conclusions preventive measures and goals for the future
Báo cáo y học: "Frontotemporal Dementias: A Review" pdf
... onset was found to be +/- 1.1 years for FTD and +/- 0.4 years for FTD-MND The median survival for the entire group was 3.0 years from the time of diagnosis, and 75% were dead within 6.0 years ... loss of speech, and stereotyped and perseverative behaviors Using these standards, the sensitivity for detecting FTD was 63.3% to 73.3% and specificity was 96.7% to 100% [35] For a quantitative ... of FTD symptoms Cognitive tests like the MMSE not readily distinguish between FTD and AD On the other hand, the FBI differentiated 98% of FTD and AD patients The FBI tests areas such as apathy,...
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Báo cáo y học: "Aplasia and Agenesis of the Frontal Sinus in Turkish Individuals: A Retrospective Study Using Dental Volumetric Tomograph"
... a metopic suture, the frontal sinuses are small or absent [8-10] The form of the face and forehead in the presence of a metopic suture conforms to the evolutionary trend of the skull [30] In ... kappa value for inter-observer reliability between observers and was 0.86 Fig Unilateral absence of the frontal sinus; on the right, the absence of the frontal sinus, and on the left, the limited ... sinus agenesis Discussion Sex The variations in the anatomy of the frontal sinus may be critical for morphological or forensic investigations and for neurosurgeons performing pterional or supraorbital...
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Báo cáo y học: "ribriform-Morular Variant of Papillary Carcinoma: Association with Familial Adenomatous Polyposis Report of Three Cases and Review of Literature"
... Cribriform areas had back-to-back follicles with anastomozing bars and arches of cells in the absence of intervening fibrovascular stroma and accounted for 30-50% of the lesions (Fig 3) The solid ... and they did not show the hot spots of the APC gene C-MV carries a better prognosis than the other aggressive variants of PTC (tall cell, columnar, diffuse sclerosing and diffuse follicular) and ... to the development of C-MV of PTC A handful of sporadic cases have also been documented [6] Table summarizes all the cases in the literature Molecular studies were performed in all our cases and...
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OFDM Multi-User Communication Over Time-Variant Channels
... Kommenda and Horst Rode, provided the basis for the work on this thesis I would like to thank my family and my friends for their continuous sympathy in my research adventure, and Dada for being the ... part of the data block (the first J symbols), the estimator will equal the exact MMSE estimator for the given pilot symbols For the data part the variances of the estimates of the unknown data symbols ... description for the wireless channel Thus, we combine the effect of the up-converter, the transmit filter hT (t), the channel h (t), the matched receive filter hR (t) and the down-converter into the equivalent,...
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Tài liệu Báo cáo khoa học: Activated Rac1, but not the tumorigenic variant Rac1b, is ubiquitinated on Lys 147 through a JNK-regulated process docx
... following the manufacturer’s procedure Each of the 18 lysine mutants of the myc–Rac1L61 sequence and the ubiquitin mutants UbR48 and UbR63 were obtained by replacing the lysine codons AAA and AAG by the ... for ubiquitin addition Therefore, the reason why Lys147 rather than Lys5 is the main acceptor site for ubiquitin in Rac1 remains to be elucidated Of note, however, is that recent studies on the ... ubiquitination and therefore not support this hypothesis Except for a recent report on the role of proteasome-mediated degradation of Rac1–GTP in hepatocyte growth factor-induced epithelial cell...
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Tài liệu Báo cáo khoa học: A novel splice variant of occludin deleted in exon 9 and its role in cell apoptosis and invasion docx
... round The PCRs were performed using the following conditions: 35 cycles of 95 °C for 30 s, 53 °C for 30 s and 72 °C for for the first round PCR; and 35 cycles of 95 °C for 30 s, 53 °C for 30 s and ... performed on the cDNA of Chang cells, and the PCR product was sequenced (D) PCRs for exon and exon 1a were performed in Huh7 and Chang cells (E) The boundary regions of exon and exon in the genomic ... methyltransferase 1, and 300 nm To investigate whether or not the occludin variant was localized in the membrane, we cloned the OccWT and OccDE9 genes into pCMV ⁄ HA and performed immunocytochemistry The expression...
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Tài liệu Báo cáo khoa học: A unique variant of streptococcal group O-antigen (C-polysaccharide) that lacks phosphocholine ppt
... 4.13 (H-1a and H-1b, of G) and to dH 4.07 (H-6a and H-6b, of D) The two phosphoethanolamine groups are therefore linked to the 6-positions of residues A and D Two peaks were obtained in the chromatogram ... residues A and D it was possible to follow the spinsystems from H-1 up to H-4 in the COSY spectrum For residues B and C it was possible to follow the whole spinsystem in the COSY spectrum, these assignments ... 1H,1H-COSY and 1H,1H-TOCSY (40 ms spin lock time) The mixing time in the NOESY experiment was 300 ms The JH1,H2 values were obtained from the 1D spectra, other couplings from the COSY spectrum The proton-carbon...
