development of lymphatic vessels
Tài liệu Translational Vascular Medicine docx
... inhibition (for example, because of loss of additional non-catalytic effects of the enzyme protein) It is worth noting, however, that supplementation of a certain brand of Canadian beer with cobalt ... therapeutic potential of HO-1 either through modulation of its expression or delivery of its products [50] However, such an approach is not straightforward in light of the potential toxicity of CO, free ... Transmission electron micrograph of a capillary A ring of endothelial cells (EC) forms the lumen of the capillary which contains several erythrocytes On the abluminal surface of the capillary, a pericyte...
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Tài liệu Báo cáo khoa học: Altered expression of CD1d molecules and lipid accumulation in the human hepatoma cell line HepG2 after iron loading pptx
... of collagen [36,37], the in vitro data presented here may be relevant for understand some of the complex mechanisms responsible for the development of fibrosis and cirrhosis in vivo A number of ... that iron deposition was detectable after week of culture ( 20% of cells positive for iron) and reached a plateau after weeks of culture ( 60% of cells positive, Fig 2A) In all subsequent experiments, ... cytometry revealed that the inhibition of cell growth was due to a decrease in the percentage of cells in the S and G2 ⁄ M phases of the cell cycle (Fig 3B) In a total of seven separate determinations,...
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Báo cáo khoa học: Tyrosine nitration in the human leucocyte antigen-Gbinding domain of the Ig-like transcript 2 protein ppt
... related to the presence of exposed Tyr residues [19–21] To our knowledge, this is the first report of a post-translational modification of the ILT2 protein The other member of the ILT family, LILRA4, ... control cells (assigned a value of 1) and are expressed as the mean ± SD of three different experiments Lower right: western blot analysis of ILT2 expression Bands of ILT2, immunodetected with HP-F1 ... b-mercaptoethanol Fig (A) Effect of DETA-NO on HLA-G-mediated inhibition of NKL cytotoxicity The data show the percentage (± SD) of specific lysis achieved by NKL cells during h of co-culture, with K562-pcDNA...
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Báo cáo khoa học: Roles of 1-Cys peroxiredoxin in haem detoxification in the human malaria parasite Plasmodium falciparum potx
... formation of the membraneassociated FP Further studies of such functions of Prx will clarify the mechanism underlying detoxification of FP by P falciparum and may facilitate development of alternative ... 7.4 most of the added FEBS Journal 272 (2005) 1784–1791 ª 2005 FEBS 1785 Roles of Prx in heme degradation of P falciparum S.-i Kawazu et al A Fig GPx activity of Pf1-Cys-Prx GPx activity of rPf1-Cys-Prx ... rate of FP degradation was [FP]-dependent with an apparent Km of 71 lm and a Vmax of 2.4 nmolÆmin)1 (Fig 1D) The rate in the presence of rPf1-Cys-Prx was also [FP]dependent with an apparent Km of...
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Báo cáo khoa học: "AMBIGUITY RESOLUTION IN THE HUMAN SYNTACTIC PARSER: AN EXPERIMENTAL STUDY" ppt
... (serious) modification of Parsifal such that when the pattern of more than one production rule is matched, a l l of those rules could be activated the most natural form of a parser which u t i ... further type of model is characterized by Immediate Parallel Analysis (IPA), in which a l l of the possib~ analyses of an ambiguity are b u i l t as soon as the ambiguous portion of the string ... embedded among a large number of f i l l e r items whose presentation stopped at a wide variety of points Many of these f i l l e r s also contained ungrammaticalities, of various sorts and in various...
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Báo cáo khoa học: Enzymes of mannitol metabolism in the human pathogenic fungusAspergillus fumigatus– kinetic properties of mannitol-1-phosphate 5-dehydrogenase and mannitol 2-dehydrogenase, and their physiological implications pot
... intracellular concentration of Fru is about two orders of magnitude below the apparent Km of 40 mm A physiological role of AfM2DH in the utilization of intracellular Man-ol via reversal of path in Scheme ... comparison of polyol substrates of AfM2DH Fig S2 Comparison of the structural model of AfM2DH with the experimentally determined crystal structure of PsM2DH (1lj8) Fig S3 Kinetic analysis of inhibition ... Af M2DH Interpretation of the kinetic properties of an enzyme in the context of its role in cellular metabolism relies on knowledge of the physiological concentrations of substrates, products,...
