dietary flavonoids as modulators of no bioavailability in acute and chronic cardiovascular diseases
Báo cáo y học: " Pharmacological characterisation of antiinflammatory compounds in acute and chronic mouse models of cigarette smoke-induced inflammation" ppt
... in rodents has both an acute phase consisting of neutrophil infiltrate peaking after one week of exposures and a chronic phase consisting of neutrophils, macrophages and lymphocytes that begins ... phosphodiesterase (PDE) inhibitor (roflumilast) and a statin (fluvastatin) As one of the primary functions of preclinical disease models is to assess the potential efficacy of candidate compounds, ... driving the acute and chronic phases of the inflammatory response Roflumilast has demonstrated very limited efficacy in the clinic as well, which has largely been attributed to doselimitation associated...
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British journal of dermatology oxygen in acute and chronic wound healing
... evaluation of wound tissue oxygenation Direct and indirect as well as invasive and noninvasive methods must be distinguished, whereas the noninvasive methods are preferable in routine clinical settings ... authors investigated wound fluids from acute and chronic wounds and showed an increased level of proinflammatory cytokines and proteases as well as a decreased level of growth factors in chronic ... demonstrated in an in vitro study that hypoxic keratinocytes showed a decreased secretion of laminin-5, a laminin isoform known to inhibit keratinocyte motility, but an increased expression and redistribution...
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Agricultural Marketing Companies as Sources of Smallholder Credit in Eastern and Southern africa docx
... linkage B Purpose of Review To increase the understanding of IFAD and its partners on the role, activities and relevance of non-financial institutions in the provision of agricultural credit in ... cost and informational constraints and the assumed limited prospects of profit making, both formal and semi-formal financial institutions have a very limited involvement in the financing of smallholder ... produce In most of the reviewed cases, this has meant a clear increase in the cash earnings of the participating households As shown in various studies, crops such as tea, various types of vegetables...
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Báo cáo y học: "Role of interleukin-7 in degenerative and inflammatory joint diseases" potx
... is a target of interest for the treatment of rheumatic diseases such as rheumatoid arthritis, osteoporosis and OA Competing interests The authors declare that they have no competing interests References ... this IL7-driven osteoclast formation [7] Interestingly, in the study of Long and colleagues, TNFα was not tested as an inducer of chondrocyte produced IL-7, nor did IL-7 stimulation lead to TNFα ... production of soluble osteoclastogenic cytokines Blood 2000, 96:1873-1878 Miyaura C, Onoe Y, Inada M, Maki K, Ikuta K, Ito M, Suda T: Increased B-lymphopoiesis by interleukin induces bone loss in mice...
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Báo cáo y học: "The role of toll-like receptors in acute and chronic lung inflammation" pdf
... important roles in the induction of lung inflammation For example, the cytoplasmic NALP3 protein, a member of the NLR family that triggers assembly of the caspase-1 inflammasome and production of mature ... immunity in acute and chronic lung inflammation A variety of host and environmental factors contribute to the development of acute and chronic lung inflammation Recognition of pathogen associated ... [90,91] Modeling of H5N1 infection in mice reproduced the pattern of damage seen in humans including increased neutrophilia, alveolar and interstitial edema, Lafferty et al Journal of Inflammation...
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Influence of CD137L reverse signaling on myelopoiesis in acute and chronic inflammation
... reverse signaling represents a novel and potent growth and differentiating factor for murine myeloid cells during acute and chronic inflammation In acute peritonitis and chronic aging model CD137L ... cells are increased in bone marrow of aged mice 105 3.3.3 Increased numbers of myeloid progenitor cells in the absence 112 of CD137 3.3.4 Increasing colony forming units of myeloid lineage of 12-months ... myelopoiesis during peritonitis 99 3.3 CD137L reverse signaling maintains myelopoiesis during aging 105 3.3.1 Numbers of myeloid cells are increased in WT during aging， 105 but not in CD137-/- and CD137L-/-...
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Role of h2s in acute and chronic inflammation
... Resulting blots were scanned and quantified using ImageJ software 2.1.5 Measurement of plasma cytokine and chemokine levels A range of cytokines and chemokines were assayed in mouse plasma using ... ischemia-reperfusion injury of small intestine and colitis [39; 40] The anti-inflammatory properties of H2S may be partly due to inhibition of phosphodiesterase activity resulting in an increased cyclic adenosine ... inflammation, another factor which may play a part in determining the involvement of this gas in inflammation, is the duration and perhaps also the intensity of the inflammatory insult [6] In addition...
