chủ trương của đảng về kết hợp sức mạnh dân tộc với sức mạnh thời đại trong giai đoạn hiện nay
Báo cáo khoa học: " Enhancement of radiosensitivity in human glioblastoma cells by the DNA N-mustard alkylating agent BO-1051 through augmented and sustained DNA damage response" potx
... is perhaps the most important determinant of irradiation sensitivity [22,34] The cell cycle is strongly affected by DNA damage, and a cell’s radiosensitivity depends on cell cycle position and...
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báo cáo hóa học:" Effects of alpha-calcitonin gene-related peptide on osteoprotegerin and receptor activator of nuclear factor-B ligand expression in MG-63 osteoblastlike cells exposed to polyethylene particles" doc
... differing OPG results might be of small relevance for the in-vivo interaction as our results show a stronger influence of particles and alpha-CGRP on RANKL than on OPG The results of our study correspond ... the past, including TNFalpha/TNFR/TRAF1 and IL-6/CD126/JAK/STAT [30,31] Osteoblast activity is strongly regulated by surrounding pH and growth factors released from resorbed Table Alkaline phosphatase...
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báo cáo hóa học:" Effects of alpha-calcitonin gene-related peptide on osteoprotegerin and receptor activator of nuclear factor-B ligand expression in MG-63 osteoblastlike cells exposed to polyethylene particles" pot
... differing OPG results might be of small relevance for the in-vivo interaction as our results show a stronger influence of particles and alpha-CGRP on RANKL than on OPG The results of our study correspond ... the past, including TNFalpha/TNFR/TRAF1 and IL-6/CD126/JAK/STAT [30,31] Osteoblast activity is strongly regulated by surrounding pH and growth factors released from resorbed Table Alkaline phosphatase...
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Báo cáo khoa học: "Increased betulinic acid induced cytotoxicity and radiosensitivity in glioma cells under hypoxic conditions" pptx
... respectively (Figure 5) However, under hypoxic conditions, the effects of BA on radiosensitivity were strongly enhanced in U251MG cells The enhancement factor at an irradiation dose of 15 Gy after 10 ... these two treatments were more effective in combination The present data also demonstrate that BA strongly enhances the radiosensitivity of U251MG cells under hypoxic conditions (Figure 5) To our...
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báo cáo khoa học: "Adenovirus-mediated delivery of bFGF small interfering RNA reduces STAT3 phosphorylation and induces the depolarization of mitochondria and apoptosis in glioma cells U251" pdf
... [31] Due to its ability to activate STAT3, the elevated IL-6 and its family members have been strongly implicated in GBM [32] Interestingly, Ad-bFGF-siRNA downregulates IL-6 expression possibly...
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molecular merchanisms underlying inhibitory effect of fuciodan on cytokine-induced inflammation in glioma cells
... Regulation of iNOS expression in glial cells Cloning of iNOS promoter from different species has strongly contributed to investigation molecular mechanisms underlying transcriptional regulation ... ICAM-1, and AD related genes was examined in the presence of fucoidan The data showed that fucoidan strongly inhibited TNF-α and IFN-γ – induced iNOS and ICAM-1 production, suggesting fucoidan as a...
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Báo cáo khoa học: "Molecular analysis of hprt mutation in B6C3F1 mice exposed to ozone alone and combined treatment of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone and/or dibutyl phthalate for 32 and 52 weeks" ppsx
... hprt mutation frequency except that DBP and DBP+ozone showed significant changes This finding strongly suggests that hprt mutation frequency rather than hprt mutation spectra may be useful for...
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Báo cáo y học: " A single dose of DNA vaccine based on conserved H5N1 subtype proteins provides protection against lethal H5N1 challenge in mice pre-exposed to H1N1 influenza virus" ppt
... intramuscular or subcutaneous injection Microbiol Immunol 2010, 54:81-88 18 Bresson JL, Perronne C, Launay O, Gerdil C, Saville M, Wood J, Hoschler K, Zambon MC: Safety and immunogenicity of an inactivated...
