current theories of comprehension the main processes involved in mental representation building by the reader
Tài liệu Báo cáo khoa học: Involvement of two positively charged residues of Chlamydomonas reinhardtii glyceraldehyde-3-phosphate dehydrogenase in the assembly process of a bi-enzyme complex involved in CO2 assimilation doc
Ngày tải lên :
19/02/2014, 16:20
... molecular modelling of all mutant GAPDHs indicate no changes of the global structure of the mutants To test whether the interactions of these mutants with the other partners of the GAPDHCP12PRK ... in addition to its role in the catalytic mechanism of GAPDH could be essential for the binding of CP12 The presence of this region at the interface of GAPDH and CP12 could also explain the kinetic ... observed for the binding of the substrate when the wild-type recombinant GAPDH interacts with CP12 [28] The differences (DDG) between the binding free energy (DGb) of the interaction between the wild-type...
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Báo cáo khoa học: Amino acid residues on the surface of soybean 4-kDa peptide involved in the interaction with its binding protein potx
Ngày tải lên :
17/03/2014, 03:20
... that of the active area in insulin (Fig 7F) If the mechanism of the interaction between the 4-kDa peptide and 43-kDa protein has the minimum components of insulin–insulin receptor interaction, the ... Nakagawa, S.H & Tager, H.S (1987) Role of the COOHterminal B-chain domain in insulin–receptor interactions: identification of perturbations involving the insulin mainchain J Biol Chem 262, 12054–12058 ... impairment in binding of the 43-kDa protein, i.e greater than a fourfold increase in the Kd value Three of the 13 variants (Asp2, Asn4 and Ser8) are located in the N-terminus of the 4-kDa peptide and their...
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Báo cáo khoa học: The 3-ureidopropionase of Caenorhabditis elegans, an enzyme involved in pyrimidine degradation pptx
Ngày tải lên :
23/03/2014, 03:20
... not lie in the degradation of pyrimidines The localization in striated muscle cells might rather point to a role in providing b-amino acids for synthesis of dipeptides such as carnosine Reporter ... Differences in the reaction mechanism as a result of the large phylogenetic distance might be responsible for such a discrepancy In plants, the 3-ureidopropionase is involved in the synthesis of the ... result of a diminishing of the normally high turnover rates and subsequent overdosing [16,17] In the genome of the nematode Caenorhabditis elegans, only the reductive pathway (and none of the alternative...
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theories of integration the integrals of riemann lebesgue henstock kurzweil and mcshane
Ngày tải lên :
06/07/2014, 15:33
... begin the book with the problem of defining and computing the area of a region in the plane including the computation of the area of the region interior to a circle This leads to a discussion of ... area of the circle, we consider approximating the area of the region R by the sums of the areas of rectangles We divide the interval [a,b] into subintervals and use these subintervals for the ... the sum of their areas is the area of A In this way, one can determine the area of irregularly shaped areas, by decomposing them into non-overlapping triangles Figure 1.1 Theories of Integration...
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This explains everything deep, beautiful, and elegant theories of how the world works john brockman
Ngày tải lên :
27/07/2014, 14:11
... In the spirit of Edge, the contributions presented here embrace scientific thinking in the broadest sense: as the most reliable way of gaining knowledge about anything—including such fields of ... be explained away with the legerdemain of the preceding paragraph He’s reproaching the eliminative explanation of explanatory beauty with ignoring the many examples in history when the insistence ... requires fine-tuning of initial conditions at the moment of the Big Bang with an incredible accuracy of about 10-60 Recent developments in string theory, the most popular candidate for the role of the...
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báo cáo khoa học: " Characterization of Vitis vinifera NPR1 homologs involved in the regulation of Pathogenesis-Related gene expression" ppsx
Ngày tải lên :
12/08/2014, 03:20
... Zinc finger (BTB/POZ) domain in the N-terminal and the Ankyrin Repeat Domain (ARD) in the middle of the protein Whereas AtNPR1 to AtNPR4 have been implicated in signalling of defense responses, ... are indicated beside the branches (B) Schematic representation comparing the structure of AtNPR1, VvNPR1.1 and VvNPR1.2, including the positions of the BTB/POZ domain, the ankyrin repeat domain ... an amino terminal BTB/POZ domain and a central ankyrin repeat domain (Figure 1B) In addition, the carboxy terminal domains of VvNPR1.1 and VvNPR1.2 are rich in basic amino acids typical of nuclear...
