colloidal carriers for drug delivery in dental tissue engineering

Báo cáo y học: "Magnetically retainable microparticles for drug delivery to the joint: efficacy studies in an antigen-induced arthritis model in mice" doc

... fixation in 4% formalin, all knee joints were cut in the sagittal direction After decalcification and embedding in paraffin, 4-μm sections were cut and stained with haematoxylin and eosin, Elastica ... results obtained for the uptake of 99mTc Discussion using a scale ranging from to sections for the total joint inflammation Histological grading of the knee4 using a scale ranging from to (-) indicates ... retention in the joint [4,5] due to the increased permeability of blood vessels in areas of inflammation [6] To overcome these limitations, we investigated magnetically retainable drug delivery...

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báo cáo khoa học: "Development of PEGylated PLGA nanoparticle for controlled and sustained drug delivery in cystic fibrosis" pptx

Danh mục: Báo cáo khoa học

... PLGA nanoparticles using ring-opening polymerization method, results in increased residence in blood (intravenous) or airway (intranasal) and enhanced accumulation in target tissues or cells [24] ... drug delivery vehicle we have tested the sustained release and delivery of FDA approved proteasome inhibitor drug, PS341 in murine lungs by its ability to control Pseudomonas aeruginosa LPS induced ... pulses) on ice in cold room using the T-PER (Pierce Biotech Inc., Rockford, IL) protein lysis buffer containing protease-inhibitor cocktail (Pierce) The protein extracts were suspended in Laemmli’s...

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nanoparticle technology for drug delivery, 2006, p.427

Danh mục: Vật lý

... issues in the manufacturing and biological application of nanoparticles Drug delivery scientists in industry, academia, and regulatory agencies, as well as students in biomedical engineering, chemical ... chemical engineering, pharmaceutical sciences, and other sciences with an interest in drug delivery, iii iv Preface will ﬁnd this book useful It can also be used as a textbook for drug delivery ... Depending on the route and purpose of drug delivery, the requirements for nanoparticulate systems can vary These aspects are discussed in Chapter for injectable delivery, Chapter for oral delivery, ...

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Báo cáo hóa học: " Human cytomegalovirus UL27 is not required for viral replication in human tissue implanted in SCID mice" ppt

Danh mục: Hóa học - Dầu khí

... xylazine (15 mg/kg) and the topical anesthetic proparacaine-HCL (0.5%) was instilled in the eyes A winged infusion needle containing mechanically dissociated human fetal retinal tissue was then inserted ... and this recombinant virus contains a deletion that eliminates the amino terminal 80% of the open reading frame starting just upstream of the start codon (coordinates 33021–34565 in X17403) Two ... used to inoculate SCID mice containing implanted retinal tissue or thymus/liver tissue [4] Briefly, four to eight week old male SCID mice were anesthetized with an i.p injection of ketamine (100...

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Báo cáo hóa học: "Single-component Polymer Nanocapsules for Drug Delivery Application" docx

Danh mục: Hóa học - Dầu khí

... polymer nanocapsules for tumor therapy via drug delivery They prepared drug- loaded polymer nanocapsules according to the outlined approach by preconjugating a model anticancer drug (Dox) to a model ... conditions resembling those within the living cells, nanocapsule uptake by LIM1215 human colorectal tumor cells, and delivery of the anticancer drug into the tumor cells, leading to tumor cell ... carboxypeptidase) with a nearlinear drug release kinetics over the ﬁrst 24 h ‘‘Moreover, for a drug delivery vehicle to be highly effective, it is desirable that it should not degrade in the blood stream;...

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SELF ASSEMBLY AND DRUG DELIVERY IN AMPHIPHILIC PEPTIDES MICROSCOPIC INSIGHTS FROM COARSE GRAINED SIMULATIONS

Danh mục: Kỹ thuật - Công nghệ

... spending precious time in examining my thesis and providing valuable comments I am thankful to A/Prof Yang Kun-Lin and A/Prof Chen Shing Bor for being the panel examiners in my oral qualifying ... dominant (54%) in the total driving force for bound state.119 The coarse-grained simulation also revealed the formation of pillar-like intermediates before forming final fiber.120 In summary, most ... secondary structures; with increasing leucine length, L5K also formed a nanofiber Therefore, a change in hydrophobic interaction and swapping of leucine with isoleucine could alter the shape and...

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Controlled release alginate based microparticulate systems for drug delivery and chemoembolization

Danh mục: Cao đẳng - Đại học

... alginate as particulate carriers for active pharmaceutical ingredients (APIs) For example, alginate microspheres had been developed as a drug delivery system (DDS) for many peptide and protein drugs ... washed before drying and milling Alginates are then extracted by heating the milled seaweed in mild alkali to convert the insoluble alginates in the seaweed to a soluble form The alginate extract ... conventional drug delivery systems such as injections, capsules and tablets, which necessitates frequent dose administration to maintain the drug concentration in the body within the therapeutic window In...

