disease modifying therapy and response to first line treatment in pediatric multiple sclerosis
Báo cáo khoa học: "Combination therapy with docetaxel and S-1 as a first-line treatment in patients with advanced or recurrent gastric cancer: a retrospective analysis" docx
Ngày tải lên :
09/08/2014, 03:21
... study Herein, we also found the tumor response to be a prognostic factor indicating increased OS, while other independent factors, such as performance status, disease status and histology metastatic ... organ function, and life expectancy of months or more Written informed consent was obtained from all patients prior to enrollment in the study according to institutional guidelines Treatment regimen ... study were to retrospectively clarify the efficacy and toxicities of the docetaxel and S-1 combination as a first- line treatment for patients with advanced or recurrent gastric cancer and to analyze...
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báo cáo hóa học:" A biregional survey and review of first-line treatment failure and second-line paediatric antiretroviral access and use in Asia and southern Africa" pot
Ngày tải lên :
20/06/2014, 08:20
... first- line regimens and as salvage therapy Finally, improving access to effective paediatric treatment also requires improved access to diagnostic tools, including PCR for early infant diagnosis and ... abacavir and didanosine to substituting with another thymidine analogue (i.e., zidovudine for stavudine) A third of the sites continued lamivudine in second -line regimens Malaysian and South ... Nationally recommended first- line ART regimens were consistent with WHO guidelines, and were most commonly combinations of stavudine or zidovudine with lamivudine and nevirapine or efavirenz The...
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báo cáo hóa học:" A biregional survey and review of first-line treatment failure and second-line pediatric antiretroviral access and use in Asia and southern Africa" pdf
Ngày tải lên :
20/06/2014, 08:20
... and : A biregional survey and review of first- line treatment failure and second -line pediatric antiretroviral access and use in Asia and southern Africa Journal of the International AIDS Society ... first- line treatment failure and second -line paediatric antiretroviral access and use in Asia and southern Africa J Int AIDS Soc 2011, 14(1):7 doi:10.1186/1758-2652-14-17 Cite this article as: and ... and Journal of the International AIDS Society 2011, 14:17 http://www.jiasociety.org/content/14/1/17 Page of Table First- and second -line antiretroviral therapy regimens in use in TREAT Asia and...
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Báo cáo y học: "Association between inflammatory mediators and response to inhaled nitric oxide in a model of endotoxin-induced lung injury" docx
Ngày tải lên :
13/08/2014, 11:23
... endotoxin infusion in pigs and tested the degree of response to INO hours and hours after onset of an endotoxin infusion [10]: a positive response, defined as a 20% PaO2 increase, was observed in ... vasodilator 6-keto-PGF1α (metabolite of prostacycline) The levels of the proinflammatory cytokine IL-8 followed the endotoxin evolution in blood Endothelin-1 and inhaled nitric oxide The ET-1 in plasma ... Inflammatory response to endotoxin There was no difference in the endotoxin concentration in plasma at hours between responders and nonresponders, but the rapid decrease in endotoxin concentration in...
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báo cáo hóa học:" Impact of HIV-1 viral subtype on disease progression and response to antiretroviral therapy" pot
Ngày tải lên :
20/06/2014, 08:20
... decline by introducing patient-specific elements (random effects) Multivariable regression analysis was used to examine for independent predictors of rate of CD4 decline using a backward elimination ... were to compare the rate of disease progression, based on rate of CD4 decline prior to ART, and the initial and subsequent virological response to ART in an ethnically diverse population in south ... rate of CD4 cell decline prior to starting antiretroviral therapy in patients infected with B and non-B subtypes (A, C, D and CRF02-AG) based on their pre -therapy longitudinal CD4 cell count...
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báo cáo khoa học: "Evaluation of HER2 and p53 expression in predicting response to docetaxel-based first-line chemotherapy in advanced breast cancer" docx
Ngày tải lên :
10/08/2014, 10:21
... dilution, then incubated in secondary biotinylated antibody and finally counterstained with Hematoxylin Immunohistochemical analyses of c-erbB-2 expression describe the intensity and staining pattern ... expression in relation to main tumor characteristics and treatment response Page of Table HER2 expression in relation to main tumor cheracteristics and treatment response p53 expression Total Low ... countries, including Italy [2] thus representing a major health problem To date, the role of chemotherapy in BC treatment is certain and taxanes are widely used in both early and advanced setting [3,4]...
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Báo cáo y học: "Serum levels of autoantibodies against C-reactive protein correlate with renal disease activity and response to therapy in lupus nephritis" pps
Ngày tải lên :
12/08/2014, 11:22
... Autoantibodies to Creactive protein (CRP) and other acute-phase proteins in systemic autoimmune diseases Clin Exp Immunol 1998, 113:327-332 Minatani M, Aotsuka S, Satoh T: Autoantibodies against ... responders to given therapy Baseline anti-C-reactive protein antibody levels in responders and nonresponders to given therapy At baseline, there was a highly significant difference in anti-C-reactive ... interval = 0.42 to 3.26) predicted response to therapy, whereas a positive anti-CRP test did (relative risk = 2.16, 95% confidence interval = 1.20 to 3.89) Response to therapy in relation to anti-CRP,...
