development of bile acids as anti apoptotic and neuroprotective agents in treatment of ocular disease
The Role of Deployments in Competency Development - Experience from Prince Sultan Air Base and Eskan Village in Saudi Arabia potx
Ngày tải lên :
23/03/2014, 01:20
... pertaining to the nature and extent of airmen development occurring within the Training, Exercise, and Deployment (TED) arena Specifically, they asked whether officers learn enough during contingency ... professionals who were not members of the project team RAND routinely reviews and refines its quality assurance process and also conducts periodic external and internal reviews of the quality of ... skill They then indicated the single “best” learning environment for the skill or competency in question Settings included initial training, on-the-job training (OJT)/normal duty assignments, schoolhouse,...
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báo cáo khoa học: " Human serum-derived hydroxy long-chain fatty acids exhibit anti-inflammatory and anti-proliferative activity" pot
Ngày tải lên :
10/08/2014, 10:21
... considered a master regulator of intestinal immunological function and activator of Page 10 of 13 factors involved in driving intestinal inflammation [44-46] NFB activation has been observed in numerous ... Alzheimer’s disease but how and why? Prostaglandins Leukot Essent Fatty Acids 2008, 78:11-19 Spiteller G: Peroxyl radicals: inductors of neurodegenerative and other inflammatory diseases Their origin and ... well-established inflammatory component of this disease [42] NFB and inflammation Besides its anti- apoptotic role, NFB represents a key link between inflammation and cancer (see [43] for review), and in...
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Báo cáo y học: " Breast conserving surgery with preservation of the nipple-areola complex as a feasible and safe approach in male breast cancer: a case report" pptx
Ngày tải lên :
11/08/2014, 23:21
... effectiveness in those patients with metastatic disease and, therefore, Tamoxifen has been incorporated in the treatment of MBC [2,3,5,11] There is not sufficient evidence for the use of aromatase inhibitors ... Journal of Medical Case Reports 2008, 2:126 Clinically, he had a lump centrally in the left breast, at a o'clock position, with skin tethering and mild inversion of the nipple Ultrasound (US) and ... which was found to be cancer on both fine needle aspiration (FNA) and core biopsy The tumour was a grade invasive ductal carcinoma (IDC) Investigations did not show any distant metastases The...
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Báo cáo y học: "Lung epithelium as a sentinel and effector system in pneumonia – molecular mechanisms of pathogen " pdf
Ngày tải lên :
12/08/2014, 16:20
... and SARS and the Spike protein of this virus reduced the expression of ACE2 [99,100] Notably, blocking of the renin-angiotensin pathway reduced the worsening of disease induced by injection of ... consisting of 22 proteins, contains NALP (NACHT-, LRR-, and pyrin domaincontaining proteins), NOD (nucleotide-binding oligomerization domain), CIITA (class II transactivator), IPAF (ICE-protease ... downstream signalling molecules IRAK1, IRAK2, TRAF6 as well as NIK (NF-κB-inducing kinase), TAB2 (transforming growth factor-β activated kinase binding protein) and TAK1 (transforming growth factor-β...
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The role of cholesterol sequestration and accumulation in the endocytic pathway in development of neurodegenerative diseases
Ngày tải lên :
14/09/2015, 14:06
... caspases cleave a variety of intracellular polypeptides, including major structural elements of the cytoplasm and nucleus, components of the DNA repair machinery, and a number of protein kinases, ... pathway, originating from the activation of cell surface death receptors such as Fas, and resulting in the activation of caspase-8 or caspase-10 (Salvesen and Dixit 1997) Following release from the ... monoclonal anti- caspase-3 and anti- nucleoporin P62 antibodies were from BD PharMingen (San Diego, CA) Rabbit polyclonal anti- AIF, mouse monoclonal anti- Smac/Diablo and anti- caspase-9 antibodies,...
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báo cáo hóa học:" Drugs targeting the mitochondrial pore act as citotoxic and cytostatic agents in temozolomide-resistant glioma cells" pptx
Ngày tải lên :
18/06/2014, 15:20
... staining assays, the apoptosis and autophagy assays, participated in the experimental design of the study MR: carried out the mitotic index and the calceine AM staining assays, participated in ... about clinical trials including CD437 and BA for glioblastoma treatment Our data as well as other literature [22, 26, 41, 48-51] confirm the antitumor activity of the novel retinoid and of the ... and Zupi G: Lonidamine induces apoptosis in drugresistant cells independently of the p53 gene J Clin Invest 1996, 98:1165–73 Costantini P, Jacotot E, Decaudin D and Kroemer G: Mitochondrion as...
