cimetidine—a rational approach to drug design
MDA: A Formal Approach to Game Design and Game Research ppt
... iterative approach to design and tuning It allows us to reason explicitly about particular design goals, and to anticipate how changes will impact each aspect of the framework and the resulting designs/implementations ... it would be beneficial to prototype a simple game-based AI for tag Your player will be a babysitter, who must find and put a single baby to sleep The demo will be designed to show off simple emotive ... discussion of dynamics to remain as concrete as possible By developing models that predict and describe gameplay dynamics, we can avoid some common design pitfalls Too Cold! Too Hot! Controller...
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Báo cáo hóa học: "Research Article A Novel Approach to the Design of Oversampling Low-Delay Complex-Modulated Filter Bank Pairs" doc
... function To this end, the AFB (or SFB) FIR prototype filter is designed subject to the stopband magnitude constraints, as given by [7], while the SFB (or AFB) prototype filter is fixed to the design ... Prototype Filter To complete the FBP design we present an example for the narrow-band FIR low-pass SFB prototype filter designed by the procedure in Section This SFB prototype filter is matched to ... factor is M = 16, resulting in an oversampling factor of O = 5.1 AFB Prototype Filter First we start with the design of a narrow-band FIR low-pass AFB prototype filter with low group delay designed...
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Báo cáo y học: "A rational approach to cancer therapy" pot
... frameshift mutation, restoring the coding sequence to the correct frame with an in-frame fusion that, while still missing parts of the protein, appears to have sufficient function to restore DNA repair ... the mutation to expand At present there is no known mechanism for a resistanceenabling mutation to arise de novo in response to drug treatment The Darwinian mechanism still remains to be tested ... high-throughput tools now available is accelerating the pace of discovery such that rational drug design will become the rule, rather than the exception Acknowledgements We thank the Victorian Breast...
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Site Analysis: A Contextual Approach to Sustainable Land Planning and Site Design
... PART IV DESIGN AND IMPLEMENTATION 207 Chapter CONCEPTUAL DESIGN Introduction Context-Sensitive Design Design Determinants Creativity and Conceptual Design The Conceptual Design Process Anatomy of ... good design is a frill, or that it simply costs too much to justify the expense There are many reasons, however, to justify the expense of investing in competent site planning and design In Designing ... photograph actually varies over the photo’s surface At the edges of the photograph, the distance depicted is greater than the same distance depicted closer to the photo’s center Horizontal distortion...
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Báo cáo hóa học: " Research Article A Systematic Approach to Design Low-Power Video Codec Cores" doc
... problems related to each design step and to evolve gradually towards a final, energy efficient implementation Additionally, such design approach shortens the design time: it favors design reuse and ... structured verification and fast prototyping The proposed design flow (Figure 1) uses different models of computation (MoC), adapted to the particular design step, to help the designer reasoning about the ... for an automatic synchronization between the actors: an actor cannot be executed prior to the arrival of its input tokens When a graph can run without a continuous increase or decrease of tokens...
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Báo cáo khoa học: " Towards a sane and rational approach to management of Influenza H1N1 2009" docx
... protein It determines whether the virus is able to bind to and infect cells of different species by its ability to attach to carbohydrate receptors on the cells The protein loops that determine ... alignment by asterisks, are identical to current human H1N1 Thus the spectrum of human infection in the respiratory tract is not likely to be unusual relative to the 2008 H1N1 or other recent influenza ... its ability to cleave neuraminic or sialic acid from complex carbohydrates such as mucins In infection it serves to allow release of newly produced virus from surface receptors and to digest mucous...
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Báo cáo y học: "A novel approach to modelling water transport and drug diffusion through the stratum corneum" pdf
... application being the analysis of drugs being applied to the stratum corneum (SC) In our approach, the SC is considered to be composed of a periodic structure of cellular skeletons, separated by intercellular ... pressure difference corresponds to 10 × 103 m and 10.002 × 103 m applied to the top and bottom boundaries, respectively These two simulations were done in order to examine Page 12 of 25 Marquez-Lago ... direction As drugs are normally applied to the outer skin surface, source concentrations were placed at the top surface of the model (i.e., the skin surface) Therefore, in order for the drug to enter...