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Tài liệu Preparedness and Response to a Mass Casualty Event Resulting from Terrorist Use of Explosives pdf
Ngày tải lên :
19/02/2014, 03:20
... efforts or gaps in decision-making and response Responding to terrorist bombings requires meta-leadership Meta-leaders are vital in preparing for and responding to bombings, and their roles extend ... simultaneous, and nonlinear in scale and scope Extensive discussion and planning support linear activation and should be reserved until after the response Time constraints The response to a TUE-MCE ... evolving Limited or ineffective situational awareness is the main factor preventing adequate response • Delayed Notification and Activation: Delays in delivering lifesaving interventions and definitive...
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Individual Preparedness and Response to Chemical, Radiological, Nuclear, and Biological Terrorist Attacks - A Quick Guide potx
Ngày tải lên :
15/03/2014, 15:20
... BUSINESS Inform individuals about official terrorism response plans Design education and training programs to explain and practice response actions Implement terrorist attack detection and warning ... certain human instincts It seems perfectly natural to stop to help others or to try to contact family and friends But, especially in the situations we are discussing here, taking the time to so could ... almost instantly and on their own to minimize exposure It is critical to know whether the attack has occurred outdoors or inside a building and to take action according to where you are in relation...
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Báo cáo hóa học: " First-line chemoimmunotherapy in metastatic breast carcinoma: combination of paclitaxel and IMP321 (LAG-3Ig) enhances immune responses and antitumor activity" pptx
Ngày tải lên :
18/06/2014, 16:20
... will be to test immunotherapy combined with chemotherapy in a first- line setting with patients with a good immune status, as here, but in randomized phase II and III clinical trials with standard ... test was used to compare the immunomonitoring and clinical values obtained at the different time points Only patients with all available time points were included in the immunomonitoring analysis ... of Helsinki, the Good Clinical Practice guidelines, and all applicable local laws and regulations The study protocol and amendments were approved by an institutional review board and an independent...
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Báo cáo khoa học: " The effects of ectomycorrhizal status on carbon dioxide assimilation capacity, water-use efficiency and response to transplanting in seedlings of Pseudotsuga menziesii (Mirb) Franco" docx
Ngày tải lên :
09/08/2014, 03:25
... in A vs C i graphs For both measurement periods and in all treatments the decline of A in response to transplanting was accompanied by increasing C and was primarily due to , i Root (fig 5) and ... the first d after transplanting In February, the recovery of g in treatments TtP and Tt took place only from d 11, and recovery of g was also observed in treatment LI alterations in the photosynthetic ... different treatments before transplanting, in the experiments TtP and LI exhibited A values significantly higher than = those in Tt both in November and in February A was higher in TtP than in LI in...
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Báo cáo y học: " Effects of disease modifying agents and dietary intervention on insulin resistance and dyslipidemia in inflammatory arthritis: a pilot study" pptx
Ngày tải lên :
09/08/2014, 06:22
... County Clare, Ireland); LDL-cholesterol (Randox Laboratories Ltd, Crumlin, UK); and plasma glucose and serum insulin (Abbott, Chicago, Illinois) Laboratory testing was done using autoanalyzers, enzymatic ... baseline CRP between dieters and nondieters did not contribute to our findings with regard to changes in total and LDL-cholesterol However, weight loss was associated with decreases in total and ... Results Changes in cardiovascular disease risk in all 22 patients The baseline clinical and biochemical features, and use of DMARDs and changes in cardiovascular risk factors in all 22 patients...
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Báo cáo y học: "Differential expression, function and response to inflammatory stimuli of 11β-hydroxysteroid dehydrogenase type 1 in human fibroblasts: a mechanism for tissue-specific regulation of inflammation" pps
Ngày tải lên :
09/08/2014, 08:22
... persistence and treatment of inflammation Conclusion Stromal cells play a pivotal role in normal, physiological inflammation and persistent inflammatory disease by expressing factors such as cytokines and ... control; IFN, interferon; IL, interleukin; TNF, tumour necrosis factor uate distinct immune responses in an autocrine fashion [37,38,40], but the manner in which they are likely to interact in specific ... difference in GR expression between tissues or in response to cytokine treatment Instead, striking variations in expression were observed for the enzyme 11β-HSD1, which exhibited cell-specific and cytokine-specific...
