... [34] between the fruit fly andthe mosquito, not only the basic principles of redox metabolism andthe genomicorganization ofthe TrxR gene, but also the mechanisticpeculiarities of these orthologous ... reaction ofthe cata-lytic cycle, of course, represents the net reaction catalyzed byTrxR.Discussion The isolation and characterization of A. gambiae TrxRcontributes to the understanding ofthe ... support the assumption that the substitution ofthe Trx system for GR, as well as the mechanistic particularities ofthe TrxR, are a commonprinciple in dipteran insects. In the context ofthe malarialsystem,...
... nullius – as if they had no biological fathers. With no linkbetween fathers and fetuses, no inheritance of harm could be attributed to the father’s use of drugs. The absence of fathers in debates ... the symbols ofthe ‘crackbaby’, ‘pregnant addict’ and ‘absent father’ emerged at the center of debateover fetal hazards. (A more detailed analysis ofthe social and politicalconstruction of ... mediacoverage ofthe issue, and since news stories began suggesting the relation onfetal health ofthe combined eVects of poverty, addiction and exposures toworkplace and environmental toxins. The precise...
... proteins. The 3D arrangement ofthe binding sitesfor TIPRL and a4 on the surface of PP2Ac shows thatthey are in close proximity, but not overlapping, whichallows the assembly ofthe TIPRL:PP2Ac:a4 ... Fig. 7. The interaction of PP2Ac with the regulatory B sub-unit requires the extreme C-terminal region ofthe cat-alytic subunit [29] andthe interaction site for TIPRLwas mapped to the C-terminal ... profiles ofthe three proteins overlap over a region that coincides with the expected molecular mass ofthe ternarycomplex ( 110 kDa). The TIPRL peak fractions indicated in the bottom ofthe left...
... Land Clearing And Conflicts The agro-industry is another major acquirer and converter of land outside the control of local farmers. Up to the end ofthe eighties smallholder land acquisition ... the new spirit of reform the people of South Sumatra will play a greater role in protecting and managing the forests and their resources. I warmly welcome the FFPCP series of reports on their ... continuum of land-use between the forest andthe mono-crop plantation. Thus the rigid dichotomy often presumed between forest and plantation is irrelevant to the understanding and management of such...
... 2007). The fluctuations of credit in the context of secured lending expose the fallacy ofthe lump of liquidity in the financial system. The language of liquidity suggests a stock of available ... The increased importance ofthe market-based banking system has been mirrored by the growth (and subsequent collapse) ofthe broker-dealer sector ofthe economy, the sector that includes the ... insert) shows the effect on new issuance of ABSs before and after the introduction of TALF. The light-colored bars on the right show that much ofthe issuance of ABSs is due to TALF, and that TALF-backed...
... during the midday hours ofthe summer, all ofthe test cells became ex-tremely hot, up to 176 degrees Fahrenheit (80°C), as they baked in the desert sun. Due to the temperature sensitivity ofthe ... within the communities of scientists, engineers, and other experts who work on solar energy. But because of spe-cialization and occupational silo effects, few of these profes-sionals capture the ... often shocked by the underwhelming performance of their solar ar-rays in the real world. For example, roof jobs may require that they disconnect, remove, and reinstall their rooftop arrays. Yet...
... the highest priority to the areas of technology and risk management. At the same time, 22 percent of respondents believe that the number of professional staff will remain about the same, and ... analysis, and research, as well as the ability to interview others well. They also need a deep understanding of their company and ofthe industry or industries that company serves, and a thorough ... internationalization of accounting standards may lead to a change in the language of accounting. The growth of outsourcing and an upsurge in the offshoring of services and manufacturing have made global...
... mortality ofthe patient. Moreover, the presence ofthe blood-brain barrier(BBB) limits the passage of a wide variety of anticancer agents. The high incidence of recur‐rence and poor prognosis of ... ependymomas. The accumula‐tion of tenascin in the ECS in high grade glial tumors can be one ofthe major factors leadingto the critical increase in ECS tortuosity andthe simultaneous enlargement ofthe ... therapies block activation of oncogenic pathways, either at the ligand-receptor interaction level or by inhibiting down‐Evolution ofthe Molecular Biology of Brain Tumors andthe Therapeutic Implications38...
... group and the oxygen at C4 lower the binding order ofthe carbon C4 and strengthen the downshift ofthe 4CẳO mode [10,11].In principle, X-ray-based structural models ofthe reactioncentre of Rb. ... afrequency shift ofthe absorption ofthe labelled group tolower wave numbers and thereby allows unequivocal bandassignment. Apart from this, bands of nearby groups, the vibrational modes of which ... cm)1,respectively.Therefore, the bands at 1288/89 and 1265 cm)1areassigned to C(5) and C(6) methoxy vibrations of UQ10at the QBbinding site. This is in agreement with the assignment of the methoxy...
... definition of hysteria (drawing on the definitions of Galien and Sydenham):“A Proteus who presents himself ina thousand guises and cannot be grasped in any of them.”46Then there is the aporia ofthe ... transfigure the visibility ofthe summoning ofthe patients into the visibility of explanation: a sign. A sign, that is, the temporal circum-scription ofthe changeable, lacunal cryptography ofthe ... after all, the word “hysteria” did not mean anything,22 and the moment ofthe “dismemberment” of hysteria, that is, the attempt of his own disciples to lay the word to rest on the death ofthe master?23The...
... Instead of being agents of propulsion, they take over the piece and threaten to strip it of anyother content. Only the references to the repeated-note figure ofthe opening hold the piece together. ... passage. First of allthere are the ‘corrections’ of Alessandro Longo, editor ofthe first complete edition of the Scarlatti sonatas in the early years ofthe twentieth century.41Among other thingshe ... soften the rugged Castilian landscape he found himself in ‘with the adorn-ments of Italian and French art and architecture’.45This is arguably reflected in the ‘landscape’ ofthe sonatas, in their...
... analyzed and assisted in the interpretation ofthe results and wrote the manuscript. JAK, LN conceived the idea, providedguidance on the data coding, assisted in the interpretation of the results and ... Interpreting the questions and determining the meaningful concepts can be influencedby culture andthe experience ofthe coders and enhance-ments to the ICF linking rules will help improve the assessment ... commented on the manuscript. ACassisted with the data coding and assisted in interpreting the results. JS, LCM and MFD were involved in the inter-pretation ofthe results and commented on the manu-script....