do somatic mutations in the atm gene play a role in sporadic tumor development

Báo cáo hóa học: " Trichloroethylene exposure and somatic mutations of the VHL gene in patients with Renal Cell Carcinoma" potx

Ngày tải lên : 20/06/2014, 00:20

... remove all paraffin Finally, the total amount of DNA was measured by Nanodrop technology (Labtech France, Paris, France) Mutation analysis Mutation screening of the VHL coding exons and exonintron ... were found It has been postulated that sporadic and familial renal cell carcinomas have a common carcinogenic pathway and that at least one gene should be altered in both forms This has been confirmed ... the cloning of the VHL gene and the identification of germline and somatic mutations of this gene in VHL patients and sporadic RCC Today, more than 400 germline mutations have been reported in...

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Báo cáo y học: "A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity" doc

Ngày tải lên : 09/08/2014, 10:21

... the manuscript Additional files 12 13 The following Additional files are available online: Additional file An Word file containing a table that shows a table of all SNPs evaluated for association ... modulates the affected disease pathway so that it mainly influences the clinical disease in RF-negative RA, specifically in men However, it is not impossible that this pathway play a role also in ... all information regarding genetic factors, antibodies and matching variables was available This same sample set was used for the frequency analysis of rs729749 We used the SAS software for Windows...

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Báo cáo y học: "Somatic mutations in the mitochondria of rheumatoid arthritis synoviocytes" ppt

Ngày tải lên : 09/08/2014, 06:23

... TTAGCTCTCACCATCGCT R1B 4239 ATTGTAATGGGTATGGAGACA F2 4184 TTCCTACCACTCACCCTAG R2 4869 CATGTGAGAAGAAGCAG 417 ATGATGGAGCAGAAGAGTACTGCA DLDb DLD – sense DLD – antisense 1088 TTTAGTTTGAAATCTGGTATTGAC aSee ... samples and helped in the analysis of data GW participated in the design of the study, analysis of data, and writing of the manuscript All authors read and approved the final manuscript Additional ... respectively) Nuclear DNA mutational burden A nuclear gene was analyzed to determine whether it, too, had increased mutations in RA, and thus reveal whether the changes in mutational frequency were...

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Báo cáo y học: "Somatic mutations in mitochondria: the chicken or the egg" docx

Ngày tải lên : 09/08/2014, 07:20

... of RA still remains unanswered Do mtDNA mutations initiate the autoimmune reaction in RA, or are they a consequence of inflammatory damage to the cell? In future, in addition to further analysis ... DNA repair in mitochondria It is feasible that increased DNA damage through ROS in RA can be compensated for in the nucleus by the upregulation of repair mechanisms, whereas in the mitochondria ... frequencies of mutations in p53 transcripts in RA than in OA [8], others could not detect any mutated p53 at all [9] Data on mutations in the H-ras gene in arthritic synovium could not be verified later...

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Báo cáo khoa học: " Linkage disequilibrium pattern of the ATM gene in breast cancer patients and controls; association of SNPs and haplotypes to radio-sensitivity and post-lumpectomy local recurrence" doc

Ngày tải lên : 09/08/2014, 10:21

... monomeric (active) and dimeric (inactive) state [16] The protein contains several important domains such as 1) the C-terminal protein kinase domain (PI3K-domain), 2) the substrate binding domain in the ... substrate binding domains, Leucine zipper, ATP-binding domains, FAT domain and PI3K domain [17] together with exonic information (The size of the exons and the distance between them are not indicative ... fossa supraclavicularis and along the arteria mammaria interna Depending on the extent of the operation and/or the expected risk of local recurrence, the thoracic wall was also irradiated [33] Late...

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Báo cáo Y học: Does phosphorylation of the cap-binding protein eIF4E play a role in translation initiation? ppt

Ngày tải lên : 23/03/2014, 21:20

... i.e has a cap and a poly (A) -tail The open reading frame of the mRNA is shown as a thick line Initiation factors are abbreviated The arrow indicates the phosphorylation of eIF4E at Ser209 by the ... appears to be the determining factor in stabilizing the eIF4EÆcap interaction [50], and could be regarded as causing the ÔclampingÕ of eIF4E to the cap) Several initiation factors have RNA-binding ... of the MettRNAMet locates the start codon (diagram I) The eIF4E i would now be less likely to remain associated with the cap, and would become available to bind other mRNAs and facilitate the initiation...

