... (go) to bed When we (write) the letter, we went to the post office C: Complete the sentences using the past perfect or the past perfect continuous By the time I got home they (eat) ... _ melt the snow to get drinking water 10 You _ all remember to lock the door when you leave C: 10 Choosethecorrectformofthe verbs: must/ can' t/ may/ might You must be/ can't be very ... to/needn 't has had to must/ has to had to must C must be can't be must be must have been can't be 10 can't have enjoyed may be delivering can't have been concentrating may be having might D 10 It must...
... (go) to bed When we (write) the letter, we went to the post office C: Complete the sentences using the past perfect or the past perfect continuous By the time I got home they (eat) ... _ melt the snow to get drinking water 10 You _ all remember to lock the door when you leave C: 10 Choosethecorrectformofthe verbs: must/ can' t/ may/ might You must be/ can't be very ... to/needn 't has had to must/ has to had to must C must be can't be must be must have been can't be 10 can't have enjoyed may be delivering can't have been concentrating may be having might D 10 It must...
... (go) to bed When we (write) the letter, we went to the post office C: Complete the sentences using the past perfect or the past perfect continuous By the time I got home they (eat) ... _ melt the snow to get drinking water 10 You _ all remember to lock the door when you leave C: 10 Choosethecorrectformofthe verbs: must/ can' t/ may/ might You must be/ can't be very ... to/needn 't has had to must/ has to had to must C must be can't be must be must have been can't be 10 can't have enjoyed may be delivering can't have been concentrating may be having might D 10 It must...
... looking at me as if she (know) me?knew 13 If I (be) a bird, I (not,want) to live in a snake.were / wouldn 't want 14 My brother managed to kill the snake just at the time when I (be) almost exhausted ... I wish out teacher would explain that lesson to us again tomrrow 11 I can hear his voice so clearly that it is as if he were hear but the fact is that he isn 't here 12 I have never met her before ... looking at me as if she knew me? 13 If I were a bird, I wouldn 't want to live in a snake 14 My brother managed to kill the snake just at the time when I were almost exhausted If he had beena little...
... greatest (satisfy) I’m not sure at all I really cant say with (certain) Travel is said to the mind (broad) Maradona is one ofthe best football in the world (play) The town is situated on the river ... am not sure at all I really cant say (certain) jobs in this company interest me very much A) Attraction B) Attractive C) Attractively D) Attracted I was ……… right when I said that the man ... (ordinarily) It is such a evening Let’s go for a walk (love) I was to get your letter this morning (delight) The lesson was so that most of them went to sleep in the middle (interest) He soon put on when...
... countryside in the area is ( charm) and most ofthe buildings there ear made from an( attract) of light stone that is particular to the Cotswold’s In the summer, the Cotswold’s can get rather( ... Next month my grandparents are going to hold a party in ( celebrate) of their fiftieth wedding anniversary 60 They attach great ( important) to the project 61 The ( decorate) touches ... natural resources is of great ( important) 117 That restaurant often attracts a lot of customers because of its( special) 118 These days it is ( possible) to open a newspaper without...
... yesterday A boy (knock) down by a car Then he (take) to the nearest hospital 47 Most ofthe Earth’s surface (cover) by water 48 The first festival (hold) nearly eight hundred years ago 49 There’s ... football but now I don t 65 I (work) on a farm once and had to get up at every morning It was difficult at first as I (not get up) so early 66 Cuckoos (not build) nests They (use) the nests of ... practice (speak) English every day 38 The movie (start) at 8.15 this evening 39 We already (finish) the first semester exams 40 Mr Binh (learn) Chinese at school, but he (forget) most of it 41...
... works - I to a great radio show on the way to work listening to listening have listening was listening - Tom's not here He's out _ his mother visit visited visiting is visiting - She _ ... have been - They _ on the project at the moment working be working is working are working - Do you still _ to the tennis club? belongs are belong belonging belong - I never _ Tim anymore ... belong - I never _ Tim anymore see has see seen seeing - I _ football after work play to play playing am play 10 - We _ a lot of volunteer work are doing does ...
... terms of this kind ofverbs so that they can apply the right use of these verbs in using the English language 1.2.2 Objectives The objectives of this study are: - To describe the syntactic and ... LIMITATIONS OFTHE STUDY Due to the limitation of time and the data collected, it is difficult for us to carry out perfectly although we have tried my best to avoid mistakes and limit shortcomings ... proposal can be accepted or rejected - To suggest something is to bring it to the mind ofthe hearer without necessarily explicitly affirming it and without a strong commitment to its truth To advise...
... leaders in the Socialist Republic of Vietnam, the study has discussed opportunities to practice the syntactic and semantic features of saying verbs, pointed out the With the scope of this paper, ... because they effect change That is the reason why Mary told They announced the name ofthe That sign says winner Big Ben tells “No entry” Our reports the time in London correspondent According to the ... researcher to provide more sufficient and often impose the use of their mother tongue on that ofthe target intensive focus on saying verbs Therefore, mistakes language is an inevitable habit To help...
