describe each of the seven guiding principles of the constitution
Tài liệu Báo cáo khoa học: Modulation of the enzymatic efficiency of ferredoxin-NADP(H) reductase by the amino acid volume around the catalytic site pptx
... probably as a result of changesintroduced by the mutations in the environment of the prosthetic group. As a result of the important changesobserved for each mutant in the differential spectraelicited ... by DNA sequencing. The design of the mutants was intended to preserve the amino acid character and to modify only the relativevolume of their R groups. The expression of the FNR mutants as soluble ... phe-nol as the tyrosine R group. This system has been usedpreviously to analyze the geometry of the tyrosinestacked on the si-face of the flavin in FNRs [12]. The single point energies of the flavin–tyrosine...
- 17
- 609
- 0
Tài liệu Báo cáo khóa học: Mutations in the hydrophobic core and in the protein–RNA interface affect the packing and stability of icosahedral viruses doc
... found with otherdissociated capsid proteins, the lack of elution of the proteins can be explained by non-specific binding of the denatured coat proteins to the gel [34,35]. The elution of some D11N ... Figure 5C shows that the spectra of the sample subjected to compression and decompression aresimilar to the non-treated sample, even in the case of the M88V mutant. The elution of the samples after ... promote significant binding of bis-ANS to any of the particles, with the exception of T45S, which bound asmall amount of bis-ANS, increasing, by twofold, the emission of the probe (Fig. 7B). M88V...
- 11
- 609
- 0
Tài liệu The 20 Key Principles of Goal Setting pot
... Kiyasaki’s “rich dad” teaches him how the mind of the rich are different than that of the poor. When the poor see something that they desire but is beyond their current budget they say, “I can’t ... move the world.” – ArchimedesLeverage is the ability to exert minimal effort for maximal achievement. An example of this is “OPK” or in other words, other people’s knowledge. One of the greatest ... your life will be with the completion of your goal. Or perhaps contemplate the opposite: how unfulfilled and stressful your life is without it. Regardless of the method of motivation, you must...
- 8
- 489
- 0
Tài liệu Fertility, Family Planning, and Reproductive Health of U.S. Women: Data From the 2002 National Survey of Family Growth doc
... Table 24 describes couple agreement or disagreement about the intendedness (at time of conception) of recent births, with the father’s attitudes based on the mother’s reports of his attitude. ... (tables 97,98) The NSFG is one of the few reliable sources of nationally representative data on the use of infertility services. Earlier reports have documented the rise in use of these services ... the percentage of woman who used any method of contraception at first premarital intercourse, by the year that first intercourse occurred. These percentages mirror the trend in use of the...
- 174
- 933
- 0
Tài liệu Báo cáo khoa học: The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid ppt
... initiation of apoptosis through the mitochondrial pathway. The key event in the mito-chondrial pathway is the release of proapoptotic fac-tors from the mitochondrial intermembrane space into the cytosol, ... release of cytochrome c and second mitochondria-derivedactivator of caspase (Smac ⁄ DIABLO) allows for the formation of the apoptosome, a complex that enables the activation of caspases within the ... The Authors Journal compilation ª 2010 FEBS 1325 The ubiquitin ligase Itch mediates the antiapoptoticactivity of epidermal growth factor by promoting the ubiquitylation and degradation of the...
- 12
- 718
- 0
Tài liệu Faultlines of Conflict in Central Asia and the South Caucasus - Implications for the U.S. Army docx
... notunderstand the “rules of the game” the way the United States does.That is one interpretation of both the crude Chinese nuclear threatsover the Taiwan crisis and Chinese views of the U.S. bombing of the Chinese ... confronta-tion between the Soviet Union and the United States was the centralreality in world politics. With the end of the Cold War and the disso-lution of the Soviet Union, the world continues ... result of agreementswith the United States and unilateral actions in the aftermath of the Cold War, and partly because of the state of the Russian economy.Even if Russia had not ratified the Strategic...
- 152
- 649
- 1
Tài liệu Báo cáo khoa học: Effect of ionic strength and oxidation on the P-loop conformation of the protein tyrosine phosphatase-like phytase, PhyAsr docx
... contact with the carbonyl oxygen of Gly255.These movements away from the oxidized cysteineincrease the space inside the P-loop to accommodate the large sulfonic acid group. The movements in the P-loop ... serve to provide room for the larger oxidizedcysteine. The key feature that dictates whether the P-loop moves upon oxidation of the catalytic cysteine is the ability of the conserved active site ... indicatethat in the absence of a ligand, the P-loop adopts the closed conformation. The only other P-loop move-ments that have been observed in PTPs are a result of oxidation of the catalytic...
- 10
- 596
- 0
Tài liệu Báo cáo khoa học: Glycation of low-density lipoprotein results in the time-dependent accumulation of cholesteryl esters and apolipoprotein B-100 protein in primary human monocyte-derived macrophages docx
... glycation, rather thanpurely the loss of the parent amino acid, which is the key factor in terms of receptor recognition [29]. Thereare no data available on the extent of Lys (and otheramino ... receptor-blockingexperiments. The rates of uptake of both the lipid andprotein components are not matched by the rate of cel-lular metabolism of these species, resulting in the accu-mulation of both unmodified ... andcontrol LDL, for 96 h. The use of LDL-free mediumduring the chase period allows the turnover of preaccu-mulated protein to be studied in the absence of furthercellular uptake. In these studies, cell...
