clinical pharmacology and toxicity typically 20 80 people

Báo cáo khoa học: " Inverse planned stereotactic intensity modulated radiotherapy (IMRT) in the treatment of incompletely and completely resected adenoid cystic carcinomas of the head and neck: initial clinical results and toxicity of treatment" potx

Ngày tải lên : 09/08/2014, 10:21

... treatment planning for tumors of the head and neck region: clinical implementation of the step and shoot approach and first clinical results Radiother Oncol 200 3, 66(3):313-321 Thilmann C, Zabel ... were seen regularly for clinical examination during and after radiation therapy Acute toxicity was specified according to the Common Toxicity Criteria (CTC) during treatment and months afterwards ... regimen All in all, acute and late side-effects were negligible in this study so far No grade IV toxicity was seen, and only 20% of the patients developed a grade III toxicity of the mucosa These...

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báo cáo khoa học: "CyberKnife for hilar lung tumors: report of clinical response and toxicity" potx

Ngày tải lên : 10/08/2014, 22:21

... esophagus and mainstem bronchus were 25 Gy (range, 11 - 39 Gy) and 42 Gy (range, 30 - 49 Gy), respectively Early Clinical and Radiographic Response All patients underwent clinical follow-up, and 14 ... declines in the maximum standardized uptake values (Figure 1) Local Control and Survival Despite excellent early clinical and radiographic responses, local control and survival outcomes beyond ... encouraging early clinical responses, acceptable acute toxicity and reliable palliation However, local control at year remains poor despite aggressive radiation doses and life threatening late toxicity...

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A textbook of clinical pharmacology and therapeutics

Ngày tải lên : 11/12/2016, 22:08

... receptors and key signal transduction elements, in cells and in transgenic animals, and are revolutionizing these areas and hopefully improving the relevance of preclinical pharmacology and toxicology ... of Pharmacology and Toxicology 200 5; 45: 1–25 Lin JH, Lu AY Interindividual variability in inhibition and induction of cytochrome P450 enzymes Annual Review of Pharmacology and Toxicology 200 1; ... 51 Drugs and the skin 411 167 PART XIII THE EYE 421 175 52 Drugs and the eye 423 177 185 196 204 211 217 PART XIV CLINICAL TOXICOLOGY 431 53 Drugs and alcohol abuse 54 Drug overdose and poisoning...

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Tài liệu Clinical Physiology and Pharmacology The Essentials ppt

Ngày tải lên : 17/01/2014, 06:20

... John Wiley & Sons, Ltd., Publication Clinical Physiology and Pharmacology Clinical Physiology and Pharmacology The Essentials Farideh Javid Division of Pharmacy and Pharmaceutical Sciences, School ... should be able to: • understand and describe the signs and symptoms of the disorder in question and its underlying pathophysiology; • understand and describe the pharmacology of agents currently ... STUDY 31 Carmen’s repeated respiratory infections CASE STUDY 32 Chandra’s chronic bronchitis 201 201 204 206 210 213 217 221 Kidney and body ﬂuid disorders CASE STUDY 33 Greg’s glomerulonephritis...

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Tài liệu CLINICAL PHARMACOLOGY 2003 (PART 20) ppt

Ngày tải lên : 26/01/2014, 19:20

... in anaesthesia were in the 20th century when the appearance of new drugs both as primary general anaesthetics and as adjuvants (muscle relaxants), new apparatus, and clinical expertise in rendering ... with analgesia and muscular relaxation) with a single drug requires high doses that will cause adverse effects such as slow and unpleasant recovery, and depression of cardiovascular and respiratory ... nervous and cardiovascular systems and there is considerable potential for interaction with anaesthetic drugs The techniques for giving anaesthetic drugs and the control of ventilation and oxygenation...

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Tài liệu Time trends in leisure time physical activity and physical fitness in elderly people: 20 year followup of the Spanish population national health survey (1987-2006) docx

Ngày tải lên : 14/02/2014, 06:20

... national and regional levels the following samples of adult aged 15 years and older were selected in the SNHS: 29,647 in 1987; 20, 707 in 1993; 21,058 in 200 1; 21,650 in 200 3; and 29,478 in 200 6 Surveys ... WOMEN: Spanish National Health Surveys (SNHS) 1987, 1993, 1995-7, 200 1, 200 3 and 200 6 SNHS 1987 SNHS 95-97 SNHS 200 1 SNHS 200 3 SNHS 200 6 N = 2,137 N = 1,303 N = 2,494 N = 3,830 N = 5,022 72.3 (0.15) ... 84.6 84.4 80. 5 77.3 ≥ 80 14.7 15.3 15.4 15.6 19.5 22.7 Marital status Unmarried/widow/divorced 20. 8 22.7 20. 2 19.4 19.0 20. 0 Married or living with couple 79.2 77.3 79.8 80. 6 81.0 80. 0 30.4 Educational...

