cell signaling in the testis

báo cáo khoa học: " Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets" potx

Ngày tải lên : 11/08/2014, 12:20

... resistance in RCC The rapamycin-like (rapalog) drug everolimus inhibits the serine/threonine protein kinase mTOR after forming a complex with the intracellular protein FKBP12 (FK506 binding protein-12) ... in RCC mTOR inhibition results in attenuation of VEGFR/phosphatidylinositol-3-kinase (PI3K)/AKT signaling and HIF down-regulation, further supporting a role for these small molecules in the inhibition ... over 60 years of age; as a consequence, the incidence of the disease is anticipated to increase in the future in the EU in the face of an aging population Individuals affected by RCC may present...

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The integration of lean man and 6 sigma

Ngày tải lên : 23/11/2013, 14:22

... that they eventually reach a point of diminishing returns That is, after re-engineering their operating and supporting systems for improvement by solving major problems and resolving key inefﬁciencies, ... chrome plating, where large batches are placed in plating tanks In wrench manufacturing, for example, steel forgings might move in a single-piece ﬂow through a U-shaped machining cell, but then accumulate ... processing claims in the insurance industry, evaluating loan applications at a bank, and treating patients in a hospital all involve performing activities synonymous with the lean management viewpoint...

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Báo cáo khoa học: "Diagram Understanding Using Integration of Layout Information and Textual Information" ppt

Ngày tải lên : 17/03/2014, 07:20

... framework for the semantic interpretation of words in the PBF diagrams by using not only the pattern (layout) information but also the natural language information The reason is as follows: there is ... to all words and sketches in the diagram S t e p describe the following kinds of information for each word in the diagram ID number writing ID number of the corresponding element type of correspondence ... relationship with the corresponding sketch These words have the same Kanji character at the end of the writing Some of these words are found in the expression pattern (a), (b), and (c) described in Section...

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Research " Inter Organizational information system use in supply chaizn : Toward an integration of competence based and transaction cost based views of the firm " pot

Ngày tải lên : 30/03/2014, 01:20

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Báo cáo hóa học: " Research Article Binocular Image Sequence Analysis: Integration of Stereo Disparity and Optic Flow for Improved Obstacle Detection and Tracking" pptx

Ngày tải lên : 21/06/2014, 22:20

... epipolar line constraint, we can search the correspondence point in the same row For a seed point at position (il , j) in the left edge image and a candidate point at position (ir , j) in the right ... ], which requires knowing the longitudinal distance Z Therefore, in practice, we ﬁrst calculate the third group of the variables and then use the obtained results for the other two groups of variables ... edge point (xl , y) in the left image, the correspondence point in the Figure 4: Disparity maps with fusion and no fusion with optic ﬂows right image is the one (xmr , ym) generating the minimum...

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INTERNATIONAL ASSIGNMENTS An Integration of Strategy, Research, and Practice ppt

Ngày tải lên : 28/06/2014, 09:20

... function in a global context—formulating and implementing strategies, inventing and utilizing technologies, and creating and coordinating information International assignments are the single most ... Appraising: Determining if People Are Doing the Right Things 144 Rewarding: Compensation and Pay 171 IV AFTER THE ASSIGNMENT 187 Repatriating: Helping People Readjust and Perform 189 10 Retaining: ... successful business in a foreign market by remote control They cannot compromise on the quality of the people they send there or on the people they hire there They cannot compromise on the thoroughness...

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Báo cáo sinh học: "Dishevelled and Wnt signaling: is the nucleus the final frontier" potx

Ngày tải lên : 06/08/2014, 18:21

... ␤-catenin into the nucleus [1] Regulation of ␤-catenin stability is mediated via a complex of proteins including Axin, glycogen synthase kinase (GSK3), GSK3-binding protein (GBP) and casein kinase ... ␤-catenin is then exported from the nucleus and degraded via the proteosomal machinery (b) For non-canonical or planar cell polarity (PCP) signaling, Wnt signaling is transduced through Frizzled independent ... pathway, signaling through the Frizzled (Fz) and LRP5/6 receptor complex induces the stabilization of ␤-catenin via the DIX and PDZ domains of Dishevelled (Dsh) and a number of factors including Axin,...

