factors hormones and signal transduction
Báo cáo khoa học: The role of helix 8 and of the cytosolic C-termini in the internalization and signal transduction of B1 and B2 bradykinin receptors potx
Ngày tải lên :
07/03/2014, 16:20
... Influence of the cytosolic carboxyl termini of human B1 and B2 kinin receptors on receptor sequestration, ligand internalization, and signal transduction J Biol Chem 273, 2617–2623 17 Blaukat A, ... differential signaling is less likely to explain differences in internalization than in two receptors signaling through different G proteins Internalization patterns of truncations I347* and N338*, and ... motifs in the region between the palmitoylated C324 and N338 Candidates would include G328-C329 and ⁄ or the negatively charged residues E332 and E337, as they are highly conserved in B2wt among...
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Plant physiology - Chapter 14 Gene Expression and Signal Transduction potx
Ngày tải lên :
07/03/2014, 21:20
... is called a signal transduction pathway Typically, the end result of signal transduction pathways is to regulate transcription factors, which in turn regulate gene expression Signal transduction ... in gene regulation by hormones and other signaling agents are called response elements As will be discussed in Chapters 17 and 19 through 23 (on phytochrome and the plant hormones) , numerous response ... protooncogenes that encode nuclear transcription factors include MYC and MYB Both phytochrome (see Chap- Gene Expression and Signal Transduction ter 17) and gibberellin (see Chapter 20) are believed...
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Báo cáo khoa học: Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death ppt
Ngày tải lên :
29/03/2014, 08:20
... et al DAPK and signal transduction to use this information to understand developmental or disease processes Classically, genetic screens in tractable organisms, such as yeast, worms and flies, ... Autophagy Fig Signalling to DAPK DAPK plays an important role in a diverse range of signal transduction pathways The biological outcome of DAPK activity depends on the input signal and includes ... apoptosis and autophagy (A) Growth factor signalling to DAPK is probably the best defined with respect to the proteins that are involved and includes the activities of Src, LAR, ERK and RSK (see text and...
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Báo cáo khoa học: Death-associated protein kinase (DAPK) and signal transduction: blebbing in programmed cell death docx
Ngày tải lên :
29/03/2014, 08:20
... adhesion and survival signalling [53], and can inhibit the association of talin head domain with integrin to suppress the integrin–Cdc42 polarity pathway [60] These studies are intriguing and suggest ... cortex is unclear Factors, such as phosphatidylinositol 4,5-bisphosphate [24] or mechanosensitive ion channels, could detect the detachment of the membrane from the cortex and start a signalling cascade, ... complex and the formin Dia1, are not present in blebs of filamin-deficient blebbing cells [4] However, the presence of regulators of actin nucleation, RhoA and RhoGEFs, at the bleb membrane and the...
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Báo cáo khoa học: Death-associated protein kinase (DAPK) and signal transduction: fine-tuning of autophagy in Caenorhabditis elegans homeostasis doc
Ngày tải lên :
29/03/2014, 08:20
... Autophagy and signaling: their role in cell survival and cell death Cell Death Differ 12(Suppl 2), 1509–1518 Meijer AJ & Codogno P (2006) Signalling and autophagy regulation in health, aging and disease ... phosphorylates and activates Ga interacting proteins and stimulates autophagy and (f) the eukaryotic initiation factor 2a, which regulates starvation- and virus-induced autophagy As these autophagy signaling ... calcineurin and DAPK signaling pathways and the systemic regulation of autophagy (Fig 3) FoxO3 FoxOs are evolutionally conserved and well-known downstream targets of the insulin signaling pathway...
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Báo cáo khoa học: Death-associated protein kinase (DAPK) and signal transduction: regulation in cancer ppt
Ngày tải lên :
29/03/2014, 08:20
... (DAPK) and signal transduction: blebbing in programmed cell death FEBS J 276, doi:10.1111/j.1742-4658.2009.07412.x Kang C & Avery L (2009) Death-associated protein kinase (DAPK) and signal transduction: ... signalling pathway and that DAPK levels are critical for modulating cell fate decisions that lead to survival or death, highlighting the capacity of DAPK to integrate signals from apoptotic and ... (BMS-354825) tyrosine kinase inhibitor suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell carcinoma and non-small cell lung cancer cells Clin Cancer Res...
