dba mice as models of sudden unexpected death in epilepsy

báo cáo khoa học: "Dysembryoplastic neuroepithelial tumor and probable sudden unexplained death in epilepsy: a case report " ppt

Ngày tải lên : 10/08/2014, 23:20

... Clinical pharmacology: drugs as a benefit and/ or risk in sudden unexpected death in epilepsy? J Clin Pharmacol 2002, 42(2):123-136 15 Asadi-Pooya AA, Sperling MR: Clinical features of sudden unexpected ... 364(9452):2212-2219 10 Nashef L, Ryvlin P: Sudden unexpected death in epilepsy (SUDEP): update and reflections Neurol Clin 2009, 27(4):1063-1074 11 Friedman R: Cardiac role in sudden unexplained death in idiopathic ... observed in cases of hemorrhagic complications [4] The lobular aspect with presence of septations can sometimes occur (as in our case) Single-photon emission CT has been used in limited fashion...

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Báo cáo khoa học: Apoptosis and autophagy: BIM as a mediator of tumour cell death in response to oncogene-targeted therapeutics pptx

Ngày tải lên : 16/03/2014, 00:20

... (BRAF), inhibit these kinases or, in the case of MEK inhibitors (such as AZD6244), inhibit one of the key signalling pathways they control; in all cases inhibition of the oncogenic kinase results in ... ATP-competitive inhibitor, which targets several protein kinases such as cyclindependent kinases (CDKs), checkpoint protein (CHK1), 3¢-phosphoinositide-dependent kinase-1 (PDK1) and protein kinase Cs ... [44–46] It is interesting to note that in all cases MEK inhibitor-induced BIM expression alone was not sufﬁcient to induce a dramatic increase in cell death; pronounced increases in apoptosis...

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Tài liệu Báo cáo khoa học: NirF is a periplasmic protein that binds d1 heme as part of its essential role in d1 heme biogenesis pdf

Ngày tải lên : 15/02/2014, 01:20

... suggestive of a binding to a nucleotide-containing cofactor This motif has also been found in several other dehydrogenases involved in tetrapyrrole biosynthesis pathways, including CysGA and SirC in ... Periplasmic NirF binds d1 heme S Bali et al In vitro binding of d1 heme to NirF As explained above, there are sequence similarities (Fig S2) between NirF and the d1 heme-binding domain of cytochrome ... selected as kanamycin-resistant gentamicin-sensitive strains Correct integration of the cassette was conﬁrmed by PCR screening Second, the deletion was made unmarked using a construct in which...

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Tài liệu Master Thesis Health Sciences: Expert Elicitation to Populate Early Health Economic Models of Medical Diagnostic Devices in Development pdf

Ngày tải lên : 20/02/2014, 16:20

... (specialized, in examining MR-images of breasts) were asked to estimate the importance of different tumor characteristics in the examination of images of breasts Following this, the performance of visualizing ... common type of invasive breast cancer is the infiltrating ductal carcinoma, accounting for approximately 60-80% of all the breast carcinomas [43] Infiltrating lobular carcinomas are the second ... performance of PAM II as well The experts participating in this study included 18 radiologists of both academic as non academic hospitals specialized in examining MR images of breasts The method was based...

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Models of Health Promoting Schools in Europe doc

Ngày tải lên : 22/03/2014, 15:20

... viewed as prescriptive, there is a danger that it might be confining and inhibiting The planning framework suggested that schools assess their own standing in each of the four areas In doing so ... OF KUOPIO (FCHP = Finnish centre for health promotion, ME= Ministry of Education, MA = Mental health association in Finland) 33 The elements of ENHPS learning process in Finland The process of ... one of two ways: - without being forced to join the official network - take advantage of joining the network on the basis of competition The new strategy of ENHPS includes also the idea of a...

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MOTIVATONAL FACTORS AS PREDICTORS OF TEACHERS’ JOB PERFORMANCE IN COLLEGES OF EDUCATION AT NORTHERN PROVINCES: A PROPOSED ENHANCEMENT PROGRAM

Ngày tải lên : 13/05/2014, 15:23

... performs in the classroom The definition of teaching performance has not been attained universally Within this context, opinions of students are being recognized as most important in determination of ... constraints, the study involved sampling Of the target population of 503 teaching staff and head teachers in colleges of education in Northern provinces, population and sampling were computed by using ... performance of teachers in the colleges of education in Northern provinces in Vietnam can be related to motivation Maslow’s Hierarchy of Needs Maslow (1943 and 1970) describes human being as a creature...

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báo cáo hóa học:" Patient-reported outcomes as predictors of 10-year survival in women after acute myocardial infarction" potx

Ngày tải lên : 20/06/2014, 15:20

... records The underlying cause of death (the disease or injury that initiated the cascade of morbid events resulting in death) was defined as the cause of death Sudden death and death not attributable ... cause of death was classified on the basis of diagnosis and discharge notes The cause of death of patients dying out of hospital was based on an assessment of discharge notes and diagnosis of the ... non-cardiac disease were classified as cardiac deaths Non-cardiac death consisted of cancer, stroke, chronic obstructive Page of 10 pulmonary disease, and one group classified as ‘other causes of death ...

