chemotherapy of bacterial infections
Chapter 127. Treatment and Prophylaxis of Bacterial Infections (Part 1) ppsx
... Prophylaxis of Bacterial Infections (Part 1) Harrison's Internal Medicine > Chapter 127. Treatment and Prophylaxis of Bacterial Infections Treatment and Prophylaxis of Bacterial Infections: ... recycling of membrane lipid carrier Not defined of Antibacterial Agents Letter for Fig. 127-1 Antibacterial Agenta Major Cellular Target Mechanism of Action Major Mechanisms of ... development of vaccines and drugs that prevent and cure bacterial infections was one of the twentieth century's major contributions to human longevity and quality of life. Antibacterial...
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Chapter 127. Treatment and Prophylaxis of Bacterial Infections (Part 2) potx
... because of a marginally broader spectrum. Chapter 127. Treatment and Prophylaxis of Bacterial Infections (Part 2) Inhibition of Cell-Wall Synthesis One major difference between bacterial ... any stage of the synthesis, export, assembly, or cross-linking of peptidoglycan lead to inhibition of bacterial cell growth and, in most cases, to cell death. Peptidoglycan is composed of (1) ... enzymes (autolysins) that cleave peptidoglycan bonds in the normal course of cell growth. In the presence of antibacterial agents that inhibit cell-wall growth, autolysis proceeds without...
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Chapter 127. Treatment and Prophylaxis of Bacterial Infections (Part 3) ppsx
... Inhibition of Protein Synthesis Most of the antibacterial agents that inhibit protein synthesis interact with the bacterial ribosome. The difference between the composition of bacterial and ... several amino acids. Inhibition of folate synthesis leads to cessation of bacterial cell growth and, in some cases, to bacterial cell death. The principal antibacterial antimetabolites are sulfonamides ... synthetase by competing with bacterial isoleucine for its binding site on the enzyme and depleting cellular stores of isoleucine-charged tRNA. Inhibition of Bacterial Metabolism The antimetabolites...
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Chapter 127. Treatment and Prophylaxis of Bacterial Infections (Part 4) pdf
... of Bacterial Infections (Part 4) Trimethoprim Trimethoprim is a diaminopyrimidine, a structural analogue of the pteridine moiety of folic acid. Trimethoprim is a competitive inhibitor of ... antimicrobial agents are inactivation of the compound, alteration or overproduction of the antibacterial target through mutation of the target protein's gene, acquisition of a new gene that encodes ... and its fluorinated derivatives (ciprofloxacin, levofloxacin, and moxifloxacin), are synthetic compounds that inhibit the activity of the A subunit of the bacterial enzyme DNA gyrase as well...
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Báo cáo sinh học: " Rapid label-free identification of mixed bacterial infections by surface plasmon resonance" pdf
... follows: 5 μlof10×PCRbuffer, 4 μlof10mmol/ldNTPmix;1μlof10μmol/l16s-a, 1 μlof10μmol/l 16s-b, 1 μlof10μmol/l 16s-c,0.5 μl of Tap polymerase, 1 μl of template and 36.5 μl of dd H2O. PCR was carried ... 9:85http://www.translational-medicine.com/content/9/1/85Page 5 of 9Preparation of bacterial DNABacteria suspension was prepared at a density of 1 × 108cfu/ml with 0.9% sterile normal saline. Then, 1 ml of bacterial suspension was ... Germany), 400 μl of the eluent wereobtained and stored at -20°C for use.Amplification of single-stranded DNA and sequencing of four bacterial genesThe mixture for PCR was as follows: 5 μlof10×PCRbuffer,...
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báo cáo hóa học:" Rapid label-free identification of mixed bacterial infections by surface plasmon resonance" pptx
... follows: 5 μlof10×PCRbuffer, 4 μlof10mmol/ldNTPmix;1μlof10μmol/l16s-a, 1 μlof10μmol/l 16s-b, 1 μlof10μmol/l 16s-c,0.5 μl of Tap polymerase, 1 μl of template and 36.5 μl of dd H2O. PCR was carried ... 9:85http://www.translational-medicine.com/content/9/1/85Page 6 of 9Preparation of bacterial DNABacteria suspension was prepared at a density of 1 × 108cfu/ml with 0.9% sterile normal saline. Then, 1 ml of bacterial suspension was ... Germany), 400 μl of the eluent wereobtained and stored at -20°C for use.Amplification of single-stranded DNA and sequencing of four bacterial genesThe mixture for PCR was as follows: 5 μlof10×PCRbuffer,...
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Tài liệu Guidelines for the Prevention and Treatment of Opportunistic Infections Among HIV-Exposed and HIV-Infected Children pdf
... HIV-Infected Children and Adolescents 7 Bacterial Infections 8 Bacterial Infections, Serious and Recurrent 8Bartonellosis 13Syphilis 16Mycobacterial Infections 19Mycobacterium tuberculosis ... absence of a laboratory isolate, differentiating viral from bacterial pneu-monia using clinical criteria can be difficult (85). In a study of intravenous immune globulin (IVIG) prophylaxis of bacterial ... the Caribbean, 60% of 462 unin-fected infants of HIV-infected mothers experienced infectious disease morbidity during the first 6 months of life, with the rate of neonatal infections (particularly...
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Tài liệu Báo cáo khoa học: Understanding the binding properties of an unusual metal-binding protein ) a study of bacterial frataxin pdf
... spectra of CyaY titrations. Superimpo-sitions of a reference [1H,15N] HSQC spectrum of CyaY (blue) witha spectrum (red) of a 1 : 1 mixture of CyaY ⁄ Gd3+(A), a 1 : 1 mix-ture of CyaY ... Fe3+Addition of Fe2+induced the displacement of severalresonances in the [1H,15N]-HSQC NMR spectrum of CyaY, but the most striking consequence of the addi-tion was the total disappearance of specific ... concomitant appearance of other signalsin other parts of the spectrum. This result could be aconsequence of the paramagnetic properties of Fe(II),or it might arise from the presence of an intermediateequilibrium...
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Tài liệu Báo cáo khoa học: Phylogenetic relationships in class I of the superfamily of bacterial, fungal, and plant peroxidases pptx
... yPUZZLE.Thelattermethod w i th the Ô+GÕ option f or rates of heterogeneityFig. 4. Structural comparison of four representatives of class I of the superfamily of bacterial, fungal, and plant peroxidases. (A) ... introduction of newÓ FEBS 2004 Molecular evolution of heme peroxidases (Eur. J. Biochem. 271) 3307Fig. 2. Multiple sequence alignment of 50selected representatives of t he superfamily of bacterial, ... basedon the analysis of three archaeal and 16 bacterial KatGs[42]. Later it was postulated that this phenomenon oftenoccurs in all lineages of hydroperoxidases capable of catalytic reaction...
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Báo cáo khoa học: Concepts and tools to exploit the potential of bacterial inclusion bodies in protein science and biotechnology pdf
... FTIR(micro)spectroscopy as a technique of choice also inthe study of the influence of the physiology of expres-sion (i.e. temperature, induction, formation of disulfidebonds) on the kinetics of aggregation and ... b-sheets. The use of this spectroscopictechnique for the study of IB aggregates is oftenlimited by the intrinsic insolubility of the samples,responsible for a high level of light scattering ... native a-helices of the N-terminal 185 residues of the functional domain of the HA2 subunit of theinfluenza virus hemagglutinin protein and to detectconformational heterogeneity of the protein...
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