cellular and molecular mechanisms of methotrexate resistance in melanoma
Báo cáo y học: " Cellular and molecular mechanisms of cigarette smoke-induced lung damage and prevention by vitamin c" ppsx
... apoptosis and lung damage in guinea pigs in vivo Effect of N-acetyl cysteine (NAC) on CS-induced protein oxidation in vitro and apoptosis and lung damage in guinea pigs in vivo A, CS-induced protein ... SD; * indicates p < 0.05 and ** indicates p < 0.001 with respect to sham controls C, Colocalization of TUNEL and DAPI staining in the nuclei of lungs of guinea pig fed mg vitamin C/day and exposed ... exposure, intratracheal instillation of p-BSQ in the lungs of vitamin C-restricted guinea pigs also produced inflammation as evidenced by marked increase in the number of neutrophils in BALF In separate...
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Cellular and molecular control of skeleton formation in fish insights from osteoblast ablation and functional characterization of lrp5 and SOst
... domain of Lrp5/6 contains Axin2 binding sites (Mao et al., 2001) Thus, binding of Axin might be the trigger for inactivation of the phosphorylation of β-catenin The binding sites are five reiterated ... rerio), to gain better understanding of the cellular and molecular processes involved in skeletal development To examine the role of osteoblasts in development of the vertebral column, I created ... great care of our fish I would also like to extend my gratitude to the Republic of Singapore and its decision making bodies for creating and maintaining this wonderful country in the heart of Southeast...
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MORPHOGENESIS THE CELLULAR AND MOLECULAR PROCESSES OF DEVELOPMENTAL ANATOMY pptx
... embryologist for testing ideas The main ways of interfering with the embryo include changing external physical or chemical factors and examining the intrinsic potential of the embryo and its constituent ... apical ends of cells in the invaginating plate He did find sparse bands of such filaments which probably contained actin in these cells, but they were indistinguishable from those elsewhere in the ... cells (Ettensohn, 1984) initially participating in invagination lessen their adhesions to one another and soflattenand increase their surface area This increase will, in principle, force the epithelium...
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Báo cáo khoa học: Cellular and molecular action of the mitogenic protein-deamidating toxin from Pasteurella multocida pptx
... protein serine ⁄ threonine protein kinase; MEK, MAPK serine ⁄ threonine protein kinase; MLCK, myosin light chain kinase (serine ⁄ threonine protein kinase); MLCPase, myosin light chain phosphatase; ... (activation) of the signaling pathway, and barred lines indicate the negative direction (inhibition) of the signaling pathway Full lines indicate interactions that are known to be direct, and broken lines ... kinase 1; PI3K, phosphatidylinositol 3-kinase; Pim-1, Pim serine ⁄ threonine protein kinase-1; PKA, cAMP-dependent protein serine ⁄ threonine kinase A; PKC, calcium-dependent serine ⁄ threonine...
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Báo cáo sinh học: "Association between neuroserpin and molecular markers of brain damage in patients with acute ischemic stroke" pot
... basal and 24 hours neuroserpin levels was defined as neuroserpin decrease All determinations were carried out in a laboratory blind to the clinical outcome and neuroimaging findings Endpoints ... Neuroserpin was used as a continuous variable since there was a linearity of the odds ratios for outcome The influence of neuroserpin decrease at 24 h on serum levels of molecular markers of brain injury ... interleukin-6 (IL-6) and Intercellular Adhesion Molecule-1 (ICAM-1) as markers of inflammatory response, and matrix metalloproteinase (MMP-9) and cellular fibronectin (cFn) as markers of blood brain barrier...
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báo cáo hóa học:" Association between neuroserpin and molecular markers of brain damage in patients with acute ischemic stroke" pdf
... basal and 24 hours neuroserpin levels was defined as neuroserpin decrease All determinations were carried out in a laboratory blind to the clinical outcome and neuroimaging findings Endpoints ... Neuroserpin was used as a continuous variable since there was a linearity of the odds ratios for outcome The influence of neuroserpin decrease at 24 h on serum levels of molecular markers of brain injury ... interleukin-6 (IL-6) and Intercellular Adhesion Molecule-1 (ICAM-1) as markers of inflammatory response, and matrix metalloproteinase (MMP-9) and cellular fibronectin (cFn) as markers of blood brain barrier...
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Báo cáo y học: "Lung epithelium as a sentinel and effector system in pneumonia – molecular mechanisms of pathogen " pdf
... human NLR family, currently consisting of 22 proteins, contains NALP (NACHT-, LRR-, and pyrin domaincontaining proteins), NOD (nucleotide-binding oligomerization domain), CIITA (class II transactivator), ... [99,100] Notably, blocking of the renin-angiotensin pathway reduced the worsening of disease induced by injection of Spike protein in mice [100] Thus, non-classical pathogen-recognizing transmembranous ... time-consuming establishment of knock out models [238-240] In addition to the analysis of host response initiation, the understanding of control mechanisms of local inflammation within the lung...
