2014, 13:20
... receptors, including human RXR (which is the ortholog of USP) have shown that an area on the surface of the ligand binding domain involving the C-terminus of a-helix 3, a-helix 4, and the N-terminus ... promoter reporter These two motifs (DR1 and IR1) contain identical half sites and the same intervening single base, the difference being the orientation of the second half site as in the same direction ... vector The green fluorescent protein (GFP)-dUSP fusion protein was prepared in pIE1-4 by subcloning the GFP coding sequence for into the EcoRI ⁄ SmaI sites of the pIE14 vector, upstream of and in the...
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Báo cáo khoa học: Calpain 1–titin interactions concentrate calpain 1 in the Z-band edges and in the N2-line region within the skeletal myofibril doc
Ngày tải lên :
23/03/2014, 13:20
... investigations towards titin–calpain interactions The binding of calpain to the N-terminal region of titin was investigated in vitro by using two distinct titin fragments: firstly, a native purified ... were then used to test whether calpain binds at the N2-line position, located approximately at the midpoint between the Z-line and the A–I junction In comparison with the control, where the primary ... primary antibody, neither calpain nor Z9–I1 is recovered in the pellet (lanes T) 2583 Calpain 1–titin interactions in myofibrils F Raynaud et al locating calpain at the midpoint of the I-band, provide...
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Báo cáo khoa học: Dissecting the role of protein–protein and protein–nucleic acid interactions in MS2 bacteriophage stability potx
Ngày tải lên :
30/03/2014, 11:20
... overexpressed in E coli from a plasmid [11] To examine the stability of the coat protein dimer in the absence of the intersubunit interactions found in the capsid, we used a mutant, named dlFG, in which the ... enters the cell together with the RNA genome, leaving behind an intact capsid The dlFG version of coat protein is dimeric and therefore lacks both the protein–protein and protein– nucleic acid interactions ... resides within the hydrophobic core of the protein The other residue, Trp82, is partially solvent-exposed [17] Its environment is determined primarily by interactions within the dimer, not by interactions...
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