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Tài liệu Clinical Physiology and Pharmacology The Essentials docx

Ngày tải lên : 17/02/2014, 05:20

... John Wiley & Sons, Ltd., Publication Clinical Physiology and Pharmacology Clinical Physiology and Pharmacology The Essentials Farideh Javid Division of Pharmacy and Pharmaceutical Sciences, School ... should be able to: • understand and describe the signs and symptoms of the disorder in question and its underlying pathophysiology; • understand and describe the pharmacology of agents currently ... STUDY 31 Carmen’s repeated respiratory infections CASE STUDY 32 Chandra’s chronic bronchitis 201 201 204 206 210 213 217 221 Kidney and body ﬂuid disorders CASE STUDY 33 Greg’s glomerulonephritis...

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Toxicology and Clinical Pharmacology of Herbal Products pdf

Ngày tải lên : 06/03/2014, 14:20

... Analysis 220 19.7 Regulatory Status 220 Page xx Chapter 20: Licorice Michael Newton and Melanie Johns Cupp 223 20. 1 History and Traditional Uses 223 20. 2 Current and Promoted Uses 223 20. 3 Products ... Regulatory Status 200 Chapter 18: Comfrey David Burch and Melanie Johns Cupp 203 18.1 History and Traditional Uses 203 18.2 Current Promoted Uses 204 18.3 Products Available 204 18.4 Pharmacologic/Toxicologic ... Pharmacologic/Toxicologic Effects 204 18.4.1 Gastrointestinal Effects 205 18.4.2 Hepatotoxicity 205 18.4.3 Carcinogenicity/Mutagenicity 206 18.4.4 LD50 207 18.5 Case Reports of Toxicity Due to Commercially...

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situation of using clinical services and effectiveness of health care model for elderly people rely on medical facilities in binh duong

Ngày tải lên : 25/07/2014, 14:07

... access to and use of medical services for elderly people and ability of commune health stations to meet the demand in Binh Duong 3.1.1 Some characteristics and living conditions of elderly people ... on facility health in Binh Duong province (201 0 -201 1) * The new contribution of the thesis: - Described the situation demands, access to and use of clinical services (CL) of EL in Binh Duong ... in 200 0 202 5 will be estimated over billion EL, accounting for 14% of the total world population And in 204 5, the first time in human history, population density in children (0-14 years) and...

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Báo cáo y học: " Bench-to-bedside review: Molecular pharmacology and clinical use of inert gases in anesthesia and neuroprotection" ppt

Ngày tải lên : 13/08/2014, 20:22

... 80: 255-256 64 Yentis SM, Hirsch NP, Smith GB: Anaesthesia and Intensive Care A–Z An Encyclopaedia of Priciples and Practice Edinburgh: Elsevier; 200 4:271 Dickinson and Franks Critical Care 201 0, ... following injury Figures adapted from: (a) Fries and colleagues [78], (b) Homi and colleagues [5], (c) Ma and colleagues [75], and (d) Coburn and colleagues [77] the plasmalemmal KATP channel ... following sources: aCRC Handbook of Chemistry & Physics [107] bSelovar [108] cTrudell and colleagues [106] dRoth and Miller [109] Dickinson and Franks Critical Care 201 0, 14:229 http://ccforum.com/content/14/4/229...

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Cambridge.University.Press.Upper.Motor.Neurone.Syndrome.and.Spasticity.Clinical.Management.and.Neurophysiology.Jun.2008.pdf

Ngày tải lên : 21/09/2012, 11:02

... Johnson and Anand D Pandyan Physiotherapy management of spasticity 79 Roslyn N Boyd and Louise Ada Seating and positioning 99 Craig A Kirkwood and Geoff I Bardsley Orthoses, splints and casts ... elicited by ankle movement (Schmidt et al., 200 2) and knee extension (Wu et al., 200 6) In animals (Harris & Clarke, 200 3) and in humans (Anderson et al., 200 4) with spinal cord lesions, the receptive ... internally rotated arm with pronated forearm and flexed wrist and fingers The leg is extended, internally rotated and adducted, and the ankle is plantar flexed and inverted, often with toe flexion Other...

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CLINICAL PHARMACOLOGY 2003 (PART 25B)

Ngày tải lên : 18/10/2013, 00:15

... reduction in mortliaty and reinfarction in patients surviving acute myocardial infarction New England Journal of Medicine 304: 803 — a classic O'Brien E et al 200 0 Use and interpretation of ambulatory ... spasm) and reduce afterload (dilate peripheral arterioles) These classes of drug complement each other and can be used together The combined nitrate and potassium-channel activator, nicorandil, ... high-dose simvastatin (20- 10 mg/d) and pravastatin (40 mg/d) Patients with previous MI constituted onethird of the Heart Protection Study of 205 36 highrisk patients Those randomly assigned to simvastatin...

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CLINICAL PHARMACOLOGY 2003 (PART 28)

Ngày tải lên : 24/10/2013, 19:15

... gland is a mixture of capsular and stromal tissue, rich in (a-adrenoceptors, and glandular tissue under the influence of androgens Both these, the a-receptors and androgens, are targets for drug ... within an hour and diuresis lasts up to hours Enormous urine volumes can result and overtreatment may lead to hypovolaemia and circulatory collapse Given i.v it acts within 30 minutes and can relieve ... ml/min or less The dose is 20- 120 mg by mouth per day; i.m or i.v 20- 40 mg is given initially For use in renal failure, special high dose tablets (500 mg) are available, and a solution of 250 mg...

