experiences with drug delivery systems
Drug Delivery Systems
Ngày tải lên :
25/10/2013, 08:20
... for Drug Delivery Systems Drug delivery systems modify the kinetics or the location of the escape of the drug from the medicine Tables 15.1 and 15.2 provide generic reasons for using drug delivery ... numerous types of protein drug [21–23] 15.6 Examples of Biodegradable Polymer Drug Delivery Systems Under Development 15.6.1 Polyketals Polyketal-based drug delivery systems are under development ... properties in drug delivery systems The drug can be dissolved in water and the polymer is dissolved in an organic solvent Suspension of very small droplets of the aqueous drug solution within the...
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Chemical Aspects of Drug Delivery Systems pptx
Ngày tải lên :
28/03/2014, 10:20
... stability Chemical Aspects of Drug Delivery Systems Table Routes of administration and general classification of drug delivery systems ROUTES OF ADMINISTRATION DRUG DELIVERY CLASS ORAL SOLIDS (e.g ... Aspects of Drug Delivery Systems Table Mechanisms and properties influencing drug release from particle carrier systems* MECHANISM OF DRUG RELEASE PROPERTIES INFLUENC~NG DRUG DIFFUSION DRUG RELEASE ... carrier materials incorporated into drug delivery systems 4 DRUG LEAKAGE+ +NON TARGET +METABOLISM /CLEARANCE IB ROUTE OF ADMINISTRATION IDRUG + CARRIER Ic IDRUG IDRUG + CARRIER P + CARRIER +NON...
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THE CHEMISTRY OF DRUG DELIVERY SYSTEMS (hoá học các hệ dẫn truyền thuốc)
Ngày tải lên :
18/04/2014, 15:37
... Generalities of drug delivery Liposomes as drug delivery systems Polymers and polymeric systems for drug delivery Dendrimers for drug delivery GENERALITIES OF DRUG DELIVERY DRUG DELIVERY SYSTEM ... Targeted drug delivery systems: deliver drug to a desired body location, organ, tissue, specific cells… Controlled-release drug delivery systems: preprogramed drug release By the route of delivery: ... Topical (local) drug delivery systems: drugs are delivered locally to the target organ/tissue without entering the systemic circulation Systemic drug delivery systems: drugs are delivered...
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nanoparticulate drug delivery systems, 2007, p.382
Ngày tải lên :
04/06/2014, 14:47
... and their delivery to where they are needed An ever increasing number of drug- and vaccinedelivery systems are being tested clinically, with many already marketed Recently, drug- delivery systems ... define drug- delivery systems of a certain size range Reflecting this trend of size definition, Nanoparticulate Drug Delivery Systems is a worthy attempt to bring together a wide range of drug- delivery ... 0‑8493‑9073‑7 (alk paper) Drug delivery systems Nanoparticles I Thassu, Deepak II Deleers, Michel III Pathak, Yashwant IV Series [DNLM: Drug Delivery Systems ‑methods Nanostructures Drug Carriers W1 DR893B...
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Báo cáo hóa học: " Nanotechnology-based drug delivery systems" pdf
Ngày tải lên :
20/06/2014, 00:20
... nanotechnology – based drug delivery Systems Nanoparticles can be used in targeted drug delivery at the site of disease to improve the uptake of poorly soluble drugs [8,9], the targeting of drugs to a specific ... drugs to a specific site, and drug bioavailability A schematic comparison of untargeted and targeted drug delivery systems is shown in Figure Several anti-cancer drugs including paclitaxel [10,11], ... Colloidal drug delivery modalities such as liposomes, micelles or nanoparticles have been intensively investigated for their use in cancer therapy The effectiveness of drug delivery systems can...
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Báo cáo hóa học: " The application of carbon nanotubes in target drug delivery systems for cancer therapies" docx
Ngày tải lên :
20/06/2014, 22:20
... the molecular transporter in drug delivery Page 14 of 22 Drug delivery targeted to lymphatic system Many cancers metastasize through lymphatic canal The drug delivery systems targeted to the lymphatic ... advantages for tracking and real-time monitoring of drug delivery efficacy in vivo Intracellular drug delivery To study the cellular drug delivery, in vitro experiments have unique advantages, ... identical with those used in drug delivery systems These functionalization methods provided candidate techniques, and there are great possibilities for them to be used in the construction of drug delivery...
