discovery and clinical evaluation of the nucleoside analog balapiravir r1626 for the treatment of hcv infection

Báo cáo hóa học: " Evaluation of the diagnostic indices and clinical utility of qualitative cardiodetect® test kit in diagnosis of ami within 12 hours of onset of chest pain in the emergency department" pptx

Ngày tải lên : 20/06/2014, 23:20

... College of Cardiology Committee (ESC/ACC) for the Redefinition of Myocardial Infarction published new criteria for the diagnosis of AMI They proposed the use of cardiac troponin (I or T) as the most ... improved the sensitivity, specificity, PPV, and NPV of the test, especially during the first h after the onset of chest pain The diagnostic accuracy of the repeat test was also superior to the Cardio ... Hisamuddin NAR and Suhailan M: Evaluation of the diagnostic indices and clinical utility of qualitative cardiodetect®® test kit in diagnosis of ami within 12 hours of onset of chest pain in the emergency...

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Báo cáo y học: "Clinical evaluation of the Life Support for Trauma and Transport (LSTAT™) platform Ken Johnson1, Frederick Pearce2, Dwayne" pps

Ngày tải lên : 12/08/2014, 19:21

... an appropriate treatment for anesthesiologists The size of the group of recovery room nurses was not large enough to merit statistical analysis and therefore only the results from the survey are ... of some of the military product developers was that the weight of the LSTAT pan and the configuration of the LSTAT as dictated by the size constraints to fit in military aircraft would make the ... respondents were the compactness of all the equipment in the LSTAT and the integration of a ventilator into the LSTAT to facilitate transport of ventilator-dependent patients environment Three of the nine...

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DELIVERING HEALTH EDUCATION VIA THE WEB: DESIGN AND FORMATIVE EVALUATION OF A DISCOURSE-BASED LEARNING ENVIRONMENT pot

Ngày tải lên : 28/03/2014, 21:20

... evidence of the efficacy of the communication capabilities of the Web in facilitating knowledge construction and attitude change in the area of health education The Faculty of Education at the University ... use The work of other researchers informed the design of the Web-based learning environment For example, Oliver, Omari and Herrington (1997) have explored the use of investigative activities and ... accuracy of information; interactivity; and, availability of Australian and international sources Annotations were provided for each link to inform the student about the topics and contents of the...

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Báo cáo hóa học: " Development and preliminary evaluation of the participation in life activities scale for children and adolescents with asthma: an instrument development study" pptx

Ngày tải lên : 18/06/2014, 22:20

... physicians' offices and schools Families interested in learning about the studies contacted the PI After being informed of the purpose and nature of the study, requirements and responsibilities of subjects, ... computing the mean scores for each of the three indicators Scoring Scoring of the Participation in Life Activities Scale is completed by computing the mean scores for each of the three indicators before ... support for the qualitatively-derived theoretical underpinnings of the instrument The PLA contributes to the advancement of science by offering a tool to measure what is hypothesized to be the primary...

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báo cáo hóa học:" A Process and Outcomes Evaluation of the International AIDS Conference: Who Attends? Who Benefits Most?" docx

Ngày tải lên : 20/06/2014, 08:20

... predictor for not recommending the IAC to a peer, and the qualitative comments referring to the lack of science, the low quality of the science presentations, and the need to balance psychosocial and ... rather than trying to compete with the IAS Conference on HIV Pathogenesis and Treatment and other science- and treatment- focused conferences, the IAC should focus on the dissemination of information ... dissatisfaction with the quality of the basic science component at the previous IACs, and/ or the decision to present basic science data at the IAS Conference on HIV Pathogenesis and Treatment and other sciencefocused...

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báo cáo hóa học:" The OnyCOE-t™ questionnaire: responsiveness and clinical meaningfulness of a patient-reported outcomes questionnaire for toenail onychomycosis" potx

Ngày tải lên : 20/06/2014, 15:20

... provided a clinical basis for estimating the MCID for each scale, as well as for generating an overall MCID for the PRO questionnaire In the estimation of the MCID, the choice of a clinical measure is ... performed the statistical analysis, and drafted the manuscript SDM assisted in the design of the validation study, participated in the design of the statistical analysis, and helped to draft the ... questionnaire at baseline and at the end of the study and who had measures of clinical efficacy (clinical assessment of target nail clearing and re-growth) Change scores were computed for each scale by...

