crossing the blood brain barrier
the blood – brain barrier
Ngày tải lên :
11/04/2014, 10:34
... junctions of the blood- brain barrier Cell Mol Neurobiol 20, 57–74 68 Brightman, M W., and Tao-Cheng, J H (1993) Tight junctions of brain endothelium and epithelium In The Blood- Brain Barrier Cellular ... molecules between the blood and adjacent neurons The epithelial cells, which delimit the circumventricular organs, however, impede diffusion into the rest of the brain and the CSF (65) Therefore, substances ... cellular permeability control at the blood- brain barrier Brain Res Rev 36, 258–264 106 Rubin, L L., and Staddon, J M (1999) The cell biology of the blood- brain barrier Annu Rev Neurosci 22, 11–28...
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báo cáo hóa học: " Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSF" potx
Ngày tải lên :
19/06/2014, 22:20
... entry into the brain because of blood- brain barrier (BBB) efflux transporters so that the brain serves as a reservoir for HIV-1 [2] and a source for viral escape [3] Therefore, HIV-1 in the brain ... blood- brain barrier to various sized molecules Am J Physiology 1985, 248:H712-H718 Chou S, Dix RD: Viral infections and the blood- brain barrier In Implications of the Blood- Brain Barrier and ... act at the luminal, but not the abluminal, endothelial surface to increase the transcellular permeability of BMECs to HIV-1 Furthermore, the results suggest that the LPS-induced increase in the...
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Báo cáo y học: "Inhibition of complement C5a prevents breakdown of the blood-brain barrier and pituitary dysfunction in experimental sepsis" ppt
Ngày tải lên :
13/08/2014, 15:21
... Under physiological conditions, the BBB maintains the cerebral micro-environment by tightly regulating the passage of molecules into and out of the brain to protect the brain from microorganisms and ... Brain Res 1999, 851:215-220 54 de Vries HE, Blom-Roosemalen MC, van Oosten M, de Boer AG, van Berkel TJ, Breimer DD, Kuiper J: The influence of cytokines on the integrity of the blood- brain barrier ... in the ICU This phenomenon is thought to represent a consequence of inflammation-mediated dysfunction of the blood- brain barrier (BBB), thus allowing neurotoxic mediators to extravasate from the...
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Application of biologically active micelles in drug delivery across the blood brain barrier
Ngày tải lên :
11/09/2015, 09:10
... parenchyma The blood brain barrier (BBB) lies between the blood flow and the brain parenchyma The BBB prohibits most foreign molecules entering from the blood to brain, including CNS drugs The limited ... in the central nervous system (CNS) is to overcome the barrier preventing the drugs moving from blood circulation into the brain parenchyma The limited penetration of drugs through the blood brain ... vectors, these two type antibiotics both have poor penetration rates through the BBB As the BBB represents an obstacle for the delivery of these antibiotics from the blood to the brain, therefore, these...
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Nanoparticles of biodegradable polymers for delivery of therapeutic agents and diagnostic sensitizers to cross the blood brain barrier (BBB) for chemotherapy and MRI of the brain
Ngày tải lên :
26/11/2015, 22:48
... INTRODUCTION 1.1 BLOOD BRAIN BARRIER 1.1.1 History and Anatomy of the Blood Brain Barrier 1.1.2 Functions of the Blood Brain Barrier 1.1.3 Clinical Significance of the Blood Brain Barrier 1.2 METHODS ... Functions of the Blood Brain Barrier The main function of the blood brain barrier is to protect the brain The BBB serves as an impermeable wall to prevent the entry of agents from outside of the brain ... the luminal and abluminal membranes of the brain capillary endothelial cell Fig The BBB as a selective sieve With these two functions of the blood brain barrier, the brain capillaries allow the...
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báo cáo hóa học:" Effective transvascular delivery of nanoparticles across the blood-brain tumor barrier into malignant glioma cells" docx
Ngày tải lên :
18/06/2014, 15:20
... the blood- brain barrier Journal of Controlled Release 2005, 108:84-96 Poduslo JF, Curran GL: Polyamine modification increases the permeability of proteins at the blood- nerve and blood- brain barriers ... of the bloodbrain tumor barrier; in addition, we validated the importance of prolonged nanoparticle blood half-life for the effective accumulation of nanoparticles within brain tumor cells Therefore, ... other charged nanoparticles [66-69] across the barrier may be from direct charge induced damage to endothelial cells of the barrier and disruption of the barrier Our proposed mechanism for the...
