chromium vi following exposure by inhalation hot spots of chromium accumulation in the lung
Heavy Metals in the Environment - Chapter 10 pps
Ngày tải lên :
11/08/2014, 15:20
... within neurons in a region containing neurofibrillary tangles However, in view of the careful evaluation of contamination by Good et al (148), and the lack of detection of Al in the toluidine ... ANIMALS 4.1 Evidence for Transfer of Al from the Gastrointestinal Tract to the Brain Only a small amount of the total ingested Al is absorbed via the gastrointestinal tract, and the majority of that ... signaling, appear to be targets of Al both in vivo and in vitro Al in drinking water decreases hippocampal inositol triphosphate levels, increases cAMP, and alters the distribution of protein kinase...
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Tài liệu Báo cáo khoa học: Identification of different isoforms of eEF1A in the nuclear fraction of human T-lymphoblastic cancer cell line specifically binding to aptameric cytotoxic GT oligomers ppt
Ngày tải lên :
21/02/2014, 00:20
... amount of recovered protein owing to the presence of a high molar excess of BSA remaining in the buffer Therefore, a fixed aliquot of the protein was incubated with the indicated probes, as previously ... basic proteins it might be that either methylation of the lysine or specific substitutions in the amino acid sequence, increasing the number of basic residues of lysine, arginine and histidine, could ... found either in the cytoplasm or the nucleus [35,36] The involvement of eEF1A in the regulation of nuclear processes includes the accumulation of a nuclear complex with vigilin, for exporting tRNA...
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Báo cáo khoa học: Bridging the gap between in silico and cell-based analysis of the nuclear factor-jB signaling pathway by in vitro studies of IKK2 ppt
Ngày tải lên :
16/03/2014, 11:20
... simplication of a cell as seen by analysis software, where the software measures the intensity of NF-jB in the nucleus when compared with the intensity of NF-jB in the cell 1686 Recombinant human ... a is the ratio of apparent dissociation constants for binding GST-IjBa in the presence and absence of ATP, and the value of a indicates whether the binding of one substrate (ATP) affects the afnity ... observed in the untreated cell population In order to shed light on the cause of this result, we carried out an in silico analysis by incorporating the inhibition kinetics within the existing computational...
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Báo cáo khoa học: A new pathway encompassing calpain 3 and its newly identified substrate cardiac ankyrin repeat protein is involved in the regulation of the nuclear factor-jB pathway in skeletal muscle pdf
Ngày tải lên :
29/03/2014, 21:20
... are involved in the transmission of mechanical signals to signaling pathways In the M line, mechanical stimulation activates the interaction of a protein complex with the kinase domain of titin, ... the binding to titin by improving the accessibility of the titin-binding domain Interestingly, the importance of CARP interaction for its function was recently demonstrated in a FEBS Journal ... pathway and an increase in muscle fiber apoptosis [8] The participation of NF-jB signaling in the pathogenesis of LGMD2A is therefore an interesting possibility The findings obtained in the present...
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Elucidating the role of dok 3 in b cell receptor signaling using gene knockout mice 2
Ngày tải lên :
14/09/2015, 09:08
... FDC in germinal centers are involved in the retention of immune complexes and in the generation of recall responses A defect in the maturation of FDC in the germinal centers was noticed in FcγRIIB-deficient ... similarity to insulin receptor substrate-1 (IRS-1), having both pleckstrin homology (PH) and phosphotyrosine binding (PTB) domains in its amino-terminal portion, followed by many binding sites for ... for SH2 domains The N-terminal region of Dok1 consists of a PH domain, that may be involved in membrane localization and a PTB domain, which binds phosphotyrosine-containing motifs of the form NPXpY...
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Elucidating the role of dok 3 in b cell receptor signaling using gene knockout mice
Ngày tải lên :
14/09/2015, 10:44
... SH3 domain binding protein Geneticin Gancyclovir Growth factor receptor-bound protein Haemagglutinin 1,3,4,5-tetrakisphosphates Immunoglobulin Interleukin Inositol 3,4,5-triphosphate Insulin receptor ... from the Biological Resource Centre who had help in the microinjection of Dok-3 ES cells, maintaining and changing the many cages of mice, and the staffs from DNA Sequencing Facility for their ... chromosome 10 Protein tyrosine kinase Ras GTPase activating protein Src-homology Src-homology SH2-containing inositol 5’-phosphatase-1 SH2-domain containing protein tyrosine phosphatase-1 Son of sevenless...
