factors signal transduction pathways and tumor suppressor genes in esophageal cancer
Báo cáo y học: "Period-2: a tumor suppressor gene in breast cancer" pdf
... breast tumor cell lines (MCF-7 and T47D lines) and one ERα-negative human breast tumor cell lines (MDA-MB-231), and was examined by Western blot analysis using an antibody directed against the ... was expressed in normal breast epithelial cell lines (HMCETert and MCF-10A) and in the ERα-negative MDA-MB231 breast tumor cell line, but not in MCF-7 and T47D breast cancer cell lines Several ... of p53 in many cancers leads to impaired cell cycle regulation, genomic instability and inhibition of apoptosis The tumor suppressor p53 can induce a transient arrest in G1 in cells, allowing cells...
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Báo cáo y học: "Hand-grip strength is a simple and effective outcome predictor in esophageal cancer following esophagectomy with reconstruction: a prospective study" ppt
... for the influence of stage of esophageal cancer, the average hand-grip strength was similar in patients having early and advanced esophageal cancer. (p value is 0.961) Advanced esophageal cancer ... Respiratory failure requiring re-intubation was found in 12 patients, pneumonia in patients, pleural effusion requiring tube drainage in 5, anastomotic leak in and other conditions in patients Surgical ... Taiwan 2Mackay Medicine, Nursing and Management College, Taipei City, Taiwan 3Graduate Institute of Mechanical and Electrical Engineering and Graduate Institute of Manufacturing Technology, National...
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Báo cáo khoa học: Salicylic acid and the hypersensitive response initiate distinct signal transduction pathways in tobacco that converge on the as-1-like element of the PR-1a promoter pot
... transcription factor TGA2.2 is the main component of as-1binding factor ASF-1 and is involved in salicylic acid- and auxininducible expression of as-1-containing target promoters J Biol Chem 275, ... it seems plausible that two distinct signal transduction pathways could be targeted by SA and by signals released during the HR, respectively, resulting in the independent activation of different ... infected with TMV, and PR-1 proteins were monitored in the necrotic tissue induced by the spreading lesions Whereas lesions and the accumulation of PR-1 proteins remained strictly localized in...
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Báo cáo hóa học: " Multiplexed methylation profiles of tumor suppressor genes and clinical outcome in lung cancer" potx
... understanding of lung cancer biology To what extent these genes contribute or are functionally involved in the different steps during tumorigenesis and cancer progression remains to be determined ... participated in acquiring clinical and laboratory data, data analysis and interpretation, and drafted the manuscript PP and LG participated in acquiring clinical and laboratory data, data analysis and ... tested in cell lines and tissue specimens representing different steps of lung cancer progression supporting the panel of the tumor suppressor genes selected to be altered in lung cancer In this...
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báo cáo hóa học:" Functional significance of the signal transduction pathways Akt and Erk in ovarian follicles: in vitro and in vivo studies in cattle and sheep" ppt
... previously in the bovine model Increases in Akt and Erk signalling proteins in response to FSH and IGF stimulation suggest a role for Akt and Erk signal transduction pathways in FSH and IGF mediated ... in mediating the effects of FSH on inhibin-A, activin-A, oestradiol and progesterone secretion and also important in mediating IGF-I stimulated inhibin-A, activin-A, follistatin, oestradiol and ... Novel signal transduction pathway for luteinizing hormone and its interaction with insulin: activation of Janus kinase /signal transducer and activator of transcription and phosphoinositol 3-kinase/Akt...
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Báo cáo y học: "Systematic detection of putative tumor suppressor genes through the combined use of exome and transcriptome sequencin" ppt
... sequencing and mapping The cell lines HCC1954 and HCC1954 were obtained from ATCC They were maintained in RPMI medium containing 10% fetal bovine serum, mM L-glutamine and non-essential amino acids ... frequency in many types of cancers, including colorectal cancer and glioblastoma [40-42] This indicates that MGMT may serve as a tumor suppressor in many types of cancer A protein-protein interaction ... mismatch repair Genetic instability caused by loss of MSH3 in cancers [44] PCGF2 Polycomb group ring finger 2, involved in protein-protein Tumor suppressor function [45] interaction and transcription...