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Báo cáo y học: "Human meniscus cells express hypoxia inducible factor-1α and increased SOX9 in response to low oxygen tension in cell aggregate culture" ppsx
Ngày tải lên :
09/08/2014, 10:20
... from the outer region In order to determine whether these differences in expression in vivo were reflected in different responses inherent in the cells present in inner and outer meniscus, we ... particular interest, because the action of HIF-1α is modulated at the post-translational level Furthermore, HIF-1α has been shown to bind to CREB (cAMPresponse element-binding protein)-binding protein/p300, ... are involved in the adaptive response of cells and tissues to low oxygen tension were expressed differently in cells in the outer and inner regions of the human meniscus [44-48] We also wished to...
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Báo cáo y học: "Human rheumatoid arthritis tissue production of IL-17A drives matrix and cartilage degradation: synergy with tumour necrosis factor-α, Oncostatin M and response to biologic therapies" ppt
Ngày tải lên :
09/08/2014, 14:22
... to act synergistically with TNF-α and OSM in upregulating proinflammatory cytokine and chemokine expression and cartilage breakdown [18,42,43] In this study for the first time we have shown in ... study was to further examine the expression of IL-17A in actively inflamed joints and to elucidate the mechanism of IL-17A, alone and in combination with TNF-α and oncostatin M (OSM) in matrix ... expressed in the inflammatory joint and drives disease activity, implicating it as a key cytokine and potential therapeutic target We have shown that IL-17A not only drives the proinflammatory response...
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Báo cáo khoa học: " Endocrine and Ovarian Changes in Response to the Ram Effect in Medroxyprogesterone Acetate-primed Corriedale Ewes" ppsx
Ngày tải lên :
12/08/2014, 15:21
... 1999) In ewes, the ram effect has been extensively used to induce out-of-season estrus in order to obtain births during autumn (Martin et al 1986) Introducing rams to previously isolated ewes induces ... of interval to estrus onset, and ovulation and conception rates in cyclic ewes primed with intravaginal sponges containing 60 mg of MAP for 12 days While Control ewes remained near rams during ... Endocrinology 1981, 108, 772-777 Hunter GL, Belonje PC, Van Niekerk CH: Synchronized mating and lambing in spring-bred Merino sheep: the use of progestogen-impregnated intravaginal sponges and...
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Báo cáo y học: " Cough in adult cystic fibrosis: diagnosis and response to fundoplication" ppt
Ngày tải lên :
13/08/2014, 08:20
... Pre- and post-operative changes in spirometry and exacerbation rate as defined by an event Table 1: Medical treatment Class of drug Proton pump inhibitor BD + H2-receptor antagonists (Ranitidine) ... indigestion, stomach acid coming up A tickle in the throat, or a lump in the throat Cough with eating (during or straight after meals) Cough with certain foods Cough when getting out of bed in the morning ... origin.[8] The medical treatment of oesophageal reflux causing cough is challenging, particularly in the presence of nonacid reflux In contrast to the treatment of gastroesophageal reflux disease...
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Leaching of arsenic in response to organic matter contamination in groundwater treatment practice
Ngày tải lên :
05/09/2013, 09:38
... reduced in the bioleaching process, re-oxidized to insoluble ferric form due to the intrusion of supernatant aerobic water into the sand-filter bed and was trapped by the mechanical straining mechanism, ... mg/L of TOC is not appropriate for drinking water treatment Due to lack of other options/sources, groundwater with high organic contamination is even used in drinking water treatment in the rural ... organic matters In order to minimize the hazardous and toxic waste generation during the research activity in the laboratory, a small cross-sectional area (diameter, φ = 25mm) was taken into consideration...
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Báo cáo khoa học: Gene expression in response to endoplasmic reticulum stress in Arabidopsis thaliana ppt
Ngày tải lên :
07/03/2014, 21:20
... suspended in the binding buffer containing m urea and mm 2-mercaptoethanol (urea-binding buffer) by sonication, and dissolved by adjusting the pH to with m NaOH and then readjusting it to with m HCl ... related to protein folding and degradation, genes related to protein translation and apoptosis are also included in the list Results Fluid microarray analysis of gene expression on TM -treatment To ... dithiothreitol or l-azetidine-2-carboxylic acid (AZC) AZC is a proline analog that is incorporated in nascent polypeptides instead of proline and prevents the folding of the polypeptides [33] Induction...
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do you really need back surgery a surgeons guide to neck and back pain and how to choose your treatment jul 2004
Ngày tải lên :
11/06/2014, 10:33
... the gastrointestinal tract (the stomach and intestines) to produce a normal lining If the normal lining is not produced Table 2.1 Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) for Pain Chemical ... meant to be a surgeon from Tony Bell, David Uttley, and Richard Winn My subspecialty skills in spine and nerve surgery developed in fellowship training with Ulrich Batzdorf, David Kline, and Duncan ... visits to the doctor as your spine problem progresses The first half of the book covers every aspect of knowledge relevant to keeping your spine healthy and understanding its pains and sprains The...
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