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Báo cáo khoa học: Molecular and genetic characterization of osmosensing and signal transduction in the nematode Caenorhabditis elegans docx
Ngày tải lên :
30/03/2014, 03:20
... accumulation and WNK and Ste20 kinase signaling C elegans will undoubtedly continue to provide new understanding of how animals detect and protect themselves from osmotic stress Given the fundamental and ... studies of osmosensing and associated signal transduction mechanisms Little is known about the molecular bases of these processes in animals The forward and reverse genetic and molecular tractability ... about the molecular mechanisms of osmotic stress resistance, osmosensing and signal transduction in C elegans Osmosensing and signaling in C elegans Osmoregulatory organs in C elegans C elegans has...
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Báo cáo khoa học: M1 – Peptidomimetics and Signal Transduction Inhibition potx
Ngày tải lên :
30/03/2014, 20:20
... target and their conversion into novel drug candidates for Mycobacterium tuberculosis infected patients M R M Fontes1, A A S Takeda1, T Teh2, R F Standaert3 and B Kobe2 Department Physics and Biophysics, ... affects SP signal transmission due to their co-existence relation To understand the time course and spatial distribution of SP with its receptor and the mutual actions in lung between SP and CGRP, ... doses 10 and 20 nmol/ mouse and indomethacin (5 and 20 mg/kg) Antinociception we observed after 15, 30 and 60 Results show that the s.c administration of all tested MCs (except c1-MSH) and HS014...
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Báo cáo y học: "Cancer, oncogenes and signal transduction" pps
Ngày tải lên :
09/08/2014, 20:20
... unidentified mechanism Signaling, growth and polarity An interesting feature of the meeting was the use of spectacular movies of live cells, which kept the audience interested and explained the physiological ... temporal signal mediated by the activation of Aurora by the Cdc2 cell-cycleregulatory kinase as well as a spatial signal provided by a complex made up of the spatially localized Par3 and Par6 ... cell-surface Wnt signal receptor and the nuclear transcription factor LEF1 Boudewijn Burgering (University Medical Center, Utrecht, http://genomebiology.com/2004/5/7/332 The Netherlands) described...
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Báo cáo y học: "Gene regulation and signal transduction in the immune system" pptx
Ngày tải lên :
14/08/2014, 20:22
... addressing how signal transduction and gene regulation control diverse and fundamental biological processes This was underscored at the 2008 meeting We look forward to the next meeting in 2010, and anticipate ... promoters of many primary response genes are marked by CpG islands, which have low histone density and not assemble into stable nucleosomes, and these promoters are induced independently of chromatin ... development by restraining the expression of pro-myeloid factors (such as Gfi1), and acting directly to induce the recombinase (Rag) genes and thereby recombination at the immunoglobulin heavy-chain...
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Structure and mechanism of hormone perception and signal transduction by abscisic acid receptors
Ngày tải lên :
10/09/2015, 09:26
... gate-latch-lock mechanism of ligand perception and signal transduction by the PYL ABA receptors 99 Figure 39 Mutations in the PYR1 latch and gate affect ABA signalling in vitro and in vivo ... responses (Pandey and Assmann, 2004; Ullah et al., 2002) and these findings has contributed to speculations that GPCRs may be involved in ABA signal transduction The third ABA receptor candidate, ... previous mentors and colleagues Also, a special mention here to Kah Ying and Terence Last but not least, I would like to thank my family and friends for being understanding and encouraging when...
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Tài liệu Báo cáo khoa học: 1. Signal Transduction 1.1 Integration of Metabolism and Survival pdf
Ngày tải lên :
19/02/2014, 07:20
... Amplification and control of B cell antigen receptor signaling M Reth and Y Kulathu Institute for Biology III and Max-Planck-Institute for Immunobiology, Freiburg, Germany E-mail: reth@immunbio.mpg.de Signal ... activated transcription factors conserved in multi-cellular eukaryotes, whose main role is to control 1.5 Signaling and Cancer: Nuclear Receptor Connection S1.5-1 Androgen action and prostate carcinogenesis ... conformation, Syk can recruit other signalling molecules thus facilitating their phosphorylation and the propagation of the BCR signal These studies, which are conducted in a novel signalling pathway reconstitution...