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analyzing and modeling large biological networks inferring signal transduction pathways
... we will present our results on discovering signaling pathways segments Using the underlying information in the signaling pathways and the protein-protein interaction networks that we have acquired ... challenging problems of interpreting and processing of this data Here, we present a new framework to identify signaling pathways in proteinprotein interaction networks Given a protein-protein interaction ... scar tissue, and clotting Examples of paracrine agents are growth factors, somatostatin and histamine In paracrine signaling, the signal originates from a nearby cell and, thus, the signal causes...
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haracterization of tumor suppressor genes hDAB2IP and DLEC1 in hepatocellular carcinoma
... overview of HCC and then review our understanding of HCC at the molecular level, including the alterations of oncogenes, tumor suppressor genes and their related genes during hepatocarcinogenesis 1.1 ... a tumor suppressor gene in solid tumors, LOH in a particular chromosomal region in a tumor may indicate the presence of a tumor suppressor gene that contributes to the tumor In HCC, tumor suppressor ... those in other cancers, such as lung, breast and colorectal cancers, the information and understanding about genetic inactivation of tumor suppressor genes in HCC is scant The mechanisms of inactivation...
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Báo cáo y học: " Low concentration of ethanol induce apoptosis in HepG2 cells: role of various signal transduction pathways"
... slight inhibition of JNK and NFκB signaling in association with a slight activation of the cell death receptor signaling In addition, ethanol also phosphorylated protein kinases belonging to signal ... Shukla SD MAP kinase signaling in diverse effects of ethanol Life Sciences 2004;74:2339-64 20 Shen K, Novak RF Fas-signaling and effects on receptor tyrosine kinase signal transduction in human breast ... representing increases of 1- and 12-fold, respectively These data confirm the effect of ethanol on intracellular signal transduction resulting in increased expression of transcription factors Int...
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Báo cáo khoa học: Bistability from double phosphorylation in signal transduction Kinetic and structural requirements potx
... buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell Curr Opin Cell Biol 15, 221–231 12 Ferrell JE Jr (2002) Self-perpetuating states in signal transduction: ... on KS1 and q is displayed in Fig 4, showing that two regions can be defined in the space of kinetic parameters (q, KS1), one resulting in bistable behavior and the other resulting in a single stable ... is ubiquitous in MAPK and other signal transduction pathways, this article also reports a new putative mechanism that per se explains multistability in signal transduction networks in which feedback...
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tumor suppressor genes, volume 1
... in- vivo microtubule-binding capacities and can nucleate microtubules in vitro 3.3 Role of APC in Chromosomal Stability/Mitotic Checkpoint Both the microtubule-binding domain and the EB1-binding ... (DLG), which binds the C-terminal 72 amino acids (46), and the protein phosphatase PTP-BL (47) Both proteins contain a PDZ domain that binds to C-terminal XS/TXV domains APC contains specifically ... speed in a microfuge for min, and drain the pellet Add 500 L of cold 70% ethanol, wash the pellet by vortexing, and spin again for at the maximun speed Drain the pellet and wash it again using...
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tumor suppressor genes, volume 2
... amino and carboxy termini of the protein 3.2 Structures of the Tumor Suppressors INK4 The cyclin-dependent kinase (CDK) inhibitors bind to CDKs and inhibit their kinase activity, thus regulating ... Ephrin tyrosine kinases, suggesting that it is a protein–protein interaction module, possibly involved in developmental processes Finally, the structure of the Ca2ϩ signaling protein S100B in ... changes resulting from posttranscriptional modification of the Wilms tumor suppressor protein (WT1) in the 4-zinc Utilizing NMR to Study Growth-Inhibitory Proteins 11 finger DNA-binding domain (60)...
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TUMOR SUPPRESSOR GENES ppt
... adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity Oncogene, ... overlapping in some cases and are present near the amino terminus where a majority of the mutations in CDK4 are found Mutations in the p16 binding site result in diminished capability of p16 binding ... of evolution, INK4C and INK4D were integrated into different chromosomes while INK4A and INK4B remained located on the same chromosome Here human chromosomes and corresponding INK4 genes are shown...