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Chemical drug assisted gene transfer a sensible approach to improve transgene expression in the central nervous system
... that need to be considered for an effective gene therapy: gene delivery systems (vectors), regulatory elements and therapeutic genes The vectors refer to the carriers of transgene into target ... compared to other non-viral vectors Gene delivery using PEI involves condensation of DNA into compact particles, uptake into the cells, release from the endosomal compartment into the cytoplasm, ... increased toxicity To overcome this problem, PEG, a nonionic water-soluble polymer, was grafted to PEI to improve the solubility of complexes, reduce aggregation in vivo, and thus reduce cytotoxicity...
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Báo cáo khoa học: "Veterinary decision making in relation to metritis - a qualitative approach to understand the background for variation and bias in veterinary medical records"
... for mandatory systematic data collection This agreement gives the farmer a more liberal access to antibiotics The intention behind this legislation probably was to motivate the farmer to enhance ... and between herds At the farm level, the veterinarians seemed to integrate farm-related information into the decision as to how to treat an individual cow for metritis When taking decisions on ... possibilities to perform epidemiological analyses or base advice on systematically collected data This motivation could potentially lead to 'justifying,' i.e., adjusting of the score to fit to the treatment...
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Báo cáo y học: " A Practical Approach to Managing Patients with HCV Infection"
... routine laboratory studies should be obtained as well to monitor for signs of adverse effects due to the drugs Repeat HVC viral load should be repeated at week 12 of treatment to document EVR ... document EVR The decision to continue treatment after week 12 would then be determined based on individual response to treatment (EVR), tolerance to the drugs, laboratory profiles, and the 66 ... heart disease Patients with autoimmune hepatitis or other conditions known to be exacerbated by interferon and ribavirin or known to have hypersensitivity to these drugs should not receive treatment...
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Báo cáo y học: "A Practical Approach to Management of Chronic Hepatitis B"
... sensitive to LAM treatment [16] Indications of HBV Treatment Historically, levels of HBV DNA and ALT, and histological activity of liver biopsy have been used as the three main factors to determine ... reasonable to reduce flare when dealing with drug resistance and planning switch these two drugs On-treatment Monitoring and Duration of Therapy Patients who receive HBV treatment should be monitored ... need to be monitored every 4-6 weeks, but those on LAM or ADV should be monitored every 3-6 months On-treatment monitoring should focus on medical adherence and Int J Med Sci 2005 2(1) 21 tolerance,...
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A New Approach to Quantum Theory
... would have had to be, were the oscillator free, to produce the actual final conditions at time T Outside the time range to T the oscillator is, of course, simply a free oscillator These expressions ... Observables 49 10 Application to the Forced Harmonic Oscillator 55 11 Particles Interacting through an Intermediate Oscillator 61 12 Conclusion 68 v vi Contents Space-time Approach to Non-Relativistic ... in his doctoral thesis of 1942 at Princeton University, which is published here for the first time His new approach to quantum theory made use of the Principle of Least Action and led to methods...
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A new approach to semantic and syntactic functions of English adjectives – A contrastive analysis with their Vietnamese equivalents
... referring to a condition or state affairs almost beyond ones ability to deal with and requiring great effort to bear or overcome easy tough difficult hard simple It is hard for Marry to operate ... functions of English adjectives Chapter III is a study to a new approach to semantic and syntactic functions of English adjectives Chapter IV is to make a contrastive analysis between English adjectives ... illustrated as follows: The concerned doctor rang for an ambulance ~ The worried doctor rang for ambulance The doctor concerned is on holiday ~ The doctor responsible is on holiday (L G Alexander...