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CLINICAL PHARMACOLOGY 2003 (PART 29)

Ngày tải lên : 24/10/2013, 19:15

... angioplasty and benefit is maintained up to years The dose causes and maintains blockade of > 80% receptors, causing > 80% reduction in aggregation Patients also receive aspirin and heparin and if ... IX and X (and also the anticoagulant regulatory proteins C and S) in the liver, active vitamin K (KH2) is oxidised to an epoxide and must be reduced by the enzymes vitamin K epoxide reductase and ... 227-231 Vandenbroucke J P et al 200 1 Oral contraceptives and the risk of venous thrombosis New England Journal of Medicine 344:1527-1535 Weitz J11997 Low-molecular-weight heparins New England Journal...

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CLINICAL PHARMACOLOGY 2003 (PART 30)

Ngày tải lên : 29/10/2013, 02:15

... (see above) but its use (200 mg/day) is not clinically important in routine therapy; desferrioxamine binds iron and reduces absorption (see Poisoning, below); tea (tannins) and bran reduce absorption ... cause the patient to abandon 589 29 CELLULAR DISORDERS AND ANAEMIAS therapy A small dose may be given at first and increased after a few days The objective is to give 100 -200 mg of elemental iron ... Treatment of acute iron poisoning is urgent and immediate efforts must be made to chelate iron in the blood and in the stomach and intestine Raw egg and milk help to bind iron until a chelating...

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CLINICAL PHARMACOLOGY 2003 (PART 31)

Ngày tải lên : 29/10/2013, 02:15

... nausea and vomiting, and bone marrow depression (delayed with carmustine and lomustine), cystitis6 (cyclophosphamide, ifosfamide) and pulmonary fibrosis (especially busulfan) Male infertility and ... drugs currently in clinical use appears in Table 30.2 Table 30.3 provides detail of toxicity of individual agents The following is an overview of the mode of action and toxicity and use of the principal ... particularly incriminated and also some antimetabolites (mercaptopurine) and cytotoxic antibiotics (doxorubicin) The risk can be as high as 10 -20 times that of unexposed people and the cancers include...

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CLINICAL PHARMACOLOGY 2003 (PART 32)

Ngày tải lên : 08/11/2013, 01:15

... action/comment CTZ and gut CTZ and gut CTZ Vomiting centre and CTZ CTZ and gut Vomiting centre and gut Gut (vomiting due to cytotoxics) and in the gastrointestinal tract Phenothiazines and butyrophenones ... diarrhoea, tiredness and muscular pain Bradycardia and cardiac conduction defects may also occur Cimetidine is a weak antiandrogen, and may cause gynaecomastia and sexual dysfunction in males In the elderly ... including lethargy, confusion and hallucinations Cimetidine inhibits cytochromes P450, in particular CYP 1A2 and CYP 3A4 and there is potential for 627 31 OESOPHAGUS, STOMACH AND DUODENUM increased...

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CLINICAL PHARMACOLOGY 2003 (PART 33)

Ngày tải lên : 08/11/2013, 01:15

... is modulated by cyclic AMP and GMP, calcium, prostaglandins and leukotrienes DIARRHOEA Diarrhoea results from an imbalance between secretion and reabsorption of fluid and electrolytes; it has ... than people with normal bowel habit, and patients with constipation have more Antimotility drugs (see below) reduce diarrhoea by increasing segmentation and inhibiting peristalsis FLUID AND ELECTROLYTE ... always be excluded by stool microscopy and culture, and testing for Clostridium difficile toxin Measures to correct anaemia, fluid and electrolyte abnormalities and to improve the general nutritional...

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CLINICAL PHARMACOLOGY 2003 (PART 34)

Ngày tải lên : 08/11/2013, 01:15

... its constipating effect alone Aspirin and other NSAIDs may exacerbate impaired renal function and fluid retention by inhibiting prostaglandin synthesis and may also precipitate gastrointestinal ... gastric varices and half die from complications of their first bleed Hypovolaemia must be corrected with plasma expanders and blood transfusion Sepsis is common; the incidence rises from 20% at 48 ... through the gut Neomycin and metronidazole both inhibit ureaseproducing bacteria and are useful, but their longterm use is limited by toxicity HEPATITIS 11 pressives Some 80% will benefit from prednisolone...

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Tài liệu CLINICAL PHARMACOLOGY 2003 (PART 1) docx

Ngày tải lên : 15/12/2013, 12:15

... Clinical Pharmacology The world of clinical pharmacology has greatly changed since 1957 when I took up my pen, and I wish my successors well D R Laurence, Professor Emeritus of Pharmacology and ... four and between the ages of 20 and 45 years a lowermiddle-class man experiences approximately one life-endangering illness, 20 disabling (temporarily) illnesses, 200 non-disabling illnesses and ... basis and practice of drug therapy It is particularly intended for medical students and doctors, and indeed for anyone concerned with evidence-based drug therapy and prescribing The scope and rate...

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