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báo cáo hóa học:" Physiologic upper limit of pore size in the blood-tumor barrier of malignant solid tumors" ppt
Ngày tải lên :
18/06/2014, 15:20
... ectopic site, the permeability of the BTB of the breast cancer tumor growing in the brain is lower than the BTB of the original tumor in breast tissue, the orthotopic site[5] The brain tissue ... of the inter-endothelial cell gaps, these pores are more numerous than the inter-endothelial cell gaps in the BTB of brain tumors and peripheral tumors[4,9,10] The higher permeability of the ... within the brain, the orthotopic site, to that of the BTB of RG-2 gliomas grown outside the brain in the temporalis skeletal muscle, the ectopic site We used this animal model to characterize the...
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báo cáo hóa học: " Anandamide inhibits Theiler’s virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB1 receptors" pdf
Ngày tải lên :
19/06/2014, 22:20
... Anandamide inhibits VCAM-1 induced by TMEV in brain endothelial cells by CB1 receptors The endothelial blood brain barrier protects the CNS from the changing environment in both physiologic and ... recruitment across the BBB through the inhibition of VCAM-1 As suggested in the cardiovascular endothelium [51,52] in the brain endothelium AEA and other endocannabinoids like 2-AG, would be synthetized ... from the own endothelial cells to regulate the response of brain endothelium to different stimuli as we observed in the case of TMEV The observation that NAPE-PLD expression is elevated on blood...
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báo cáo hóa học: " Neuro-Inflammation, Blood-Brain Barrier, Seizures and Autism" pot
Ngày tải lên :
19/06/2014, 22:20
... Erickson, M A.: The blood- brain barrier and immune function and dysfunction Neurobiol.Dis 2010, 37:26-32 44 Quan, N.: Immune-to -brain signaling: how important are the blood- brain barrierindependent ... trigger mast cells to release mediators that could disrupt the gutblood barrier and blood- brain barrier (BBB), thus contributing to the pathogenesis of autism [27] Many mediators, such as IL-6 ... and Theoharides, T C.: Corticotropin-releasing hormone (CRH) and brain mast cells regulate blood- brain- barrier permeability induced by acute stress J Pharmacol Exp Ther 2002, 303:1061-1066 51 Theoharides,...
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Hình thái và chức năng của hàng rào máu não (blood brain barrier)
Ngày tải lên :
19/07/2014, 20:48
... dụ: nhồi máu não, xuất huyết não chấn thương sọ não ), có chứng tượng mở hàng rào máu não (Brain- Blood Barrier opening) bù trừ có tính chọn lọc phá hủy mặt cấu trúc giải phẫu cách đơn (Lee et ... trúc phức tạp tinh vi, chúng nối vùng đỉnh khe liên tế bào biểu mô với hàng rào nội mô (endothelial barrier) Chúng có chức “dây kéo” (zipper) nhằm liên kết màng tế bào vùng đỉnh (apical membrane) ... nhân, đa nhân, lympho 5.2.Các bệnh thần kinh tác động lên hàng rào máu não 5.2.1.Phù não (Brain edema) Theo Klatzo, phù não phân thành hai loại khác khác dựa vào đặc điểm hình thái chúng 34 -...
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Báo cáo y học: "Effect of magnesium sulfate administration on blood–brain barrier in a rat model of intraperitoneal sepsis: a randomized controlled experimental study" ppt
Ngày tải lên :
12/08/2014, 20:20
... through suppression of the endothelial cells It was suggested that even before magnesium reaches the brain site it interacts with the endothelial cells forming the BBB and inhibits their activation ... of the effect of gram-negative endotoxin on the blood brain barrier J Comp Neurol 1966, 127:183-198 22 Jeppson B, Freund HR, Gimmon Z, James JH, von Meyenfeldt MF, Fischer JE: Blood brain barrier ... intra-abdominal sepsis, the cultures of brain specimens taken after the experiment were all sterile (data not shown) One of the major pitfalls in the interpretation of the data was the difficulty of...
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Leading strategic change breaking through the brain barrier
Ngày tải lên :
30/11/2015, 01:05
... task, they put their heads together and figured out how they would approach the challenge If their efforts failed, then the next time that task arose, they would be inclined to devise another ... Gregersen push the change leaders to explore how they think about or ‘map’ the world in which we live These maps become either a critical barrier or an asset to their ability to lead change The authors ... Apply The Fundamentals of Change 10 CHAPTER Brain Barrier #1: Failure to See 17 Blinded by the Light 20 Overcoming the First Brain Barrier 43 CHAPTER The Keys to Seeing: Contrast and Confrontation...
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CROSSING THE DIVIDE
Ngày tải lên :
16/10/2013, 16:15
... Iterator The BO is the communication front between the controller and the model layer It provides coarse grained operations to the controller The BO uses the DAO, and DAGO, but hides these objects ... based on the name of the foreign table not the name of the foreign key column in the local table We can then call getTeacher() to get Listing 5 10 11 12 13 14 15 16 17 18 // Get a list of all the ... slightly differently You create the object with the create() function on the persistence manager, but it is stored by calling the commit() method on the manager, rather than the object itself This makes...
