combined cancer therapy by micellar encapsulated drugs and ultrasound
nanotechnology for cancer therapy, 2007, p.810
Ngày tải lên :
04/06/2014, 14:30
... 409 Vladimir P Torchilin q 2006 by Taylor & Francis Group, LLC Chapter 21 Combined Cancer Therapy by Micellar- Encapsulated Drugs and Ultrasound ... for Cancer The role and function of the services provided by NCL is supported by the NCI, and works in concert with the National Institute of Standards and Technology (NIST) and the U.S Food and ... Aliabadi, H M and Lavasanifar, A., Polymeric micelles for drug delivery, Expert Opin Drug Deliv., 3(1), 139–162, 2006 36 Rapoport, N., Combined cancer therapy by micellar- encapsulated drug and ultrasound, ...
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Báo cáo khoa học: Protein transport in chloroplasts ) targeting to the intermembrane space pptx
Ngày tải lên :
23/03/2014, 07:20
... of ATP- and timedemands for import of Tic22, MGD1 and SSU Import into intact pea chloroplasts was performed under standard conditions, by incubating in vitro synthesized [35S]pTic22 and [35S]pMGD1 ... temperature, followed by centrifugation at 256 000 g for 10 at °C The pellet and the supernatant were analyzed by SDS ⁄ PAGE and immunoblotting a-MGD1, a-Tic22, a-Tic110 and a-Toc75 were used ... CS150GX centrifuge and S150AT rotor (Hitachi, Tokyo, Japan) and resuspended in either 0.1 M Na2CO3 (pH 11.5) (lanes 3, 4, and 10), M urea (lanes 1, 2, and 8) or M NaCl (lanes 5, 6, 11 and 12) for 20...
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Báo cáo khóa học: Fidelity of targeting to chloroplasts is not affected by removal of the phosphorylation site from the transit peptide doc
Ngày tải lên :
23/03/2014, 12:20
... SSU and dual-targeted Arabidopsis CtRS and HtRS (A) The consensus phosphorylation motif described by Waegeman and Soll [13] (B) The transit peptides of tobacco and pea SSU and Arabidopsis CtRS and ... phosphorylation and n is a spacer of 0–3 residues (Fig 1A) Figure 1B indicates the phosphorylation motifs in the transit peptides of tobacco and pea preSSU, and the dualtargeted CtRS and HtRS from ... precursors were incubated with isolated pea chloroplasts, followed by reisolation of the organelles, and the proteins were analysed by SDS/PAGE and fluorography (Fig 2) Figure 2A shows the results for GFP...
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Báo cáo Y học: The C-terminal domain of perfringolysin O is an essential cholesterol-binding unit targeting to cholesterol-rich microdomains pptx
Ngày tải lên :
23/03/2014, 21:20
... between T144 and H145 in MCh and BCh (B) SDS/PAGE of purified toxin fragments and derivatives Toxin fragments (T2¢ and D4) were expressed in E coli and purified from the cytoplasmic fraction by a series ... lgÆmL)1 aprotinin and 20 lgÆmL)1 soybean trypsin inhibitor Then the TX-100soluble and -insoluble fractions were separated by centrifugation at 15 000 g for 15 and analyzed by Western blotting ... (V337-N472)-encoding region was pre- pared by digesting pNSP10 with SpeI and XhoI and inserting it between the NheI and XhoI sites on the 3¢ side of the sequence encoding His-tag and a thrombin-cleavage site...
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drug targeting, strategies, principles, and applications
Ngày tải lên :
10/04/2014, 22:17
... antibody by From: Methods in Molecular Medicine, Vol 25: Drug Targeting: Strategies, Principles, and Applications Edited by: G E Francis and C Delgado © Humana Press Inc., Totowa, NJ Ghetie and Vitetta ... that is 12 Ghetie and Vitetta recognized by the lectin receptor of the reticuloendothelial cells of the liver and spleen and is responsible for the liver toxicity of both RT and RTA (28) Therefore, ... secretarial and graphic work References Ghetie, V and Vitetta, E S (1994) Immunotoxins in the therapy of cancer: from bench to clinic Pharmacol Ther 63(3), 209–234 Thrush, G R., Lark, L R., and Vitetta,...
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Nanosized magnetofluorescent fe3o4–curcumin conjugate for multimodal monitoring and drug targeting
Ngày tải lên :
02/07/2014, 14:14
... carried out by Philips Intera 1.5 T MR scanner (Netherlands) with the slice thickness of mm on transversal and coronal planes, and using two sequences – T2weighted and T1-weighted Results and discussion ... localization was visualized by green fluorescence of Cur, actin proteins and nucleus were colored by Red Texas and blue respectively) Next, the uptake of the conjugate by human monocytes-derived ... of CSF–Cur by mouse macrophages (d) Phagocytosis of OLF–Cur by mouse macrophages (Nanoparticles localization is visualized by autofluorescence of Cur Actin is colored by Red Texas and nucleus...
