... PXR-3 contains an inStephen 2004 in frame deletion of 37 amino acids inthe ligand-binding domain The lack of ligand binding ability might be responsible for the failure of this transcript in transactivating ... three main functional domains: an amino terminal domain that contains activation function (AF-1), a highly conserved DNA binding domain (DBD), and a carboxyl terminal ligand binding domain (LBD) ... 2004) The cross-species variation of amino acid identity inthe ligand binding domain accounts for the different ligand recognition and activation profile of PXR in both human and mouse (Bertilsson...
... By considering only thermal population effects inthe range of 15–60 K, we have imposed and solved a set of rate equations The solutions gave us the expressions for the intensities I1, I2 and ... experiments In light of these results we can associate the transitions |1i and |2i to carrier recombination from ± 1U and ± 1L states andthe transition |3i to a surface states emission By analysing the ... Discussion In Fig 1A the temporal evolution of CdSe/ZnS QDs PL spectra is shown The spectra consist of three emission peaks evolving in time The blue peak |1i evolution is the fastest (see Fig 1A) and...
... (2.11) with F being the force of indentation, δ the depth of indentation and θ the inclination angle ofthe triangular faces Chapter Literature review 30 Indentation of adherent cells has also ... membrane and spectrin network to the large deformation of red cellsOnthe other hand, the continuum modeling approach treats the cell as a continuum material with certain mechanical properties ... both the external environmental and internal physiological conditions Depending onthe direction, magnitude and distribution of these mechanical stimuli, cells can respond in a variety of ways...
... rectal bleeding, which is one ofthe dose-limiting complications, may prevent escalation ofthe dose and therefore adversely affect treatment outcomes The volume ofthe rectum included inthe high ... assessed on randomly selected 10 sample patients by a blind repetition of rectum contouring on randomly chosen CT scans The mean intra-observer variability was 0.7 mm inthe cranial and 0.9 mm inthe ... increase inthe dose-limiting, late rectal toxicity, mainly manifested by rectal bleeding [6,7] The major predictor of rectal bleeding is the volume ofthe rectum included inthe high dose region [8,9],...
... at the FASB is part ofthe mission ofthe organization, which is, ―to establish and improve standards of financial accounting and reporting for the guidance and education ofthe public, including ... EDs contain an almost final pronouncement of a new or amended financial accounting standard or concept statement As such, EDs contain the provisional positions ofthe FASB at the time oftheir ... mission to ― establish and improve standards of financial accounting and reporting for the guidance and education ofthe public, including issuers, auditors, users of financial information‖(FASB,...
... effects inthe organizational context, focusing for example onthe leadership style and its impact on employees’ innovativeness [20] Theinfluenceofthe patient’s participation in decision making on ... influenceon innovative behavior and patient satisfaction Although the concept of knowledge sharing focuses mainly on HCPs, the interaction with the patient, andin particular the process of shared ... describe the study plan and discuss central contributions of this study Knowledge sharing and its influenceon innovative behavior and patient satisfaction We define innovative behavior as the introduction...
... for the characterization and identification ofthe EPR signals displayed by the FeFe protein component ofthe Fe-only nitrogenase (Rc1Fe), investigations onthe MoFe protein were included in this ... pre-steady kinetics of MoFe protein reduction and hydrogen evolution under conditions of limiting electron flux show that the rates of association with the Fe-protein and electron transfer are independent ... identification ofthe Fe-only cofactor by EPR is still lacking Nevertheless, based onthe results of preceding investigations [8], the FeFe protein exhibited several interesting and, with respect to the...
... gesting that the left hairpin of LuIII does constitute a replication origin inthe extended double stranded hairpin configuration Given the functionality ofthe left hairpin of LuIII as an origin ... alternate secondary structures ofthe hairpin inthe flip conformation The expected fragments for the digestion ofthe flip and flop conformations ofthe left hairpin are very similar in size, any ... and, LuIII Lt-Lt/pCMVNS1, contributed inthe analysis and interpretation ofthe data, participated inthe design ofthe models proposed andinthe drafting and revision ofthe manuscript 11 12 13...
... gesting that the left hairpin of LuIII does constitute a replication origin inthe extended double stranded hairpin configuration Given the functionality ofthe left hairpin of LuIII as an origin ... alternate secondary structures ofthe hairpin inthe flip conformation The expected fragments for the digestion ofthe flip and flop conformations ofthe left hairpin are very similar in size, any ... and, LuIII Lt-Lt/pCMVNS1, contributed inthe analysis and interpretation ofthe data, participated inthe design ofthe models proposed andinthe drafting and revision ofthe manuscript 11 12 13...
... during the conversion of blue spruce stands even under environmentally highly stressing conditions, (2) to assess the foliar nutrient status ofthe alder as a precondition of positive influenceon ... significant in 2003, 2004 and 2008 only The cumulative effect ofthe higher annual increment values inthe fertilized variant during the period since 2002 finds its expression inthe mean values of periodic ... unusually warm and dry weather in spring 2000; see the climatic data in Balcar and Kacálek (2008b) The rise in mortality rate during the period of 2001 and 2002 is in line with expectations The trees...