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Listening to Patients A Phenomenological Approach to Nursing Research and Practice
... have to want to things If you want to sit in a wheelchair okay So my husband pushed me down to therapy the first day And this big man approached me and said Tm here to help you I'll teach you to ... we hope it will prove to be a useful addition to the extant body of literature on this topic This book is unique in its philosophical basis (Merleau-Ponty), its approach to clinical practice and ... wanted to say to nurses but struggled to find ways to say it Writing is always a humbling experience The philosopher Maurice MerleauPonty, on whom we rely heavily for inspiration, understood how...
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Module 3: Services-Based Approach to Solution Design
... Services-Based Approach Module 3: A Services-Based Approach to Solution Design Activity 3.1:Identifying Services Value of a Servicesbased Approach Module 3: Services-Based Approach to Solution Design ... Application Model in designing solutions 58 Module 3: Services-Based Approach to Solution Design ! Services-Based Approach Slide Objective To provide an overview of the services-based approach Lead-in ... Services-Based Approach to Solution Design Activity 3.1: Identifying Services Slide Objective To introduce the activity Now that you have learned about the MSF services-based approach to design, you...
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Managing and Practicing OD in an IT Environment - A Structured Approach to Developing IT Project Teams
... specific OD approaches or orientations This chapter presents a general approach that can be used in most technical projects and with many OD approaches This chapter brings IT and OD together to minimize ... 1995, pp 13-15) Dyer goes on to satisfy the last item by defining teambuilding as an activity whose purpose is to help those who must work together to accomplish results, to identify any condition ... competence, and asking for help is analogous to admitting fault IT and OD practitioners are experts brought into an organization to solve the toughest problems, not to introduce new ones Whether from arrogance...
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College writing - A personal approach to academic writing
... comes to mind If neither author nor research issue comes to mind, enough preliminary reading and research to allow you to choose well, or to allow your interest to kick in and let the topic choose ... distinctive uses to which you can put your writing: to communicate, to imagine, and to explore WRITING TO COMMUNICATE It is easiest to describe writing as communication because this is the use to which ... use it to meet, greet, and persuade people; to ask and answer questions; to pose and solve problems; to argue, explain, explore, and discover; to assert, proclaim, profess, and defend; to express...
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Tài liệu Instructor Notes Module 3: Services-Based Approach to Solution Design pptx
... understand this concept Instructor Notes Module 3: Services-Based Approach to Solution Design Module Strategy Use the following strategy to present this module: ! Services-Based Approach In this section, ... services-based or multiple layer approach to design, may feel that breaking the application into multiple service layers is a waste of time Be prepared with examples showing the value to an organization of ... computer to emphasize this point Note This course uses the term “layer” to refer to the logical constructs of user interface, user services, business services, data services, and data store The...
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Tài liệu The New Face oF GoverNmeNT: How Public Managers Are Forging a New Approach to Governance pdf
... that led to their success in the past renders them ill-equipped to launch transformation efforts that are needed today Public administrators find themselves forced to refocus their goals, design ... government First, administrators are being required to transform the traditional maintenance model of public administration to a business-driven, public management approach to the governance of agencies ... order to survive The crisis must be recognized by all senior administrators and be great enough to send a message that a change is absolutely necessary Interested parties then come together to formulate...
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Tài liệu A Strategic Approach to Cost Reduction in Banking - Achieving High Performance in Uncertain Times docx
... compromising operational stability or customer service, and positioned the bank to meet aggressive growth targets Industrialize Operations Taking a balanced approach to cost cutting requires banks to develop ... $500m to $1b Net Benefit (Benefit - Cost) Tactical - $50m to $100m = Reinvesting tactical benefits into transformational initiatives Year • Investment portfolio review • Contractor / supplier rationalization ... face: • Uncertainty as to when the bottom of this downturn will be reached • Unprecedented levels of operational risk • Highly complex operating models which make it difficult to reduce costs quickly...
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