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Design and fabrication of microneedles for drug delivery

Danh mục: Cao đẳng - Đại học

... micromolding, wire electro discharge machining, laser machining, ion and electro beam machining and dicing were also exploited for miniaturization [19] The surface micromachining and bulk micromachining ... deliver insulin to diabetic hairless rats in vivo using the microneedles in Figure 2.2-(h) [14] The microneedle array was inserted into skin using a high-velocity injector A solution of insulin was ... designed for transdermal therapies to deliver drugs such as insulin and heparin On the other hand, microneedles can also be used for local delivery of other drugs, for example, drugs in anti-restenosis...

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Particle development for drug delivery

Danh mục: Cao đẳng - Đại học

... characteristics of the starting materials to the products Increasing milling energy input as indicated by the increasing rotational speed of the beater system resulted in the production of finer products with ... divided into stream and field scanning In stream scanning, particles are examined singly and its interaction with the measuring property of the instrument is taken as a measure of size, whereas in ... feed load for 101 the investigation of the air classifying system Table 11 Particle size of nifedipine batches prepared by sieving, milling 104 and micronisation Table 12 Formula codes for interactive...

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MATLAB FOR ENGINEERS – APPLICATIONS IN CONTROL, ELECTRICAL ENGINEERING, IT AND ROBOTICS doc

Danh mục: Kỹ thuật lập trình

... Note 10 MATLAB for Engineers – Applications in Control, Electrical Engineering, IT and Robotics that controller design in R MS using the feedback system as in Fig results in infinite spectrum ... examples of MATLAB usage from different areas of engineering and will be useful for students of Control Engineering or Electrical Engineering to find the necessary enlargement of their theoretical ... following results are valid in general for DPS given on compexshape definition domains in 3D both for continous or discrete distributed quantities, in the space relation as well In the time domain,...

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MATLAB FOR ENGINEERS – APPLICATIONS IN CONTROL, ELECTRICAL ENGINEERING, IT AND ROBOTICS pot

Danh mục: Kỹ thuật lập trình

... Note 10 MATLAB for Engineers – Applications in Control, Electrical Engineering, IT and Robotics that controller design in R MS using the feedback system as in Fig results in infinite spectrum ... examples of MATLAB usage from different areas of engineering and will be useful for students of Control Engineering or Electrical Engineering to find the necessary enlargement of their theoretical ... following results are valid in general for DPS given on compexshape definition domains in 3D both for continous or discrete distributed quantities, in the space relation as well In the time domain,...

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Báo cáo y học: "Endogenous and exogenous stem cells: a role in lung repair and use in airway tissue engineering and transplantation" pdf

Danh mục: Báo cáo khoa học

... hydrogel D networks containing a cell-binding site for ligation of cell-surface integrin receptors and substrates for MMPs, proteases implicated in wound healing and tissue regeneration [51,52] ... II and VI collagen bind matrix receptors (integrins) Type II collagen can also bind to anchorin CII, whereas fibronectin binds to integrins A large proteoglycan aggregate forms when multiple ... (Figure 1) They include structural matrix proteins (collagens, laminin, fibronectin, fibrin, etc.) and molecules modulating cell migration (integrins), cell-cell and cell-substrate interactions...

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Nanofabrication, architecture control, and crosslinking of collagen scaffolds and the potential in corneal tissue engineering application

Danh mục: Cao đẳng - Đại học

... goals in tissue engineering fields 2.2 Scaffold Materials The first issue with regard to tissue engineering is the choice of suitable materials for scaffolding The materials for tissue engineering ... a high-risk investment, more than $3.5 billion has been invested in worldwide research and development in tissue engineering [32, 33] Tissue engineering firms have increased spending at a compound ... AND CROSSLINKING OF COLLAGEN SCAFFOLDS AND THE POTENTIAL IN CORNEAL TISSUE ENGINEERING APPLICATION ZHONG SHAOPING (M.ENG INSTITUTE OF PROCESS ENGINEERING, CHINESE ACADEMIC SCIENCES, BEIJING, PRC)...

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Báo cáo hóa học: " The application of carbon nanotubes in target drug delivery systems for cancer therapies" docx

Danh mục: Hóa học - Dầu khí

... photoluminescence, afford additional advantages for tracking and real-time monitoring of drug delivery efficacy in vivo Intracellular drug delivery To study the cellular drug delivery, in vitro experiments ... surge in the number of publications in this interesting field Apart from their uses in the cellular imaging with diagnostic effects in nanomedicine [4,5], CNTs are promising drug carriers in the ... diseases [10] This delivery system provided the first instance for nanocarriers to deliver drugs into neurons in the central nervous system, opening the door for the drug delivery system for the treatment...

