... and -D, structure and function L J Reigstad et al endothelial growth factors (VEGF) andthefamily is therefore often referred to as the PDGF ⁄ VEGF familyThe PDGF familyof growth factors The ... perivascular lymphoid cell infiltrates ofthe lung and fibrosis in the liver [110] Conclusions The novel members, PDGF-C and -D, ofthe PDGF subfamily ofthe cystine knot familyof growth factors are potent ... removal ofthe CUB domains and thereby activation ofthe growth factor domains PDGF-C and -D contain both the CUB and growth factor domains when they are secreted and proteolytic cleavage is therefore...
... illustrating the arrangement of all domains in the five-domain membersofthe GH 13, can be taken as an approximation ofthe first three domains in the four-domain members It also shows the typical ... cluster of Bacillus and Thermoanaerobacter CGTases andthe remaining enzymes The positions ofthe two CGTases from K pneumoniae and Nostoc sp PCC-9229 are, however, in agreement with the values of ... part ofthe same enzymes (Figs and 4) can be seen in the present study The four- and five-domain membersof GH 13 can be Fig The proposed relationship between four- and five-domain GH 13 members...
... by the recent findings that different membersofthe HSF family are able to interact, both structurally and functionally, thereby impacting the actions of their partners The interplay among the ... interactions and post-translational modifications HSF1 is the prototype of all HSFs andthe mammalian counterpart ofthe single HSF of yeasts, nematodes and fruit flies [3,27–29] Deletion experiments ofthe ... knockout of Hsf1 and Hsf4, the abnormal levels of FGF-7 returned to normal, and proliferation and differentiation ofthe epithelial cells were stabilized These findings indicate that HSF1 and HSF4...
... cotyledons and mature leaves, whereas, in the flowers, the anthers, connectives and filaments andthe base and tip ofthe stigmata were stained Similar to BPM2, BPM3 and BPM5 promoter:GUS lines, the root ... cotyledons and in the central cylinder ofthe root, but not in the lower parts ofthe hypocotyl (a) Rosette leaves were stained in the vascular tissue ofthe leaf blade, whereas the petiole and older ... with membersofthe ERF ⁄ AP2 family (A) Y2H assays demonstrate the assembly of BPM1(1–189) and BPM3 with RAP2.4 and RAP2.13, respectively (B) Schematic drawing ofthe BPM1 fragment used for the...
... H Shimano Physiology and pathophysiology ofthe SREBP family SREBP-1c and lipogenesis The SREBP family consists of three isoforms: SREBP1a, SREBP-1c, and SREBP-2 Each isoform has a different ... Physiology and pathophysiology ofthe SREBP family H Shimano at G1 [19] In particular, p21 is a direct target of SREBP [20] The role of SREBP-1a in the regulation of cell growth andthe cell cycle ... conditions of overnutrition, SREBP-1c expression is elevated, and consequently, the levels of nuclear SREBP-1c protein and lipogenesis are enhanced in the liver and adipose tissues Intake of energy...
... employed andthe presentation ofthe material in this publication not imply the expression of any opinion whatsoever on the part ofthe World Health Organization concerning the legal status of any ... However, the published material is being distributed without warranty of any kind, either expressed or implied The responsibility for the interpretation and use ofthe material lies with the reader ... management of childhood illness: caring for newborns and children in thecommunity v Contents: Manual for thecommunity health worker Facilitator notes Photo book: identify signs of illness...
... lg of protein) of YYY49 and YYT42 contained approximately and ng of hHSF2, and those of YYT50 and YYT17 contained approximately 0.01 and 0.1 ng of hHSF4, as judged by the intensity of each band ... hHSF4–VP16, without changing the magnitude ofthe heat shock response (cp3) The mutational analysis ofthe CRYGA and CRYGC HSEs suggests that the nucleotide sequences and configuration of nGAAn-like units ... promoters These results show that the configuration of nGAAn units in the promoter is important in determining which hHSF members are involved in the regulation ofthe gene Footprint analysis of the...
... Resolution ofthe structure of NADP+-bound FeR revealed that the nicotinamide moiety of NADP+ faces the re-side ofthe isoalloxazine ring, and that the 2Â-P-AMP moiety is held in the groove between the ... Pro154, Ile156 and Pro161 ofthe other monomer Similarly, Gly175Ala181 forms an anti-parallel intermolecular b sheet with the b12 ofthe other monomer, and towards the C-terminus, the subsequent ... ofthe logarithms ofthe concentration ratios for oxidized and reduced forms ofthe mediator versus that of recombinant avoredoxin Reduction titration of avoredoxin by NAD(P)H The reduction of...
... important One of these, the TRP sequence, includes the start ofthe C-terminal helix as well as the structured loop between the 1440 ATPase domain andthe C-terminal helix and in the 3D structure ... alignments of some ofthe proteins listed in the PFAM database that contain the Vps4 C-terminal oligomerization domain (PF09336) The sequence ofthe SRH of each protein is also shown The sequence ofthe ... clade AAA ATPases and have the AAA domain helix andthe C-terminal helix, but not the b domain The distinguishing feature ofmembersofthe meiotic clade of AAA ATPases is the SRH motif, which...
... 205 and 215 nm, indicating that Rv1399c is composed of 22% of a-helices, 25% of b-strand and 39% of random coil The catalytic triad is located at the bottom of a small ˚ ˚ pocket, 20 A length and ... by the amides of Ala163, Gly89 and Gly90, the latter’s being found in the HGGG consensus sequence motif characteristic ofmembersofthe HSL family [35] Our model shows that the architecture of ... experimentally Indeed, the presence of Arg213 along with the proximity ofthe charge relay Asp260 within the active site could be responsible for the modification ofthe catalytic properties ofthe catalytic...