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Báo cáo y học: "The Frizzled family: receptors for multiple signal transduction pathways" docx
... rat frizzled2 can cause an increase in intracellular calcium in zebrafish and can activate protein kinase C and calcium/calmodulin-dependent protein kinase (CaM kinase) in Xenopus [7] This pathway ... including Wnts and Norrin The carboxyl terminus is intracellular and contains a proximal KTXXXW motif (in the single-letter amino-acid code, where X is any amino acid), which is highly conserved in ... Wnt/β-catenin signaling Hs FZD2 Hs FZD7 Hs FZD4 Hs FZD9 Hs FZD10 Hs FZD5 Figure Motifs in Frizzled proteins SS, signal sequence; CRD, cysteine-rich domain The CRD is extracellular and binds ligands, including...
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báo cáo khoa học: "Down-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer properties" pot
... found in cancer There is increasing evidence that Ubiquitin-like containing PHD Ring Finger (UHRF1, also known as ICBP90 or Np95) plays a fundamental role in these processes by being involved in ... domains facing either DNA or histones Abbreviation: UBL, Ubiquitin-like domain; TTD, cryptic Tandem Tudor Domain; PHD, Plant Homeo Domain; SRA, Set and Ring Associated; RING, Really Interesting ... which increases genomic instability and activates growth-promoting genes (proto-oncogenes), promoters of tumour suppressor genes are frequently hypermethylated and this contributes to carcinogenesis...
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Báo cáo y học: " Effects of Liver × receptor agonist treatment on signal transduction pathways in acute lung inflammation" potx
... opened and the pleural cavity rinsed with ml of saline solution containing heparin (5 U ml-1) and indomethacin (10 μg ml-1) The exudate and washing solution were removed by aspiration and the ... and subjected to a skin incision at the level of the left sixth intercostals space The underlying muscle was dissected and saline (0.1 ml) or saline containing 2% l-carrageenan (0.1 ml) was injected ... immersed in terminal deoxynucleotidyltransferase (TdT) buffer containing deoxynucleotidyl transferase and biotinylated dUTP in TdT buffer, incubated in a humid atmosphere at 37°C for 90 min, and then...
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Báo cáo y học: "Systems biology-defined NF-κB regulons, interacting signal pathways and networks are implicated in the malignant phenotype of head and neck cancer cell lines differing in p53 status" pps
... involving a trimeric inhibitor-kappaB kinase (IKK)α/β/γ and casein kinase complexes modulating NFκB1, RELA and cREL, and alternative pathways involving NF-κB inducing kinase and IKKα modulating ... extravasation signaling Wnt/β-catenin signaling Xenobiotic metabolism signaling IL-6 signaling p38 MAPK signaling Wild-type p53-deficient Cell cycle:G2/M DNA damage checkpoint regulation Mutant p53 Genes ... molecular components of PI3K and protein kinase C pathways, both important signal pathways implicated in promoting tumorigenesis, especially in epidermis and epithelia [72-75] The involvement of NF-κB...
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Selection of aptamers for signal transduction proteins and development of highly sensitive aptamer probes
... variety of intracellular signaling molecules implicated in cell migration, including MAPK cascades, lipid kinases, phospholipases, serine/threonine and tyrosine kinases and scaffold proteins Rho ... these signal transduction proteins Various experimental conditions, including (1) type and length of capillary, (2) sample injection volume, and (3) type, pH and concentration of run buffer and incubation ... binding protein (Cdc42-GTP) and wild type Cdc42-GDP (21 kDa; pI 5.255), recombinant human p21activated kinase protein (PAK1) and inactive PAK1 (62 kDa; pI 5.686), MRCK kinase domain (MRCK-KD) and...
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Báo cáo khoa học: In vivo studies of altered expression patterns of p53 and proliferative control genes in chronic vitamin A deficiency and hypervitaminosis pot
... liver and lung indicating that the amount of p53 protein was significantly increased in the liver and lung from vitamin A-deficient rats that in controls c-Jun protein was significantly decreased in ... changes induced in the control of proliferative genes by vitamin A Within the nucleus, retinoic associated with a lower risk of lung cancer, and the intakes acid binds to RAR/RXR (heterodimeric retinoic ... [27] In rats Fig Western blot analysis of p53 and c-Jun in liver and lung Total protein extracts were obtained as described in experimental procedures A single band of about 53 kDa was detected in...
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