concurrent use of erlotinib and dexamethasone where steroids help to reduce toxicity
EXPLORING THE ROLE OF PHARMACOKINETIC ALTERATIONS IN TYROSINE KINASE INHIBITORS (TKIS) ASSOCIATED TOXICITIES
Ngày tải lên :
09/09/2015, 08:14
... high-grade hepatotoxicity 140 Figure All-types all-grades hepatotoxicity 141 Figure High-grade hepatotoxicity due to ALT elevation 142 Figure High-grade hepatotoxicity due to AST ... Strategies to overcome TKI-induced hepatotoxicity 165 Table 27 The use of corticosteroids to manage TKI-induced hepatotoxicity 168 Table 28 Patient demographics and disease characteristics (erlotinib ... associated toxicities: a focus on hepatotoxicity 132 6.1 Hepatotoxicity with tyrosine kinase inhibitors 132 6.2 Risk of tyrosine kinase inhibitor-induced hepatotoxicity ...
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Managing people working as individuals and in groups
Ngày tải lên :
14/09/2012, 11:41
... formal and informal meetings can be held ©Ian Sommerville 2004 Software Engineering, 7th edition Chapter 25 Slide 37 Office layout Meeting room Office Office Comm unal area Office Office Office Office ... Staff selection factors Educational background This may provide an indicator of the basic fundamentals that the candidate should know and of their ability to learn This factor becomes increasingly ... workforce capability To ensure that software development capability is not reliant on a small number of individuals To align the motivation of individuals with that of the organisation To help retain...
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Tài liệu Báo cáo khoa học: Human enhancer of rudimentary is a molecular partner of PDIP46/SKAR, a protein interacting with DNA polymerase d and S6K1 and regulating cell growth docx
Ngày tải lên :
19/02/2014, 05:20
... plasmids using Lipofectamine Reagent according to the manufacturer’s suggested protocol (Invitrogen) Briefly, a mixture of lg of the plasmid DNA and lL of Lipofectamine in mL of antibiotic- and serum-free ... insert was found to consist of 666 bp containing the 3¢ end of the POLDIP3 coding sequence (with the stop codon) and coded for 163 amino acids present at the C-terminus of both isoforms of PDIP46 ⁄ ... bait and separated by one-dimensional SDS ⁄ PAGE there was a band of a protein with electrophoretic mobility of approximately 46 kDa, which corresponds to the molecular mass of isoform ⁄ a of PDIP46...
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Tài liệu Hotel Valuation Techniques By Jan deRoos, Ph.D., and Stephen Rushmore, CHA, MAI ppt
Ngày tải lên :
19/02/2014, 10:20
... Land Basis 39 years 70% of value and 30% of CapEx reserve years 10% of value and 70% of CapEx reserve 20% of value (land is not depreciated) Public Company Information Cost of Debt Debt to Total ... stream into an estimate of value, the anticipated net income is allocated to the mortgage and equity components based on market rates of return and loan -to- value ratios (similar to the band -of- investment) ... the use of a cost estimating guide or guides to arrive at a cost to determine the replacement cost of the property Appraisers often use a unit-in-place method to estimate value of the building and...
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100 + Diverse National and State Groups Support Speier’s H.R. 1608 Bill ppt
Ngày tải lên :
06/03/2014, 04:21
... Network, Washington Alice Woldt, Washington Association of Churches John R Jones, Washington ACORN Bruce Neas, Columbia Legal Services, Washington, on behalf of clients Will Pittz, Washington Community ... Clinic, Indiana Victor Elias, Child and Family Policy Center and Iowa Coalition Against Abusive Lending, Iowa Larry M McGuire, Minister, Community of Christ and Inter-Religious Council of Linn County, ... be able to set lower rate caps to protect their citizens, such as New York’s 25 percent criminal cap and Arkansas’s constitutional cap We urge quick action to implement the FAIR cap to stop usurious...