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Tài liệu Báo cáo khoa học: Activation loop 3 and the 170 loop interact in the active conformation of coagulation factor VIIa pdf
Ngày tải lên :
18/02/2014, 08:20
... not included in the published alanine scanning mutagenesis study of FVIIa [13], and investigated the effects of the mutation on the enzymatic maturation of FVIIa and on the response of FVIIa ... bonds involving Gly372 in factor VIIa especially in the vicinity of the S1 pocket [11,34], in the rst part of activation loop 3, and in the area of the TF-interactive helix and the 170 loop [8,35], ... Hydrogen bonds involving Gly372 in factor VIIa functional tests were based on the results of the titration experiment Enzymatic activity, inhibitor reactivity and sTF binding of G372A-FVIIa The very...
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Báo cáo khoa học: Crystal structure of salt-tolerant glutaminase from Micrococcus luteus K-3 in the presence and absence of its product L-glutamate and its activator Tris pdf
Ngày tải lên :
06/03/2014, 09:22
... Determination of overall structure In a previous study [10], we determined the F structure containing the truncated region of the C-terminal domain; however, we failed to determine the structure of ... 428 aa; nine aa in total) were located near the interface of the physiological dimer The Cterminal domain may contain structural features involved in protein–protein interactions to form the physiological ... conformations of the regions at 100-105 and 303-309 aa in the N form, and we investigated the following points First, these areas are not involved in any contacts with other molecules in crystals in all the...
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Báo cáo khoa học: Identification of tyrosine-phosphorylation sites in the nuclear membrane protein emerin pot
Ngày tải lên :
07/03/2014, 12:20
... characterized by a mislocalization of emerin that is caused by the loss of emerin binding to lamin A (X- linked form) or by the loss of lamin A (autosomal dominant form) [22,23] Several emerin binding ... phosphotyrosine immunosignal may be misleading, since the affinity of phosphotyrosine-specific antibodies is always in uenced by amino acid residues surrounding the phosphotyrosine Finally, emerin in ... improving the search for phosphopeptides containing phosphotyrosine, we identified one of the well-defined integral INM proteins Emerin is a type-II integral membrane protein of 34 kDa, which is inserted...
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Báo cáo khoa học: Regulation of arginase II by interferon regulatory factor 3 and the involvement of polyamines in the antiviral response potx
Ngày tải lên :
07/03/2014, 21:20
... involved in the biosynthesis of natural polyamines (putrescine, spermidine and spermine) through conversion of l-arginine into l-ornithine [16] The latter is in turn used by ODC to produce putrescine, ... iodide (PI) staining of apoptotic cells was quantified in VSVinfected Jurkat T cells in the absence or presence of spermine As shown in Fig 7, the presence of spermine during VSV infection strongly ... Polyamine depletion of cells reduces the infectivity of herpes simplex virus but not the infectivity of Sindbis virus Life Sci 42, 2011–2018 Clarke JR & Tyms AS (1991) Polyamine biosynthesis in...
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Báo cáo khoa học: 15-Deoxy D12,14-prostaglandin J2 suppresses transcription by promoter 3 of the human thromboxane A2 receptor gene through peroxisome proliferator-activated receptor c in human erythroleukemia cells ppt
Ngày tải lên :
07/03/2014, 21:20
... further evidence for the role of PPARc in the regulation of TP gene expression within the vasculature and point to further critical differences into the modes of regulation of TPa and TPb in ... largely independent of 15d-PGJ2 stimulation Examination of PPARc ⁄ RXRa interactions within the PPRE To further investigate the identity and specificity of the DNA ⁄ protein interactions within the ... [48] and thereby implies that PPARc isoforms may have a role in mediating the 15d-PGJ2 –inhibition of Prm3 activity The involvement of both PPARc and the retinoic acid X receptor (RXR) in the regulation...
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Báo cáo khoa học: Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase pdf
Ngày tải lên :
08/03/2014, 08:20
... activation of GS to a level similar or greater than that by insulin Since the activity of GS depends on the relative activities of GS kinases and PP1G, inhibiting GSK3 (one of the principal GS kinases) ... (1994) The inhibition of glycogen synthase kinase-3 by insulin or IGF-1 in the rat skeletal muscle cell line L6 by wortmannin, but not rapamycin: evidence that wortmannin blocks activation of the ... nM insulin for 10 prior to assaying incorporation of glucose from uridine diphospho-[6-3H]-D-glucose into glycogen and expressed as a ratio of the activity in the absence divided by that in the...