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Báo cáo y học: " Inhibitors of inflammation and endogenous surfactant pool size as modulators of lung injury with initiation of ventilation in preterm sheep" ppt
... efficiency index decreased and oxygenation index increased in lambs with Sat PC < μmol/kg, indicating decreased gas exchange over time Oxygenation index at h was measured on an FiO2 of 1.0 Compliance ... suggesting differing roles of NF-B in stretch injury verses oxidative injury [31] In these three animal models of acute respiratory failure and in these preterm lambs, blockade of NF-B was unable ... cytokines based on Sat PC levels in BALF of individual lambs show decreased injury in lambs with Sat PC level > μmol/kg Cytokine mRNA levels were determined by RNase protection assays with L32 as...
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Báo cáo y học: " Low NO bioavailability in CCl4 cirrhotic rat livers might result from low NO synthesis combined with decreased superoxide dismutase activity allowing superoxide-mediated NO breakdown: A comparison of two portal hypertensive rat models wit
... epinephrine and others act as vasoconstricting agents [1–6] NO is produced by different nitric oxide synthase (NOS) isoforms: neuronal NOS (nNOS), inducible NOS (iNOS) and endothelial NOS (eNOS) [1] ... Furthermore, the reason of decreased hepatic NO bioavailability in case of cirrhosis is not yet elucidated One of the inhibitors of eNOS catalytic activity is caveolin-1 [14], whereas endothelin-1 counteracts ... nNOS protein was http://www.comparative-hepatology.com/content/2/1/2 not detected in any liver homogenate (Fig 2C) In Western blots of iNOS and nNOS but not in those of eNOS, some atypical bands...
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The Potential of Biofumigants as Alternatives to Methyl Bromide for the Control of Pest Infestation in Grain and Dry Food Products
... protection has increased and stands as the main alternative to methyl bromide Lately, insect resistance to phosphine has become an important issue for effective grain treatment (Nakakita and Winks, ... availability of plant essential oils and their terpenoids, and their use in cosmetics and as flavoring agents in food and beverages, is a good indication of their relative safety to warm-blooded animals and ... followed by CS2 and C7 H6 O CS2 , according to Winburn (1952), was one of the most effective grain fumigants as viewed from efficiency and low cost points of view C7 H6 O occurs in kernels of bitter...
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Tài liệu Báo cáo khoa học: Diversity and junction residues as hotspots of binding energy in an antibody neutralizing the dengue virus doc
... constants kon and koff were measured at 25 °C with the Biacore instrument, with MalE–E3-H6 in the immobile phase and Fab4E11H6 in the mobile phase The mean and associated SE values of koff in measurements ... the numbering of the aminoacid sequences of immunoglobulins and the definition of their CDR loops, as described from 1997 [13] The numbering and definition of the L-CDR3 and H-CDR3 loops of mAb4E11 ... residues were introduced during the formation of the VH-D and D-JH junctions, likely by the terminal deoxynucleotidyl transferase, and they translate into the amino-acid residues H-Gly95 and H-Gly98,...
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Báo cáo khoa học: Small-molecule modulators of zymogen activation in the fibrinolytic and coagulation systems pptx
... 1), a family of thiopeptide metabolites from Streptomyces sp., as modulators of plasminogen binding Thioplabin B enhances the binding of both Glu-plasminogen and Lys-plasminogen to fibrin It also ... preferred ligand for the lysine-binding site in K1, K2 and K4 Thus, aminohexyl or lysine analogs can interfere with PAN–K5 binding and relax Glu-plasminogen conformation, rendering Glu-plasminogen susceptible ... circulating form of plasminogen (Glu-plasminogen) is a single-chain zymogen consisting of 791 amino acids, which form the following domain structures: a plasminogen ⁄ apple ⁄ nematode (PAN) domain,...
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ag doped wo3-based powder sensor for the detection of no gas in air
... increased In general, resistance of WO3-based sensors reported in the literature increases upon exposure to NO in air using dc measurement It is ascribed to the NO or NO2 (product of NO oxidation ... four-fold sensitivity increase (from S to 16 for 40 ppm NO) It is noted that these metal promoters including Ag are also well known to be capable of catalyzing NO to NO2 and NO2 is known to display ... responses of the sensor materials were measured in a ¯owing stream of pure air or in 40 ppm NO in air (60:40 mixture from an air cylinder with another cylinder (BOC special gases) containing ca...