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Báo cáo hóa học: " Research Article Sensitivity-Based Pole and Input-Output Errors of Linear Filters as Indicators of the Implementation Deterioration in Fixed-Point Context Thibault Hilaire1 and Philippe Chevrel2" pot

Ngày tải lên : 21/06/2014, 09:20

... δZ controlling a plant in a feedback scheme The problem has an important practical interest in the context of robust control theory [30], when considering the model uncertainties of the process ... implemented in 16-bit fixed point 14 EURASIP Journal on Advances in Signal Processing Acknowledgment Input: u: 16 bits integer Output: y: 16 bits integer Data: xn: array [1· · · 5] of 16 bits integers ... Filtering Problems, Springer, Berlin, Germany, 1993 [2] T Hilaire, D M´ nard, and O Sentieys, “Bit accurate roundoff e noise analysis of fixed-point linear controllers,” in Proceedings of the IEEE International...

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Báo cáo y học: "Opitz trigonocephaly syndrome presenting with sudden unexplained death in the operating room: a case report" docx

Ngày tải lên : 10/08/2014, 23:21

... not find vascular malformation or connective tissue anomalies that could have explained death during surgery However, as in Opitz’s patient the cause of death was an unexpected massive bleeding ... presenting with sudden unexplained death in the operating room: a case report Journal of Medical Case Reports 2011 5:222 surgery may have clinical implications: diagnosing OTCS in trigonocephalic ... evaluation of risks and benefits of craniosynostosis repair Consent Written informed consent was obtained from patient’s next -of- kin for publication of this case report and accompanying images A copy of...

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Báo cáo y học: " The mode of lymphoblastoid cell death in response to gas phase cigarette smoke is dose-dependent" potx

Ngày tải lên : 12/08/2014, 14:20

... Some cases showed a dose-dependent increase of activated caspase-3 [31,32] There has also been evidence for caspase-independent apoptosis in CSE-treated cells, as shown with the use of caspase inhibitors ... of death of cells challenged with different doses of cigarette smoke [16-19] Taking this into consideration, there has been increasingly intense interest in the effects of GPS A common denominator ... caspase-3 activation was most prominent in the sample treated with puff (Figure 6) Detection of the cleaved caspase-3 gradually decreased in the rest of the samples, as the number of puffs increased...

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Báo cáo y học: "Respiratory symptoms and disease characteristics as predictors of pulmonary function abnormalities in patients with rheumatoid arthritis: an observational cohort study" pps

Ngày tải lên : 12/08/2014, 14:21

... the date of diagnosis The RA Disease Activity Score in 28 joints was calculated, including C-reactive protein [37] Joints were examined for swelling and tenderness by a single trained examiner The ... limiting its suitability for screening of asymptomatic individuals Pulmonary function testing has proved valuable in early detection of RA-associated lung disease Nevertheless, the cost of screening ... limited the understanding of the natural history of RA-associated lung disease by identifying patients primarily later in disease, and has contributed to the difficulty in assessing therapeutic agents...

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Báo cáo khoa học: " Contributions to variability of clinical measures for use as indicators of udder health status in a clinical protocol" docx

Ngày tải lên : 12/08/2014, 18:21

... older cows is not surprising Often this type of asymmetry is caused by the wear of the milking machine or the fact that quarters have been dried off after a case of a case of mastitis [11] Similarly, ... agreement between observers was seen in pathological findings, in contrast to estimating e.g udder tissue consistency Generally, observers are more trained in classifying pathological conditions, ... indication of spread of the parasite after introduction to the milking stable Animals not seem to rid themselves of this infestation once infested, and as these infested older cows are reintroduced...

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Báo cáo y học: "Matrix metalloproteinase-9, -10, and tissue inhibitor of matrix metalloproteinases-1 blood levels as biomarkers of severity and mortality in sepsis." pptx

Ngày tải lên : 13/08/2014, 19:20

... = interleukin; MMP = matrix metalloproteinase; TIMP = tissue inhibitor of matrix metalloproteinase; TNF = tumor necrosis factor Inflammatory status was assessed in sepsis patients by measuring ... were included Matrix metalloproteinases (MMPs) are a family of zinc-containing endoproteinases implicated in degradation and remodelling of the extracellular matrix (ECM) They can be classified ... beneficial effect of targeting MMPs with the administration of sub-inhibitory doses of tetracycline reported in animal models of sepsis [47,48] Whereas the strength of our study was the relatively...