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Báo cáo khoa học: A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP docx
... antibodies The integrity of the substrate-binding domain of CtBP2 is required for recognition of the GLDLSKK motif Crystal structure analyses of the substrate-binding domain of CtBP1 have highlighted ... with 250 ng of the pG5-luc reporter (schematically drawn), 50 ng of the pSG5-lacZ construct as a control of transfection efficiency, 50 ng of the indicated Gal4 construct and 150 ng of the VP16 ... potential of full-length HIC1 U2OS cells were transfected with 225 ng of the indicated expression vector, 225 ng of the reporter 5xHiRE-luc plasmid and 50 ng of the pSG5-lacZ construct as control of...
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Báo cáo khoa học: Human-blind probes and primers for dengue virus identification Exhaustive analysis of subsequences present in the human and 83 dengue genome sequences doc
... (22-mers) of the viral genome is comprised of n-mers that are not present in any of the other dengue genomes For example, in the genome of the DENV-4 China Guangzhou B5 strain (AF289029), 75.4% of the ... expression patterns for two pairs of genomes for the set of 216 probes The distribution of the number of probes present on the 216-probe set microarray for each of 83 genomes ranges from 61 to ... dramatically reduces the number of available sequences (Table 1) Such sequences are ideal primers ⁄ probes for identification of dengue because of their decreased probability of a false positive, yet...
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Báo cáo khoa học: Etoposide upregulates Bax-enhancing tumour necrosis factor-related apoptosis inducing ligand-mediated apoptosis in the human hepatocellular carcinoma cell line QGY-7703 pdf
... significantly decreased in the presence of zVADFMK However, the decrease of Bax in the presence of zVAD-FMK was not as marked as that of cytochrome c Fig The enhanced cleavage of caspases by combined treatment ... effect involves the upregulation of Bax and tBid, but not of DR4 or DR5 The interaction between Bax and tBid results in the amplification of mitochondrial release of cytochrome c and Smac/DIABLO, ... concentration of · 106 cellsÆmL)1 One-hundred microlitres of this resuspended solution (1 · 105 cells) was transferred to a 5-mL culture tube After incubation with lL of Annexin V–FITC and 10 lL of phosphatidylinositol...
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Báo cáo khoa học: Probing the access of protons to the K pathway in the Paracoccus denitrificans cytochrome c oxidase pdf
... activity of E78IIQ matched that of wild-type, while the activity of the E78IIA mutant was lowered to about 50% (Table 1) Given the lower activity of the E78IIA mutant, the kinetics of reduction of ... absence of NO acting as a trapping ligand for reduced heme a3 [27] Proton-pumping activity Fig Kinetics of heme a3 reduction of wild-type and mutant P denitrificans oxidase Degassed samples of the ... the absorbance change of the pH-sensitive dye phenol red [29] Experiments in the absence and presence of the uncoupler CCCP gave a H+ ⁄ e– ratio of 0.9 very similar to that of the wild-type enzyme...
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Báo cáo sinh học: " PET kinetics of radiolabeled antidepressant, [N-methyl-11C]mirtazapine, in the human brain" ppt
... of the slope of the linear part of the Logan plot, curvature of the plot throughout the duration of scanning impairs the estimation of the binding potential (see Figure 3) Since the binding of ... estimates of the distribution volumes (VT = (K1/k2) (1 + k3/k4)) and binding potentials (BPND = k3/k4) Method C provides estimates of VT as the slope of a linear regression to the late linear part of ... to variable estimates of VT and BPND that differed markedly from the values obtained with other methods This lack of robustness of method B limits its use for modeling of the [N-methyl-11C]mirtazapine...
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báo cáo hóa học:" Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone" pptx
... expression profiles of VEGF and the VEGF receptors in GCT specimens TRAP Page of staining demonstrated the presence of bone-resorbing OCs (data not shown) To determine the immunolocalization of VEGF ... article as: Matsumoto et al.: Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone Journal of Orthopaedic Surgery and Research ... possible role of the VEGF-Flt-1-FAK pathway in the pathogenesis of bone destruction in GCTs Methods Patients and tissue specimens The Institutional Review Board of Kyushu University School of Medicine,...
