classify the severity of the blockage
Tài liệu Báo cáo khoa học: Investigation and prediction of the severity of p53 mutants using parameters from structural calculations pptx
... advantage of p53 mutation analysis, and a unique feature of this database, is the availability of the residual activity of the majority of p53 missense mutants The biological activity of mutant ... the cross indicates the cut-off value used in PREDMUT The limit between the classes was set to the activity value of 25%, because this value was observed to be a natural divider of the data The ... favour of a severe mutant At the other end of the spectrum, where we have low energy, there is 75% probability for the mutation to be nonsevere if the energy is 0.125 or lower Thus, on the basis of...
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Tài liệu Báo cáo khoa học: Induction of uPA gene expression by the blockage of E-cadherin via Src- and Shc-dependent Erk signaling docx
... suppressed the disruption of cell–cell adhesion, the scattered phenotype of the cells and the redistribution of E-cadherin into the cytoplasm (Fig 5C) C a b c d e f g h i j k l B Fig Involvement of Src ... Shc isoforms, which carry silent mutations at the targeting site of the siRNA These cell lines were further used for siRNA transfection to knockdown the endogenous proteins without affecting the ... and results in the recruitment of the Grb2–son of sevenless (Sos) complex to the vicinity of Ras, where Sos acts as a GTP exchange factor for Ras In contrast, 228 the largest isoform p66Shc has...
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Báo cáo y học: "Complement C3 serum levels in anorexia nervosa: a potential biomarker for the severity of disease" pdf
... several components of the complement cascade and analyzed the activities of the alternative complement activation pathways [24] Serum levels of C3, Factor B and D, hemolytic activity of the alternative ... manuscript CSL reviewed the manuscript All authors contributed to the revisions of the text and approved the final version of this manuscript Competing interests The authors declare that they have no competing ... progression of disease [4,12] Complement represents one of the phylogenetically oldest cascade systems As an important effector of the innate immune response, the complement system represents the ‘first...
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Báo cáo y học: "The angiogenesis inhibitor protease-activated kringles 1–5 reduces the severity of murine collagen-induced arthritis" ppsx
... to assess the effect of K1–5 on established CIA, treatment was commenced from the first day of the onset of the clinical symptoms of arthritis, which was considered to be the day when the first ... which shows the absolute values for the clinical scores (a composite index of disease severity and the number of limbs affected) and the paw thickness In order to normalize the data, these parameters ... adjuvant (Difco, Detroit, MI, USA) at the base of the tail The first clinical signs of arthritis, as assessed by oedema and/or erythema involving any of the paws, appeared between days 14 and...
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Báo cáo y học: "THR0921, a novel peroxisome proliferator-activated receptor gamma agonist, reduces the severity of collagen-induced arthritis" pps
... removed, and 100 µl of dimethyl sulphoxide were added The plates were agitated in the dark for 10 minutes to dissolve the MTT formazan crystals The absorbance of the samples was then recorded at ... condition Data are presented as the percentage of the cells cultured with medium alone The results are displayed as the mean ± standard error of the mean (SEM) of three separate experiments Enzyme-linked ... ∆∆CT value was then calculated by subtracting the ∆CT value of the control from each group Fold changes compared with the control were then determined by raising to the ∆∆CT power The primer pairs...
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Báo cáo khoa học: " SemiCytokines levels, Severity of acute mucositis and the need of PEG tube installation during chemo-radiation for head and neck cancer a prospective pilot study" ppt
... the wells and color developed in proportion to the amount of the cytokine bound in the initial step By comparing the optical density of the samples to a standard curve, the concentration of the ... Radio-chemotherapy leads to various side effects in the irradiated area These side effects are acute and chronic, and have an influence on the quality of life of the patients [14] Mucositis is one of the ... answer to the question of the relationship between levels of IL-6 and IL-8 and severity of mucositis during and after radiotherapy In addition, it should be emphasized that because of the small...
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Báo cáo y học: "Ischemic preconditioning reduces the severity of ischemia-reperfusion injury of peripheral nerve in rat" pptx
... shows the scores in the groups MDA levels in sciatic nerve During the occlusion of aorta and iliac arteries, the measurements of femoral blood pressure aproximated to zero values in rats of all the ... reperfusion A total of 70 rats were used in the study The study was divided into two part Part included the biochemical examination of Ischemia, I/R and I/R+IP on sciatic nerves of rats at the early period ... rapid release, when needed Measurements of the femoral blood pressure (BP) were used to monitor the completeness of the occlusion, and direct inspection of the sciatic nerve epineurial vessels showed...