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Báo cáo y học: "Effect of the molecular adsorbent recirculating system and Prometheus devices on systemic haemodynamics and vasoactive agents in patients with acute-on-chronic alcoholic liver failure" potx
Ngày tải lên :
13/08/2014, 01:20
... results in an activation of endogenous vasoconstrictor and water-retaining and sodium-retaining systems such as the renin–angiotensin–aldosterone system and the sympathic nervous system, and in the ... nonosmotic release of arginine vasopressin Persistent activation of these systems appears to worsen the increased intrahepatic resistance, thus playing a central role in the aggravation of portal ... evidence of extrahepatic cholestasis, of coma of nonhepatic origin or of active gastrointestinal bleeding in the past five days before inclusion, if they had comorbidities associated with poor outcome...
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Báo cáo Y học: Functional analysis of the rat bile salt export pump gene promoter Regulation by bile acids, drugs and endogenous compounds potx
Ngày tải lên :
17/03/2014, 23:20
... amplified by PCR using the genomic clone as a template and then inserted into the promoterless luciferase vector pGL3 basic The plasmid p+80–1453 containing the same nucleotide sequence in antisense orientation ... the minimal Bsep promoter containing one FXRE close to the TATA motif Incubation with bile acids and assays of promotor activities were carried out as in (A) *P < 0.05 Fig Functional analysis of ... receptor FXR (lanes and 4), or against retinoid X receptor (RXR) (lanes and 6) or a combination of both (lanes and 8) resulted in a reduction of signal intensities of The ability of drugs to regulate...
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Báo cáo y học: "Anti-tumorigenic and Pro-apoptotic effects of CKBM on gastric cancer growth in n" potx
Ngày tải lên :
08/08/2014, 18:20
... apoptosis by inhibiting androgen receptor expression [1] Besides, soybeans contain various anti- carcinogenic compounds including lunasin and lectins that were shown to induce apoptosis in malignant ... Editor and Editor -in- Chief of Biological Signals and Biological Signals and Receptors, Adjunct Professor of University of Toronto and is Honorary or Visiting Professor of over ten universities Int ... of apoptotic cells in the gastric tumors after 14 days of drug treatment (Figure 3A) However, prolonged treatment of CKBM to 28 days dose-dependently exhibited an induction of apoptosis in gastric...
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Báo cáo y học: "The in vivo expression of actin/salt-resistant hyperactive DNase I inhibits the development of anti-ssDNA and anti-histone autoantibodies in a murine model of systemic lupus erythematosus" ppt
Ngày tải lên :
09/08/2014, 07:20
... (Figure 1d) DNase activity was mainly measured from urine instead of serum because the absence in urine of natural inhibitors of DNase activity such as G-actin To test if the expression of DNase I from ... hands, high levels of IgM anti- ssDNA antibodies were induced in all mice following the injection of LPS, although no subsequent development of IgG anti- ssDNA antibodies was observed In contrast ... inhibitors of DNase I and having increased activity, can provide some protective effect against the development of autoantibodies in mice However, the reduction in the autoantibody level obtained in...
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Báo cáo khoa học: " AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis" pdf
Ngày tải lên :
09/08/2014, 10:20
... Saxena S, Kharbanda S: Bcl-xL blocks activation of related adhesion focal tyrosine kinase/proline-rich tyrosine kinase and stress-activated protein kinase/c-Jun N-terminal protein kinase in the cellular ... Radiation and gossypol induce apoptosis In both U937 and Jurkat T cells, radiation induced a timeand dose-dependent increase in apoptosis, measured by bisbenzimide staining and FACScan analysis, as ... combination of stat3 decoy and AT-101 as well as the triple combination of erlotinib, stat3 decoy and AT101 showed significant enhancement of growth inhibition [26] Also in vivo the combined treatment...
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Báo cáo y học: " Maleic anhydride-modified chicken ovalbumin as an effective and inexpensive anti-HIV microbicide candidate for prevention of HIV sexual transmission" pdf
Ngày tải lên :
12/08/2014, 23:23
... resulting from the hydrolysis by proteases like trypsin Since trypsin is the major protease in human and predominantly cleaves peptide chains at the carboxyl side of the amino acids lysine and arginine ... body, especially in the vaginal flora, which predominantly hydrolyzes proteins/peptides at the carboxyl side of arginine and lysine residues Since most lysine and arginine residues in OVA had been ... ELISA for measuring the binding of ML-OVA to monomeric gp120 or sCD4 Anhydride-modified animal proteins of non-bovine origin were potent inhibitors of HIV-1 infection The binding effect of ML-OVA...
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Báo cáo sinh học: "Development of avian influenza virus H5 DNA vaccine and MDP-1 gene of Mycobacterium bovis as genetic adjuvant" pptx
Ngày tải lên :
14/08/2014, 19:22
... containing 50 μg/ml ampicillin was cultured using the glycerol stock of target plasmid overnight at 37°C A single colony from the plate was cultured in ml of LB broth containing 50 μg/ml ampicillin ... ability of the constructed H5 and MDP1 vaccines in inducing mRNA expression for H5 and MDP1 was studied using RT-PCR following intramuscular immunization of the SPF chickens, respectively Bands of ... recombinant vaccines against avian influenza H5N1 virus which are able to induce different levels of protective immunity, such as DNA plasmidbased vaccine, baculovirus recombinant H5 vaccine, and...