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Tài liệu Báo cáo Y học: Interallelic recombination is probably responsible for the occurrence of a new as1-casein variant found in the goat species potx
... (a, b, c, d, and e) Two of these (a and c) appear to be shared with variants A and F, while components e and d seem to be in common with the A variant Therefore, band b represents the only component ... wonder whether the donor allele of the 5¢ part is the F allele or another allele belonging to the same B allelic lineage (excluding B1 and C), as they share the same simplified haplotype formula, ... Ser64 in the M variant The sequence determined is consistent with the molecular mass measured for the native protein The phosphorylated residues are therefore Ser46, 48, 65, 67, 68 (fully), and Ser41...
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Báo cáo khoa học: SAF-3, a novel splice variant of the SAF-1/MAZ/Pur-1 family, is expressed during inflammation pptx
... to the ATG start codon of the SAF-3 cDNA The probe and RNA were heated at 90 °C for 15 in 80% formamide, 40 mm Pipes pH 6.4, 400 mm NaCl, mm EDTA buffer, and then incubated overnight at 50 °C The ... boxes, and 5¢ and 3¢ UTRs by speckled boxes The introns and UTRs are not drawn to scale The positions of the primers used for RT-PCR are indicated by bold lines (B) Sequence of exon 1A in SAF-3 The ... template for the second PCR The SAF-3 primers for the second PCR primers were 5¢-CCGCCATGGATCCCAGCAACTGGAGCAGC-3¢ (forward) and 5¢-GAGAACCGGGAGCAAGTCCAC-3¢ (reverse) The amplification product of the second...
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Báo cáo khoa học: Androgen receptor function is modulated by the tissue-specific AR45 variant ppt
... 2004 FEBS Androgen receptor variant form primer directed against the hinge domain of the AR and a forward primer recognizing the common 5¢ end of the reverse-transcribed RNA This allowed the amplification ... pCR-TOPO II (Invitrogen) and sequenced Site-directed mutagenesis of AR45 to generate the C31G, DR84 and R243H forms, and of b-catenin to generate the S33F form was performed with the QuickChange kit ... experiments and the bars are the mean ± SEM of sextuplicate values Position of the mutations was indicated relative to the AR45 amino sequence For clarity, the corresponding location in the AR was...
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Báo cáo khoa học: Molecular and functional characterization of a novel splice variant of ANKHD1 that lacks the KH domain and its role in cell survival and apoptosis docx
... we focus on the biochemical and functional characterization of the novel VBARP-L and VBARP-S transcripts Bioinformatics analyses show that VBARP-L and VBARP-S are comprised of 11 and exons, respectively ... by VBARP and Vpr antibodies, respectively, whereas VBARP and Nef did not form a complex, indicating that the interaction between VBARP and Vpr is specific The input panel represents the amount ... detected by the IP followed by immunoblotting, further confirming the specificity of this interaction Based on these results we were able to demonstrate the formation of a complex between Vpr and VBARP...
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Báo cáo khoa học: Identification and characterization of B¢¢-subunits of protein phosphatase 2 A in Xenopus laevis oocytes and adult tissues Evidence for an independent N-terminal splice variant of PR130 and an extended human PR48 protein pot
... for PCR 3) and the anchor primer supplied in the 5¢-RACE kit For amplification of specific XPR130 5¢-end RACE fragments, the primer 5¢-TGGACTGACAGTTGGAG TAAGG-3¢ was used for the RT reaction, and ... analysis of the structure of the latter made it possible to improve the current knowledge of the mammalian PR48 cDNA To extend these findings, the genomic structures of the human PR130 and PR48 genes ... and Xenopus lysates, which recognises the PR65 a and b isoforms equally well The best anti-C monoclonal was found to be F2 6A10, and it recognizes PP2AC in rabbit, mouse and Xenopus oocytes and...
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Báo cáo Y học: Assignment of molecular properties of a superactive coagulation factor VIIa variant to individual amino acid changes potx
... using the PhastSystem (Amersham Pharmacia) and followed by silver staining to check the purity of the FVIIa mutants and to verify their conversion to the activated, two-chain form Factor X (FX) and ... was measured for The inherent activity of the FX substrate and of the FVIIa/sTF mixture were subtracted and the net amount of factor Xa generated was derived from a standard curve The kinetic ... region in the regulation of the activity of free FVIIa, the rst dealing with the structural requirements for FVIIa to be in an active conformation [8], whereas the other tries to explain the effects...