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TT17H.BC: Đối tượng lĩnh tiền chế độ qua tài khoản thẻ ATM ký xác nhận chữ ký định kỳ vào tháng 5 và tháng 11 hàng năm doc

Ngày tải lên : 10/07/2014, 11:21

... Kết việc thực TTHC: Danh sách chi trả có chữ ký xác nhận đối tượng Các bước Mô tả bước Tên bước tháng tháng 11 hàng năm đối tượng lĩnh tiền chế độ qua tài Đối tượng khoản thẻ ATM đến đại diện chi ... tượng không đến ký xác nhận vào cuối Danh sách chuyển BHXH huyện Thông báo tạm dừng in danh sách chi trả lương hưu, trợ cấp BHXH hàng tháng chuyển đến đ a đối tượng không đến ký xác nhận chữ ... đại diện chi trả để ký xác nhận Danh hưởng sách chi trả Đối tượng không đến ký xác nhận bị tạm dừng chi trả Đại diện chi trả BHXH huyện thông báo thời gian, đ a điểm để đối tượng đến ký xác nhận...

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Báo cáo toán học: "Differential display identifies overexpression of the USP36 gene, encoding a deubiquitinating enzyme, in ovarian cancer" pot

Ngày tải lên : 08/08/2014, 17:20

... ggatccatttaggtgacactatagaagtacctgaaaggaagcttttttttttcg aggatttcctgtatttattaagttacaagttggcaggcacagcttgagcaacat agaaaagtaatcttcttgagttatacaatcatttaaattccaaagcactcacaa aattgagcaaacaaagccactatttgcatatttgggaaaggaaacatattgct ... ttacaagttggcaggcacagcttgagcaacatagaaaagt aatcttcttgagttatacaatcatttaaattccaaagcactcacaaaattgagca aacaaagccactatttgcatatttgggaaaggaaa-3’) The membrane was hybridized in buffer containing 1.6 x 107 cpm/ml probe and ... GTCATCTTGCTGAGCCCTTC AATTTTGTGCTTGGGAATGG ATGTGGTCCAGGAACTGCTC ATGACTGGGACGAAGAGTTTGAC GAAAGGAGGTGCAGAGGATG ACTCTCCCAGACACCCACAC GGCATTCTCTCCACTCAGGA TTTTTTTCACAGAACCGGAG CCCACCTCACCCTTACACC CTACACACATACACGGCACACAC...

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Báo cáo khoa học: "Does the surgeon still have a role to play in the diagnosis and management of lymphomas?" docx

Ngày tải lên : 09/08/2014, 07:21

... with a ratio of 1:4 [1] Table 1: Anatomical location of lymphomatous lymph nodes (n = 62) Anatomical location Number of cases Cervical Inguinal Axillary Intra-abdominal Supraclavicular Submandibular ... lymphomas, one of the important roles of FNAC is the exclusion of metastatic squamous carcinoma as this requires an alternative therapeutic approach There is a question as to the accuracy of FNAC in ... prepared the draft manuscript PC and SK provided the pathological data and helped in preparing the manuscript, AV and TGH reviewed and edited the manuscript and helped in preparing the final version...

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báo cáo khoa học: " Do mitochondria play a role in remodelling lace plant leaves during programmed cell death?" pps

Ngày tải lên : 11/08/2014, 11:21

... significant decrease in perforation formation within the lace plant via CsA application indirectly indicates that the PTP pathway may play a role in cellular death within this system Although the involvement ... of the PCD gradient within a window stage lace plant leaf The three-part differentiation of an areole within a stage 2, or window stage leaf A) A detached stage 2, or “window” stage leaf Note the ... that cyclosporine A (CsA) can act in disrupting the PTP by displacing the binding of CyD to AdNT [19] within animal systems The theory that CsA can inhibit PTP formation has lead to key advances...