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Tài liệu Báo cáo khoa học: Separation of a cholesterol-enriched microdomain involved in T-cell signal transduction doc
Ngày tải lên :
20/02/2014, 03:20
... separation of the plasma membrane depending on cholesterol content might be involved in segregating signalling molecules from each other to maintain the ‘off’ state of T-cell signalling Taken together, ... were determined as the amounts of inorganic phosphorus bAmount of proteins in the BCh-bound membrane fraction was estimated by subtracting the amount in the unbound fraction from that in the total ... cholesterol by approximately 30% abolishes their binding to plasma membranes [17–19] This is in remarkable contrast to cell binding by filipin, another cholesterol-binding reagent Filipin staining is...
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Báo cáo khoa học: Molecular cloning and characterization of methylenedioxy bridge-forming enzymes involved in stylopine biosynthesis in Eschscholzia californica doc
Ngày tải lên :
07/03/2014, 10:20
... was all the highest in root, and sanguinarine is found exclusively in root (data not shown), root is likely the main organ for the biosynthesis and storage of sanguinarine in E californica These ... protein for CYP719A3) The assay mixture was incubated at 30 °C for 30 min, except for the determination of kinetic parameters (for 5–10 min), and then the reaction was terminated by the addition of ... estimated by using a calibration curve of (S)-scoulerine (pmol versus peak area) at 285 nm To determine the kinetic parameters of CYP719A3, the amount of nandinine produced was estimated by using the...
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Báo cáo khoa học: An inserted loop region of stromal ascorbate peroxidase is involved in its hydrogen peroxide-mediated inactivation pot
Ngày tải lên :
16/03/2014, 14:20
... through removal of the inserted sequence of the loop region We created a gene for such a chimeric APX by inserting the loop region of APX-B (lacking insert) into the stromal APX of spinach Unfortunately, ... pH 7.0, and incubated at 25 °C Bovine serum albumin at 10 lgÆml)1 was also included in the buffer to eliminate the possibility that small amounts of contaminating proteins could interact nonspecifically ... lm These values were similar to those of APX-B and the stromal APX of spinach For chimeric APXs in the elution buffer, the wavelength of the Soret peak ranged from 405 to 407 nm, lying in the...
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Báo cáo khoa học: Structural basis of p63a SAM domain mutants involved in AEC syndrome ppt
Ngày tải lên :
22/03/2014, 16:20
... the SAM domain family SAM domains, in general, were initially thought to be involved in protein–protein interactions by forming homo- or heterooligomers with other SAM domains or by interacting ... sites in the protein The solution structure of p63a SAM domain 1RG6 provided an insight into how several of the AEC mutations observed may cause destabilization of the domain, and indeed two of the ... and C561) in p63a SAM domain are also reduced as in the p73a SAM domain The inclusion of a reducing agent in the crystallization of p63a SAM domain would potentially have contributed to the reduced...
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Báo cáo khoa học: Inhibition of aryl acid adenylation domains involved in bacterial siderophore synthesis ppt
Ngày tải lên :
23/03/2014, 11:20
... structural information, by comparing models of the aryl acid binding pockets of the two domains Results and Discussion Inhibition of DhbE with SAL-AMS and a set of new modified inhibitors In order ... (striped) are indicated (C) Alignment of DhbE and YbtE amino acids forming the aryl substrate binding pockets The differing amino acids are indicated by asterisks The amino acids with the highest ... differences between the amino acid residues forming the aryl acid binding pockets according to the nonribosomal code of A domain specificity [7,14] Therefore, a model of a putative binding pocket valid...
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Báo cáo y học: "Using theories of behaviour to understand transfusion prescribing in three clinical contexts in two countries: Development work for an implementation trial" pps
Ngày tải lên :
11/08/2014, 05:21
... relevant theoretical domains; use consensus processes to map these domains on to theories of behaviour; develop questionnaires based on these theories; and mail them to each group of physicians in the ... reproducing these domains and the theoretical constructs they include is shown in Additional File These theoretical domains offer a comprehensive list of potentially relevant constructs for the behaviour ... change interventions, the chances of finding a significant improvement in response to a specific set of interventions should increase, thereby reducing the number of costly trials evaluating different...
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báo cáo khoa học: " Dissection of genetic and environmental factors involved in tomato organoleptic quality" doc
Ngày tải lên :
11/08/2014, 11:21
... diameter the PC2 factor determined the location of Sarno ecotypes in the lower left-hand part and those of Sorrento in lower right-hand part of the graphic Instead, the PCA plots obtained by combining ... Six principal components were obtained that explained approximately 80.3% of the variability in the dataset The first two factors explained about 38% of the variation in the data, with the first ... Results of the sensory tests on the ecotypes harvested in the three different fields are shown in Figure The profiles obtained through the panel test summarise the sensory attributes of the ecotypes...
