... and in inducing and maintaining remission in patients with active CD ACCENT I was a multicenter randomized double-blind international trial studying retreatment and remission maintenance in adult ... favorable maintenance of clinical remission Since CD may progress from intestinal inflammation to strictures and penetrating disease, including fistulas and abscess formation, mucosal healing has ... weeks for maintenance of remission After 54 weeks, the initial clinical response was maintained in only 17% of patients in the single dose group compared to 43% of patients maintained on 5 mg/kg...
... 366:287-2106 Vicini F, Kestin L, Chen P, Benitez P, Goldstein NS, Martinez A: Limited-field radiationtherapyin the management of early stage breast cancer J Natl Cancer Inst 2003, 95:1205-1210 King TA, ... seen in consultation by her surgeon and radiation oncologist Radiation treatment options were explained to the patient, including the standard of care, 6– weeks of whole breast radiation therapy, ... radiation oncologist remained in the room during the radiation delivery either wearing lead aprons or standing behind a mobile radiation shield At the completion of the radiation, the balloon and...
... carcinoma in complete surgical remission after induction chemotherapy: a randomized, controlled, clinical trial comparing whole abdominal radiotherapy, chemotherapy, and no further treatment Int ... complications in patients treated with abdomino-pelvic radiationtherapy for ovarian carcinoma Int J Radiat Oncol Biol Phys 1992, 22:847-51 Lindner H, Willich H, Atzinger A: Primary adjuvant whole abdominal ... body volume included in the CT scan minus the PTVs), the integral dose, “DoseInt” was defined as the integral of the absorbed dose extended to over all voxels excluding those within the target...
... analyzed using the grading scale introduced by Ballo et al in 2006 [9] The classification consisted in grade toxicity for an asymptomatic finding noted at the time of the follow-up physical examination; ... without radiation therapy, and without systemic therapy Having four or more involved lymph nodes, extracapsular extension and node size greater than centimetres were our main indications for radiation ... symptomatic finding requiring any form of medical therapy (e.g., compressive sleeve for lymphedema, physical therapy for neuropathy, or long-term use of pain medication); and grade for toxicity requiring...
... cavity According to literature [6,8-25], it is possible to obtain local control in the range of 89-100% using radiotherapy in low or moderate doses as 25-36 Gy A summary of findings of some of ... reported in any patient Keratitis occurred in patients (10.6%), xerophthalmia in (19.1%), cataract in 12 (25.5%), corneal ulceration occurred in one patient (2.1%), and minor retinopathy in one ... failure of 44 months: two patients relapsed in the other eye, at ipsilateral laterocervical nodes, in the abdomen, in the mediastinum, in the trunk skin, and in a vertebral bone All relapsed patients...
... palliation of brain metastases Final results of the first two studies by the RadiationTherapyOncology group Int J Radiat Oncol Biol Phys 1980, 6:1-9 Vermeulen SS: Whole brain radiotherapy in the treatment ... partitioning analysis (RPA) of prognostic factors in three RadiationTherapyOncology Group (RTOG) brain metastases trials Int J Radiat Oncol Biol Phys 1997, 37:745-754 Patchell RA, Regine WF: ... demonstrated in table Discussion Brain metastases are the most common form intra cranial tumor accounting significantly more than one- half of brain tumors in adults Because of advanced in the diagnoses...
... of radiation may be informative Cytokine and cellular responses to radiationtherapyin the skin have been investigated to identify targets to mitigate the consequences of ionizing radiationtherapy ... comparing Best Supportive Care to Biafine as a prophylactic agent for radiation- induced skin toxicity for women undergoing breast irradiation: RadiationTherapyOncology Group (RTOG) 97-13 Int ... assessing the effectiveness of Biafine cream as a prophylactic agent for radiation- induced acute skin toxicity to the breast in women undergoing radiotherapy with concomitant CMF chemotherapy Int...
... distinguish positive tumor areas within individual cores of the TMA slide Both staining intensity and its relative area within a specimen were quantified Staining intensity was acquired in a ... RadiationOncology 2008, 3:32 Background Nestin is an intermediate filament protein that was initially identified during studies involving cellular organization of the developing rat ... evaluating nestin expression in GBM may be more informative when studied in the context of markers more specific to tumor stem cells, including CD133 [5] In addition, future investigations evaluating...
