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Báo cáo khoa học: Modulation of IMPDH2, survivin, topoisomerase I and vimentin increases sensitivity to methotrexate in HT29 human colon cancer cells docx

Ngày tải lên : 07/03/2014, 16:20

... were incubated with increasing concentrations of the TOP1 inhibitor, camptothecin, in the presence and in the absence of 10)5 m MTX The cytotoxic effect of camptothecin alone was enhanced by the ... (IUPUI, Indianapolis, IN, USA), or the TOP1 inhibitor camptothecin (Sigma, Madrid, Spain), in the presence or absence of MTX IMPDH activity inhibitors were added simultaneously to MTX Camptothecin, ... cytotoxicity by themselves, according to the role of FEBS Journal 272 (2005) 696–710 ª 2005 FEBS IMPDH activity in DNA synthesis, which was increased when combining them with MTX Therefore, by...

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Báo cáo khoa học: LmbE proteins from Bacillus cereus are de-N-acetylases with broad substrate speciﬁcity and are highly similar to proteins in Bacillus anthracis pot

Ngày tải lên : 15/03/2014, 11:20

... underlined H and D residues in the ﬁrst motif and the last H of the second motif are zinc binding ligands Moreover, it has been proposed for other members of the family that the underlined H and the ... water and acetate atoms were removed Hydrogen atoms were added to the crystal structure, and the substrates and atomic partial charges were assigned to the protein and carbohydrate atoms Atomic interaction ... revealed the presence of three protein bands The position of the main band is in agreement with the predicted molecular mass of the hexahistidine fusion protein (27 kDa) The N-terminal amino acid...

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English gerunds and present participles – how to use in building a sentence

Ngày tải lên : 18/03/2014, 17:17

... the language Writing this paper I try to: - Point out the theoretical background including the traditional concepts and the modern point of view concerning the English –ing participle, the finite ... “shopping”, etc.These words can be formed from any verb by adding -ing and inserting “of” before the noun phrase: The painting of Brown The explaining of the teacher The girl's beautiful dancing ... oneself to accustom(oneself) to resort to face up to sink to in addition to be used to look forward to get used to object to be reduced to For examples: - I am looking forward to meeting her...

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**Car Ownership and Mode of Transport to Work in Ireland* potx**

Ngày tải lên : 30/03/2014, 09:20

... KAVANAGH and A MCELWAIN, 2005 “Origins, Destinations and Catchments: Mapping Travel to Work in Ireland in 2002” Paper presented to the Statistical and Social Inquiry Society of Ireland, October ... likely to choose all options in favour of owning a car and travelling by motorised means to work This reflects the importance of public transport provision in influencing modal choice In other ... kilometre variable using information on public transport fares and car operating costs (including fuel) We assume zero costs for the walking and cycling modes (in common with others in the literature...

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Influence of different breeds, feeding and housing systems on sow reproductive performance and piglet''''s resistance to diseases in Central Vietnam pdf

Ngày tải lên : 21/06/2014, 06:20

... partners and approach to small holding pig farms in Thua Thien Hue and Quang Nam 2.2 Training for interviewers Before starting of the survey, project partner coordinator has instructed to interviewers ... side and feed intake, daily gain, and protein and fat accretion on the other side This indicates that selection for increased survival will definitely influence finishing traits, but also that intense ... administered in the present invention are not specifically defined For instance, the composition may contain from 10 to 15% by weight of crude proteins and from to 5% by weight of crude fats The...

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Don’t cross your bridges until you come to them ppsx

Ngày tải lên : 02/08/2014, 10:20

... but what if the committee doesn't accept it? (Đề nghị chuẩn bị sẵn sàng ủy ban không chấp nhận nó?)  B: Don't cross your bridges before you come to them We will see what happens then (Em đừng ... come to it" để ám tôi/ không lo lắng điều thật xảy Ví dụ:  A (man): I'll introduce you to my parents tonight (Anh đưa em mắt bố mẹ anh tối nay.)  B (the man's girlfriend): Okay , but they might ... like me (Nhưng bố mẹ anh không thích em) · A: Don't worry We'll cross that bridge when we come to it (Đừng lo, em yêu Đến lúc hay) Vậy bạn chuẩn bị sẵn sàng cho việc bạn bình thản chờ đợi, điều...