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Báo cáo khoa học: " Science review: Mechanisms of impaired adrenal function in sepsis and molecular actions of glucocorticoids" pdf
... are continuous with the sinuses of the medulla, which drain into the central vein of the medulla The right adrenal vein drains into the inferior vena cava and the left into the renal vein Hence, ... receptor binding domain of GRinteracting protein Thus, TNF-α may induce glucocorticoid resistance acting upstream and independently of nuclear factor-κB (NF-κB) [72] Molecular action of glucocorticoids ... corticosteroidbinding globulin and the free cortisol index during septic shock and multitrauma Intensive Care Med 2001, 27:1584-1591 46 Garrel DR: Corticosteroid-binding globulin during inflammation and burn injury:...
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Báo cáo y học: "Molecular basis of telaprevir resistance due to V36 and T54 mutations in the NS3-4A protease of the hepatitis C virus" pdf
... to protein-ligand interactions in the network of non-covalent interactions (a) residue S139 and of Q41 and its binding to the cyclopropyl group of VX-950 In vitro analysis of the V36G resistance ... protein center and away from the ligand-binding pocket; and one Cγ atom in the side chain of the mutant residues and a second Cγ atom of the wild-type V36 point towards the aromatic ring of F43 ... discussed in this study Analysis of NS3-4A protease structures and ligand binding modes The mutated positions V36 and T54 are buried in the protease domain of NS3-4A in the two β-strands β1 and β3 of...
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Tài liệu Global action plan to control the spread and impact of antimicrobial resistance in Neisseria gonorrho pdf
... species and closely related bacteria The development of a pool of resistance genes and the ability of the gonococci to maintain these determinants of resistance within their genetic coding is part of ... (for instance swabs, transport media and candle jars) • training laboratory technicians and building capacity for performing culture and AMR testing • increasing the availability of routine laboratory ... producing and disseminating standards for performing N. gonorrhoeae culture and AMR testing • working with WHO collaborating centres and other international and national reference centres to maintain...
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Báo cáo khoa học: Viral entry mechanisms: cellular and viral mediators of herpes simplex virus entry potx
... 7229 Cellular and viral mediators of HSV entry J Akhtar and D Shukla with a cellular membrane results in content mixing and the eventual release of the viral nucleocapsid and tegument proteins into ... These include B5 and avb3 integrins [39,40] Expression cloning in porcine kidney cells resistant for HSV-1 entry has led to the discovery of B5, a type-2 membrane protein containing an extracellular ... that binding of gD to one of its cognate receptors induces conformational changes in gD that mobilize a fusion active multi-glycoprotein complex involving gB, gD, gH and gL (Fig 2) [8] Fusion of...
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báo cáo hóa học:" Molecular Etiology of Hearing Impairment in Inner Mongolia: mutations in SLC26A4 gene and relevant phenotype analysis" ppt
... of Translational Medicine 2008, 6:74 Introduction Every year in China, about 30,000 children, compared to 840 in UK and one of every one thousand infants in US, are born with congenital hearing ... sampling Parents were interviewed for age of onset, family history, mother's health condition during pregnancy and patient's clinical history including infection, possible head or brain injury and ... patients and provide effective genetic testing and accurate counseling for hearing loss patients and families in China, we performed SLC26A4 sequence analysis in hearing impairment patients in Chifeng...
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Báo cáo sinh học: " Molecular biodiversity of cassava begomoviruses in Tanzania: evolution of cassava geminiviruses in Africa and evidence for East Africa being a center of diversity of cassava geminiviruses" pptx
... containing single virus infection are shown Plants A and B contained a single infection of EACMV-[KE/TZM], C and D contained ACMV-[TZ], E and F were infected by EACMCV-[TZ1] and G and H by EACMV-UG2 ... cassava pandemic was first reported in East Africa, we investigated the extent of inter-CMG recombinations and examined their role in the evolution of CMGs in Africa Results Assessment of CMD symptoms ... classification of apparent recombinant begomoviruses infecting tomato in the Nile and Mediterranean Basins Phytopathology in press Legg JP: Emergence, spread and strategies for controlling the pandemic of...
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báo cáo hóa học:" Molecular biodiversity of cassava begomoviruses in Tanzania: evolution of cassava geminiviruses in Africa and evidence for East Africa being a center of diversity of cassava geminiviruses" pot
... containing single virus infection are shown Plants A and B contained a single infection of EACMV-[KE/TZM], C and D contained ACMV-[TZ], E and F were infected by EACMCV-[TZ1] and G and H by EACMV-UG2 ... cassava pandemic was first reported in East Africa, we investigated the extent of inter-CMG recombinations and examined their role in the evolution of CMGs in Africa Results Assessment of CMD symptoms ... classification of apparent recombinant begomoviruses infecting tomato in the Nile and Mediterranean Basins Phytopathology in press Legg JP: Emergence, spread and strategies for controlling the pandemic of...
