clinical trials in retina
Tài liệu Clinical trials in gynecological cancer ppt
Ngày tải lên :
13/02/2014, 07:20
... valuable information for first-line therapy Infrastructure for clinical trials In the remainder of the article, we have set forward our thoughts on infrastructure issues to support clinical trials ... regulations Financial support for clinical trials The effective conduct of clinical trials requires a major commitment of time and other resources An ongoing commitment to clinical trials in gynecological ... clinical trials, and all the physicians and patients must be encouraged to participate in the trials increase into clinical trial recruitment, already exceeding the government set targets Gaining...
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Access to unapproved therapeutic goods Clinical trials in Australia pdf
Ngày tải lên :
07/03/2014, 08:20
... goods Clinical trials - an overview Classification of clinical trials Clinical trials of medicines Medical device trials Regulation of medicine and medical device clinical trials in Australia An Introduction ... 67 67 67 Reporting of adverse reactions during a clinical trial of medicines 69 Definitions Reporting of adverse reactions occurring in clinical trials Clinical trial event reporting algorithm ... Administration Classification of Clinical Trials Clinical Trials of Medicines Clinical trials of medicines are generally classified according to the phase of the medicine’s development While individual...
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Báo cáo y học: "Discontinuation rates in clinical trials in musculoskeletal pain: meta-analysis from etoricoxib clinical trial reports" ppt
Ngày tải lên :
09/08/2014, 10:23
... in clinical trials that is paramount There are few comparisons on which to draw, although it is generally assumed that discontinuation rates are higher in clinical practice than in clinical trials ... discontinuations with placebo in This does not prevent discontinuations from being a useful measure, perhaps as much or more so in clinical practice as in clinical trials, although discontinuations ... in clinical trials in rheumatology, as with meloxicam in ankylosing spondylitis [37] In clinical practice, discontinuation rates for adverse events and lack of efficacy has been used to distinguish...
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Báo cáo y học: " What have we learned from clinical trials in primary Sjögren’s syndrome about pathogenesis" ppsx
Ngày tải lên :
12/08/2014, 15:22
... Aproliferation-inducing ligand) – has not yet been studied in pSS Finally, briobacept – a fusion protein of IgG–Fc and the extracellular domain of the BAFF receptor – has not yet been used in clinical trials ... antibodies in pSS Surprisingly, instead of targeting this proinflammatory cytokine, IFNα itself has been used as a therapeutic agent in pSS Shiozawa and colleagues found an increase in saliva production ... labial salivary gland biopsies in nine patients showed a decrease in lymphocytic in ltration These data were confirmed in a phase II clinical trial in which oral IFNα (in lozenges of 150 IU three...
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Báo cáo khoa học: " Hemodynamic goals in randomized clinical trials in patients with sepsis: a systematic review of the literature" pptx
Ngày tải lên :
13/08/2014, 03:21
... monitoring may improve clinical research in the field of sepsis Key messages • Most sepsis clinical trials reviewed did not include hemodynamic goals of therapy Of note, the four largest clinical trials ... hemodynamic goals in clinical trials and whether this variation is associated with patient outcomes To better understand the hemodynamic goals in clinical trials in the sepsis research, and to inform future ... sepsis clinical trials has two major findings First, of the 126 clinical studies that were reviewed in full, 73% did not include hemodynamic goals of therapy Of the 13 studies that met our inclusion...
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The use of hypothesis-testing statistics in clinical trials
Ngày tải lên :
01/11/2013, 11:20
... often intuitively more understandable by clinicians Thus, it is typical for a clinical treatment study in psychiatry to be designed mainly 46 Chapter 8: Clinical trials to describe a change in depressive ... analyses in such a large sample The primary outcome of the study was a comparison of aspirin versus streptokinase for prevention of myocardial infarction, with a finding in favor of aspirin In subgroup ... kind of measurement, such as points on a depression rating scale This measurement can be defined in various ways; for example, it can reflect the actual change in points on a depression rating...