- 12
- 604
- 0
Tài liệu Báo cáo khoa học: Binding of ligands originates small perturbations on the microscopic thermodynamic properties of a multicentre redox protein pptx
... by the replacement of Fe by Zn in the rubredoxin given the identical structures of the twoprotein forms [38,39]. Therefore, at the concentrationsused in the NMR experiments over 90% of the cytochrome ... of the haem methyl groups in the fully reduced stage 0 are not plotted because they are unaffected by the pH. The solid lines represent the best fit of the shifts for DvHc3:Pi to the model of ... is bound to the rubredoxin and the effectobserved in the signals of the haem methyls of DvHc3:ZnRb complex vs. the results in the isolatedcytochrome is close to the full effect of complex...
- 10
- 640
- 0
Tài liệu Báo cáo khoa học: Proton transfer in the oxidative half-reaction of pentaerythritol tetranitrate reductase Structure of the reduced enzyme-progesterone complex and the roles of residues Tyr186, His181 and His184 pdf
... productive binding of steroid substrates:in the first, a (small) sub population of enzyme bindsdirectly the steroid in the reactive conformation, with the remainder of the enzyme binding the unreactiveconformation. ... grossly perturb the overall framework of the enzyme or the active site. The active sites of the enzymes are shown in stick format with the sigmaA weigh-ted 2F0-Fcdensity for the Y186F mutant ... bond inclose proximity of the N5 atom. A putative flippingmotion of the progesterone molecule along an axisparallel to the FMN plane aligns the C1-C2 with the plane of the isoalloxazine ring...
- 12
- 603
- 0
Tài liệu Báo cáo khoa học: NMR structure of AII in solution compared with the X-ray structure of AII bound to the mAb Fab131 pptx
... of the structure of AII in solution with the X-raystructure of AII complexed to the Fab131 mAb. In Fig. 7A, asequence alignment is represented of the backbone of the conformational ensemble of ... alignment of the fragment 4–7 of the backbone of the 13 ensemble solution structures of AII (brown colour) superimposedon the X-ray structure (dark blue colour) and (B) structure alignment of the ... of the fragment 4–7 of the 13 ensemble structures of AII to the fragment 3–6 of the X-ray structure of AII.Fig. 6. Structure of a representative folded conformer of AII showing the van der Waals...
- 12
- 597
- 0
“Marketing is the whole business, taken from the customer’s point of view.” - Peter Drucker docx
... ShoppersElectronically or the Old Fashioned Way Market newsletters are a great method of reminding your shoppers of why they love the market. The trend in this type of communication is the e-newsletter ... effectively. The following general principles of marketing can be helpful in guiding your market in getting the most from your money.80/20 ruleKeep the 80/20 rule in mind: 80% of your business ... Marketing the MarketKatherine Kelly and Joan Vibert, vendors at Kansas City’s Brookside Farmers’ Market, offer the following possibilities for vendors to contribute to the success of the market...
- 6
- 431
- 0
Báo cáo khoa học: The role of evolutionarily conserved hydrophobic contacts in the quaternary structure stability of Escherichia coli serine hydroxymethyltransferase pptx
... counteracts the effect of the mutations, stabilizing the dimericform. The stabilizing effect is even more pronounced ifl-serine binds to the cofactor at the active site, as isevident in the case of the ... region in this group of enzymes, interacting with the phosphate moiety of PLP. Therefore, the capability of the third cluster of CHCs to confer stability to the polypeptide loops of the active site ... structure.Discussion The decrease of hydrophobic contact area determinedby the mutations in the third cluster of CHCs caused ashift of the equilibrium between dimeric and monomericforms of eSHMT in favor of the...
- 12
- 578
- 0
Báo cáo khoa học: Interactions of HIPPI, a molecular partner of Huntingtin interacting protein HIP1, with the specific motif present at the putative promoter sequence of the caspase-1, caspase-8 and caspase-10 genes pdf
... at the last base, G to A, abolished the interaction of HIPPI, so the last motif would notinteract with HIPPI. The other two motifs might be the target of HIPPI. In the upstream sequence of the Table ... positions of the motifs are indicatedby distance from the transcription start site (TSS). The position upstream of the TSS of any gene is denotedby ‘–’ followed by the distance from the TSS. In the caspase-8 ... confirmed the in vitro resultthat mutation of the motif abolished the binding of HIPPI to the specific sequence of the caspase-1 geneupstream sequence, and the increased expression of caspase-1...
- 14
- 393
- 0
Báo cáo khoa học: Dissociation/association properties of a dodecameric cyclomaltodextrinase Effects of pH and salt concentration on the oligomeric state pot
... in the presence of KCl.Considering also the 3D structure of CDase I-5, the analysis of the quaternary state of CDase I-5 revealedFig. 8. Fluorescence spectra of CDase I-5. (A) - - - -, the ... of the corresponding species;v, the partialspecific volume of the protein (calculated as described byZamyatnin [20] and assumed to be independent of the state of oligomerization); qo, the ... the adjacentmonomer, of which G538 forms a hydrogen bond to the carbonyl oxygen of M51. Two residues at the N-terminus (H49 and H89) of a subunit were locatedclose to the C-domain of the other...
- 13
- 511
- 0
Tìm thêm: xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25