... suppression of respiration during hypoxia Inthe absence of differential regulation of a specific nuclear gene coding for the subunits of CytOX, changesinthe microenvironment ofthe cell may induce ... the effects of hypoxia on the steady state levels of nuclear genome encoded CytOX IV and Vb mRNAs There was no change inthe levels of these mRNAs in macrophages at h of hypoxia, the time point ... assayed in membrane fragments (SMP) by the method of Smith [20], wherein the rate of oxidation of ferrocytochrome c was measured by following the decrease in absorbency of its a band at 550 nm The...
... the biotinylated tag at the C-terminus oftheIN protein, which can be detected in virions, becomes inaccessible for streptavidin binding after entry into the cell Biotinylation and capture of ... amino-acid biotin acceptor domain (BAD) (Fig 1A) [16] was introduced inthe pCMVΔR8.74 [43] either at the C-terminus ofIN (pCMVΔR8.74 -IN- BAD) or inthe N-terminal region of MA For pCMVΔR8.74 -IN- BAD, ... titer in MAGI-5 cells and in integrase activity in vitro [15] In SupT1 cells, replication kinetics of NLXINB is delayed in comparison to either NLX or NLXMAB Furthermore the biotinylation of the...
... is critical in providing proper docking sites, either directly or indirectly, by modifying the conformation of PSII on the lumenal side, making efficient binding of PsbQ and PsbP ofthe OEC possible ... Dynamic interaction between the D1 protein, CP43 and OEC33 at the lumenal side of photosystem II in spinach chloroplasts: evidence from lightinduced cross-linking ofthe proteins inthe donor-side ... accumulating all three proteins ofthe OEC and traces ofthe D2 and CP43 core proteins as well (Fig 1B) The presence of minor amounts of D2 in both DpsbE and DpsbF supports the suggestion that the...
... conditions are met: • the power to revoke the trust remains with the grantor (the owner ofthe interest), and • the grantor (the owner ofthe interest) is a trustee ofthe trust If the owner ceases ... Provision of this agreement Excerpt LIMITING THE TRANSFER OF OWNERSHIP INTERESTS the transferring owner But inthe real world, the continuing owners may think highly of a person who wants to buy the ... transfer of an ownership interest to a trust as long as the following conditions are met: i) the power to revoke the trust remains with the grantor (the owner ofthe interest), and ii) the grantor (the...
... variables, all the information needed to determine the criticality ofthe bifurcation is contained inthe fast subsystem but in other cases there is crucial information inthe slow dynamics that ... exploit the separation of time scales inthe analysis of these (k + l)-dimensional models by splitting the system into the k-dimensional fast subsystem obtained inthe singular limit ε → of (1) ... counterintuitive since one does not expect that the small (O(ε)) terms ofthe slow c equation in (15) play an important role inthe calculation ofthe first Lyapunov coefficient Inthe following,...
... fluctuations inthe intensity of swarming were due to low evening and night temperatures (rain) During the entire period of swarming the males outnumbered the females (Fig 3) Inthe subsequent ... females inthe time of swarming; the swarming of females culminated at the time when the swarming of males was on the wane (Fig 13) In both cases, males significantly prevailed in samplings (2005: ... feeding ofthe adults Inthe past two decades the grubs of M. hippocastani Fabr seriously hindered the regeneration of forest stands in some regions The results of evaluations ofthe abundance of...
... likely the existence of blocks of genes affecting bristle number As a result, the disequilibrium generated during the period of inbreeding will decrease very slowly after the size ofthe lines ... variance ofthe trait inthe i th line is V and ; , the mean and the variance ofthe distribution ofthe variances ofthe lines are V and V(1; ), respectively In each line, the phenotypic variance ... selection The response to one generation of divergent selection inthe i th line is R and the mean and the variance ofthe distribution ofthe responses ; , obtained in different independent lines...
... (B) The use of fenofibrate was related to significant decreases inthe expression in circulating leukocytes of CX3CL1 and CCR2 genes and a significant increase inthe expression of SDF-1 Page of ... disturbances with the addition of fenofibrate in patients with HIV, which is accompanied by significant changesinthe pattern of chemokine gene expression in circulating leukocytes The data suggest ... useful inthe attempt to decrease the risk of atherosclerosis and may act as modulators of systemic inflammation and the associated vascular response However, further studies in other type of populations...
... regardless ofthelow abundance ofthe TaVRN3 transcript, transcripts of TaVRN1 exhibited an increase over the time-course Inthe light ofthe evidence against TaVRN2 being a repressor of TaVRN1, the ... of flowering gradually accumulates through time allowing plants to eventually become competent to flower even inthe absence of cold Thus, given the later hypothesis, even following a mild winter, ... complete lack of response inthe spring variety, Paragon, is intriguing: does the gibberellin pathway not function to promote flowering in spring varieties of wheat? GA pathway genes The Affymetrix...