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Báo cáo sinh học: "Shipping blood to a central laboratory in multicenter clinical trials: effect of ambient temperature on specimen temperature, and effects of temperature on mononuclear cell yield, viability and immunologic function" potx
Ngày tải lên :
18/06/2014, 19:20
... shipping of blood in insulated containers by contracted overnight carriers is associated with large seasonal variations in temperature inside the packaging, ranging from -1°C in winter to 35°C in ... changes in temperature inside packages of blood specimens during shipping in the U.S., 2) changes in temperature inside packages simulating hot or cold ambient temperatures during shipping, and ... holder Each type of shipping container was tested for its ability to maintain temperature in cold ambient conditions (e.g.: during winter months) Forty heparinized vacutainers were filled with...
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Báo cáo hóa học: " The Reflux Disease Questionnaire: a measure for assessment of treatment response in clinical trials" pdf
Ngày tải lên :
18/06/2014, 22:20
... status Ascertaining the minimal clinically important difference Control Clin Trials 1989, 10:407-415 Juniper EF, Guyatt GH, Willan A, Griffith LE: Determining a minimal important change in a disease-specific ... instrument for assessing symptom severity and response to treatment in clinical trials of patients with GERD 10 11 12 Competing interests The authors declare that they have no competing interests 13 ... The baseline characteristics and clinical information for patients with data from both a baseline and subsequent visit are provided in Table GERD was proven in 82% of subjects while in 18% the...
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Báo cáo sinh học: " Biomarkers in T cell therapy clinical trials" potx
Ngày tải lên :
18/06/2014, 22:20
... integration of biomarker development from the preclinical through the clinical trial process T cell therapy clinical trials The concept of enhancing cellular immunity through the transfer of ex-vivo ... endogenous and infused T cells with equal efficiency, definitive quantification of infused cells using this approach is not possible This approach has been used in a number of clinical trials to evaluate ... evaluated and confirmed in primate models [64], and a number of clinical trials are being planned at multiple institutions that involve the specific transfer of memory cell populations into patients A...
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báo cáo hóa học:" Biomarkers in T cell therapy clinical trials" docx
Ngày tải lên :
20/06/2014, 04:20
... integration of biomarker development from the preclinical through the clinical trial process T cell therapy clinical trials The concept of enhancing cellular immunity through the transfer of ex-vivo ... endogenous and infused T cells with equal efficiency, definitive quantification of infused cells using this approach is not possible This approach has been used in a number of clinical trials to evaluate ... evaluated and confirmed in primate models [64], and a number of clinical trials are being planned at multiple institutions that involve the specific transfer of memory cell populations into patients A...
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Báo cáo khoa học: "rimary care patients in psychiatric clinical trials: a pilot study using videoconferencing" pps
Ngày tải lên :
08/08/2014, 23:20
... between the two disciplines in clinical research Primary care settings provide unique opportunities to improve the methodology of clinical trials Traditionally, clinical trials in depression primarily ... check -in from their primary care physician inviting them to participate in a study of the usefulness of telemedicine in evaluating patient symptoms Those who were interested in participating completed ... results as when administered face-to-face [11-20] The current study examined the feasibility of identifying, recruiting and screening primary care patients for clinical trials, and examined patient...
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Báo cáo y học: "An analysis of correlations among four outcome scales employed in clinical trials of patients with major depressive disorder" pdf
Ngày tải lên :
08/08/2014, 23:21
... antidepressants, including tricyclic antidepressants, selective serotonin reuptake inhibitors, and serotonin-norepinephrine reuptake inhibitors [5,6] The trials in this analysis all included patients ... Montgomery-sberg Depression Rating Scale, the Hamilton Depression Rating Scale and the Clinical Global Impressions Rating Scale in antidepressant clinical trials Int Clin Psychopharmacol 2002, 17:281-285 ... Montgomery-sberg Depression Rating Scale, the Hamilton Depression Rating Scale and the Clinical Global Impressions Rating Scale in antidepressant clinical trials: a replication analysis Int Clin Psychopharmacol...
