educate enough but not too much
Báo cáo y học: "Chiropractic care for children: too much, too little or not enoug" ppt
... 10.1186/1746-1340-18-17 Cite this article as: French et al., Chiropractic care for children: too much, too little or not enough? Chiropractic & Osteopathy 2010, 18:17 ... series addresses the question "Is more research enough? " [18] The authors tackle this question by proposing that more research in this area is not enough, in that research needs to be appropriate ... covered in the commentary by Leboeuf-Yde and Hestbaek in this series [18], but we would add to this High quality research does not come cheaply and funds must be spent wisely The chiropractic profession...
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Báo cáo y học: "is enough oxygen too much" pot
... capillary density [9] So high overall blood flow does not guarantee uniform oxygenation In summary, hypoxia triggers protective responses, but not all of these are adaptive at the tissue level A ... Oncol Biol Phys 1989, 17:91-99 doi:10.1186/cc9201 Cite this article as: Schumacker PT: Is enough oxygen too much? Critical Care 2010, 14:191 ... enzyme essential for alveolar edema reabsorption [8] Hence, responses triggered by hypoxia may not optimize tissue repair and survival in the critically ill Finally, intensivists need to know...
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Báo cáo y học: "Genetic polymorphism of p53, but not GSTP1, is association with susceptibility to esophageal cancer risk – A Meta-Analysis"
... Pro/Arg+Pro/Pro genotypes, compared with the Arg/Arg genotype Figure ORs (log scale) of esophageal cancer associated with GSTP1 Ile106Val for the Ile/Val+Val/Val genotypes, compared with the Ile/Ile genotype ... polymorphism and esophageal cancer, but this conclusion was consistent with Hiyama T et al’ s review.[40] These findings suggest that the GSTP1 Ile105Val genotype alone does not show any association with ... smoking, though there were not enough report support us to make meta-analysis in current research Studies with a larger sample size, especially including smoking or another environment factors...
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Báo cáo y học: "TPO, but not soluble-IL-6 receptor, levels increase after anagrelide treatment of thrombocythemia in chronic myeloproliferative disorders"
... with PR+F (not shown) Reliable methods for the measurement of anagrelide metabolites were not available at the time of study Effects on TPO and sIL-6R levels TPO PV and ET patients did not differ ... at start did not indicate whether a patient would obtain CR or not Likewise, there was no statistically significant difference at months between those achieving CR and those who did not (95.3±103 ... the most pronounced rise of TPO Future studies of TPO interactions with its receptor, not only on platelets but also on megakaryocytes, might yield a better understanding [9] One may ask if the...
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Five stories that are almost true, but not quite
... am not overambitious I am happy with my work I am not famous but I have independence I cannot create some of the more daring clothes that I would perhaps have been able to create in Europe but ... romantic one at that by attributing my failure at university to the love affair which took too much of my time “Oh Anna, please don't exaggerate, I can without compliments I cannot believe in.” “On second ... mistress He even wanted to buy me jewelry but I did not accept That's why I am not wearing any.” “They would add nothing to your appearance Nobody would notice them,” I said “That's sweet Don't...
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Tài liệu Báo cáo khoa học:Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau ppt
... able to interact, but to differing extents, with Fyn-SH3 This suggests that the results shown here are not artefactual, owing to incorrect folding of the tau mutants, at least not in the regions ... a major role in mediating interactions between tau and Fyn-SH2 However, a contribution from other tyrosines cannot be excluded, as a greater proportion of Y18F than of YallF mutant tau cosedimented ... phosphorylation of Tyr394 did not appear to influence the binding of tau to Fyn-SH2, as there was no significant difference in the amount of Y394F 2930 Fig Tau interactions with Fyn-SH3 are not influenced by...
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Tài liệu Báo cáo khoa học: Dual P2Y12 receptor signaling in thrombin-stimulated platelets – involvement of phosphoinositide 3-kinase b but not c isoform in Ca2+ mobilization and procoagulant activity pdf
... additional effects (not shown) In marked contrast, post-addition of MRS2179 did not affect the thrombin-induced Ca2+ response (Fig 1) To determine whether the P2Y12 contribution to the thrombin-evoked ... not shown) As a comparison, the general PI3-K inhibitor wortmannin was given after thrombin + ADP; wortmannin had a slower, but similar type of effect as AR-C (Fig 2B) To quantify the contribution ... either case, AR-C (but not MRS2179) suppressed the Ca2+ integral to a similar degree; 38 ± 1% and 37 ± 1% (n = 3) Thus, the P2Y12-dependent part of the Ca2+ signal with thrombin does not rely on PAR4...