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Báo cáo y học: "Nonimmunoglobulin E–Mediated Immune Reactions to Foods" pptx
Ngày tải lên :
08/08/2014, 21:20
... typical morphology, and distribution of the lesions In infancy, the face and the extensor surfaces of the arms and legs are most commonly affected In older children and adults, a scaly and lichenified ... lesions and healthy skin of patients with AD.16,17 Reekers and colleagues found that T cells isolated from the skin biopsy sites and peripheral blood react to foods related to birch pollen, and clinical ... FPIES has been reported from grains (rice, oats, and barley), vegetables (sweet potatoes, squash, string beans, and peas), and poultry (chicken and turkey).21 The only reported laboratory findings...
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báo cáo khoa học: "Adenovirus-mediated siRNA targeting Bcl-xL inhibits proliferation, reduces invasion and enhances radiosensitivity of human colorectal cancer cells" ppt
Ngày tải lên :
09/08/2014, 02:21
... cells was analyzed by MTT and colony formation assay The migration and invasion of CRC cells was determined by wound-healing and tranwell invasion assays Additionally, the in vitro and in vivo radiosensitivity ... and conformed by DNA miniprep and PacI digestion Plasmids from correct clones were amplified by transforming into DH5K cells Adenoviral DNA (Ad/shBcl-xL or Ad/shcontrol) was prepared by a standard ... project and drafted the manuscript MS participated in cell culture AZ and CL carried out the operation and participated in the data collection WD and ZW acted as corresponding author and made...
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Báo cáo y học: "CD134 as target for specific drug delivery to T cells in adjuvant arthritis" pps
Ngày tải lên :
09/08/2014, 06:22
... (Maastricht, The Netherlands) and were used between and 10 weeks of age The animals were kept under conventional conditions and had access to standard pelleted rat chow and acidified water ad ... stands for heat shock protein 60), Mt HSP60211–225 (AVLEDPYILLVSSKV) and OVA323–339 (ISQAVHAAHAEINEAGR) (OVA stands for Ovalbumin) were obtained from Isogen Bioscience (Maarssen, The Netherlands) ... provided by Dr GJ Strous (Department of Cell Biology R605 and Institute of Biomembranes, University Medical Center, Utrecht, The Netherlands) mAbs were isolated from hybridoma supernatant by affinity...
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Báo cáo y học: "Magnetically retainable microparticles for drug delivery to the joint: efficacy studies in an antigen-induced arthritis model in mice" doc
Ngày tải lên :
09/08/2014, 14:20
... NB and CAS helped to perform the experiments, design the study and draft the manuscript GP, P-AG, CG and ED helped to design the study, participated in the analysis and interpretation of data and ... perform the experiments and design the study, participated in the analysis and interpretation of data and helped to draft and critically review the manuscript All authors read and approved the final ... PBS-treated animals in the presence and absence of a magnet at days and after injection In groups treated with DXM suspension and microparticles embedding DXM and SPIONs, a diminution of the inflammation...
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báo cáo khoa học: "Reactive oxygen species-mediated apoptosis contributes to chemosensitization effect of saikosaponins on cisplatin-induced cytotoxicity in cancer cells" pdf
Ngày tải lên :
10/08/2014, 10:20
... cervical cancer cell lines HeLa and Siha, an ovarian cancer cell line SKOV3, and a non-small cell lung cancer cell line A549 were from American Type Culture Collection (ATCC, Manassas, VA, USA) and ... investigated We addressed this question by treating a cervical cancer cell line HeLa with SSa and cisplatin alone or both Cell death was detected and quantified by an LDH release assay While treatment ... ovarian cancer cell line SKOV3, and a lung cancer cell line A549 treated under similar experimental conditions (Figure 1E, 1F, and 1G) These results suggest that both saikosaponin-a and -d could...
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báo cáo khoa học: " The Washington Needle Depot: fitting healthcare to injection drug users rather than injection drug users to healthcare: moving from a syringe exchange to syringe distribution model" pps
Ngày tải lên :
11/08/2014, 18:21
... agencies delivering the service (PHS and VANDU) Further to the sudden closure and confiscation of the table, tent and needle exchange equipment, the police and city representatives argued that ... they demanded a written plan describing the longer-term vision for needle exchange for the City and a direct connection between needle exchange, treatment and detox By having seized and closed ... harm reduction and needle distribution by reiterating that: " prevention of HIV infection must be the mainstay of national, regional and international responses to the pandemic, and therefore...
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Báo cáo sinh học: " Anti-metastatic effects of viral and non-viral mediated Nk4 delivery to tumours" doc
Ngày tải lên :
14/08/2014, 19:22
... University Hospital Breast fund and Cork Cancer Research Centre SAC and JPvP are funded by Science Foundation Ireland MT is funded by the Health Research Board of Ireland, SFI and ICS http://www.gvt-journal.com/content/7/1/5 ... cellular and clinical implications in cancer Crit Rev Oncol Hematol 1999, 29:209-248 Matsumoto K, Nakamura T: NK4 (HGF-antagonist/angiogenesis inhibitor) in cancer biology and therapeutics Cancer ... analysed 100 μl mg/ml luciferin (Biosynth, Switzerland) was injected i.p and i.t Mice were anaesthetised by i.p administration of 100 μg xylazine and mg ketamine Ten minutes post-luciferin injection,...