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báo cáo hóa học:" Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone" potx
... expression profiles of VEGF and the VEGF receptors in GCT specimens TRAP Page of staining demonstrated the presence of bone-resorbing OCs (data not shown) To determine the immunolocalization of VEGF ... article as: Matsumoto et al.: Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone Journal of Orthopaedic Surgery and Research ... possible role of the VEGF-Flt-1-FAK pathway in the pathogenesis of bone destruction in GCTs Methods Patients and tissue specimens The Institutional Review Board of Kyushu University School of Medicine,...
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Báo cáo hóa học: " Research Article Robust Object Categorization and Segmentation Motivated by Visual Contexts in the Human Visual System" docx
... analysis Top-down synthesis Figure 8: The overall flow of object categorization of human visual system Region of interest For 2D object: region of interest (object center, scale) Figure/ground mask ... Prob of feature position 1 0.8 0.4 0.2 (a) 0.5 0.3 0.4 0.2 Prob of feature position 0.3 0.2 0.1 0.2 0.4 p(σ | F) 0.6 0.4 0.8 0.6 Prob of scale 0.1 (b) Figure 17: Probability distribution of a ... codebook that suffers less from the curse of dimensionality [22] Zhang et al proposed a learning method of multiple nonredundant codebooks for the categorization of complex objects that produced upgraded...
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Báo cáo y học: "Eotaxin and FGF enhance signaling through an Extracellular signal-related kinase (ERK)-dependent pathway in the pathogenesis of Eosinophilic Esophagitis" doc
... expression of ERK in the PBMC of EoE subjects, and it is possible that, together with eotaxin, FGF enhances activation of eosinophils in EoE specifically Page of The increased global expression of bFGF ... the investigation of the local expression bFGF of the esophageal biopsies of the subjects Our data show that FGF, as assessed by IHC of local tissue and bFGF assessed by QT-PCR of PBMC, are upregulated ... expression of bFGF and ERK, suggesting that the upregulation of bFGF may also influence the upregulation of ERK Figure 2b: There is a positive correlation between the fold expression of ERK and...
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Báo cáo y học: "Differential binding of chemokines to macrophages and neutrophils in the human inflamed synovium" pps
... and the severity of disease In addition, administration of chemokines to the joints of animal models results in inflammation and leukocyte recruitment The biological effects of chemokines are ... bind members of the class of chemokines with two adjacent cysteine (C) residues near the NH2-terminus (CC; e.g CCL2, CCL3 and CCL5) and CXC receptors (CXCR) bind members of the class of chemokines ... percentage of positive cells in inflamed compared to noninflamed intima The rank order of Arthritis Research Vol No Patterson et al Table The number of cells binding chemokines per 500 µm of intima...
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Báo cáo y học: " NeMeSys: a biological resource for narrowing the gap between sequence and function in the human pathogen Neisseria meningitid" pot
... (24 out of 28) of the genes longer than kbp were hit 5.7 times on average, 62% (58 out of 94) of the genes between and kbp long were hit 3.7 times on average, while only 21% (14 out of 66) of the ... pentose-phosphate and Entner-Doudoroff pathways) and may be capable of de novo synthesis of all 20 amino acids Inspection of the non-core Table Summary of the (re)annotation effort of eight Neisseria genomes ... example, through completion of the collection of mutants (either through gene-by-gene or systematic targeted mutagenesis of the missed genes), further improvement of the accuracy of the annotation by...
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Báo cáo y học: " Contrasting chromatin organization of CpG islands and exons in the human genome" pot
... difference between the set of spliced exons and that of highly expressed exons Calculating the strength of exon splice sites The sum of the scores of the splice sites of each internal exon was ... density of H3K36me3 does not show exon-specific enrichment My hypothesis Page of is as follows The relative density of H3K36me3 differs between highly and lowly expressed genes It is the density of ... exons of the transcript in question The difference between the read count of each exon and the average read count of all exons can indicate how inclusive or exclusive the mature transcript is of...
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