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báo cáo khoa học: " Using theories of behaviour to understand transfusion prescribing in three clinical contexts in two countries: Development work for an implementation trial" pptx
Ngày tải lên :
11/08/2014, 16:20
... relevant theoretical domains; use consensus processes to map these domains on to theories of behaviour; develop questionnaires based on these theories; and mail them to each group of physicians in the ... reproducing these domains and the theoretical constructs they include is shown in Additional File These theoretical domains offer a comprehensive list of potentially relevant constructs for the behaviour ... change interventions, the chances of finding a significant improvement in response to a specific set of interventions should increase, thereby reducing the number of costly trials evaluating different...
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Báo cáo Y học: Fluorescent analogs of UDP-glucose and their use in characterizing substrate binding by toxin A from Clostridium difficile pdf
Ngày tải lên :
08/03/2014, 22:20
... concentrations, as the metal binding event would be totally independent of the interactions involved in the enzyme–substrate complex The binding of MUG and Mg2+ are not independent, however, but instead ... available for the acceptor to approach the glycosyl donor involved in the transferase Fig Diagram showing the thermodynamic equilibria and their dissociation constants involved in the binding of UDP-Glc, ... presence of saturating concentrations of the metal cofactor Together, these data are indicative of two modes of substrate binding (i.e open and closed) The closed, active form of UDP-Glc binding is...
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Báo cáo hóa học: " Investigation of Nucleation Mechanism and Tapering Observed in ZnO Nanowire Growth by Carbothermal Reduction Technique" ppt
Ngày tải lên :
21/06/2014, 08:20
... at the base and decreases as the length of the wire increases, with the diameter being directly controlled by the shrinking radius of the contact area R at the droplet tip The average rate of ... respectively The droplet at the tip of the nanowire has a contact area of radius R and τ is the line tension The increase in the contact angle b causes a decrease in the contact area and a decrease in the ... the alloy continues till the ratio of Zn in the Au–Zn alloy increases beyond a certain thermodynamic limit, leading to the formation of the nucleus In contrast to the islands, the nucleus has...
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báo cáo khoa học: " Identification of miRNAs and their target genes in developing soybean seeds by deep sequencing" doc
Ngày tải lên :
11/08/2014, 11:21
... 3, the miRNAs denoted by a) The target of gma-miR1530 was found to be a transketolase gene (Figure 6d), the product of which may participate in the Calvin cycle of photosynthesis The Calvin cycle ... accumulation of dry matter for seed germination is the main task of developing seeds, and a large number of target genes may participate in these processes The known and new miRNAs identified in this ... Glyma05g00200* SBP domain protein I 42 1202 CDS Glyma04g32070* SBP domain protein II 42 130 3’UTR Glyma17g08840* SBP domain protein I 42 1011 CDS Glyma05g38180# SBP domain protein I 33 1356 CDS Glyma08g01450#...
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Báo cáo y học: "Systematic review of safety and tolerability of a complex micronutrient formula used in mental healt" pptx
Ngày tải lên :
11/08/2014, 15:22
... replicated the results, finding 34% fewer reported prison ‘incidents’ for the group receiving the active formula, and a 14% increase in those who were taking the placebo [12] In a study of 225 hospitalized ... Zealand, the U.S.), involving scientists at multiple academic institutions, in addition to replications by clinicians in their private practices; none of the studies have been financially Page of Table ... all involved in design and implementation of some of the data collection, as well as interpretation of the results All authors read drafts near the completion of writing, and all have given final...
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Characterization of TROM, a novel transcription repressor in human cancers identified by modified suppression subtractive hybidization (MSSH)
Ngày tải lên :
12/09/2015, 09:59
... of the disease Gene profiling inarguably accelerates the process of acquiring insights into the pathologenesis of cancer However, low abundance genes have often being left out in these profiling ... alterations in the regulation of thousands of genes involved in the circuits of pathways that intersect with one another (Figure 1.7) Although quite a few key players involved in these pathways ... strand of the cDNA during second strand synthesis Section Introduction In brief, to tackle these problems, we use the concept of oligo(dT)-T7 priming, by incorporating the T7-promoter sequence to the...
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Báo cáo khoa học: Amino acid limitation regulates the expression of genes involved in several specific biological processes through GCN2-dependent and GCN2-independent pathways ppt
Ngày tải lên :
07/03/2014, 03:20
... contribute to these multistep processes, including the metabolic conditions of the cell, nature of the stimulus, RNA binding factors and the sequence of the target mRNA [35] Another amino acid sensing ... devoid of a given essential amino acid Our data suggest that the GCN2 pathway is directly involved in the regulation of amino acid and protein metabolism, as many of the genes involved in these processes ... 1.8-fold) The expression levels of the vast majority of genes (about 99%) remained unaffected by amino acid starvation The mechanisms involved in the up-regulation of gene expression by amino acid...
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