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Ophthalmic Drug Delivery Systems - part 1 pptx
Ngày tải lên :
10/08/2014, 00:20
... ophthalmic drug delivery systems, but the knowledge in this field is rapidly expanding Systems range from simple solutions to novel delivery systems such as biodegradable polymeric systems, corneal ... to provide maximal benefit, improvements in ocular drug delivery are essential Drug delivery is no less vital than drug discovery Although many drugs can be safely delivered by eye drops, effective ... Mitra 251 III Drug Delivery Systems A: Conventional Systems Ocular Penetration Enhancers Thomas Wai-Yip Lee and Joseph R Robinson 281 10 Corneal Collagen Shields for Ocular Drug Delivery Shiro...
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Ophthalmic Drug Delivery Systems - part 2 pdf
Ngày tải lên :
10/08/2014, 00:20
... (1990) Ocular drug delivery Pharmacokinetic considerations Clin Pharmacokinet., 18:255 Lang, J C., and Stiemke, M M Biological barriers to ocular delivery In: Ocular Therapeutics and Drug Delivery ... consideration in topical ocular drug delivery Clin Exp Pharmacol Physiol., 27:558 Schoenwald, R D (1993) Ocular pharmacokinetics/pharmacodynamics, Ophthalmic Drug Delivery Systems (A K Mitra, ed.), ... liquid chromatography coupled with mass spectrometry (HPLC/MS or HPLC/MS/MS) Most topical ocular drugs demonstrate a tissue distribution pattern within the eye consistent with corneal penetration,...
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Ophthalmic Drug Delivery Systems - part 4 doc
Ngày tải lên :
10/08/2014, 00:20
... may change indirectly with changes in the pathophysiology of the eye is the diffusivity of drugs in the vitreous Changes in drug diffusivity will be most significant when drugs of different molecular ... increased as the drug diffusivity was reduced Furthermore, the rate of drug elimination, which is inversely related to the drug s elimination halflife, decreased significantly as the drug diffusivity ... selecting drugs and doses, particularly if the blood-retinal barrier has been compromised Drug elimination was higher in an aphakic eye model than in a phakic eye model, especially for drugs with...
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Ophthalmic Drug Delivery Systems - part 5 doc
Ngày tải lên :
10/08/2014, 00:20
... phase-change polymers for ocular drug delivery Adv Drug Delivery Rev 16:45–50, 1995 Salminen, L., and Urtti, H Prolonged pulse-entry of pilocarpine with a soluble drug insert Graefes Arch Clin Exp ... enhance delivery of TFT to the cornea with an intact epithelium In corneas with poor epithelium, drug penetration was higher but variable They concluded that the role of collagen shields as a drug delivery ... Ophthalmic Drug Delivery Systems (A K Mitra, ed.), Marcel Dekker, Inc., New York, pp 261–273 12 Artandi, C (1964) Production experiences with radiation sterilization, Bull Parenteral Drug Assoc.,...
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Ophthalmic Drug Delivery Systems - part 6 docx
Ngày tải lên :
10/08/2014, 00:20
... systemic delivery of peptide drugs via the ocular route with surfactants, Drug Dev Res., 27:177–183 80 Harris, D., Liaw, J H., and Robinson, J R (1992) Routes of delivery: case studies (7) Ocular delivery ... protein drugs, Adv Drug Delivery Rev., 8:331–339 81 Chiou, G C Y (1994) Systemic delivery of polypeptide drugs through ocular route, J Ocul Pharmacol., 10:93–99 82 Morgan, R V (1995) Delivery ... (1998) Ophthalmic drug delivery systems recent advances, Prog Retinal Eye Res., 17:33–58 95 Robinson, J C (1993) Ocular anatomy and physiology relevant to ocular drug delivery Drugs Pharm Sci.,...