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Báo cáo " DENOTING THE NUCLEAR ISOTOPES IN EXPERIMENTAL GAMMA SPECTRUM" pptx
Ngày tải lên :
14/03/2014, 13:20
... and on the taste of user In our case, it is contained in a file and is loaded in to the memory of computer to construct the dynamical linked namelist of the spectrum before analysis by using function ... performing the spectrum, then a loop is worked for checking if these nominal isotopes are in the spectrum Fig The flowchart of the isotope making the experimental gamma spectrum 48 Nguyen Trung Tinh ... making the spectrum Because of the error of experiment, energy levels in a experimental spectrum are not exactly the same with the ones of the testing isotopes; therefore, an energy level of the...
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Báo cáo khoa học: Liver receptor homolog-1 localization in the nuclear body is regulated by sumoylation and cAMP signaling in rat granulosa cells docx
Ngày tải lên :
23/03/2014, 06:20
... synthesized and subjected to in vitro sumoylation reactions Proteins SUMO-1, E1 and UBC9 are required for the in vitro sumoylation of LRH-1 (B) Showing in vitro sumoylation reactions of in vitro ... protein of SUMO modification [32,33] The hinge region lysine, residue 289 in the mouse and 224 in the human LRH-1, was the major SUMO conjugation site Sumoylation of LRH-1 is associated with the ... observed in present study Some other factors may also enhance SUMO modification of LRH-1 in vivo, such as E3 proteins, or promote the targeting of sumoylated LRH-1 into nuclear bodies The expression of...
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FUTURE OF THE NUCLEAR SECURITY ENVIRONMENT IN 2015 pptx
Ngày tải lên :
29/03/2014, 18:20
... secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public The Institute acts under the responsibility given to the ... to be installed in other buildings at the Institute One of the main aims of monitoring is to raise the level of workplace discipline of staff and ensure that they follow the rules for handling ... from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine The members of the committee responsible for the report were chosen for their...
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Báo cáo khoa học: The in vitro nuclear aggregates of polyamines pot
Ngày tải lên :
29/03/2014, 23:20
... ivNAPs in vitro model in order to investigate some of the features of the polyamine–phosphate interactions Specifically, we examined the role played by each polyamine in the self-assembly of in vitro ... on the assembly of polyamines and phosphates (the extractive NAPs) The initial step is the self-arrangement of polyamines in disk-like unimers by means of their terminal interactions with the ... were integrated using the software provided with the HPLC instrument The determination of polyamine concentrations in the GPC peaks allowed us to calculate the chromatographic recovery in mL of...
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Báo cáo khoa học: The C-terminal region of the proprotein convertase 1⁄ 3 (PC1⁄ 3) exerts a bimodal regulation of the enzyme activity in vitro pdf
Ngày tải lên :
30/03/2014, 08:20
... cells expressing the recombinant mPC1 ⁄ 3, the presence of the 87 kDa form in excess of the 66 ⁄ 71 kDa facilitates isolation of the enzyme and helps in maintaining the enzymatic activity at a proper ... thus insuring cell-surface anchoring [37] In other cases, the CT-peptide contains integral transmembrane motifs affecting the sorting and recycling of furin and PC5 ⁄ 6B [38–40] In the case of ... achieved in order to fully activate the zymogen Most often in these cases, the need to remove these sequences to obtain full activation is explained by the role of C-terminal determinants in allowing...
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báo cáo hóa học:" yuDetecting the percent of peripheral blood mononuclear cells displaying p-STAT-3 in malignant glioma patients" pot
Ngày tải lên :
18/06/2014, 15:20
... tumors and the surrounding brain parenchyma [30] These immune cells may then traffic outside the CNS [31,32] by following the lymphatic drainage through the brain via the Virchow-Robin spaces ... uncertain which of these, either individually or in combination, is the etiological agent for inducing p-STAT-3 in PBMC Alternatively, there may be other yet-unidentified factors that induce ... of STAT-3 in both the tumor cells and the immune cells within the tumor microenvironment is initiated as proposed by Kortylewski [21] The cumulative response of activating the STAT3 pathway in...
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Báo cáo sinh học: " Strategically examining the full-genome of dengue virus type 3 in clinical isolates reveals its mutation spectra" ppt
Ngày tải lên :
19/06/2014, 08:20
... isolates 3H was caused by the value of of dS at the denominator The positive selection on the domain III is not surprising since domain III contains the receptorbinding domain and major type-specific ... nucleotides in length covering 413 amino acids which included 40 amino acids at the N terminal end of NS1 protein, the NS3 region was 866 nucleotides in length covering 288 amino acids, and the NS5 ... regions Figure in RNA of DENV-3 Strategy1 clonal-sequencing the whole genome of genomic Strategy in clonal-sequencing the whole genome of genomic RNA of DENV-3 Clonal sequencing of the heterogeneous...
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