... delivering stereotactic body radiotherapy is crucial Image-guided respiratory-gated radiationtherapy has been a major advancement in minimizing inter- and intra- fractional target variations To minimize ... 1997; Spitz et al 1997; Klinkenbijl et al 1999) In an effort to increase the number of patients receiving adjuvant therapy, chemotherapy and radiationtherapy can be administered pre-operatively ... US Intergroup study compared gemcitabine vs infusional 5-FU chemotherapy for one month prior to and three months after chemoradiation, consisting of continuous infusional 5-FU, as adjuvant therapy...
... treatments, including radiotherapy One could interfere with EGFR binding or with individual steps in downstream processes For that purpose, a number of protein kinase inhibitors are currently under investigation ... transcription allowing cell progression into S phase The action of cyclin D/cdk4 on Rb phosphorylation can be inhibited by a number of genes including p27, p21, and INK (inhibiting kinases) that include ... to radiation- induced apoptosis Radiation and EGFR Signaling There is growing evidence that ionizing radiation can mimic the action of ligand-receptor binding, which triggers downstream signaling...
... Surgical margins were intra-operatively assessed in all cases and, when these were close to being positive, in some cases the margin was widened to include one arytenoid Definitive surgical margins were ... months, postradiotherapy) In case #8, concomitant chemoradiotherapy was used However, radiotherapy doses were only able to be accurately established in four cases because the remaining cases were ... gastrostomy; NFT = nasogastric feeding tube; AMI = acute myocardial infection; GI = gastrointestinal; CWI = cervical wound infection, RP = Rupture of the pexy control was obtained in 7/8 patients (87%) (Table...
... head-and-neck patients, including nodal mass shrinkage and patient weight loss during the course of radiation therapy, can occur [28,29] For these cases, repeat CT imaging and re-planning may be essential ... sets Finally, the initial dose distribution matrix calculated on the planning CT was imported in the treatment planning system and displayed on the kV-CBCT dataset using scripts developed in- house ... different image modalities is widely used in radiotherapy for delineating the region of interests[27] As the registration algorithms in the commercial treatment planning systems generally use rigid body...
... randomized intergroup study J Clin Oncol 1996, 14:2527-2539 Intensity modulated radiationtherapy collaborative working group: Intensity modulated radiotherapy: current status and issues of interest Int ... L, et al: Role of mitomycin in combination with fluorouracil and radiotherapy, and of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal: ... patients including iliac crests sparing measurements Methods Patient selection, simulation and treatment planning Ten patients with localized anal canal carcinoma treated with IMRT in our institution...
... without pain, or skin fibrosis due to radiation exposure In an effort to explain the increased breast reconstruction complications in patients due to increased radiation dose to the skin, a separate ... skin thickness Skin reactions occurring within a time interval of up to three months following irradiation are defined as early reactions and reactions presenting after three months following ... resection and radiationtherapy [34] The authors also observed an increase in skin thickness followed by a decrease in four of nine patients for whom serial ultrasound scans were performed beginning one...
... Society of Clinical Oncology Postmastectomy radiotherapy: clinical practice guidelines of the American Society of Clinical Oncology J Clin Oncol 2001, 19:1539-1569 10 Recht A, Bartelink H, Fourquet ... LRR Clinical characteristics of patients with LRR are shown in Table LRRs’ histologic types were invasive ductal carcinoma for patients and invasive lobular carcinoma Cosar et al RadiationOncology ... give us better information the role of PMRT in this patient group [6] Radiation oncologists often confront patients with 1-3 positive lymph nodes following MRM in their routine clinical practice...
... 3DCRT [8,16,17] In our study, in addition to these findings, we found IMRT capable of reducing small bowel volumes receiving potentially toxicity-inducing intermediate- and low-dose irradiation, at ... Chemoradiotherapy Utilizing Intensity Moldulated RadiationTherapy (IMRT) in Combination with Capecitabine and Oxaliplatin for Patients with Locally Advanced Rectal Cancer [http://www.rtog.org/ClinicalTrials/ProtocolTable/StudyDetails.aspx? ... gastrointestinal toxicity in these patients treated with IMRT Furthermore, reduction in the small bowel V45Gy using IMRT may lead to lower rates of late gastrointestinal toxicity [20] Again, in the...
... thyroid gland sizes ranging from 3.6-6 cm in length, 1.5-2 cm in width and 1-2 cm depth are reported [23], which are more in agreement with our study Finally, as our findings are principally based on ... body irradiation A median thyroid dose in Bonato et al.’s study was 42 Gy (inter-quartile range: [27-72Gy]) [15] After high-dose radiotherapy the years incidence of Johansen et al RadiationOncology ... The clinical target volume, both lungs and the heart, but not the thyroid gland were routinely delineated in the planning CT images Treatment planning and dose calculation were performed using...