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Ophthalmic Drug Delivery Systems - part 8 docx
Ngày tải lên :
10/08/2014, 00:20
... future We hope that novel drug delivery systems will be developed to deliver potent polypeptide drugs through the ocular route REFERENCES Lee, V H L (1987) Ophthalmic delivery of peptides and ... insulin, Int J Pharm., 62:53 51 Su, K S E (1991) Nasal route delivery of peptide and protein drug delivery In: Peptide and Protein Drug Delivery V H L Lee (ed.) Marcel Dekker, New York, Chap 13 ... enhancers (78) VI ENHANCED SYSTEMIC ABSORPTION WITH PERMEATION ENHANCERS One of the major problems associated with the ocular delivery of peptide drugs is their poor systemic bioavailability This...
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Ophthalmic Drug Delivery Systems - part 9 pot
Ngày tải lên :
10/08/2014, 00:20
... (2000) Bispecific Mab aided liposomal drug delivery J Drug Target, 8(4):257–266 160 Cristiano, R J., and Roth, J A (1995) Molecular conjugates: a targeted gene delivery vector for molecular medicine ... intravitreal or via brain delivery has been found to be promising Delivery of adenoviral vectors with the gene encoding for brainderived neurotropic factor (BDNF) to Muller cells of rats with axotomized ... spontaneously with DNA Charge limitations and the need to separate DNA-liposome complexes after delivery have led to the development of positively charged cationic lipids These interact with DNA more...
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Ophthalmic Drug Delivery Systems - part 10 ppt
Ngày tải lên :
10/08/2014, 00:20
... therapeutics: drug delivery and targeting Adv Drug Delivery Rev., 18:115–131 167 J W Jaroszewski, and J S Cohen (1991) Cellular uptake of antisense oligodeoxynucleotides Adv Drug Delivery Rev., ... Drug Delivery with Particulate Systems (J E Diederichs and R H Muller, eds.) MedPharm Scientific Publishers, Stuttgart, pp 11–16 229 S K Das, K J Miller, and S C Chattaraj (1998) Facilitated delivery ... Section 201(p)) New drugs require INDs for conducting clinical investigations and NDAs for marketing approval The terms drug and new drug are inclusive of the drug substance and the drug product It...
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Ophthalmic Drug Delivery Systems - part 1 ppsx
Ngày tải lên :
10/08/2014, 03:20
... ophthalmic drug delivery systems, but the knowledge in this field is rapidly expanding Systems range from simple solutions to novel delivery systems such as biodegradable polymeric systems, corneal ... to provide maximal benefit, improvements in ocular drug delivery are essential Drug delivery is no less vital than drug discovery Although many drugs can be safely delivered by eye drops, effective ... Mitra 251 III Drug Delivery Systems A: Conventional Systems Ocular Penetration Enhancers Thomas Wai-Yip Lee and Joseph R Robinson 281 10 Corneal Collagen Shields for Ocular Drug Delivery Shiro...
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Ophthalmic Drug Delivery Systems - part 4 pdf
Ngày tải lên :
10/08/2014, 03:20
... may change indirectly with changes in the pathophysiology of the eye is the diffusivity of drugs in the vitreous Changes in drug diffusivity will be most significant when drugs of different molecular ... increased as the drug diffusivity was reduced Furthermore, the rate of drug elimination, which is inversely related to the drug s elimination halflife, decreased significantly as the drug diffusivity ... selecting drugs and doses, particularly if the blood-retinal barrier has been compromised Drug elimination was higher in an aphakic eye model than in a phakic eye model, especially for drugs with...
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Ophthalmic Drug Delivery Systems - part 7 docx
Ngày tải lên :
10/08/2014, 03:20
... pharmaceutical drug delivery system Copyright © 2003 Marcel Dekker, Inc Microparticles and Nanoparticles in Ocular Drug Delivery II PARTICULATE SYSTEMS IN OCULAR DRUG DELIVERY A 441 Topical Systems ... Drug Delivery 455 compared to the free drug, but the drug levels with the former remained constant for 14 days, unlike the free drug The drug concentration diminished to undetectable levels with ... Ocular drug delivery Mechanism(s) of corneal drug transport and mucoadhesive delivery systems, S.T.P Pharma, 5:839 11 Mikos, A G., and Peppas, N A (1986) Systems for controlled release of drug...
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