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Báo cáo y học: "What should be the core outcomes in chronic pain clinical trials" ppt
Ngày tải lên :
09/08/2014, 01:23
... assessing multiple areas of functioning and well-being In addition to relieving clinical symptoms and prolonging survival, a primary objective of any intervention is improvement of functioning ... are what distinguish global ratings from other measures, and such ratings provide sufficient unique information to warrant inclusion in all clinical trials of treatments for chronic pain Symptoms ... Competing interests None declared Acknowledgement This paper is based on the consensus meeting of the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) held in...
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Báo cáo y học: "Tolerability and adverse events in clinical trials of celecoxib in osteoarthritis and rheumatoid arthritis: systematic review and meta-analysis of information from company clinical trial report" potx
Ngày tải lên :
09/08/2014, 06:22
... gastrointestinal adverse events, we included an overall measure of gastrointestinal tolerability as well as individual gastrointestinal adverse events of nausea, vomiting, abdominal pain, dyspepsia, ... anti-inflammatory drug Clinical ulcers and bleeds Clinical ulcers and bleeds in the company clinical trial reports were as reported by investigators, and were not subjected to independent, blinded ... company clinical trial reports Deeks and co-workers [29] examined 15,000 patients in nine of the earlier trials of celecoxib, and Edwards and co-workers [30] examined some 5,700 patients in nine trials...
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báo cáo khoa học: "Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents" ppt
Ngày tải lên :
10/08/2014, 22:20
... with ionizing radiation and other DNA-damaging agents in pre -clinical studies [75] Recent pre -clinical data have suggested that it may act, in part, by inhibiting DNA repair resulted in a synergistic ... hematological and solid malignancies Vorinostat clinical trials have been updated lately [13,74] This review focuses on recent development in clinical trials testing newer HDAC inhibitors as anti-tumor agents ... was concluded to have insufficient activity for further investigation in this patient population [96] Clinical trial in lung cancer exhibited minimal clinical efficacy Nineteen patients with...
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Can patient decision aids help people make good decisions about participating in clinical trials? A study protocol potx
Ngày tải lên :
11/08/2014, 05:21
... databases contain information on all institution-specific research projects, only non-industry studies labelled as clinical trials involving adults will be eligible for inclusion Principal investigators ... benefits might be attained when deciding whether to participate in a clinical trial Furthermore, the related findings that DAs improve understanding, that improved understanding can increase trial participation ... aids For information producers, the benefits of presenting DAs online include easy updating compared to print media, and easy dissemination via the internet [55] For patients, advantages include...
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báo cáo khoa học: " Can patient decision aids help people make good decisions about participating in clinical trials? A study protocol" pptx
Ngày tải lên :
11/08/2014, 16:21
... databases contain information on all institution-specific research projects, only non-industry studies labelled as clinical trials involving adults will be eligible for inclusion Principal investigators ... benefits might be attained when deciding whether to participate in a clinical trial Furthermore, the related findings that DAs improve understanding, that improved understanding can increase trial participation ... aids For information producers, the benefits of presenting DAs online include easy updating compared to print media, and easy dissemination via the internet [55] For patients, advantages include...
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Báo cáo y học: " Maintenance of response with atypical antipsychotics in the treatment of schizophrenia: a post-hoc analysis of 5 double-blind, randomized clinical trials" ppsx
Ngày tải lên :
11/08/2014, 16:23
... within the Eli Lilly and Company Clinical Trial Database, met inclusion criteria, including trial each comparing olanzapine to risperidone [13], quetiapine [14], and aripiprazole [15], and trials ... for time remaining in aripiprazole (p = 97) Olanzapine-treated patients had significantly more weight gain and triglyceride elevations in both studies Data regarding time maintaining response ... procedure Definitions Clinical response was defined as a ≥ 20% improvement over baseline PANSS1–7 Total score ("minimal clinical improvement." [11]) This threshold has been widely used in antipsychotic...
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