... modelling The aim ofthe present work was to study the diversity of trypsins in the digestive gland of P argus, with focus on: (a) the position of lobster trypsins within the brachyurins familyand ... the wall ofthe binding pocket and allow the access of bulky residues, like Arg and Lys, whereas the basic side chain of these residues is stabilized by Asp189 (chymotrypsin numbering) near the ... in all other clones PaTry4 was the largest andthe least anionic of all trypsins found in P argus No cationic form ofthe enzyme was found in this work The coding regions of PaTry1a and PaTry1b...
... of degenerate and specific primers and by rescreening the cDNA libraries The partial clones of XHIVEP2 and -3 covered 5.9 and 3.2 kb ofthe respective 3¢ ends and included 3¢-UTRs and poly(A)-tails ... representation ofthe full length XHIVEP1 andthe Myc-tagged (MT) deletion mutants Black and white boxes indicate the position ofthe Znf domains andthe serine-rich stripe, respectively The relative ... over the proteins, including several serine-rich stretches [9] The 8578 bp cDNA sequence of XHIVEP1 contains 242 bp ofthe 5¢-UTR, an open reading frame of 7734 bp and 602 bp ofthe 3¢-UTR The...
... participated; the participant was required to be the primary caregiver ofthe child, and had to be willing to participate throughout the course ofthe study and to complete the questionnaires at Weeks and ... female, usually mothers, with a mean age of 37.1 years (Table 1) The majority ofthe subjects were white Because only one ofthe adults taking part in the study was not the parent ofthe participating ... coordination ofthe study and helped to draft the manuscript RD participated in the design and coordination ofthe study XL contributed statistical analysis and helped to draft the manuscript RA and LA...
... SMP, IAP, JWV and PJA conceptualized the rationale and design ofthe study, ACS and CMV performed the statistical analysis and interpretation ofthe data, ACS, SMP and PJA drafted the manuscript ... cross-cultural adaptation, the group of specialists stated that the concept ofthe impact of childhood cancer on the quality of life ofthe families used for development ofthe original instrument was ... Health and Quality of Life Outcomes 2008, 6:35 the health-related quality of life of parents/guardians The score is computed as the sum ofthe 20 item scores on the Physical, Emotional, Social and...
... direct role in the disruption ofthe immune response ofthe infected lepidopteran larva, but rather that they contribute to the manipulation of lepidopteran host larval growth and development ... Variations in the number of transcripts during the first day after parasitism have also been suggested for membersof this gene family by Northern-blot analysis [14] Altogether, these results ... co-localizes with the rep5 segment and secondly with another segment of lower size (Figure 1, rep6 lane) The faint hybridization band obtained with the rep7 probe had a size similar to that ofthe lower...
... participated; the participant was required to be the primary caregiver ofthe child, and had to be willing to participate throughout the course ofthe study and to complete the questionnaires at Weeks and ... female, usually mothers, with a mean age of 37.1 years (Table 1) The majority ofthe subjects were white Because only one ofthe adults taking part in the study was not the parent ofthe participating ... coordination ofthe study and helped to draft the manuscript RD participated in the design and coordination ofthe study XL contributed statistical analysis and helped to draft the manuscript RA and LA...
... important to the lives ofthe riverines andthe presence of these tools in every visited house may be an indicator ofthe relative abundance ofthe species in the reserve Feathers ofthe bare-faced ... ofthe caoutchouc epoch, in the second half ofthe XXth century, many residents ofthe reserve had migrated to the cities, leading to a decrease ofthe local population, and a diminution ofthe ... effectively estimate the population size of these species, hence their conservation status, and to deepen our understanding ofthe role of Cracidae in the forest equilibrium of this region ofthe Oriental...
... and five orders, finds acceptance as food by the locals Out ofthe 81 species, are representatives ofthe Odonata, 17 ofthe Orthoptera, 16 ofthe Hemiptera, 15 ofthe Hymenoptera and 24 ofthe ... rainfall of 3000 mm and temperatures ranging from 5°C in the month of December to 38°C in the month of July The total population ofthe district, which is inhabited by not only membersofthe Galo, ... stages of insects taken are quite similar between the two tribes However, the total number of species consumed by the Nyishi Bangni ofthe East Kameng district is higher than that ofthe Galo of the...
... medicinal by membersofthe Irular, Mudugar and Kurumbar tribes ofthe Western Ghats of Kerala [60] Except for the Ao Naga of Nagaland [49] andthe Nyishi and Galo of Arunachal Pradesh the use ofthe ... Naga of Nagaland use the same material to improve the overall vitality of a person andthe fat of this reptile to treat rheumatism and pains ofthe joints [49,59,60] The flesh ofthe crow is used ... use the fat ofthe crow in cases of smallpox and malaria [27] Membersofthe Nyishi and Galo tribes use the gall bladder ofthe mithun (Bos frontalis) in potions to stop dysentery, cough, and...
... performed the literature search and assisted in the writing ofthe manuscript MJW oversaw the study and assisted with the writing ofthe manuscript All authors read and approved the final version ofthe ... interpretation of patient samples Authors’ contributions TWC was involved in the design ofthe study, assisted in the literature search and wrote and revised the manuscript DF was involved in the design of ... laboratory, radiological and clinical details of these cases and our own are shown in Table Ofthe 21 cases retrieved in our literature search, 57% ofthe patients were men, and overall the patients’ median...