... seedlings were planted into 70 L containers (20 seedlings per container) containing forest soil [13] In order to ensure that the seedlings received the same microclimatic conditions as the leaves ... 4-year-old seedlings were grown inthe upper and lower canopy of a 55-year-old forest stand [32] throughout one growing season The contents of protective pigments and antioxidants of seedling and adult ... photosynthesis (Pn), stomatal conductance to water vapour (gH2O), and CO2 concentration inthe mesophyll internal air spaces (Ci) in leaves of seedlings (located inthe sun and shade crown of adult...
... regulation of microfilament polymerization upon binding to actin [14] In plant cells, profilins play a role in cytokinesis, cytoplasmatic streaming, cell elongation as well as growth of pollen ... proposed that polcalcins function inthe control of intracellular calcium levels during pollen germination [34] Interestingly, the calcium-binding property of polcalcins affects both the molecule’s ... allergens FF conceived ofthe manuscript and participated in its design and discussion ME wrote the introduction, participated inthe design and discussion, and coordinated and drafted the manuscript...
... analyzed the data and drafted the manuscript UR contributed to the conception andthe design ofthe study TB acquired the data IK contributed to the analysis JK contributed to the intellectual content ... Periodogram of incidents per hour The periodogram is applied to the 35064 hours ofthe four year sampling period The period of 168 hours (one week), 24 hours (one day) andtheir corresponding harmonic ... comparing all weekdays as we did in section The findings of a 24 hour period on every day could be for example associated with the hormones testosteron and serotonin Both of them show a nycthemeral...
... determination of rate constants of initiator, promoter and inhibitor in water ozonation The new Rct expression andthe new method for the determination of rate constants of initiator, promoter and inhibitor ... Determination ofthe initiation, inhibition and promotion rate constants for NOM isolates 54 4.3 Determination ofthe initiation, inhibition, promotion and direct reaction rate constants of ... Validation ofthe new Rct expression andthe new method for the determination of rate constants of initiator, promoter and inhibitor in water ozonation 21 2.4.2 Determination ofthe rate...
... inthe cross-linking medium andthe extent of interaction between the cross-linker and polymer chains, bringing the chains closer together The findings 149 Uncrosslinked SA Absorbance Crosslinked ... proportions of alginate and pectin were converted to alginic acid and pectinic acid Being poorly soluble, they probably helped to maintain the integrity ofthe matrix In contrast to the other cross-linked ... revealed that there might be varying affinity ofthe polymers for Ca2+ thus introducing the potential for varying degrees of cross-linking inthe film matrix The interaction between pectin and Ca2+...
... thickness Onthe other hand, evolution of CO2 from the reaction between H+ and CaCO3 resulted inthe formation of abundant minute cavities, hence, contributing to volumetric increase ofthe internally ... mechanisms andtheir effects on matrix integrity would assist inthe control ofthe interaction between Ca2+ and alginate with the use of more appropriate cross-linking techniques C Mechanisms of external ... for crosslinking action at pH values above the pKa of alginates Immersion of alginates in media with a pH lower than the pKa value would result inthe conversion ofthe alginates to alginic acid...
... between the viscosity of sodium alginate andthe Ca2+ content, indicating a strong influenceofthe polymer viscosity onthe extent of cross-linking inthe microspheres In film formation, the sodium ... more conclusive evidence onthe effects of alginate composition andthe extent of calcium crosslinking onthe drug encapsulation efficiency and release propertiesofthe microspheres with defined ... supported the earlier suggestion that the viscosity ofthe alginate would influencethe interaction between calcium and alginate to a greater extent than the monomeric composition ofthe alginate...
... MATERIALS AND METHODS Phosphorylation of ACL Purication ofthe recombinant Cl -ACL Construction ofthe expression vector pETACL harboring the aclBA genes from C limicola strain M1, andthe expression ... lanes and 2) Efcient dissociation ofthe individual subunits ofthe wild type ACL was conrmed in lanes andThe individual subunits ofthe H273A mutant Fig Phosphorylation and dephosphorylation of ... physiological conditions, the majority of Cl-ACL binds to only one molecule of citrate Inthe presence of sufcient levels of ATP, the low Ks1 value would contribute to the efcient conversion of citrate...
... dehytion ofthe serous-producing salivary cells occurs dration), medications (both prescription and nonvia a process termed “apoptosis.” Within one week prescription), head and neck irradiation and ... oropharyngeal health, and it serves many functions inthe oral and gastrointestinal environment Saliva aids in swallowing, oral cleansing, speech, digestion and taste When salivary hypofunction and xerostomia ... basis of clinical findings, although microscopy can confirm the clinical diagnosis via the observation of mycelia or pseudohyphae in a direct smear Candida may colonize the corners ofthe mouth...