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Báo cáo y học: "Custom astrocyte-mediated vasomotor responses to neuronal energy demand" pptx
Ngày tải lên :
14/08/2014, 21:20
... high (95%) O2, and that Volume 10, Issue 2, Article 209 LeMaistre and Anderson 209.2 mGluR-mediated vasoconstrictions can be converted to dilations by adding exogenous adenosine and PGE2 Overall, ... arachidonic acid (AA) formation (7) and vasoconstriction following 20-HETE production by cytochrome P450 ω-hydroxylase (8) and continuous prostaglandin E2 (PGE2) generation by cyclooxygenase (COX) (9) ... dictated by tissue metabolic status In this light, one can envisage a ‘see-saw’like balance between vasodilation and vasoconstriction with weight for vasoconstriction provided by 20-HETE and intracellular...
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Advanced control strategies for automatic drug delivery to regulate anesthesia during surgery
Ngày tải lên :
14/09/2015, 08:25
... compensation, handling of input and output constraints and drug minimization 1.2 Drugs and their Effect during Anesthesia • A well-designed drug administration policy should suppress the inter- and intra-individual ... disturbances and noise in the measured BIS Finally, MPC strategy was extended for the simultaneous regulation of hypnosis and analgesia by infusing propofol and remifentanil The infusion rates of both drugs ... caused by movements of the patients Relaxation is provided by administration of neuromuscular blocking agents (NMBs) and can be assessed by measuring the force of thumb adduction induced by stimulation...
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Báo cáo sinh học: " In vivo transcriptional targeting into the retinal vasculature using recombinant baculovirus carrying the human flt-1 promoter" potx
Ngày tải lên :
18/06/2014, 18:20
... evaluated by phase-contrast microscopy (a, e) and by anti-von Willebrand factor antibodies coupled to TRITC (red) and GFP green fluorescence Merge images illustrate the colocalization of red and green ... reactivation by butyrate (92.6 ± 2.8-Fold), followed by BUVECE6E7-1, and HEK-293 cells (33.4 ± 5.3 and 10.1 ± 3.6Fold, respectively) In an attempt to reactivate gene expression by DNA methylation ... VEGFR1 and VEGFR2 mRNA and Flt-1 protein have been localized to the inner nuclear and in the ganglion cell layer of the rat retina [40,41] By immunohistochemical staining with the von Willebrand...
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Báo cáo hóa học: " In vivo transcriptional targeting into the retinal vasculature using recombinant baculovirus carrying the human flt-1 promoter" docx
Ngày tải lên :
20/06/2014, 01:20
... evaluated by phase-contrast microscopy (a, e) and by anti-von Willebrand factor antibodies coupled to TRITC (red) and GFP green fluorescence Merge images illustrate the colocalization of red and green ... reactivation by butyrate (92.6 ± 2.8-Fold), followed by BUVECE6E7-1, and HEK-293 cells (33.4 ± 5.3 and 10.1 ± 3.6Fold, respectively) In an attempt to reactivate gene expression by DNA methylation ... VEGFR1 and VEGFR2 mRNA and Flt-1 protein have been localized to the inner nuclear and in the ganglion cell layer of the rat retina [40,41] By immunohistochemical staining with the von Willebrand...
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Báo cáo y học: "Blood autoantibody and cytokine profiles predict response to anti-tumor necrosis factor therapy in rheumatoid arthriti" pps
Ngày tải lên :
09/08/2014, 14:21
... HSP90, and BiP; hnRNP-A2/B1; histones H2A and H2B; and cartilage oligomeric matrix protein (COMP), vitronectin and fibronectin Candidate antigens were selected based on literature searches and screening ... cross-validation by which 90% of the training samples are randomly selected 10 times, followed by one -by- one class prediction of the remaining 10% of samples, thus identifying classification errors and overfitting ... etanercept therapy (equivalent to response ≥ ACR50 for the ABCoN and Swedish cohorts, and to response ≥ ACR70 for the Japanese cohort), and to predict lack of response to etanercept therapy (response...
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Tài liệu Báo cáo khoa học: Steady-state and time-resolved fluorescence studies of conformational changes induced by cyclic AMP and DNA binding to cyclic AMP receptor protein from Escherichia coli ppt
Ngày tải lên :
20/02/2014, 23:20
... F and Fcor are uorescence intensity before and after the correction, and P and DA denote the initial sample absorbance at the excitation wavelength and the change in absorbance introduced by ... 1ị where SD and SRF are the respective areas under the emission spectra of the donor and a reference compound, and ARF and AD are the respective absorbances of the reference compound and donor ... apo-CRP structure induced by binding of cAMP and DNA by measuring uorescence resonance energy transfer (FRET) and uorescence anisotropy decay Two tryptophan residues, Trp13 and Trp85, were used as...
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