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2-D and 3-D Image Registration for Medical, Remote Sensing, and Industrial Applications pptx
Ngày tải lên :
06/03/2014, 12:20
... bimodal histogram may not segment an image properly A better approach will be to use gradient information to select pixels that belong to region boundaries and use intensities of those pixels to determine ... Maurer and Fitzpatrick [268], Maintz and Viergever [256], Lester and Arridge [239], Pluim et al [311], and Zitova and Flusser [432] A book covering various landmark selection methods and their ... interactively or automatically selected and used to segment an image When a single threshold value is used, image intensities equal to or greater than it are assigned to one class and the remaining...
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Empirical Evidence From Swedish Manufacturing Firms Relationship between R&D and Productivity doc
Ngày tải lên :
08/03/2014, 04:22
... Professor Hans Lööf I am grateful to him for kind direction I am also grateful to Professor Borje Johansson, Almas Heshmati, Martin Anderson and other professor in the department of Economics of ... means random effect model is more efficient than the fixed effect estimator and safe to use in the productivity analysis Random-effects estimator considers weighted average of the fixed and between ... the autoregressive parameters are too large or the ratio of the variance of the panel-level effect to the variance of idiosyncratic error is too large Building on the work of Arellano and Bover...
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“Village Banks (Village Savings and Credit Groups) in Vientiane Capital, Laos” – Roadmap Scenarios for a Sustainable Future potx
Ngày tải lên :
15/03/2014, 10:20
... ratio of 5%, a risk-weighted CAR of 12%, liquidity ratios of 4% of cash in hand and 20% overall, and investments of up to 10% of registered capital but restricted to other MFIs DTMFIs have to be ... coverage had also expanded to 52 villages Total assets amounted to 2.61 billion Kip, loans outstanding to 2.14 billion, total savings to 1.99 billion and paid-up share capital to 0.30 billion Net ... member-controlled In contrast, the DTMFIs are private and investor-driven (like Beer Lao as one of the investors) and under the control of major investors; small investors have little, if any, control institutions...
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INTERNATIONAL AGENCY FOR RESEARCH ON CANCER WORLD HEALTH ORGANIZATION: Vitamin D and Cancer pptx
Ngày tải lên :
28/03/2014, 23:20
... exogenous sources of vitamin D 15 Toxicity of vitamin D and long term health effects 21 5.1 Acute toxicity of vitamin D 21 5.2 Long-term use of less than 25 ... 2.4 pmol/L d stands for deci; m stands for milli; stands for micro; n stands for nano; p stands for pico; and f stands for femto Abbreviations for measure of risk in epidemiological and clinical ... the risk of cancer 2.2 Objectives of the report In the recent past, vitamin D has been the focus of keen interest and of much work on its potential to reduce the risk of cancer and of other chronic...
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Báo cáo khoa học: Redox-sensitive loops D and E regulate NADP(H) binding in domain III and domain I–domain III interactions in proton-translocating Escherichia coli transhydrogenase potx
Ngày tải lên :
31/03/2014, 09:20
... reaction mechanism of the intact enzyme The regions at the C-terminal end of the b sheet comprised of residues bG389-bI406 (part of loop D, linking b-strands and 5) and bG430–bV434 (part of loop E, linking ... measure of the affinity of the complex formed for rrI and ecIII [10] and may be used to gain information about the role of a particular amino-acid residue in the interactions with dI However, because ... the proton pumping mechanism of transhydrogenase have been suggested to be dependent on binding/release of NADP(H) and the redoxstate of this substrate [2,4] The exact location of NADP+ and the...
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buildings and classical groups - p. garrett
Ngày tải lên :
31/03/2014, 16:18
... Lemmas on isometries 16.4 Subsets of apartments 16.5 Con gurations of chamber and sector 16.6 Con gurations of sector and three chambers 16.7 Con gurations of two sectors 16.8 Geodesic rays 16.9 The ... folding to f Proof: If there were an opposite folding f to f , then the set of chambers in the half-apartment f X would have to be the complement of the set of chambers in And, for a pair of adjacent ... gallery from C to D 6= C to stutter, as claimed Thus, the retraction : X ! C gives a labeling of X by subsets of C Further, map the poset of subsets of C to the poset of subsets of S by sending...
