... Wilhelm, and Howard I. MaibachBioengineering of the Skin: Cutaneous Blood Flow and ErythemaEnzo Berardesca, Peter Elsner, and Howard I. MaibachBioengineering of the Skin: Water andthe Stratum ... MaibachPigmentation and Pigmentary DisordersNorman LevineNickel andthe Skin: Immunology and ToxicologyHoward I. Maibach and Torkil MennéBioengineering of the Skin: Skin BiomechanicsPeter ... MaibachBioengineering of the Skin: Skin Surface, Imaging, and AnalysisKlaus P. Wilhelm, Peter Elsner, Enzo Berardesca, and Howard I. MaibachBioengineering of the Skin: Methods and InstrumentationEnzo...
... In the same way, all critical functions in the development and acquisi-tion of drugsand biologics in the United States lead to and throughFDA. The agency regulates drug development in the ... and acceptance by mili-tary personnel andthe wider public—underline the importance oflicensed drugs. By contrast, the regulatory requirements of IND use, the burden of recordkeeping, andthe ... to drugsand biologics for CBW defenseinto a single OSD office. The two candidates for this responsibilityare the ASD(HA) andthe DATSD(CBD). Health Affairs lacks authorityfor research and...
... whether these messagesare translatable. In the second step, we characterized theircoupling to different signaling pathways and their modu-latory role on the CRFR1a activity.Materials and ... expressionTo verify that the constructs produce proteins of the expected masses, we attached the V5 epitope to the Cterminus of the CRFR1 isoforms (Fig. 1C). The predictedmasses of the isoforms without/with ... E27(5¢-GGTAGTGCACCTTGCTTTTTTTCTCTCCCCA-3¢) and attached to another fragment of CRF receptor in the final PCR by primers E3 and E11.To attach V5 epitope to the CRFR1a,g,h2ande2isoforms we amplified the corresponding DNA...
... signal intensities of the specific band. Supershifted bands were rather weak and only detectable after overexposure of the autoradiograph.These findings are consistent with the observation that ... BglII site. The PCR amplicons were cloned into the EcoRV site of the pMOSBlue vector (Amersham PharmaciaBiotech) and subsequently excised with MluIandBglII. The DNA fragments were then cloned ... report [6]. Furthermore the present study indicates the ability of drugsand endogenouscompounds to affect Bsep transcription, thus alteringhepatic bile flow and clearance.MATERIALS AND METHODSGenomic...
... class diagram shows the existence of classes and their relationships in the logical view of a system UML modeling elements in class diagrams- Classes and their structure and behavior- Association, ... info7: addsection 135 The State of an class A state chart diagram shows - The life history of a given class- The events that cause a transition from one state to another- The actions that result ... relationships within the implementation environmentComponents represent all kinds of elements that pertain to the piecing together of software applications. Among other things, they may be simple...
... narrative structure, and to the kind of stories that gettold and retold about the Irish, so as to reveal both the regularity ofEnglish colonial discourse on Ireland andthe Irish andthe mutations ... organic growth of the plant (the great British oak) to the countryside, the country house and the georgic ideal of retirement, the estate, the aristocratic family and itsgenerations, the inviolability ... Susan and Judy; andthe bright lightsof the next generation – Lauren, Brendan, Conor, Mara, Liam, and Brigit – for putting up with it, and with me. Always and everywhere,Regenia Gagnier and Rob...
... from the lands controlled by the PenthieÁvre family, settled on these estates. The other contingent lacked the unity of the Richmond tenants. Thesewere Bretons from the north-east of the duchy ... forti®cations without the permission of the duke;± The barons of LeÂon and PenthieÁvre had the right of wreck on the shores oftheir lands;± The barons of LeÂon and PenthieÁvre were ... salt-works, the castellany of Blain and the forest of Le GaÃvre.24South of the Loire, ducal domains included the castellany of Le Pallet,25estates on the south bank of the Loire and another in the...
... MafekingNight andthe following day, they were ‘‘everyone’’ and ‘‘London’’ and even ‘‘England.’’ They were created as a group by the newspapers, and this chapter examines the mechanism of their creation and ... food stocks, andthe mood of the garrison. The tacticsof the Daily Mail captured the attention of the nation; the newspaperdramatized the situation of the town by emphasizing the danger that ... race, sex, and class and of the ways in which, hand in hand, the New Imperialism and the New Journalism brought Britain into the twentieth century. The war at homewhich included the direct...
... Moses)22 and others including Emperor Justinian, Frederick the Great and French6 Globalisation andthe Western Legal Tradition19See Richard Posner, Law and Legal Theory in England and America ... lists the heightening of global consciousness in the late 1960s andthe inclusion of the Third World, civil rights, interest in worldcivil society and world citizenship, the increase in the number ... 11.1 The Western legal tradition 31.2 Patterns of law and authority: from the celestial to the terrestrial 81.3 Grand theory in the human sciences 101.4 General jurisprudence 121.5 Danger and...
... for the eye of the writer. The publicforget the youth, and dwell only on the positive merits or demerits of the writing.''3ThesecondsentenceoftheTamerlane preface explains that the poems ... generous The student andthe book 3their attitudes toward the novel-as-genre shaped their understandingof Poe's book. The chapter closes with a discussion of the second and only other book-length ... to print these poems not because of their quality; rather,he did not print them because they belonged to the manuscripttradition. In other words, Poe did not publish them because theywere...
... entrepreneurs, they served to represent the needs of politicalinterest groups and above all the rulers of the continentalstates wherethey were based until the end of the eighteenth century and beyond. ... sympathy; and another summary report in the same issue talks disdainfully about the ‘vile populace’ and their hopes of pillage amidst the disorder.A survey of reports in four other gazettes shows the ... including one on the concept of Fatherland in the Netherlandsfrom early modern times till World War II and one on Dutch lieux-de-m´emoire.Introduction (as developed by Gutenberg in the mid-fifteenth...
... story of the fragmentationof the ideal of literature as a public sphere. The excesses gener-ated by the French Revolution, on the one hand, and by the infor-mation revolution, on the other, converged ... against . . . the THE CRISIS OFLITERATURE IN THE 1790sPrint Culture andthe Public SpherePAUL KEENProblems now and then 15was crucial because it allowed people to understand themselves asa ... reason.But these shifts cannot erase the important continuities thatexisted between the lyrical ideals of the poets andthe more secu-lar ambitions of other authors. It is impossible to understand the poets’...
... triangle having the same base as the segment and an equal height.3Later, theorems worthy of mention suggested themselves to us, and wetook the trouble of preparing their proofs. They are these: first, ... equal to the line drawn from the vertex of the segment to the circumference of the circle which is the base of the segment.5Next to these, that, in every sphere, the cylinder having a1 The later ... smaller./3/ And similarly, that among surfaces, too, which have the samelimits (if they have the limits in a plane) the plane is the smallest. /4/ And that among the other surfaces that also have the...