endothelial function and oxidative stress in cardiovascular diseases
Báo cáo y học: "Nifedipine decreases sVCAM-1 concentrations and oxidative stress in systemic sclerosis but does not affect the concentrations of vascular endothelial growth factor or its soluble receptor" potx
... CD40 ligand, interleukin 1, or interleukin 6 [10]. Oxi-dative stress also promotes angiogenesis [13]. The linkbetween oxidative stress and angiogenesis is emphasised in SSc by the baseline correlation ... early interactions between endothelial cells and mononuclear cells [22].We previously demonstrated a sustained major decrease in oxidative stress in response to treatment with dihydropyrid-ine-type ... nifedipine can ameliorate endothelium injury in SSc and that VEGF signalling may by impaired in this diseasewithout implication of the sVEGFR-1.Endothelium injury is critical in SSc and is...
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Báo cáo y học: "NITRIC OXIDE (NO), CITRULLINE – NO CYCLE ENZYMES, GLUTAMINE SYNTHETASE AND OXIDATIVE STRESS IN ANOXIA (HYPOBARIC HYPOXIA) AND REPERFUSION IN RAT BRAIN"
... synthase. The increased activities of argininosuccinate synthetase and argininosuccinate lyase suggest the increased and effective recycling of citrulline to arginine in anoxia, making nitric ... arginine at the site of synthesis. Arginine is a semi essential amino acid and in CNS, its availability depends upon: (a) uptake from the circu-lating arginine and (b) recycling of citrulline ... hypoxia) and reperfusion damage in brain. The increased activities of AS and AL indicate the effective recycling of citrulline to arginine and suggest a functional role to citrulline –NO cycle...
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Báo cáo khoa học: Calcium, mitochondria and oxidative stress in neuronal pathology Novel aspects of an enduring theme pdf
... by proteins resi-ding in both the inner and outer mitochondrialmembrane, that is activated by mitochondrial Ca2+overloading and other factors including oxidative stress [88,89]. In neurons ... of KGDHC in yeast equivalent to E2 in mammals),have two or more different functions, in addition tohaving supporting functions for oxidative defences [79],involving the thioredoxin system ... element binding protein, iso-citrate dehydrogenase is an RNA-binding protein, whilekgd2p is a mitochondrial DNA binding protein [81–84].Mitochondria from different brain regions containdifferent...
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báo cáo hóa học: " Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis" pptx
... implicating both oxidative stress and inflammatory mechanisms in AD pathogenesis.Effect of indomethacin plus vitamin E supplementation on sol-uble Aβ levelsFigure 3Effect of indomethacin plus ... therapeutic interventions suppressed brain inflammatory and oxidative stress responses in the mice. This effect was accompanied by significant reductionsof soluble and insoluble Aβ1-40 and Aβ1-42 in ... flurbiprofen, indomethacin) reducedbrain inflammation and Aβ levels in addition to the dep-osition of Aβ in brain [13,14]. Despite this evidence, and the considerable theoretical and therapeutic interest,...
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Báo cáo y học: " Impaired glucose transporter-1 degradation and increased glucose transport and oxidative stress in response to high glucose in chondrocytes from osteoarthritic versus normal human cartilag" pps
... Portugal3Division of Veterinary Medicine, School of Veterinary Science and Medicine, Sutton Bonington Campus, University of Nottingham, Sutton Bonington LE12 5RD, UKCorresponding author: Alexandrina F Mendes, ... IL-1β-induced 2-DG uptake, including theaffinity (1.066 ± 0.284 and 1.49 ± 0.59 mM) and maximalvelocity (0.27 ± 0.08 and 0.33 ± 0.08 nmol/μg protein/hour), and GLUT-1 content were identical in ... local inflammation and changes in the subchondralbone. Increasing age, excessive loading or injury, genetic pre-disposition and obesity are important risk factors for the devel-opment and progression...
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Báo cáo y học: "Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function" pptx
... Our findingsclearly show the presence of oxidative stress in degenerat-ing cartilage, and the resultant telomere erosion and dys- function of chondrocytes in vitro and in vivo, suggesting arole ... senescence and oxidative stress in OA cartilage, as discussed above, wepostulated that oxidative stress induces telomere instability and dysfunction in chondrocytes, subsequently resulting in cartilage ... maintain thechondrocyte telomere length and proteoglycan remaining in thecartilage explants, suggesting that oxidative stress induceschondrocyte telomere instability and catabolic changes in cartilage...
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Báo cáo khoa học: Cotton GhMPK2 is involved in multiple signaling pathways and mediates defense responses to pathogen infection and oxidative stress doc
... MPK3 and MPK6 in Arabidopsis (group AMAPKs), SIMK and SAMK in alfalfa, and LeMPK1 ⁄ 2(Lycopersicon esculentum SA-induced pro-tein kinase) and LeMPK3 (L. esculentum wound-induced protein kinase) ... protein kinase and wound-induced protein kinase, two MAPKs in group A, wereactivated by inoculation with the tobacco mosaic virus(TMV) [10]. Their orthologs in other plant species,including ... accumulation in wild-type and transgenicplants in response to abiotic and abiotic stresses. (A) Virus infec-tion-induced H2O2accumulation detected by DAB staining. (B) Abi-otic stress- induced...
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Báo cáo khoa học: Pyruvate:ferredoxin oxidoreductase and bifunctional aldehyde–alcohol dehydrogenase are essential for energy metabolism under oxidative stress in Entamoeba histolytica pdf
... indicating the presence of two catalyticallyindependent domains, the N-terminal domain, display-ing ALDH activity, and the C-terminal domain, con-taining an iron-binding domain, which is involved ... against oxidative stress damage, have not been reported. In vivo effects on glucose-fermenting enzymes and fluxes under oxidative stress Recently, we reported that amebas incubated for30 min in ... solubilized extract were incubated in such buffers for 4 hon ice, and the remaining enzyme activity was determined. Inset: EhPFOR time stability in N2-saturated buffer in the absence or presenceof...
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Báo cáo khoa học: "Comparative study of PM2.5 - and PM10 - induced oxidative stress in rat lung epithelial cells" pptx
... study of PM2.5 - and PM10 - induced oxidative stress in rat lung epithelial cellsJin-Hyuk Choi, Jun-Sung Kim, Young-Chul Kim1, Yoon-Shin Kim2, Nam-Hyun Chung3 and Myung-Haing Cho*Laboratory ... protectionstandards for PM by adding an indicator for even “fine”particles (PM2.5). In this trend, our government is trying toupdate on ongoing litigation over PM2.5 standard. However,relative less information ... study,PM2.5 induced more MDA formation than PM10suggesting that PM2.5 induced more oxidative stress thanPM10. In the single strand breakage assay using pBR322DNA, the ratio of changed form II/total...
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Báo cáo lâm nghiệp: "Response to an ozone gradient of growth and enzymes implicated in tolerance to oxidative stress in Acer saccharum (Marsh.) seedlings" pot
... processes.However, after 85 days, the NR activity in the seedlings waslower and decreased with increasing O3. At that time in theseason and with increasing oxidative stress, NH3may havebeen provided ... 10.1051/forest:2006019Original articleResponse to an ozone gradient of growth and enzymes implicated in tolerance to oxidative stress in Acer saccharum (Marsh.) seedlingsCatherine Ga,b*,NadineCc,PaulWc, ... material from a single leaf was sam-pled from each flush of each seedling, cut into 2 × 2 mm pieces and incubated in 5 mL of 100 mM phosphate buffer (pH 7.5) containing40 mM KNO3 and 1.5% 1-propanol....
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