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research report 'using the activity in pairs and in groups to teach writing in english'
Ngày tải lên :
29/06/2014, 19:15
... half of the class to work in pairs on one text, and half to work in pair on the other text Procedure: - Ask the students to get into pairs Give out copies of one text to half of the class and ... students read the story aloud 3.4 Writing stories Procedure: - This game is used in groups of ten - The teacher chooses a story that is interesting enough to stimulate the students to start writing ... No matter what sorts of books are used, no matter how good and useful the books are, the basic teaching techniques and supplementary activities are of significant importance to a writing lesson...
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Báo cáo toán học: "Asymptotics of generating the symmetric and alternating groups" docx
Ngày tải lên :
07/08/2014, 13:21
... pointed out to me that a theorem of M Hall shows that the number N(n, 2) of subgroups of index n in a free group of rank is equal to n!ntn (see (1) below and [6]) On the other hand, a result of Comtet ... Generalization to more than two generators In view of the theorem of M Hall mentioned in Remark there is some interest in extending the analysis for tn to the case of r generators where r ≥ Let tn (r) be the ... (Π)) be the number of pairs (x, y) of elements from An (respectively, Sn ) such that the parts of Π are the orbits of the group x, y generated by x and y Similarly let gA (Π) and gS (Π), respectively,...
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Báo cáo toán học: "Hurwitz Equivalence in Tuples of Generalized Quaternion Groups and Dihedral Groups" docx
Ngày tải lên :
07/08/2014, 21:20
... suffices to find a set of representatives of the Bn -orbits in each of A, Bν,τ and Cν,τ the electronic journal of combinatorics 15 (2008), #R80 For a = (αi1 β j1 , , αin β jn ) ∈ Cν,τ , where ... (4.2) n−1−s where ≤ i1 ≤ · · · ≤ is < pm , n − − s > 0, min{νp (i1 ), , νp (is ), m} ≥ ν + 1, ≤ e < pm−ν , e ≡ (mod p) Proof The proofs of (i) and (ii) are identical to those of the corresponding ... Theorem 3.1 and Corollary 3.2 allow us to compute the number of Bn -orbits in Qnm and the cardinality of each Bn -orbit Corollary 3.3 The total number of equivalence classes in Qnm is Qnm /∼...
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Báo cáo toán hoc:" Hurwitz Equivalence in Tuples of Dihedral Groups, Dicyclic Groups, and Semidihedral Groups" pptx
Ngày tải lên :
08/08/2014, 01:20
... of N, and then show how the proof can be modified to work for even values of N Observe that it suffices to prove that we can obtain the conditions in parts (c)–(g), since we can then use (2.3) and ... α−1 Analogous to elements of D2N , each element of Dic 4M can be uniquely written in the form αi β j , where i < 2M and j It is easy to check that equations (2.1) and (2.2), and hence (2.3)–(2.6), ... 3, it is easy to see that each of A, Bν,τ , and Cν,τ is invariant under the Hurwitz action, so that it suffices to find a set of representatives of the Bn -orbits in each of A, Bν,τ , and Cν,τ the...
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Báo cáo toán học: "GBRDs with block size three over 2-groups, semi-dihedral groups and nilpotent groups" docx
Ngày tải lên :
08/08/2014, 12:23
... square is a generator of Φ(G), and is hence of order 2n−1 This element generates a cyclic subgroup of G of index The 2-groups with cyclic subgroup of index are well known, and are listed in ... have non-trivial automorphisms of odd order p In particular, because the automorphism group of the cyclic group of order 2n is of order 2n−1 , the Sylow 2-subgroup group N of G is not cyclic ... if and only if G is cyclic Note that, because the Frattini subgroup is the intersection of the maximal subgroups of G, there is a one -to- one correspondence between the maximal subgroups of G and...
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