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Tài liệu Báo cáo khoa học: Activated Rac1, but not the tumorigenic variant Rac1b, is ubiquitinated on Lys 147 through a JNK-regulated process docx
... not involved in contacts with any of the interacting proteins described so far, and is not affected by the 19-residue insertion in Rac1b Therefore, the impairment of Rac1b ubiquitination is not ... Lys48 (UbR48) or Lys63 (UbR63), we found that ubiquitin chain synthesis on Rac1L61 was markedly but not completely inhibited by UbR48 and that, by contrast, UbR63 supported the formation of polyubiquitinated ... increase in Rac1b ubiquitination (see white bars in Fig 3A below for quantitative analysis), but did not sensitize it significantly to proteasome-mediated degradation in HEK293 cells (Fig 1D, right...
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Cytoskeleton reorganization mediates alpha beta integrin-associated actions of laminin on proliferation and survival, but not on steroidogenesis of ovine granulosa cells pdf
... These observations indicate that ECM components contribute to the microenvironment of GC, but their specific roles in follicular development have not yet been established LN is one of the most abundant ... index and pyknotic index GC proliferation and survival were assessed by measuring the thymidine labeling index (percentage of labeled cells) and the pyknotic index (percentage of pyknotic cells) ... containing different ratios of LN and RGD peptides that specifically recognize the α5/ α8/ αv/ αIIb but not the α6 integrin subfamilies [35] Lastly, the consequences of inhibiting the ERK1/2 (Extracellular...
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What happens if we’ve paid you too much tax credit? ppt
... care charges have stopped We issue you an award notice on 30 July, but it still shows your eldest child included in the award You not check the award notice until 30 September and see this mistake ... award How much we reduce your payments by will depend on how much you’re getting We reduce awards at different levels, see the table on page 10 COP26 What happens if we have paid you too much tax ... should be on your award notice We expect you to tell us if you get any payments that don’t match what is shown on your award notice • If you spot a mistake on your award notice you should tell...
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Blackwell Science, Ltd Group breeding dramatically increases reproductive success of yearling but not older female scrubwrens: a model for cooperatively breeding birds? ppt
... although yearlings are much more successful when breeding in groups, older females not benefit at all How could breeding in a group provide a major benefit to yearlings but no benefit to older females? ... conditions may be even lower It is therefore not surprising that many studies have not detected group-size effects A greater ratio of effect in poor conditions does not necessarily mean that there is a ... distributions for the two classes of female were directly comparable Some females were represented in both the ‘yearling’ and ‘older’ class, which enabled pairwise comparisons (Results), but many...
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Dangerous But Not Omnipotent pptx
... East As a result of these perceived attributes, the Iranian leadership has shown a marked tendency not only to push for a greater role in regional affairs but also to exaggerate Iran’s strategic ... international s ystem but not because of its revolutionary foundations Iranian leaders no longer seek to radically reshape the regional order as they did after the revolution, but rather to raise ... Division, Center for Strategic Research, Expediency Council, 2006 14 Dangerous But Not Omnipotent In recent years, these attributes have informed a policy outlook that attaches inflated geopolitical...
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Báo cáo khoa học: Protein crystallography for non-crystallographers, or how to get the best (but not more) from published macromolecular structures potx
... symmetryequivalent contributors) is not the most useful indicator, because it does not take into account the multiplicity of measurements More elaborate versions of Rmerge have been proposed [32,33], but they ... introduced too many parameters The structure 1q1p mentioned above is an example of such an approach (refinement of too many parameters and addition of too many solvent molecules often go together) Another ... refinement not only permits finer structure details to be observed, but also removes possible bias from the model, as higher resolution improves the data-to-parameter ratio It has to be noted that...