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Báo cáo y học: "Retroperitoneal packing as part of damage control surgery in a Danish trauma centre – fast, effective, and cost-effective" pot

Ngày tải lên : 13/08/2014, 23:20

... team training is an invaluable part of trauma care in any trauma organisation The retroperitoneal packing training sessions have aided in developing professional multidisciplinary teamwork in real ... studies and clinical guidelines support damage control surgery Retroperitoneal packing is being increasingly recommended as a lifesaving procedure to be used in the hyper acute phase where the ... only been applied in two cases, but was indicated in a number of cases where it was not performed During the first year (2007) after the course, packing was performed 11 times Trauma audits after...

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Báo cáo y học: "Virus-associated hemophagocytic syndrome as a major contributor to death in patients with 2009 influenza A (H1N1) infection" potx

Ngày tải lên : 14/08/2014, 07:21

... defined as those requiring invasive mechanical ventilation, having a fraction of inspired oxygen level greater than 60% or receiving intravenous infusion of vasopressor or inotropic medication ... support was necessary in 17 patients In each case, the diagnosis of A/H1N1/2009 infection was confirmed by real-time reverse transcriptase polymerase chain reaction (RT-PCR) assay [17] Page of Data ... minor criterion (evidence of hemophagocytosis in bone marrow samples or increase in serum level of sIL-2R or ferritin, respectively) were present [18] We further obtained information regarding...

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Novel mechanisms of programmed cell death in the protozoan parasite blastocystis

Ngày tải lên : 16/10/2015, 15:35

... protease activity as well as in a caspase-dependent manner by binding to inhibitor of apoptosis proteins (IAPs) and subsequently activating caspases (Hegde et al., 2002; Suzuki et al., 2001) Caspase-independent ... the precursor form of effector caspases, such as caspases-3, caspases-6 and caspases-7 Activated effector caspases in turn cleave a specific set of cellular substrates, leading to the biochemical ... 1D5, cystatin and caspase-1 inhibitor It was found that inhibition of legumain activity induced apoptosis-like PCD in Blastocystis, observed by increased externalization of phosphatidylserine (PS)...

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Báo cáo khoa học: New roles of flavoproteins in molecular cell biology: An unexpected role for quinone reductases as regulators of proteasomal degradation pptx

Ngày tải lên : 16/03/2014, 02:20

... proteasome Quinone reductase as regulator of the proteasome Further results indicate that NQO1 inhibits the degradation of p33ING1b and that ultraviolet irradiation stabilizes p33ING1b by inducing ... perhaps other intrinsically unstable proteins such as ODC by the QR The active site of the enzyme with its ﬂavin cofactor – FAD in the case of the mammalian enzymes and FMN in the case of the homologous ... cellular functions in addition to their metabolic function as an enzyme [16] For example, glutathione S-transferase associates with c-Jun N-terminal kinase leading to inhibition of kinase acti- FEBS...

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báo cáo hóa học:" General anxiety, depression, and physical health in relation to symptoms of heart-focused anxietya cross sectional study among patients living with the risk of serious arrhythmias and sudden cardiac death" doc

Ngày tải lên : 20/06/2014, 15:20

... the final models In line with research of anxiety and gender, male gender was associated to less anxiety [34] Not surprisingly, increasing age and clinical Hamang et al Health and Quality of Life ... the independent variables (avoidance, attention, and fear) was not too high to include them as independent determinants in the regression models To investigate the ability of the models (which includes ... disease leading to a prolonged QT interval with an increased propensity to ventricular tachycardia manifesting as torsade de pointes [5,6] HCM is defined by the presence of increased ventricular...

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Báo cáo y học: " Characterization of protein tyrosine phosphatase H1 knockout mice in animal models of local and systemic inflammation" docx

Ngày tải lên : 11/08/2014, 03:20

... stand phase is indicated as the time of contact (in seconds) of one paw with the glass plate in a single step cycle and the swing phase is indicated as seconds of non-contact with the plate during ... in the KO mice group was detectable at this time point A genotype-related 50% decrease in MCP-1 release in plasma was recorded in LPS-treated KO vs WT mice (PKOvsWT < 0.05) IL10 levels in plasma ... end of both inflammatory models, a panel of cytokines was analyzed in blood At sacrifice whole blood was collected from the heart of the animals and plasma was obtained by centrifugation 25 μl of...

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báo cáo khoa học: " A case report: Pavlovian conditioning as a risk factor of heroin ''''overdose'''' death" pot

Ngày tải lên : 11/08/2014, 20:20

... conditioning in an accustomed place (A1) and in a new place (A2), and in a case B Heroin conditioning Heroin concentration levels in a case A after conditioning in an accustomed place (A1) and in a new ... opiate antagonist medication was not necessary The concentration in the blood of morphine, the catabolite of heroin, was 0.05 mg/l At the time of admission no internal medicine or neurological disorder ... benzodiazepines, barbiturates) were not found Heroin 'overdose' was given as the cause of death Conclusion The fatal consequence of the heroin injection may have been caused by the failure in the...

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