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Báo cáo khoa học: "Molecular analysis of hprt mutation in B6C3F1 mice exposed to ozone alone and combined treatment of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone and/or dibutyl phthalate for 32 and 52 weeks" ppsx
... determined the genotoxic effects of ozone, NNK, DBP, and two or three combination of these toxicants on splenic T-cells of male and female mice following in vivo 32- and 52-wk exposures Materials and ... treatment of 2-amino-3,8-dimethylimidazo[4,5-f] quinoxaline in gdp delta transgenic mice caused the increase of G : C to T : A trasversion in both time- and dose-dependent manner Their findings support ... locus of lymphocytes isolated from spleens of mice following exposure to ozone, NNK, and DBP, and combined treatments of NNK and DBP on ozone for 32- and 52-wk The procedures for isolating lymphocytes...
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Báo cáo khoa học: "Antimicrobial susceptibility and molecular detection of chloramphenicol and florfenicol resistance among Escherichia coli isolates from diseased chickens" docx
... tnatsiser-locinehpmarolhc ytneves eht fo hcae morf AND cimoneg latot eht gnisU giF ni dedivorp era stnanimreted ecnatsiser locinehpmarolhc dna locinefrolf rof gnidocne seneg eht rof stcudorp noitacifilpma ... ,1-tac ,Almc ,Rolf( stnanimreted ecnatsiser locinehpmarolhc dna locinefrolf rof gnidocne seneG o o o stnanimreted ecnatsiser-locinehpmarolhc dna locinefrolf fo noitceteD snoitanimreted CIM eht ... elbaT( )lm/gµ 46≥( detavele erew setalosi eseht rof sCIM locinehpmarolhc dna locinefrolf htob dna ,seneg Almc dna Rolf eht htob rof evitisop eb ot dnuof erew )%01( setalosi iloc E neves ,yllanoitiddA...
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Báo cáo khoa học: "Detection and molecular characterization of infectious bronchitis virus isolated from recent outbreaks in broiler flocks in Thailand" potx
... to vaccine strains used in Thailand including Ma5, H120, M41, and Connecticut New serotypes or variant strains can emerge as a result of only a few changes in the amino acid composition of S1 ... the wide spread use of vaccines, recombination as a consequence of mixed infections, or the decrease of dominant serotypes as a result of vaccination, allowing other field strains to emerge [19] ... identities of 97∼ 98% and amino acid sequence identities of 96∼98% with Chinese IBVs (strain A2, SH and QXIBV) Discussion One of the major problems of IBV is the frequent emergence of new variants...
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Báo cáo y học: "Molecular action of methotrexate in inflammatory diseases" ppt
... diminish inflammation in the joint is by diminishing cytokine production Numerous studies have demonstrated diminished levels of inflammatory cytokines in the serum of patients The adenosine ... that intracellular accumulation of specific intermediates in the de novo synthesis of purines leads to adenosine release [32] and from our interest in the anti-inflammatory effects of adenosine, ... focus of interest [86] In animal models of chronic arthritis, methotrexate was thought to be useful in reducing the production of IL-1 [87,88] In support of these findings, clinical studies of RA...
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Báo cáo y học: " Effector mechanisms of interleukin-17 in collagen-induced arthritis in the absence of interferon-γ and counteraction by interferon-γ" pot
... importance of STAT1 and IRF-1 in the inhibitory action of IFN-γ, the percentage of inhibition of the expression of GCP-2, RANKL and IL-6 mRNA induced by synergistic action of IL-17 and TNF-α was ... immunization by injecting 20 μg of CII in the left ears and vehicle in the right ears Bars in Figure 3d represent the percentages of swelling in the CII-challenged ears, normalized to the swelling of the ... cytokine by expanding myeloid progenitors and initiating proliferation of mature neutrophils [42] It has been described to induce the secretion of hematopoietic cytokines such as IL-6 and G-CSF in...
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Báo cáo y học: " Effectiveness of antiretroviral therapy and development of drug resistance in HIV-1 infected patients in Mombasa, Kenya" doc
... Prevalence and risk factors for developing K65R mutations among HIV-1 infected patients who fail an initial regimen of fixed-dose combination of stavudine, lamivudine, and nevirapine J Clin Virol ... monitoring in these patients however are running behind A random sample survey is often the only way to assess treatment efficacy and the selection of drug resistance in treatment programs in Africa ... carried out molecular work and sequence analysis and prepared the manuscript SL and CV assisted in designing the study and drafting the manuscript KD and JR performed viral loads and genotyping KM...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam nội dung cụ thể cho từng kĩ năng ở từng cấp độ phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến tốc độ rôto n fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008