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Synthesis and biological evaluation of isoindigo derivatives as anti proliferative agents
Ngày tải lên :
10/09/2015, 08:38
... Structures of Indigo, Indirubin and Isoindigo……………………………… … Figure 1-2: Structures of selected indirubins with kinase inhibitory properties………… … Figure 1-3: Intramolecular hydrogen bonding in indirubin ... interest in the anticancer potential of indirubins and led to the initiation of clinical trials on the efficacy of indirubin for the treatment of CML.12 These trials, which were carried out in ... Notably, indirubin derivatives such as 5-chloroindirubin, indirubin-5-sulfonate and indirubin-3’-oxime (Figure 1-2) are potent inhibitors of CDK1, CDK2 and CDK5.2, 5-7 In other reports, derivatives of...
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Development of bordetella pertussis as a live vehicles for heterologous antigens delivery, and its application as a universal influenza a vaccine
Ngày tải lên :
11/09/2015, 10:00
... potential of recombinant B pertussis strains expressing antigen candidates from influenza virus as live recombinant vaccines against influenza virus, thus combining the nonspecific anti- inflammatory ... immunity induced by influenza virus infection and influenza vaccines have been covered in the first part of that chapter in order to provide a basis for discussing influenza vaccine design and development ... properties of BPZE1 and the specific anti- influenza immune responses In particular, the universal influenza vaccine candidate M2e was expressed in BPZE1 as a FHA-(M2e)3 chimera and the nasal administration...
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Development of high contrast coherent anti stokes raman scattering (CARS) and multiphoton microscopy for label free biomolecular imaging
Ngày tải lên :
11/09/2015, 10:00
... fibrosis, and rate of fibrosis progression in NASH Steatosis is increasingly recognized as a determinant of hepatic fibrosis in both alcoholic liver disease and in NAHS [172] In addition, it has been ... procedures of sample preparation including dehydration, fixation, staining and sectioning and is laborious and time-consuming, and may also be influenced by 38 the skill and experience of the reading ... CARS and TPEF images of ORO-stained fat droplets in liver…….… 106 Digital mask processing for quantitative assessment of lipid droplets in diseased liver tissue……….………………………………… ……….107 Quantitative...
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DEVELOPMENT OF e SRS (ENVIRONMENT SENSING RESPONSE SYSTEM) AS a NOVEL METHOD TO DISTINGUISH GENETIC ENVIRONMENTS AND RESOLVE CLOSELY RELATED NUCLEIC ACID SEQUENCES
Ngày tải lên :
04/10/2015, 15:52
... equipment/expertise demanding (e.g thermal cyclers or melting curve analysis in quantitative PCR) and are laborious and time consuming (e.g gel running and staining) In addition, PCR detection of SND is also ... show a Proof -of- Concept in the application of e-SRS as a potentially rapid and simple way to distinguish strains of Plasmodium falciparum with closely related sequences (including single base differences ... vitro and cell line assays were carried out 3) Application of e-SRS in the detection of Nucleic Acids in test tubes using RSs We selected targets for detection: strains of Malaria parasites (Plasmodium...
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Development and validation of classroom assessment literacy scales english as a foreign language (EFL) instructors in a cambodian higher education setting
Ngày tải lên :
04/12/2015, 14:04
... language proficiency (Neau, 2003; Clayton, 2008; Howes & Ford, 2011) The last phase was the integration of Cambodia into the Association of Southeast Asian Nations (ASEAN) Becoming a member of ASEAN, ... Purposes instruction assessment of learning placement evaluation assessment is for teaching accountability assessment as learning assessment for learning The main purposes for conducting classroom assessment ... learning approach (i.e., memorising facts and details of the learning materials to handle the assessment tasks) rather than using a deep learning approach (i.e., understanding, integrating and...
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The research is a sure-fire solution to apply on realistic condition due to its feasibility and low cost for a development of sustainable agriculture in Vietnam as the top aims of Sony Green competition
Ngày tải lên :
15/01/2016, 16:17
... basin: waste concentration 100% with plants equation has brass basin: + Brass basin 1: waste concentration 100% + Brass basin 2: waste concentration 50% + Brass basin 3: pure water equation has repeat ... data of study and conclude about the waste treatment of Ludwigia - Experiment is disposed such as: Each brass basin has 10l (waste or pure water) with plants same size (35±2cm) Figure: Brass basin: ... environment and develop sustainability in agriculture - Concrete objectives: + Investigate some chemical-physical index in waste water with Ludwigia + Investigate a growing capability of Ludwigia in waste...
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