... Identification of Induced Protein Spots Given that recombinant XacPNP causes rapid and sustained physiological changesinthe host, we were interested in investigating if these changes are also reflected in ... catalyzes the rate-limiting step in cytokinin biosynthesis, causes an elevation in cytokinindependent photorespiration, which can explain the protection of photosynthetic processes beneficial during ... which in turn down regulates tubulin a-chain and the b-tubulin encoding genes The latter two are up-regulated by the cytokinin hormone zeatin and down-regulated by the pathogen P syringae The stimulation...
... Page of 11 Figure The effect of smoking cessation on smoke-induced changesin cytokine and chemokine levels in BALF Levels ofthe proinflammatory cytokine IL-12 (A), the regulatory cytokine IL-10 ... after smoking cessation, suggesting that the Th1 skewing will diminish after smoking cessation Despite ofthe decrease in cell numbers and the reduction in cytokine and chemokine levels inthe BALF ... after smoking cessation [24,25] In contrast, other studies indicate that there is an ongoing airway inflammation in COPD patients who had stopped smoking [29-32] These findings indicate that inflammatory...
... constriction increases the thoracic flow asynchronously with the nasal flow, resulting in an increase inthe box pressure signal Penh is an empiric parameter that reflects changesinthe waveform ofthe ... cycle ofthe animal A pneumotachograph with defined resistance inthe wall ofthe main chamber acts as a low pass filter and allows thermal compensation The time constant ofthe box was determined ... (Model 49C; Thermo Environmental Instruments Inc., Franklin, Mass) The air-sampling probes were placed inthe breathing zone ofthe mice The mean chamber ozone concentration ( ± SEM) during the hr...
... amputations in 8%, skin grafts in 16% and skin scarring in 48% of survivors of meningococcal disease with PF, combined with orthopedic sequelae in 14% [15] These Page of patients did not receive PC In ... defined borders The diagnosis of PF was regarded as unclear inthe presence of just livid to partly necrotic lesions without any ofthe other criteria The diagnosis of PF was not confirmed in ... Figure Flow of patients through the study and exclusions of patients The diagnosis of purpura fulminans (PF) was regarded as definite inthe presence of livid to partly necrotic lesions of irregular...
... deformations were obtained from the Finnish rainbow trout breeding programme The broodstock fish were held at the fresh water breeding station located in Tervo, Central Finland The lifecycle ofthe fish is ... heritability estimates from these previous studies, the pattern found inthe Finnish data remained (Fig 1) Inthe regression model ofthe combined data (R2 = 79.2%, n = 12), both the linear (5.9 ± 1.08, ... equal-tailed posterior density interval for genetic parameters was calculated by identifying the cut points leaving 2.5% ofthe estimates at the lower and upper tails ofthe marginal posterior distribution...
... divided into two groups The two groups include those containing the TA domain (containing first three exons), directed by the P1 promoter and the ∆N domain (containing 4-14 exons), directed by the ... serine-20, displacing Mdm2 from the N-terminus, leading to an increase inthe protein levels of p53 (Figure 1.2) Activated p53 is then capable of inducing the transcription of genes that lead to cell ... activated at the transcriptional level in response to a DNA damaging drug, Campothesin (Chen et al., 2001) In addition, information is lacking about the interactions ofthe different splicing isoforms...
... participates inthe assembly ofthe mitotic spindle of E focardii and that both isotypes are involved inthe nucleation of other microtubule structures Finally, we examined the distribution of E focardii ... striking substitution at position 72: glycine in place ofthe c-T1 ⁄ consensus arginine (Figs 2–4) The presence of glycine at this position in c-T2 has only been observed in E focardii and inthe ... at the plus-end facilitate longitudinal interaction with the a-tubulin subunit located at the minus-end ofthe tubulin heterodimer [12] or lateral interactions with the b-tubulin subunit [61] These...
... acids inthe protein, we calculated the sum ofthe relative entropy of each amino acid weighted by its relative frequency inthe protein The measure of synonymous codon usage bias, designated as the ... , Ew = (4) i=1 where s is the number of different amino acid species inthe protein and wi is the relative frequency ofthe ith amino acid inthe protein as a weighting factor Ew ranges from (maximum ... (97.6% ofthe total) are on the upper left ofthe line y = x, indicating that GC3 contributed more to synonymous codon usage bias than did GC1 in most ofthe genomes analyzed Inthe scatter plot of...
... decreased pain and regional osteoporotic findings inthe foot or ankle Also, since the discontinuation ofthe bisphosphonate treatment, our patients have not complained of bone pain, and normal ... reports have indicated that administration of bisphosphonate results in a significant reduction in pain [8-11,13,14] However, in these studies, the method of administration was intravenous or in high ... osteoporotic changesin his Figure Change in bone pain (visual analog scale, or VAS) The reduction in VAS score after the oral administration oflow doses of bisphosphonate Aln, duration of treatment...