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Soil microbial indices as bioindicators of environmental changes in a poplar plantation pot
... it was executed once per week during the growing season and lasted for 16 weeks Fertilizer was supplied weekly in constant dose to a final total amount of 212 kg N In the 2003 growing season ... addition of easily available organic substrates or of inorganic nitrogen fertilizers to the soil This phenomenon, the so-called priming effect, is due to an increase of microbial activity resulting in ... the interaction between the two factors was determined in not fertilized plots (years 2000–2003, n = 36) The significance of fertilization and its interaction with FACE and time was determined in...
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Benthic algae as bioindicators of agricultural pollution in the streams and rivers of southern Que´bec docx
... in the structure and functioning of stream ecosystems Modern intensive agriculture is responsible for chemical and physical alterations such as increased contaminant and nutrient runoff, an increase ... sites, but no significant grouping was observed related to the intensity and type of agriculture, indicating the greater importance of local farming practices The use of periphyton as a bioindicator ... ecosystem integrity has increased the interest in finding biolog- ical indicators that provide a more accurate guide to changes in ecological conditions From the earliest years of the last century,...
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Báo cáo khoa học: "Ovular secretions as part of pollination mechanisms in conifer" doc
... glutamate, alanine and serine [55] The amino acids found in Thuja were: serine, glycine, alanine and glutamate in descending order of concentration [10] The amino acids present in Taxus were glutamate, ... coated with concanavalin A binding sites These binding sites as well as the presence of lectins on the stigma could be involved in the inhibition of incompatible pollen germination Cell surface ... liquid rich in sugars and amino acids, in which every fungus and bacterium ought to thrive Sarvas [54] noted that the mechanical function of the pollination drop of Pinus was so undiscriminating that...
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Báo cáo y học: "Statins as modulators of bone formation" pot
... respectively, alkaline phosphatase expression and mineralisation or expression of BMP-2 and osteocalcin However, pravastatin, in contrast to simvastatin, did not induce BMP-2 expression of human osteosarcoma ... conceivably increase bone formation Statins produce increased proliferation and differentiation of progenitors of endothelial cells [18] In addition, atorvastatin increased the numbers of circulating ... explain the lack of effect seen in the analysis of the LIPID study, in which all the patients were taking pravastatin All the other epidemiological studies included a minority of patients taking...
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Báo cáo y học: "Anti-Sa antibodies and antibodies against cyclic citrullinated peptide are not equivalent as predictors of severe outcomes in patients with recent-onset polyarthritis" pdf
... alternative definitions of persistent arthritis, such as nonremission defined by DAS28 (namely presenting a DAS28-3 score of at least 2.6) Non-remission defined by DAS28-3 was present in 45% of our aggressively ... enzyme-linked immunosorbent assay (ELISA), designed with in vitro citrullinated bovine myelin basic protein (MBP) MBP and vimentin have similarly high proportions of arginine Most positive results in ... developed standardized and less expensive assays We screened several cell lines and identified the ECV 304 endothelial cell line as rich in both vimentin and peptidylarginine deiminases (PADIs)...
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Báo cáo y học: "Open Access Substance abuse and psychiatric co-morbidity as predictors of premature mortality in Swedish drug abusers a prospective longitudinal study 1970 - 2006" docx
... 021), as Information of date and place of death was available for 204 dead persons in the cohort Information of the causes of death was missing in two cases The coding of the 204 deceased individuals ... the case-finding study [23], the age in 1978:was 26 vs 27 years and the dominant pattern of substance abuse: opiates 37% vs 28%, and amphetamine 31% vs 32% The incidence of injection use was 79% ... diagnoses were collected in a standardized manner Standardized clinical interviews (SWEDATE) and hospital records contained background data and mandatory information on length and intensity of...
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Báo cáo y học: " Comparison of ankle-brachial pressure index and pulse wave velocity as markers of cognitive function in a community-dwelling population" potx
... compared as markers of cognitive impairment in a community-dwelling population, and MMSE was used to assess cognitive status The ABI and PWV were measured as indicators of arterial structure and function ... Yamashina A: Comparison of ankle-brachial pressure index and pulse wave velocity as markers of the presence of coronary artery disease in subjects with a high risk of atherosclerotic cardiovascular ... finding was consistent with that of previous reports In Baltimore longitudinal Study of aging [17], persons with higher baseline PWV also exhibited prospective decline on tests of verbal learning and...
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