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NHÂN TỐ TÁC ĐỘNG ĐẾN THÁI ĐỘ CỦA NGƯỜI DÙNG THẺ ATM ĐỂ THANH TOÁN QUA MÁY POS.PDF

Ngày tải lên : 09/08/2015, 16:15

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báo cáo hóa học:" Spontaneous regression of curve in immature idiopathic scoliosis - does spinal column play a role to balance? An observation with literature review" pot

Ngày tải lên : 20/06/2014, 04:20

... data and analysis and interpretation of data; and KPV and NM have contributed in revising the manuscript critically All authors read and approved the final manuscript Competing interests The authors ... changed training conditions [24] During a muscle training program lasting several weeks, a distinct increase in activity occurs during the first weeks; the activity then drops to the initial value ... conception and design and acquisition of data, analysis and interpretation of data, drafting the manuscript and revising it critically, SWS has contributed in conception and design of data, drafting the...

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Nghiên cứu chất lượng dịch vụ thẻ ATM BIVD của khách hàng tại thành phố Buôn Ma Thuột, Đăk Lăk.

Ngày tải lên : 16/05/2015, 13:44

... Eximbank ch a a dạng so với ngân hàng mạnh ACB, Sacombank, bao gồm: huy động vốn, tín dụng, toán phát hành thẻ, toán quốc tế, kiều hối, kinh doanh vàng, đầu tư tài tiền tệ, kinh doanh đ a ốc ... kinh doanh Nguồn vốn huy động đủ giải ngân cho dự án đầu tư, th a mãn nhu cầu vốn đầu tư phát triển vốn kinh doanh khách hàng Tốc độ tăng trưởng thời gian qua cao, công tác huy động vốn, doanh ... Eximbank Buôn Ma Thuột Ngân Hàng TMCP XNK Việt Nam Eximbank – Chi nhánh Buôn Ma Thuột tổ chức kinh doanh tiền tệ, tín dụng dịch vụ ngân hàng thành phần kinh tế Nhiệm vụ trọng tâm Eximbank Buôn Ma...

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Nghiên cứu chất lượng dịch vụ thẻ ATM BIVD của khách hàng tại thành phố Buôn Ma Thuột, Đăk Lăk - (Phạm Duy Hòa)

Ngày tải lên : 19/07/2015, 22:24

... 3.7: H s KMO ki m ñ nh Bartlett’s c a bi n ño lư ng ch t lư ng d ch v th ATM BIDV KMO and Bartlett's Test Kaiser-Meyer-Olkin Measure of Sampling Adequacy .757 Approx Chi-Square 1260.904 df 136 Sig ... ATM h ng vàng (Gold-Card), th ATM h ng ñ c bi t (VIP-Card), th ATM ngũ hành (Harmony) 2.2.2 Các d ch v ti n ích c a th ATM BIDV - Rút ti n, v n tin s dư, ñ i Pin t i máy ATM - Chuy n kho n cho ... 2003) Parasuraman V .A Zeithaml L.L Berry ñ nh ngh a ch t lư ng d ch v kho ng cách mong ñ i v s n ph m d ch v c a khách hàng nh n th c, c m nh n c a h s d ng qua s n ph m d ch v ñó Paurasuraman (1991)...

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Reactive oxygen species mediated regulation of the na+ h+ exchanger, NHE 1 gene expression a new mechanism for tumor cells resistance to apoptotic cell death

Ngày tải lên : 16/09/2015, 08:31

... within the distal C-terminal cytoplasmic domain The major intracellular signal that leads to increase in NHE1 activity is an increase in H+ concentration (Lacroix J et al, 2003) In addition, there ... pivotal role in determining the shape and motility of a cell and also associate with the dynamic extensions like lamellipodia (Lagana A et al, 2000) NHE1 interacts directly to actin-binding proteins ... It acts as a structural anchor that is involved in organization of the cytoskeleton (Denker SP et al, 1998), thus playing an integral role in cell shape and movement Actin filaments play a pivotal...