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Báo cáo khoa học: H2O2, but not menadione, provokes a decrease in the ATP and an increase in the inosine levels in Saccharomyces cerevisiae An experimental and theoretical approach pot
... different concentrations of menadione (10, 30, 83, 90 and 110 mM) on cell viability (results not shown) and noticed that 83 mM menadione produced a viability similar to that evoked by 1.5 mM H2O2 ... and results not shown) Although its UV spectrum coincides with that of adenosine, both compounds are different because (a) they elute in a slightly different chromatographic position (not shown) ... 2, and mM H2O2 A concentration of H2O2 as high as mM did not change the HPLC nucleotide prole obtained with untreated cells (results not shown) In a different experiment, yeast cells were grown...
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Báo cáo Y học: Ruk is ubiquitinated but not degraded by the proteasome ppt
... 2002 Ruk is ubiquitinated but not degraded by the proteasome (Eur J Biochem 269) 3407 proteins Many ubiquitinated proteins are targeted for degradation by 26S proteasomes, but some undergo endocytosis, ... human and yeast proteins Therefore, Ub is not an optimal antigen and anti-Ub Ig rarely possess good affinity Taking this into account and that anti-Ruk Ig are not very efficient in immunoprecipitation ... were probed in Western blotting with anti-EE Ig Ruk S is detected only on a much longer exposure (Fig 2B) We have also noted that the longest isoform of Ruk (Ruk L) exhibits the strongest association...
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He knows too much
... `He knows too much I must ask you to nothing.' `But this time I caught him in the act I have proof, witnesses, everything There is no possible doubt Surely ' `I said he knows too much! The ... meal He also noted that there had been no shortage of genuine Scotch whisky, a drink not easily available on the local market It was not long, however, before Dick began experiencing another side ... mixture of veiled threats and vague promises Lennox had made `He knows too much' ± the words still rang in his ears He wondered, not for the last time, just what it was that Vish, the of®ce manager...
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Báo cáo khoa học: Amyloid structure – one but not the same: the many levels of fibrillar polymorphism potx
... conditions, is a general property of the polypeptide chain [10,11] This ability not only has pathological consequences, but can be turned into good use as functional amyloid, serving as structural ... three different types of amyloid according to solid-state NMR [39] that differ from one another in subtle but distinct ways, such as variations in the mobility of the aromatic Tyr ring There is ... [33], b2-microglobulin [34], Ab [35] and glucagon [27] fibrils demonstrated that strain behavior was not limited to proteins with a prion-like sequence Recently it has been demonstrated that even small...
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Báo cáo khoa học: Insulin is a kinetic but not a thermodynamic inhibitor of amylin aggregation pot
... of both peptides are much higher than those in extracellular spaces, the enhanced fibrillization is more likely to occur intracellularly It is noticeable that insulin was not reported as the main ... long-term incubation These results indicate that insulin may be not only a natural inhibitor of amylin aggregation, but also a contributor to the amyloid formation and pathogenesis of T2D We also ... caseins during their fibrillation Altogether, these results indicate that insulin is a kinetic but not a thermodynamic inhibitor of amylin aggregation, and insulin can eventually promote fibril...
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Báo cáo khoa học: Novel isoenzyme of 2-oxoglutarate dehydrogenase is identified in brain, but not in heart potx
... signal transduction Regulated by thioredoxin, OGDHC is at the intercept of not only energy production and glutamate turnover, but also mitochondrial production ⁄ scavenging of reactive oxygen species ... et al the distribution of OGDHC activity between the supernatant and the detergent extract of the broken mitochondria pellet Mitochondrial disruption with the probe sonicator did not reproducibly ... two-saturation model is obvious not only from visual inspection of the coincidence between the experimental points and theoretical curves in Fig 4B compared with Fig 4A, but also from an increase in...
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Báo cáo khoa học: The activation of gelsolin by low pH The calcium latch is sensitive to calcium but not pH docx
... is not reduced by low pH It is possible therefore that in pH-activated gelsolin, the helical latch may be the last event to occur being triggered not by direct disruption of the interface but ... ionpair exchanges, presumably initiated at histidine residues, that also disrupts interdomain bonds but not those formed through the G2–6 interface Methods Proteins and peptides Rabbit skeletal muscle ... similar to those obtained at pH 7.5 It appears that the interaction between G2 and G4–6 is calcium but not pH sensitive Fig Binding of G4–6 domain with 159–193 and 197–226 fragments derived from gelsolin...
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