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the situation of diabetes, pre-diabetes to the khmer in hau giang province and an evaluation of the efficacy of some interventional methods

Ngày tải lên : 25/07/2014, 11:36

... at the research area New points of science and reality value of the topic - It is a research which can determine the prevalence of diabetes of the Khmer - It can determine the prevalence of pre-diabetes ... 16,5 % The prevalence of diabetes of people who live in the countryside is 12,7 % The prevalence of diabetes of farmers is 13,1%, that of hired labor is 13,3% The prevalence of diabetes of literacy ... prevalence of Type diabetes for the next 10 years of the Khmer will be 13,39% 3.2 AN EVALUATION OF THE EFFICIENCY OF INTERVENTIONAL MODEL ON THE PREVETION OF PREDIABETES, DIABETES TO THE KHMER Intervention...

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Báo cáo y học: "Developments in the scientific and clinical understanding of the spondyloarthritides" pptx

Ngày tải lên : 09/08/2014, 01:22

... the performance of treatment trials and the establishment of effective therapies for these patients Finally, only a better understanding of the pathogenesis will give the possibility of finding ... In the center of the discussion about the pathogenesis of the SpA is still the interaction between bacteria and HLA-B27 because of the known triggering bacteria in reactive arthritis [53] and the ... that the demonstration of the good or very good efficacy of TNF blockers in the treatment of patients with active AS can be regarded as a breakthrough in the therapy of these AS patients These...

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Báo cáo y học: "Developments in the scientific and clinical understanding of autoinflammatory disorders" doc

Ngày tải lên : 09/08/2014, 01:22

... than accumulation of the enzyme’s substrate [38,39] The relationship of the isoprenoid pathway to inflammation is of all the more interest given the anti-inflammatory properties of statin drugs ... role of IL-1 in the pathogenesis of this acquired disorder has lately been suggested by remarkable therapeutic efficacy of anakinra in a number of patients [64] Gout and pseudogout A place for these ... Page of 10 (page number not for citation purposes) The Scientific Basis of Rheumatology: A Decade of Progress This article is part of a special collection of reviews, The Scientific Basis of Rheumatology:...

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Báo cáo y học: "The role and clinical implications of G6PI in experimental models of rheumatoid arthritis" pptx

Ngày tải lên : 09/08/2014, 06:22

... narrows the gap between the TCR transgenic K/B×N model and the situation in patients Some of the major clinical and immunological similarities and differences between CIA, the K/B×N model and G6PI-induced ... Both the KRN TCR and one copy of the NOD I-Aβg7 MHC molecule are necessary for development of arthritis in K/B×N mice Neither KRN TCR transgenic C57BL/6 mice nor the F1 from crosses of the transgene-expressing ... pathogenesis, the question remains of whether the immunological events that lead to the development of arthritis in the K/B×N model are involved in human RA Both experimental and clinical data...

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Báo cáo y học: "Developments in the scientific and clinical understanding of inflammatory myopathies" pps

Ngày tải lên : 09/08/2014, 13:21

... (even before the development of myositis), capillaries often having the appearance of high endothelial venules (HEVs) and an expression of adhesion molecules, interleukin-1-alpha (IL-1α) and/ or ... training as a component of modern treatment of polymyositis and dermatomyositis Another finding characteristic for these diseases is the presence of specific autoantibodies and T cells in muscle ... that of differentiated muscle fibres Taken together, the data on the function of T cells in myositis are insufficient and this needs further investigations Dendritic cell expression and the type...

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Báo cáo y học: "Developments in the scientific and clinical understanding of gout" docx

Ngày tải lên : 09/08/2014, 13:22

... on the luminal side of the proximal renal tubule URAT-1 is part of the family of organic anion transporters and is the major mechanism for reabsorbtion of urate in the human kidney Mutations of ... acid is the end result of the purine metabolic pathway and the product of the conversion of xanthine, by the action of xanthine oxidase, to uric acid As uric acid is a weak acid, its main form in ... therapy to prevent gout flares at the initiation of any hypouricemic therapy As of this writing, febuxostat has been approved for prescription in the European Union in the treatment of gout and...

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Báo cáo y học: "The biological and clinical importance of the ‘new generation’ cytokines in rheumatic diseases" pot

Ngày tải lên : 09/08/2014, 14:20

... define the biologic role and therefore therapeutic utility of this cytokine in pathology A further intriguing approach is to modulate the synthesis and release of IL-18 Whereas the inhibition of ... increased in the paws of mice with CIA during the inflammatory early phase of the disease Administration of neutralising anti-ST2 antibodies reduced the severity of CIA and the production of interferon-gamma ... analysis of the cell infiltrate and the expression of mediators of synovial inflammation and joint destruction in the synovium of patients with psoriatic arthritis: implications for treatment...