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báo cáo hóa học: " Beyond platinum: synthesis, characterization, and in vitro toxicity of Cu(II)-releasing polymer nanoparticles for potential use as a drug delivery vector" ppt

Danh mục: Hóa học - Dầu khí

... contained in the original loading solution determined Cu loading, resulting in values ranging between 12 and 16 wt.% based on these reactions conditions XPS was used to further confirm Cu loading ... 215 nm was determined via dynamic light scattering (DLS) ICP MS Cu-loading studies For Cu-loading studies, the Cu-loading solution containing CuSO4 and nanoparticles was dialyzed in 1.5 L of ultrapure ... the differences in modes of internalization for the two forms of Cu Free copper would be taken up by the cell via normal metal trafficking pathways that utilize metal-binding proteins located on...

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Báo cáo hóa học: " Investigation of utilization of nanosuspension formulation to enhance exposure of 1,3dicyclohexylurea in rats: Preparation for PK/PD study via subcutaneous route of nanosuspension drug delivery" doc

Danh mục: Hóa học - Dầu khí

... integrated in the model [27] to estimate the amount of drug entering the small intestine as a function of time M = D e−Ke(t) where M is the mass of the drug remaining in the stomach, D is the drug ... Nanopharmaceuticals in China Nano Biomed Eng 2009, 1(1):1-18 20 Liu Y, Miyoshi H, Nakamura M: Nanomedicine for drug delivery and imaging: a promising avenue for cancer therapy and diagnosis using targeted ... suitable formulations in time for a drug candidate’s in vivo evaluation remains a big challenge In general, formulations made at this early stage need to be prepared on a small scale using common...

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Báo cáo y học: "CD134 as target for specific drug delivery to T cells in adjuvant arthritis" pps

Danh mục: Báo cáo khoa học

... investigating in vitro binding and internalization contained 0.1 mol% Texas red-phosphatidylethanolamine (Molecular Probes Europe) Liposomes used for studying drug delivery in vitro and for the ... with drug- containing anti-CD134 liposomes Next, we investigated whether local targeting to CD134+ T cells in the joint-draining PLN would affect the course of actively induced arthritis in the ... a drug targeting system To investigate the possibility for therapeutic intervention in arthritis, antiCD134 liposomes were loaded with a cytostatic drug and administered early in actively induced...

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Development of multi functionalized polymeric carriers for delivery of anticancer drug combinations

Danh mục: Cao đẳng - Đại học

... 4.3.3 In vitro drug release and drug loading of singe drug- loaded micelles 82 4.3.4 In vitro drug release and drug loading of dual drug- loaded micelles 84 4.3.5 Cytotoxicity enhancement of drug- loaded ... in combination therapy depends on many factors such as the therapeutic mechanism of the drugs, the respond of certain cell lines to drugs, the combination ratio A combined chemo -drug system for ... requirements for an ideal drug delivery system as mentioned above Therefore, multifunctional delivery systems (Figure 1.6) which are aimed for working in a synergistic manner have been investigated in...

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Evaluation of advanced paclitaxel drug delivery implants for controlled release post surgical treatment against glioblastoma multiforme in the brain

Danh mục: Tổng hợp

... tissue before releasing them in the free form for tissue binding Another alternative would be for molecular modification of paclitaxel based on a pro -drug concept which inhibits tissue binding though ... affects drug transport from the implant through drug loss from interstial tissue across BBB into cerebral spinal fluid (CSF) circulation besides drug diluting effects due to CSF coming into the interstial ... on ice for 10 minutes before adding 50 µl of 2x Reaction Buffer (containing 10 mM DTT) to each sample µl of the mM DEVD-AFC substrate were then added before incubating at 37oC for hours before...

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Báo cáo khoa học: NovelN,N¢-diacyl-1,3-diaminopropyl-2-carbamoyl bivalent cationic lipids for gene delivery – synthesis,in vitro transfection activity, and physicochemical characterization docx

Danh mục: Báo cáo khoa học

... only a single amine in the polar headgroup, elicited transfection activity Addition of a second amine group and the subsequent increase in rM increased the Novel cytofectins for gene delivery ... cytofectins for gene delivery M Spelios and M Savva Cationic lipidpDNA binding studies Binding curves of EtBr-intercalated pDNA titrated with aliquots of cationic lipid dispersions are shown in Fig ... there was a reduction in plasmid compaction efciency with increasing hydrophobic chain length Interestingly, the transfection-inactive lipid 1,3lb1 was the most efcient at condensing pDNA, with complete...

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