... respect to the mature part As neither the interaction with BMPR-IA nor with noggin was affected in quantitative terms, the pro-peptide moiety probably does not obstruct the key residues of BMP-2 that ... In the case of BMP-9, the pro-peptide appears not to alter significantly the activity ofthe mature part [17] For the pro-peptide of BMP-7, a targeting role to the extracellular matrix [18] has ... we attempted to obtain an insight into the function of proBMP-2 In order to obtain more information about the role ofthe pro -form, proBMP-2, i.e BMP-2 with the covalently attached pro-peptide,...
... to the position ofthe active site lip and closure ofthe C-terminal end over the active site However, it is reasonable to expect these two events to be associated but the structural change that ... mechanism of regulation that generates the apparently attractive feature of an increase in both S0.5 and the sigmoidity ofthe saturation curve for dCTP in response to the binding of dTTP to the enzyme ... ordered C-terminal fold The dotted arrow points to the region in the active site constituted by residues 120–125 that deviated in position between the dCTP ⁄ dUTP complexes and the dTTP complex The...
... point which is very close to the galactic center It is than that he discovered that the arrow ofthe Sagittarius is placed there to point directly at the center ofthe Milky Way All the stars ... for construction purposes Despite the fact that some ofthe scientists consider that they weight around 800 tons, the truth is that no one with 100% certainty can not say how much actually they ... science”, are still considering the Time as Linear and that it flows in just one direction On the other hand, the “Ones” that left the knowledge to the Mayas clearly pointed out that the Time actually...
... bound to the C-terminus of p22phox to the same extent; the binding was completely abolished by the P156Q substitution in p22phox, a mutation leading to defective interaction with the SH3 domains of ... structures within the cytoplasmic compartment Less association of Noxo1c with the membrane-integrated protein p22phox, the partner of Nox1 (Fig 4A), may be consistent with the finding that Noxo1c ... 7) The difference may be due to the fact that the significance ofthe PX-mediated lipid binding depends on the type of Nox, although the PX domain of Noxo1 by itself is indispensable for supporting...
... group of enzymes with the overall retention ofthe anomeric configuration ofthe substrate The conserved RDP motif in the vicinity ofthe active site ofthe enzyme is important for substrate recognition ... Enzymatic properties ofthe recombinant protein were identical to those ofthe native B longum KN29.1 b-fructofuranosidase, which suggests that the point mutation does not affect the enzymatic activity ... oxygens of ˚ these two residues, 5.7 A, proves that the enzyme belongs to the group of hydrolases acting with retention of substrate configuration The other residues involved in interactions with the...
... correlates with the interaction with 5542 Pol e, it is tempting to speculate that the interaction may be mediated by the CTD, in particular when phosphorylated at the repeated serine residues, although ... correlated strictly with phosphorylation ofthe CTD In support of this view, chemical kinase inhibitors that prevent phosphorylation-dependent transition from the initiation to the elongation of transcription ... interaction does not depend on DNA replication Pol e is one ofthe three major replicases in the eukaryotic cell [22] Therefore, we tested the effect ofthe replicative state ofthe cell on the...
... 1.2 Table According to the activity assay, the activity was retained above 95% (data not shown) and the recovery is 24% during the heat-treatment It implied that PKIb was a thermostable protein ... 1.2% (Table 1) The purified PKIb showed a single band by SDS/PAGE (Fig 2) The assay of its activity demonstrated that the purified PKIb inhibited the catalytic subunit of cAPK with the specific activity ... calculated According to the above peak assignment, the relative contents of secondary structure in the human PKIb based upon the fitted spectrum are shown in Table The CD spectrum of human PKIb at...
... that the cleft ofthe active site will be located in the interface between the two structural domains of CPY and would be filled by the propeptide, thus uniting the two domains in a body, as if the ... deconvoluted into two peaks with Tm1 of 57.0 and Tm2 of 62.1 °C, as shown by the dashed lines of Fig 1B This strongly suggests that the thermal unfolding of CPY involves a multistate transition The temperature ... it has been reported that neither changes in the secondary structure nor the activity of CPY are irreversible but those of proCPY are reversible [5] These results support the view that the mature...
... changes in the surface ofthe protein because ofthe interactions ofthe cofactor with the protein This is further substantiated when one overlays the two forms ofthe protein (Fig 5B) The Plasmodium ... consistent with the LEM of protein unfolding [29] It is apparent from the solution denaturation studies that the holo formofthe protein has greater stability than the apo formThe differences in the ... unfolding thermodynamic parameters ofthe two forms are given in Tables 13 In the entire experimental regime, it is seen that the holo form presents better stability than the other form (Fig 4C) The...