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Báo cáo y học: "Developments in the scientific and clinical understanding of fibromyalgia" pdf

Ngày tải lên : 09/08/2014, 14:21

... the heterogeneity of the diagnosis of FM and have implications for treatment of subgroups of patients [15] Page of (page number not for citation purposes) A study by Giesecke and colleagues using ... fulfilled the 1990 ACR classification criteria for the diagnosis of FM [28] The authors have further reported that the prevalence of FM among blood relatives of patients with FM was 26%, and that the ... in reducing the scores for pain, the short-form McGill Pain Questionnaire, the sleep index, fatigue, patient and clinician global impression of change, and four of the eight short-form SF-36 domains...

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báo cáo khoa học: "Profiling and quantitative evaluation of three Nickel-Coated magnetic matrices for purification of recombinant proteins: helpful hints for the optimized nanomagnetisable matrix preparation" pps

Ngày tải lên : 11/08/2014, 00:23

... affinity of interaction between matrix and the protein of interest which in turn is determined by the number of coordination bands available in the matrix According to the information provided by the ... of the type of protein Another important factor which should be taken in mind for all protein purification systems is the strength needed for elution of the proteins from matrix The harsher the ... yield and protein recovery of three Nickel-magnetic matrices for His-ProT and His-Mre11 recombinant proteins Purification yield was defined as the sum of the percents of the specific band densities...

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báo cáo khoa học: " Defining the effect and mediators of two knowledge translation strategies designed to alter knowledge, intent and clinical utilization of rehabilitation outcome measures: a study protocol [NCT00298727]" docx

Ngày tải lên : 11/08/2014, 05:22

... evaluation of the long-term benefits of continuing education within a Northern Outreach Program for PT and OT They proposed a 4-stage model of evaluation Stage involves participant evaluation of the ... insure they have a comprehensive understanding of the interpretation of responses during the chart-stimulated recall Their orientation will consist of training on the theory and methods of chart-stimulated ... discussion, the use of problems to match new knowledge to the clinical context, and the activation of prior knowledge have been recognized as active components of PBL [56] Therefore PBL helps in the...

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Báo cáo y học: " Resource utilization in patients with schizophrenia who initiated risperidone longacting therapy: results from the Schizophrenia Outcomes Utilization Relapse and Clinical Evaluation (SOURCE)" pdf

Ngày tải lên : 11/08/2014, 16:20

... the 12 weeks before study entry to 30% during the first 12 weeks of treatment The need for outpatient consultations remained stable during the remainder of the treatment period No change in the ... CC, CMK, RD, and LM contributed to the conception and design, acquisition of data, analysis and interpretation of data, and drafting of the manuscript and its critical revision for important ... density was defined as the total number of events for the study population divided by the total length of time the population was at risk for these events in follow-up years The bootstrap resampling...

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Báo cáo y học: "Clinical and serological evaluation of a novel CENP-A peptide based ELISA" pdf

Ngày tải lên : 12/08/2014, 14:21

... obtained from the respective Institutional Review Board The study was carried out according to the Directive 98/79/ EC of the European Parliament and of the Council and the German law for medical ... Peptides and protein antigens The N-terminal sequence of human CENP-A was used as the template for the commercial synthesis of synthetic peptides (Peptides & Elephants, Berlin, Germany) The quality and ... cut-off of 1.5 RU, the sensitivity and specificity was 36.6%/97.0% for CENP-A and 37.4%/94.8% for CENP-B (Table 2) The highest positive likelihood ratio was 49.1 at a cut-off of 1.75 RU for CENP-A...

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Báo cáo y học: "Natural history and clinical significance of MRI-detected bone marrow lesions at the knee: a prospective study in community dwelling older adults" pot

Ngày tải lên : 12/08/2014, 15:22

... consisted of 5, 17, and questions each; therefore, the range for each of these is from to 45, to 153, and to 18, respectively Page of 12 In further analysis, knee pain was assessed using the five ... error and the correlation between the BML measurements at baseline and follow-up The formula was as follows: LSC = 1.96 ×  2(1 −  ) where s is the standard error of the mean and r is the serial ... scored the BMLs by measuring the maximum area of the lesion at baseline and at the first follow-up The observer manually selected the MRI slice with the greatest BML size The BML with the highest...

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Báo cáo khoa học: "Clinical review: The implications of experimental and clinical studies of recruitment maneuvers in acute lung injury" pptx

Ngày tải lên : 12/08/2014, 19:22

... areas in these patients Rothen and coworkers [22] found that a pressure of 40 cmH2O maintained for 7–8 s entirely re-expanded the collapsed lung tissue in anesthetized humans, although the net ... found when the strategies are combined The presence of lung infection must be considered a major limitation for aggressive RMs because translocation of bacteria and the occurrence of systemic ... Finally, large randomized studies not support the use of RMs in patients with ARDS In conclusion, the use of RMs cannot be recommended in the light of current knowledge, and if RMs are used they should...

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