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Báo cáo y học: " Effect of recombinant IL-10 on cultured fetal rat alveolar type II cells exposed to 65%-hyperoxia" pps
... vasculogenesis and alveolarization is essential for lung development [24], therefore, they are strongly considered to be under paracrine regulation, while VEGF expression reduced by hyperoxia ... anti-inflammatory cytokines is shifted by a combination of an increase of pro-inflammatory cytokine and a stronger decrease of an anti-inflammatory cytokine rather than by increase in pro-inflammatory cytokines ... growth factor patterns in bronchopulmonary dysplasia Pediatr Res 2010, 67:83-89 56 Thickett DR, Armstrong L, Christie SJ, Milar AB: Vascular endothelial growth factor may contribute to increased vascular...
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Báo cáo y học: "Isoniazid prophylaxis differently modulates T-cell responses to RD1-epitopes in contacts recently exposed to Mycobacterium tuberculosis: a pilot study" pdf
... boosts of vaccination; at the time of the present study, reinfection may have caused a rapid and strong effector/memory response caused by the expansion of this pool of central memory cells [32] ... monitoring virus-associated diseases Nat Rev Immunol 2006, 6:417-23 Mollet L, Li TS, Samri A, Tournay C, Tubiana R, Calvez V, Debre P, Katlama C, Autran B: Dynamics of HIV-specific CD8+ T lymphocytes...
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báo cáo khoa học: "Osthole induces G2/M arrest and apoptosis in lung cancer A549 cells by modulating PI3K/Akt pathway" pptx
... growth in an animal model Lung Cancer 2009, 66:162-8 Oltersdorf T, Elmore SW, Shoemaker AR, Armstrong RC, Augeri DJ, Belli BA, Bruncko M, Deckwerth TL, Dinges J, Hajduk PJ, Joseph MK, Kitada S,...
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Báo cáo y học: "Cell cycle G2/M arrest through an S phase-dependent mechanism by HIV-1 viral protein R." pps
... Chk1-Ser345 phosphorylation was observed as early as hours after the DT release in all three treatments Strong γH2AX-Ser139 phosphorylation was also observed in the UV-treated cells (Figure 3A, second ... small but perhaps insignificant decrease of Cdc25C over time; in contrast, Vpr induced a rather strong reduction of Cdc25C over time (Figure 5A-a, second row, lanes 8-10) To ascertain Vprmediated ... basal level phosphorylation of Chk1-Ser345 Consistently, cells transduced with Adv-Vpr showed strong phosphorylation of Chk1-Ser345 even with pretreatment of control siRNA (Figure 6B-a, lane...
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Báo cáo Y học: Early growth response-1 gene (Egr-1 ) promoter induction by ionizing radiation in U87 malignant glioma cells in vitro pot
... dimethylsulfoxide and directly added to the culture medium to make a ®nal concentration of 10 lM Being a strong and speci®c activator of adenylate cyclase, forskolin induces increased levels of cAMP in ... bovine serum concentration (Fig 5) RhEGF-treatment Treatment with 10 ngámL)1 rhEGF resulted in the strongest phosphorylation and activation of ERK1/2 (T202/Y204) (Fig 5), re¯ecting the highest Egr-1 ... antibodies as controls for ATF-2 (T71) and c-Jun (S73) levels the expression of both proteins was strongly upregulated PD98059 As illustrated in Fig 5, PD98059 as an inhibitor of MEK1, clearly prevented...
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báo cáo hóa học:" Drugs targeting the mitochondrial pore act as citotoxic and cytostatic agents in temozolomide-resistant glioma cells" pptx
... compensatory pathway that allows the tumour to survive For these reasons novel therapeutic approaches are strongly needed Mitochondria-directed chemotherapy is emerging as a promising tool to combat apoptosis-resistant ... cells (N/T ratio) was calculated Cells that were hoechst 33342 and PI negative and that showed a strong calcein staining were considered live cells The ratio between live and total cells (L/T ratio) ... esterases remove the acetomethoxy group allowing the molecule to bind calcium and to produce a strong green fluorescence As dead cells lack active esterases, only live cells are labeled As shown...
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