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Look both ways before crossing the network
Ngày tải lên :
22/10/2013, 18:15
... each for the transmit and receive circuits Whenever a connector is cleaned or new circuits turned up, there is the potential for damaging dust or dirt to enter other connectors within the fiber ... without exposing the other fiber to the risk of breaking and taking down service Many transmission equipment vendors build in performance monitoring functions into their equipment There is a mistaken ... opportunity to test,” the argument goes There are several value propositions to counter these perceptions One way to look at operations cost includes asking the question, “What is the cost of service...
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Tài liệu Look both ways before crossing the network doc
Ngày tải lên :
10/12/2013, 16:15
... luck, the CLEC can find the one or two prevent loss of business It people who are familiar with the gives the service provider equipment, then wait for them to go flexibility in choosing the test ... traffic The pattern is carried on the network or circuit under test, then test equipment at the receive point determines whether the transmission is successful (without errors) At this point, the ... to the rear, the other to the front lems For example, an ILEC hands off OC-12 One approach is to (622-Mbit/sec) optical bandwidth to disconnect the connecan Internet service provider (ISP); the...
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Mind Games - the aging brain and how to keep it healthy
Ngày tải lên :
27/12/2013, 15:19
... with some of the vocabulary and imagery needed to talk about and visualize brain structure neuron—nerve cell in the brain The neuron is the basis of the brain It is estimated that the brain contains ... injected into the bloodstream using glucose as the carrier The radioactivity allows external monitoring of the metabolism of the brain Sensors around the volunteer’s head monitor the radioactivity ... adult, you need to know the facts about how your brain operates in order to affect the processes Please keep reading The Adult Brain By the time the baby becomes an adult, the brain weighs approximately...
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Tài liệu Histology of the Blood Normal and Pathological pptx
Ngày tải lên :
17/02/2014, 22:20
... of the lymphocytes of the blood; Frọnkel like Uskoff regards it as the emigration of the young forms of the white blood corpuscles into the blood He concludes logically from the diminution of the ... scarcely a drop of blood can be obtained, while in others the blood flows freely One will not err in assuming in the former case a diminution of the quantity of the blood The fulness of the peripheral ... between the number of red blood corpuscles and the amount of hổmoglobin be considerably disturbed, the influence of the stroma of the red discs on the specific gravity of the blood will then be...
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THE WORD BRAIN- HƯỚNG dẫn học NGOẠI NGỮ NHANH NHẤT
Ngày tải lên :
03/03/2014, 13:22
... m co The Word Brain nl in e Hướng Dẫn Cách Học Ngoại Ngữ Nhanh Nhất Ti en gA nh O www.TheWordBrain.com Mục lục 13 Listening 19 Reading 29 Giáo viên ... m ‘Once upon a time there lived in a certain village a little country girl, the prettiest creature who was ever seen Her mother was excessively fond of her; and her grandmother doted on her still ... trước du lịch nước hữu ích phạm vi sách Quyển The Word Brain bàn nỗ lực mà người lớn cần phải thực để nói hiểu ngoại ngữ Tôi định nghĩa ‘nói ngoại ngữ’ theo cách rộng Nói ngoại ngữ bao gồm khả có...
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The Female Brain is one of the most-talked-about books of the year. ppt
Ngày tải lên :
08/03/2014, 23:20
... ONE The Birth of the Female Brain 11 T WO Teen Girl Brain 31 T HREE Love and Trust 57 FOUR Sex: The Brain Below the Belt 77 FIVE The Mommy Brain 95 SIX Emotion: The Feeling Brain 117 SEVEN The ... The Mature Female Brain 135 EPILOGUE The Future of the Female Brain 159 vii C o n t e n ts APPENDIX ONE: The Female Brain and Hormone Therapy 165 APPENDIX T WO: The Female Brain and Postpartum ... as boys Their brains are different by the time they’re born, and their brains are what drive their impulses, values, and their very reality The brain shapes the way we see, hear, smell, and taste...
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100 fascinating facts you never knew about the human brain
Ngày tải lên :
11/03/2014, 00:06
... elephant’s brain) , meaning humans have the largest brain to body size 12 Blood vessels There are 100,000 miles of blood vessels in the brain 13 Fat The human brain is the fattest organ in the body ... 10 No pain There are no pain receptors in the brain, so the brain can feel no pain 11 Largest brain While an elephant’s brain is physically larger than a human brain, the human brain is 2% of ... permanently affect brain development Brain Function From the invisible workings of the brain to more visible responses such as yawns or intelligence, find out how the brain functions with these facts...
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