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Running and adult neurogenesis does septohippocampal sonic hedgehog play a role

Ngày tải lên : 14/09/2015, 14:09

... pyramidal neurones then send axons to the ipsilateral CA1 pyramidal cells via the Schaffer Collateral pathway and contralateral CA3 and CA1 pyramidal cells via the Associational/Commissural fibres ... especially in animals where locomotion and learning are inseparable in real life Sustained physical activity and cognitive challenges will maintain a pool of neurones that will allow that brain to accommodate ... phosphorylated calcium/calmodulin protein kinase II (CAMKII) and phosphorylated mitogen-activated protein kinase II ( MAPKII) (Vaynman et al., 2003)and (iii) a rise in vesicular budding protein synapsin...

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Tài liệu Báo cáo khoa học: A genetic screen identifies mutations in the yeastWAR1 gene, linking transcription factor phosphorylation to weak-acid stress adaptation docx

Ngày tải lên : 19/02/2014, 00:20

... AGGTATGTTATTGCGTTATTTTG-3¢ 5¢-CAAAATAACGCAATAACATACCTCAT TTTGTAAAGAGAGTTGTTGAAG-3¢ 5¢-CCCTTCAACAACTCTCTTTACAAATTTTATGTTATTGCGTTATTTTGTC-3¢ 5¢-GACAAAATAACGCAATAACATAAAATTTGTAAAGAGAGTTGTTGAAGGG-3¢ This This ... K762Ns K762Nas F763Ms F763Mas R764Ds R764Das 5¢-CCCTTCAACAACTCTCTTTACAAC TTTAGGTATGTTATTGCG-3¢ 5¢-CGCAATAACATACCTAAAGTT GTAAAGAGAGTTGTTGAAGGG-3¢ 5¢-CTTCAACAACTCTCTTTACAAAATG AGGTATGTTATTGCGTTATTTTG-3¢ ... impaired dimer formation of War1p or a lack of DNA binding Indeed, in the case of War1-42p, in vivo footprinting data (Fig 5) indicate an inability to bind to the WARE, which is normally decorated...

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Báo cáo sinh học: " Functional relevance of nonsynonymous mutations in the HIV-1 tat gene within an epidemiologically-linked transmission cohort" pot

Ngày tải lên : 18/06/2014, 18:20

... tat protein J Virol 1989, 63(3):1181-1187 Kuppuswamy M, Subramanian T, Srinivasan A, Chinnadurai G: Multiple functional domains of Tat, the trans-activator of HIV-1, defined by mutational analysis ... were assessed using a luciferase reporter assay The luciferase reporter contains the HIV-1 LTR upstream of the luc gene meaning that specific binding of Tat to an RNA structure (the transactivation ... http://www.virologyj.com/content/4/1/107 transactivation ability [15-17], and R52 participates in the binding of Tat to TAR and is involved in the nuclear localisation of Tat [18,19] The strong or total suppression of transactivation...

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Báo cáo hóa học: " Functional relevance of nonsynonymous mutations in the HIV-1 tat gene within an epidemiologically-linked transmission cohort" pot

Ngày tải lên : 20/06/2014, 01:20

... tat protein J Virol 1989, 63(3):1181-1187 Kuppuswamy M, Subramanian T, Srinivasan A, Chinnadurai G: Multiple functional domains of Tat, the trans-activator of HIV-1, defined by mutational analysis ... were assessed using a luciferase reporter assay The luciferase reporter contains the HIV-1 LTR upstream of the luc gene meaning that specific binding of Tat to an RNA structure (the transactivation ... http://www.virologyj.com/content/4/1/107 transactivation ability [15-17], and R52 participates in the binding of Tat to TAR and is involved in the nuclear localisation of Tat [18,19] The strong or total suppression of transactivation...

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Báo cáo y học: "The VH gene repertoire of splenic B cells and somatic hypermutation in systemic lupus erythematosus" potx

Ngày tải lên : 09/08/2014, 01:21

... photosensitive skin rash, an autoimmune haemolytic anaemia, lymphopaenia, thrombocytopaenia, and homogeneous antinuclear antibodies characterized as anti-DNA antibodies At the time of splenectomy the patient ... Only AGC and AGT serine codons produced replacement mutations in the CDRs Of these, the mutation from serine to asparagine was the most prevalent, which is in accordance with mutational analysis ... complexes containing alkaline phosphatase/anti-alkaline phosphatase were detected by incubation with new fuschin substrate, and the sections were counter-stained with Mayer’s haematoxylin (Sigma) Microdissection...

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