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Báo cáo y học: "Neurophysiological study to assess the severity of each site through the motor neuron fiber in entrapment neuropathy" potx
... peak of the M-wave Motor distal latency (MDL) was obtained from the onset latency of the M-wave The latency between the anterior cells and the muscle was calculated according to the formula of ... muscle from the onset latency of MEPcr The latency from the anterior horn cells to the rootlet (CRL) was calculated by subtracting the onset latency of the MEPcv from the latency between the anterior ... and colleagues found that the extent of the retrograde changes correlated with the degree of CTS severity [28] The sensory fibers of the median nerve that transverses the carpal tunnel originates...
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Báo cáo y học: " Repetition and severity of suicide attempts across the life cycle: a comparison by age group between suicide victims and controls with severe depression" ppsx
... controls A majority of the suicide attempts were made in close connection to admission (often a cause of admission), 89% of the suicide attempts in the suicide group and 84% in the control group ... assumed, but not proven Time of the suicide attempt and thus age at the event could be stated with certainty in 84% of the controls and 89% of the suicide victims, as the attempts were made in connection ... attempts in older age The case records were performed for a thorough evaluation of the suicide victims and matched controls from the total sample, in which the rater was unaware of the suicidal outcome...
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Báo cáo y học: " A polymorphism in the interleukin-4 receptor affects the ability of interleukin-4 to regulate Th17 cells: a possible immunoregulatory mechanism for genetic control of the severity of rheumatoid arthritis" doc
... basis of the rate of accumulation of joint damage over a specific interval of time, and therefore an effect of I50V on severity may have been overlooked The pattern of IL-17 suppression seen in the ... http://arthritis-research.com/content/13/1/R15 Page of the healthy control group genotypes There was a more pronounced suppression of the percentage of IL-17+ cells in the I/I genotype culture, as shown in the top row of Figure 3A, ... significant decrease in the measured IL-17 level with the addition of IL-4 to the Th17-stimulatory conditions (Figure 1) We then further examined these groups by specific genotype In the I/I genotype...
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Báo cáo y học: "Outcome after acute respiratory failure is more dependent on dysfunction in other vital organs than on the severity of the respiratory failure" ppt
... discharged from the ICU, data were entered into the clinical database by one of the ICU physicians (HF) and processed using the equations for the SOFA score For a single missing value (most often thrombocytes ... was calculated using the mean value of the results on either side of the absent result When there was no obvious central nervous system dysfunction or cerebral pathology, the Glasgow Coma Scale ... most common cause of death in the ICU The majority of such patients also have severe ARF, and often ALI or ARDS The mortality rate in severe respiratory failure is therefore often caused by combined...
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Báo cáo khoa học: "Performance of six severity-of-illness scores in cancer patients requiring admission to the intensive care unit: a prospective observational study" pot
... 76% died in the hospital [33] In the present cohort about 37% of patients received MV Whether studying the entire population or the subgroup of nonscheduled surgical patients, all of the general ... coworkers [14] analyzed the impact of sample size on the accuracy of MPM II models by performing computer simulations They showed that the smaller the sample size, the better the model calibration, ... curves for the six severity- of- illness scores (solid lines) for the sample (excluding scheduled surgical patients; nn= 542) The diagonal dotseverity -of- illness scores (solid lines) for the sample...
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Báo cáo khoa học: "Bench-to-bedside review: Oxygen debt and its metabolic correlates as quantifiers of the severity of hemorrhagic and posttraumatic shock" pptx
... quantifier of severity of posttrauma hemorrhagic shock, Siegel [29], Rutherford [47], Davis [50], and Rixen [49] and their groups studied the value of BD as a single predictor of the severity of post-trauma ... Survival Survival Survival Survival MOF, sepsis MOF, ARDS Survival MOF MOF, ARDS Intracranial pressure MOF, survival Survival MOF Survival Survival MOF MOF MOF MOF, survival Infection, survival ‘Postoperative ... reflect well the severity of shock or the effectiveness of volume resuscitation However, these endpoints are well defined in a quantitative manner by the magnitude of the O2D and by its rate of resolution...