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Báo cáo khoa học: Bistability from double phosphorylation in signal transduction Kinetic and structural requirements potx
Ngày tải lên :
16/03/2014, 13:20
... linked to multifunction and crosstalk between signal transduction networks, which explains how the same signal transduction pathway can be responsible for the transduction of signals resulting in ... cycle (steps and 2) and cycle (steps and 4) (Eqn 7) and the values of a, c and b only depend on the KS value (Eqn 8) The concentrations of interconvertible forms are: c¼a¼ þ KS and b¼ À KS ð8Þ ... requirements in signaling are constrained: a and c only vary between ⁄ and ⁄ 2, whereas b varies between and ⁄ is studied for different sets of parameters, resulting in (a) a single steady state and (b)...
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Báo cáo khoa học: Principles behind the multifarious control of signal transduction ERK phosphorylation and kinase/phosphatase control potx
Ngày tải lên :
16/03/2014, 18:20
... both duration and integral signal strength The control for all processes together equaled for peak amplitude and nal signal strength and it equaled )1 for duration and integral signal strength ... amplitude of signaling; the nal intensity of signaling; the duration of signaling and the integral signal intensity (which corresponds to the area-under-the-curve) For MAPK and other signaling pathways, ... concerning protein kinase signaling, such as the possibility of spatially resolved signaling [21] and have also shed light on the control of kinases and phosphatases on signal transduction [22] For...
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Báo cáo khoa học: Salicylic acid and the hypersensitive response initiate distinct signal transduction pathways in tobacco that converge on the as-1-like element of the PR-1a promoter pot
Ngày tải lên :
23/03/2014, 15:21
... factors TGA factors from Arabidopsis and tobacco share an Fig Proposed model for the induction of the tobacco PR-1a gene via two distinct signal transduction pathways elicited during the HR and ... the tobacco PR-1a promoter is targeted by at least two distinct signal transduction pathways, elicited by SA and by a yet unknown signal produced during the HR, respectively, which mediate PR-1a ... view of the results presented, it seems plausible that two distinct signal transduction pathways could be targeted by SA and by signals released during the HR, respectively, resulting in the independent...
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biochemistry of signal transduction and regulation 3d ed - gerhard krauss
Ngày tải lên :
08/04/2014, 12:41
... structural and biochemical properties of signaling molecules and their regulation, the interaction of signaling proteins at VIII Preface the various levels of signal transduction and to work ... Branching and Crosstalk 124 Variability and Specificity of Receptors and Signal Responses 126 Extracellular Signaling Molecules 128 The Chemical Nature of Hormones 128 Hormone Analogs: Agonists and ... Receptor 135 Signal Amplification 139 Regulation of Inter- and Intracellular Signaling 141 Membrane Anchoring and Signal Transduction 142 Myristoylation 144 Palmitoylation 145 Farnesylation and Geranylation...
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signal transduction and human disease
Ngày tải lên :
11/04/2014, 10:31
... Cell-Related Diseases: Genetics, Signaling Pathways, and Novel Therapies 307 Michael A Beaven and Thomas R Hundley 11 Rheumatology and Signal Transduction 357 Keith M Hull and Daniel L Kastner 12 Molecular ... for- Signal Transduction and Human Disease, Edited by Toren Finkel and J Silvio Gutkind ISBN 0-471-02011-7 Copyright © 2003 John Wiley & Sons, Inc ATHEROSCLEROSIS: SIGNAL TRANSDUCTION BY OXYGEN AND ... host defense or signal transduction (Fig 1.7) 13 14 ATHEROSCLEROSIS: SIGNAL TRANSDUCTION BY OXYGEN AND NITROGEN RADICALS Figure 1.7 The divergent role of high and low levels of RNS and ROS A potential...
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báo cáo hóa học:" Functional significance of the signal transduction pathways Akt and Erk in ovarian follicles: in vitro and in vivo studies in cattle and sheep" ppt
Ngày tải lên :
20/06/2014, 07:20
... of bands after background subtraction and are relative to white (value 0) and black (value 256) The blots each show a single band for Akt and p-Akt at about 60 kDa and each show a double band ... bovine model Increases in Akt and Erk signalling proteins in response to FSH and IGF stimulation suggest a role for Akt and Erk signal transduction pathways in FSH and IGF mediated granulosa cell ... double band for Erk and p-Erk at about 44 and 42 kDa Experiment Effects of LH in combination with PD98059 and/ or LY294002 on cell number and secretion of androstenedione and progesterone from...
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