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Báo cáo khoa học: Biochemical properties of the human guanylate binding protein 5 and a tumor-specific truncated splice variant Mark Wehner and Christian Herrmann doc
... dissociation constants for GDP and GppNHp [guanosine 5¢-(b,c-imino)-triphosphate], with Kd values of 11 and lm for hGBP5ta and 7.2 and 2.6 lm for hGBP5a ⁄ b, respectively For the non-hydrolysable ... from the relationship Kd = koff ⁄ kon Acknowledgements We thank Professor Dr Michael Sturzl for providing ¨ the cDNA for hGBP5, the Deutsche Forschungsgemeinschaft for financial support, and the ... are responsible for the lack of GMP formation (see Fig S2) The similar hydrolytic activities of the a ⁄ b and C-terminally truncated forms of hGBP5 are in contrast to that of the analogous deletion...
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Báo cáo khoa học: Frontal affinity chromatography analysis of constructs of DC-SIGN, DC-SIGNR and LSECtin extend evidence for affinity to agalactosylated N-glycans potx
... Man9GlcNAc2-methotrexate for DC-SIGN, Mana13Man-PA for DC-SIGNR and NGA2-Fmoc for LSECtin (Fig S2) As shown in Fig 1, the Bt and appKd values were 1.72 nmol and 49.4 lm for DC-SIGN, 4.25 nmol and 136.4 lm for DC-SIGNR, ... DC-SIGN and DC-SIGNR Also, the presence of the terminal GlcNAc at the GnT-I position was essential for LSECtin binding, and addition of the GlcNAc residue transferred by GnT-IV abolished the binding ... residue of the a1-6Man branch forms hydrogen bonds and ⁄ or van der Waals contacts (Asn311 and Phe313 of DC-SIGN; Asn323 and Phe325 of DC-SIGNR) In the case of LSECtin, for which neither crystallographic...
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Báo cáo khoa học: Mutational analysis of substrate recognition by human arginase type I ) agmatinase activity of the N130D variant pot
... N130D variant On the other hand, as a potential ligand for a primary amino group, Asp130 would contribute to the increased affinity of the mutant enzyme for agmatine and putrescine and, thus, to ... 2-fold) On the other hand, upon dialysis 5628 against EDTA, the N130Q variant behaved exactly as described for the wild-type species The presumed conformational change accompanying the Asn130 ... are indicated by the numbers on the right side The migration of the protein markers is indicated by pencil marks on the membrane The arrow indicates the position of the wild-type and N130D variants...
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Báo cáo khoa học: Characterization of the dimerization process of a domain-swapped dimeric variant of human pancreatic ribonuclease pdf
... the partial heat capacity of the protein relative to the heat capacity of the protein in the native state the monomerization of the dimer), and the latter process precludes the study of the former ... subunit and Arg104 residues of the other [8] In this dimer, the relative positions of the two subunits would prepare the molecule for the swapping of the N-terminal domain while, in the hinge ... dimeric forms in an aqueous solution On the other hand, these interactions could be more favoured in the crystal owing to the low dielectric constant of the precipitant solution BS-RNase and bovine...
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Báo cáo khoa học: Production and characterization of a noncytotoxic deletion variant of the Aspergillus fumigatus allergen Aspf1 displaying reduced IgE binding ppt
... of the A fumigatus allergen Aspf1 (Fig 8) On the other hand, there are essential residues for epitopes in Aspf1 that are changed in wild-type a-sarcin, as the response against the sera of the ... is still lower for the latter than for the Aspf1D(7–22) mutant (Tables and and Fig 8) In summary, the deletion mutant variant genetically engineered has lost its cytotoxicity and the NH2-terminal ... stability [7] as now observed for Aspf1 On the other hand, it is known that A fumigatus, the mold responsible for the production of Aspf1, grows optimally at 37 °C whereas the producer of a-sarcin,...
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Báo cáo khoa học: Molecular cloning and functional expression of the human sodium channel b1B subunit, a novel splicing variant of the b1 subunit potx
... cycles of 94 °C for s and 72 °C for min; five cycles of 94 °C for s and 70 °C for min; and 20 cycles of 94 °C for s and 68 °C for The RACE–PCR product was then cloned into the PCR-ScriptTM Amp Cloning ... placed on the slides for 30 Subsequently, the slides were washed in NaCl/Pi and the avidin–biotin complex (ABC; Vector Laboratories) was applied to the cells for 30 The presence of the primary ... for anchoring the protein into the membrane [14] Therefore, the additional extracellular region is probably responsible for the differences of regulatory functions between the b1B and b1 subunit...
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Báo cáo khoa học: "Text Summarization Model based on Maximum Coverage Problem and its Variant" pot
... of the word in the document cluster and the position of the word instance and others themselves are not novel, this work is the first to apply the greedy algorithm with performance guarantee, the ... an adversative effect on performance and therefore the coverage is important Table 5: ROUGE-1 of MCKP-Rel with interpolated weights The values in the parentheses are the corresponding values of ... is to find the binary assignment on xi with the best coverage such that the summary length is at most K: is, the words with high relevance to the topic of the document cluster They used the centroid...
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