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Báo cáo khoa học: "Cutaneous vascular reactivity and flow motion response to vasopressin in advanced vasodilatory shock and severe postoperative multiple organ dysfunction syndrome" pot

Ngày tải lên : 12/08/2014, 23:22

... were administered Norepinephrine infusion was adjusted to maintain MAP above 65 mmHg In patients in the norepinephrine group, a MAP above 65 mmHg was achieved by adjusting the norepinephrine dosage ... this finding may indicate that AVP/ norepinephrine does not result in further deterioration in microcirculatory oxygen supply in skin These findings are in striking contrast to the results of a ... measurements and documentation WRH conceived the study protocol, and helped to interpret the data and to draft the manuscript BF helped to interpret the data and to draft the manuscript HK conceived the...

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use of ontologies and probabilistic relational models to aid in cyber crime investigation decision support

Ngày tải lên : 14/11/2014, 08:59

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What to look for when you want to invest in a company by geoffrey byruch

Ngày tải lên : 30/11/2015, 10:43

... not, then not invest If they are, then continue your research Certain questions you want to ask are: • Do you share the same vision and goals of the CEO of the Company? • Do you believe in the ... are thinking about investing in DO YOUR HOMEWORK • But what if you didn’t your due diligence? What if you decided to go on a whim? • Imagine investing in stock from an unknown company All you ... HOMEWORK! THE RISK • One thing you want to keep in mind is that there is no such thing as a sure thing • Investing in a private company has many risks, especially when you are talking about your life...

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CANCER AND THE ENVIRONMENT: What You Need to Know What You Can Do doc

Ngày tải lên : 06/03/2014, 01:20

... cancer in humans and are found in industrial and occupational settings such as coal mines, mills, granite quarrying and processing, crushed stone and related industries, and sandblasting operations ... cadmium into the air, surface water, ground water, and topsoil where it can be taken up by both land and water plants and, in turn, transferred to animals Contaminated topsoil that allows uptake into ... water and drain pipes, hosing, flooring, windows, and credit cards Human exposure can occur primarily in workers in the plastic industry, not by using the end products such as vinyl siding or hosing...

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Leadership the Hard Way: Why Leadership Can’t Be Taught and How You Can Learn It Anyway

Ngày tải lên : 16/03/2014, 21:03

... Turning requires banking, and banking accelerates the plane with the nose down If the storm winds are strong enough, they can force you into a dive, causing the plane to stall and go into a spin ... was monitoring the stormscope, saw a break in the storm to the northeast We radioed Athens for a change in course, and within about ﬁve minutes things began to calm down Then, with no warning, we ... against the current has to know how to manage the tension between, on the one hand, persevering in the face of opposition, and on the other, encouraging dissent and responding to it Leading against...

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Breaking the Slump: How Great Players Survived Their Darkest Moments in Golf—and What You Can Learn from Them pot

Ngày tải lên : 31/03/2014, 23:20

... going to lose it, and when you lose it, you never think you re going to get it back The best thing you can in your ‘self-talk’ is to remind yourself what you ve done in the past You ve done this ... in many ways You have to believe in yourself, and you have to believe in your ability to turn things around.” There is more “Most people try to something they can’t They’re trying to play like ... years slowly pulling back the string of a bow and I finally let it go.” With the Cup in tow, he will venture across town later in the week to throw out the first pitch in Game Two of the first ever...

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clear blogging how people blogging are changing the world and how you can join them

Ngày tải lên : 31/05/2014, 23:30

... out there? Do you think it’s going to be a mandatory thing, to have a blog, if you re going to have web presence? A No, I don’t think it’s going to be a mandatory thing, but I think it’s going to ... easy to subscribe to a blog Instead of visiting the blogs you follow one by one, you subscribe to them, and postings to that blog appear in your RSS reader, whether online or on your desktop From ... available to them to that Q Including blogging, but also the other social networking things? A Including blogging Podcasting is another one, social tagging—all of that is just going to evolve...