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Báo cáo khoa học: "Luminal concentrations of L- and D-lactate in the rectum may relate to severity of disease and outcome in septic patients" ppt
... early shock [21] These discrepancies currently cannot be explained The novelty of the present study is the set of additional measurements of luminal values of L- and D-lactate The much higher ... independent of the site of infection More importantly, these changes correlated to severity of disease and outcome This indicates that elevated luminal concentrations of L- and D-lactate are markers of ... unaffected by hyperlactataemia [8] Others have proposed the plasma values of the D-isoform of lactate, which is a metabolic product of luminal bacteria, as a possible marker of intestinal perfusion disturbances...
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Báo cáo y học: "Role of the eosinophil count in discriminating the severity of community-acquired pneumonia in HIV-infected patients" pps
... patients Moreover, the prognostic value of eosinopenia was not tested We therefore cannot ascertain the value of this marker to predict mortality in the ICU Concerning the severity of infection, Perello ... because of the suggested floor effect of eosinopenia Furthermore, in the study of Perello and colleagues there was no noninfection group enrolled (HIV patients without CAP) to test the value of eosinopenia ... the emergency department point of view – departments that usually are overcrowded [2] – any tool that allows the physicians to better approach the severity of the infections in general, and the...
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Báo cáo y học: "The impact of the severity of sepsis on the risk of hypoglycaemia and glycaemic variability" ppt
... using the Statistica 8.0 software (StatSoft Inc., USA) Results Comparison of the severity of sepsis Table shows the baseline characteristics according to the severity of sepsis and table shows the ... to the ICU during the same hospital admission, duration of the septic episode for the groups stratified by the severity of sepsis, length of mechanical ventilation, length of stay (LOS), and ... analysis of the mean BG level per day is sufficient and appropriate for the analysis of BG dynamics The aim of this study was to analyse the quality of BG control using different parameters and the...
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Báo cáo y học: "Is cost-effectiveness analysis preferred to severity of disease as the main guiding principle in priority setting in resource poor settings" doc
... study population We then explored the general view of the consideration of cost-effectiveness of interventions or severity of disease by asking whether or not the respondents felt they were important ... interviews with the development partners Whereas the vast majority of the survey respondents preferred severity of disease to cost-effectiveness of intervention as the guiding principle, most of the development ... respondents, both from the in-depth interviews and the survey, gave reasons for their choices These are presented in Table Most of the survey respondents' favoured severity of disease as the guiding principle...
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Báo cáo y học: "The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsis" ppt
... human patients at the time of emergency department (ED) presentation with the goal of gaining further insights into the activation state of the endothelium in different stages of sepsis To that ... correlate with the degree of severity Since PAI-1 is largely restricted in its expression to endothelial cells, these findings add further support to the conclusion that the endothelium becomes ... transformed throughout the analysis As a comparator, we also examined the correlation of IL-6 and serum lactate with SOFA score Next, to compare the strength of association between each of the biomarkers...
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Báo cáo y học: " Can ‘permissive’ hypercapnia modulate the severity of sepsis-induced ALI/ARDS" doc
... sepsis-induced ALI/ARDS These studies reveal the importance of severity, site, and stage of the infective process, the need for antibiotic therapy, and the utility of buffering the hypercapnic acidosis ... suppress the immune response, although the net effect of its multiple actions appears to vary depending on the site of infection Page of and also on whether the acidosis produced by the hypercapnia ... to enhance the antigen presenting capacity of dendritic cells [30] The net effect of these contrasting actions of metabolic acidosis on the adaptive immune response is unclear However, the demonstration...
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Streptococcus pneumoniae Coinfection Is Correlated with the Severity of H1N1 Pandemic Influenza
... also at higher risk for more severe disease in the context of H1N1pdm, we compared the severity of disease in subjects ,6 years of age or 55 years of age MassTag PCR assays MassTag PCR detected ... selected at ANLIS by review of deidentified clinical information provided to ANLIS from hospital and point -of- care institutions on the basis of their review of charts in their own institutions INEI ... coinfection, the total number of bacterial or viral agents detected in NPS, and the presence of a medical risk factor All variables were checked for correlation with each other and with the disease severity...
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