discuss the role of a security manager in enhancing security in an organization
Tài liệu Báo cáo khoa học: Local stability identification and the role of a key aromatic amino acid residue in staphylococcal nuclease refolding pdf
... state may bemaintained mainly by key amino acids. In this study, two point-mutatedproteins each with a single base substitution [alanine for tryptophan(W14 0A) and alanine for lysine (K13 3A) ] and ... the mutants without tryptophan at 140(W14 0A and W140O) was much lower than both the wild-type protein and mutants E142O and K13 3A. Thermal analysis of protein unfolding The DSC curves of the wild-type ... investigated. Two point-mutated proteins, with a singlebase substitution of alanine for tryptophan (W14 0A) and alanine for lysine (K13 3A) , and two truncatedfragment proteins, with fragments...
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Tài liệu Báo cáo Y học: Exploring the role of a glycine cluster in cold adaptation of an alkaline phosphatase pdf
... Exploring the role of a glycine cluster in cold adaptation of an alkaline phosphataseKonstantinos Mavromatis1,*, Iason Tsigos2,*, Maria Tzanodaskalaki2, Michael Kokkinidis1,3and Vassilis ... the aromatic ring of Tyr269, and theseunfavorable interactions could lead to a decrease of localflexibility and an increased E a value. The validity of the above interpretation was furtherreinforced ... exhibits an E a almost the same as in the caseofthenativeenzyme(Table1).Thermal inactivation of mutant and wild-type enzymes In order to investigate the effects of mutations on the stability of psychrophilic...
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Báo cáo khoa học: Characterization of the role of a trimeric protein phosphatase complex in recovery from cisplatin-induced versus noncrosslinking DNA damage potx
... ataxia telangiectasia mutated (ATM) ⁄ataxia telangiectasia and RAD53 related (ATR)kinases at the site of DNA damage may decrease the kinase ⁄ phosphatase ratio and allow the phosphatase todephosphorylate ... lying in the more stable interaction of the Pph3 phosphatase withcH2AX as opposed to a transient interaction with Rad53p.AbbreviationsATM, ataxia telangiectasia mutated; ATR, ataxia telangiectasia ... the cisplatin response [9]. Cisplatin interferes with DNAfunction by causing intrastrand and interstrand cross-linking of nucleotide bases and, in replicating cells,DNA damage usually induces an intra-S-phase...
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Tài liệu Báo cáo Y học: Interallelic recombination is probably responsible for the occurrence of a new as1-casein variant found in the goat species potx
... amplicationbetweenC7UandC8L.Primersinitalicswereusedinthegenotyping of allele M.C1U5Â GAG AGG AAC TGA ACA GAA CAT TG 3ÂC1L 5Â CAA CTG CGT ATT AGT GAA GAA TG 3ÂC2U 5Â AAT CAA ATT TTA TTA TAA GAC C 3ÂC2L5Â AAT AGC TAA TTA GAG ACC AT 3ÂC3U 5Â GGT GTC AAA ... 5Â ATA CAC ACA AAC TCA CAA GG 3ÂMWU 5Â CAA CAT ATT TTA AAT AAA ATT GAC AAT 3ÂC9LM* 5Â ATA AAA ATG GTA TAC CTC ACT TGT*C 3ÂC9UM1 5Â TAA CAA TGA TTC TCT TTC TTT TAG 3ÂC9LM1 5Â AAT CTT TAT TTT ... TGG CAC AAC ATT GTA CAT TCT TGG G 3ÂC9U 5Â GTA TGG AAG TGT GGA ATA GTT T 3ÂC9L 5Â GGA CAC CAC AGA TAT CCA ATA G 3ÂC1011U 5Â CAT AAA ACT AAC AAT ACA TGT 3ÂC1011L 5Â TAG CAG ATA TTG AAA AGG AG...
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Báo cáo "The role of color luminescence centers Mn, Cu, Co in the semicondutors with wide band gap ZnS, ZnO and their applications " pptx
... intensity. As concentration of Mn increases, the intensity of the blue band decreases while the intensity of the yellow-orange band increases gradually and reaches to the maximum at xMn = ... a blue band at 476 nm, there is one more green band at around 533 nm characterized by Cu2+ ions (Fig. 3). Intensity of the green band is greater than that of the blue band. As increasing the ... of these two bands are equal to each other and they merge into one wide band ranging from 476 nm to 533 nm. The blue and green bands are characterized by radiation transition of electrons from...
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Báo cáo lâm nghiệp: "Rationalization of the performance of a mobile off-road system working in the forest environment with respect to its emission load" doc
... Dimensional changes in stages (material flows processed by the logging and transport systems), resulting from the changed performance of the system, do not always cause a change in power and material ... suitable machinery, and in using acceptable methods for the employment of machines with the rational performance. Pos-sibilities to determine the rational performance of machines are further ... suitable rational performance. e most important measures compensating the environment con-tamination by extraneous substances are preventive measures that can be applied on a larger part of the...
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Báo cáo khoa học: "The role of Bcl-xL and nuclear factor-kB in the effect of taxol on the viability of dendritic cells" ppsx
... Morisaki T, Matsumoto K, Tasaki A, Yamanaka N, Nakashima H, Kuroki H, Nakamura K, Nakamura M, Katano M. Paclitaxel probably enhances cytotoxicity of natural killer cells against breast carcinoma ... agent. J Natl Cancer Inst 1990, 82, 1247-1259.22. Wiseman LR, Spencer CM. Paclitaxel. An update of its use in the treatment of metastatic breast cancer and ovarian and other gynaecological ... D, Mackay JA, Evans WK. Lung Cancer Disease Site Group of Cancer Care Ontario’s Program in Evidence-based Care. Taxanes as first-line therapy for advanced non-small cell lung cancer: a systemic...
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Báo cáo y học: "The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis" ppt
... encompass an oxygen-dependentdegradation domain, responsible for hypoxic stabilization of α-subunits, and two transactivating domains, namely the amino-terminal transactivating domain and the carboxyl-terminal ... hypoxia may regulate many other features that areimportant in RA, such as cell trafficking and matrix degradation. An understanding of the biology of the HIF transcription family mayeventually ... mediateubiquitination of various target proteins, and the intracellulardomain of the Notch receptor (involved in the maintenance of cells in an undifferentiated state), both of which notablycontain ankyrin...
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Báo cáo y học: "The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis" pps
... that anabolic synthesis of aggrecan aggregatecomponents may be affected by neutralisation of thesecytokines.We also studied the expression of the aggrecanasesADAMTS4 and ADAMTS5 in five patients. ... matrix metalloproteinase (MMP), link protein, and ADAMTS analysis, derived as described in Materials and methods and in Figures 5 and 7Polymerase chain reaction data from matrix metalloproteinase (MMP), ... aggrecanase-1 (ADAMTS4) [24] andaggrecanase-2 (ADAMTS5) [25]. IL-1 and TNF-α can mediate the catabolism of aggrecan, but whereas ADAMTS5 is consti-tutively expressed, ADAMTS4 is induced after...
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