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Why the User Experience of Enterprise Software sucks and what you can do about it

Ngày tải lên : 03/06/2014, 18:29

... magazine modified the “sports” model of some production car to get the fastest possible standing quarter mile You know how they did it? They cut off all the crap the manufacturer had bolted onto the ... OF BUSINESS STRATEGY ENTERPRISE SOFTWARE VENDORS MUST REINFORCE THEIR BRAND IN THE PRODUCT TO STRENGTHEN OFFLINE RELATIONSHIPS Our brand is the only that (category) (benefit) IN A WORLD ... Consulting “as relevant as general health and safety considerations in the workplace.” out of 10 people recalled the last time they saw a product they just had to have, and it was because of the...

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the undercover economist exposing why the rich are rich the poor are poor--and why you can never buy a decent used car nov 2005

Ngày tải lên : 11/06/2014, 02:14

... of the negotiating table and on the other side is a landlord who owns a single prime coffee-bar site By playing them off against each other, the landlord should be able to dictate the terms and ... them “Marginal” land is of central importance The shifts in bargaining power don’t have to stop there While the farming story can be elaborated indefinitely, the basic principles remain the same ... that by the time you finish this book, you ll be able to see the same things But please buy it first, before the store manager throws you out Your coffee is intriguing to the economist for another...

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do you really need back surgery a surgeons guide to neck and back pain and how to choose your treatment jul 2004

Ngày tải lên : 11/06/2014, 10:33

... brought back to the pain, the pain becomes a problem again in full force Types of Pain Pains vary in regard to the way your nerves transmit them, the quality of discomfort they cause, and the types ... that is pinching a nerve in the spine If the nerve pinched is the nerve that goes out to your big toe, you will feel pain in your big toe even though the actual problem is in the spine, two or ... down the back of the leg, and out into at least one of your toes This is called sciatica Sometimes back pain arising in the spine’s joints or disks will also cause pain to be experienced in part...

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The Minimum You Need to Know About Java and xBase potx

Ngày tải lên : 28/06/2014, 14:20

... an existing file. When the database is shiny and new, you must create the column objects, then add them to the database object. The act of adding them to the object actually creates the columns in the database. When you are using an existing database you must pull the field definitions out of ... only to find all previous apps were now incompatible (The machine running my C program which took a whole floppy continued to keep the business it supported running while much screaming and fingerpointing was going on all around it.) ... data tend to be far more reliable from a data integrity standpoint. All indexes are always kept in sync by the library/engine. xBASE type files store the indexes off in different files. You can add all of the records you want to an xBASE data file without ever updating an index...

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muolo -$700 billion bailout; the emergency economic stabilization act and what it means to you, your money .. (2009)

Ngày tải lên : 01/11/2014, 12:19

... have been floated by academics and politicians to either merge them into one or eventually fix them and sell them to the private sector Given the depth of the financial crisis, the best immediate ... and Lehman Brothers the big three of the crisis—wanted to create bonds backed by mortgages so they could sell them to institutional investors in the United States and overseas Institutional investors ... Your Money Now (Hint: Not in a Vacation Home) The Day the Flipping Stopped The Contrarian Play in Vacation Homes Investing in Foreclosures Stocks: Is Now the Time to Get In? Once You Decide to...

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makansi - lights out; the electricity crisis, the global economy, and what it means to you (2007)

Ngày tải lên : 03/11/2014, 15:34

... surreal You begin to feel the difference in everything you do, in almost every step you take In a very real sense, the lack of electricity drains the lifeblood out of you You certainly begin to feel ... trained workers and engineers in the coming years Ninety thousand! I don’t know where those workers are coming from, and neither does anyone in the industry They are not yet loitering in the ... recently, the utility hasn’t been able to monitor the system in a way that allows it to accurately estimate demand Therefore, they have difﬁculty determining the supply that needs to go into the system...

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