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báo cáo khoa học: "Different patterns of NF-B and Notch1 signaling contribute to tumor-induced lymphangiogenesis of esophageal squamous cell carcinoma" ppt

Ngày tải lên : 10/08/2014, 10:21

... “decisions” involved in cell- fate determination, including those involved in mammalian vascular development [15] The finding that genes of the Notch signaling cascade are robustly expressed in the vasculature ... that Notch signaling guides endothelial cells and associated mural cells through the cell- fate decisions needed to form and maintain the vascular system [16] Although Notch signaling anomalies ... immunohistochemical staining Nuclear staining of NF-B and cytoplasmic staining of Notch1 and VEGF-C were scored in this study The intensity of NF-B, Notch1, podoplanin, and/or VEGFC staining was score...

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Báo cáo y học: " Bringing metabolic networks to life: integration of kinetic, metabolic, and proteomic data" pptx

Ngày tải lên : 13/08/2014, 16:21

... Original value Figure Posterior distributions in the threonine model Posterior distributions in the threonine model Left: prior and kinetics-based posterior in the threonine model All sysG tem kinetic ... combining both kinds of information, we can obtain a posterior distribution, which describes how plausible certain parameter sets appear, taking into account both the prior information and the ... solving the steady state equations Computing the posterior distribution Theoretically, we can obtain the posterior distribution p(θ|x*, y*) by inserting the distributions (5), (6), and (7) into...

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$integration of fracture, reservoir and geomechanic Modeling for shale gas reservoir development$

integration of fracture, reservoir and geomechanic Modeling for shale gas reservoir development

Ngày tải lên : 04/10/2014, 22:11

... most of these spikes in gas rate with a fracturing event taking place in the close vicinity of the pad These observations suggest well-to-well connectivity during a fracturing operation when the ... respectively A 3D finite element model of a single well was developed to verify the assumption of 2D plane strain in the FEA models used in the integrated modeling approach Figure shows the 3D finite element ... during their fracturing Figure 13 highlights one of the chemical tracers injected into Wells and While not shown, similar plots were obtained for the other chemical tracers used in these wells The...

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The study of interactions of transmembrane receptors and intracellular signaling proteins in live cells by fluorescence correlation and cross correlation spectroscopy

Ngày tải lên : 14/09/2015, 14:25

... C-terminus domain, to expose binding sites for Src-homology-2 (SH2) domain-containing proteins and phosphotyrosine-binding (PTB) domain-containing proteins Adaptor proteins with a SH2-binding domain ... hemagglutinin epitope tag heparin-binding epidermal growth factor protein kinase C-related kinase homology region IQ motif containing GTPase activating protein infrared insulin receptor tyrosine kinase ... results in conformational changes of the C-terminus domain of the receptor, so that intracellular adaptor proteins or other enzymes can bind to the phosphorylated sites of the receptor These intracellular...

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The convergence challenge global survey into the integration of governance, risk and compliance

Ngày tải lên : 06/12/2015, 23:16

... reduction is a driver – which is surprising given the growing investment in GRC Which of the following factors are influencing your organisation’s interest in the convergence of governance, risk ... agility in decision-making Increased use of outsourcing and offshoring 8% Increased technological complexity 8% Increasing risk incidents More stringent requirements from rating agencies None of the ... naturally With the right GRC model in place, leaders should get the information they need to understand and respond to the risks facing the business, as well as anticipating and meeting changing stakeholder...

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The convergence evolution global survey into the integration of governance, risk and compliance

Ngày tải lên : 06/12/2015, 23:16

... focused on where the company is going in terms of its strategy, and then optimizing the strategy as new risks emerge, it is spending time addressing the wrong things.” By co-ordinating their GRC activities ... fortunate in being based in some of the fastest-growing economies in the world Maybank, the Malaysian bank, is one financial institution that is reaping the rewards from this rapid growth Already the ... GlaxoSmithKline In the wake of the financial crisis, Boards were criticized for not performing their oversight role as thoroughly as they should Although Boards in financial institutions were the main...

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Tài liệu Transformation through Integration An Activity Theoretical Analysis of School Development as Integration of Child Care Institutions and the Elementary School ppt

Ngày tải lên : 16/01/2014, 16:33

... Today, in the spring of 2003, the 5thD is still operating in the school I will in this thesis account for the role the 5thD played in the VT and in what way it contributed to change in the school ... dimensional learning contexts three inter-dimensional learning contexts, which I call the intercultural learning context, the intergenerational learning context, and the interinstitutional learning context ... socializing task But as Isling claims, in the struggle between these two tasks the qualifying assignment has been dominant The double requirement has resulted in effects all the way into the classroom...

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Báo cáo khoa học: Regulation of Cyr61/CCN1 gene expression through RhoA GTPase and p38MAPK signaling pathways Role of CREB and AP-1 transcription factors doc

Ngày tải lên : 08/03/2014, 08:20

... lie within their respective mRNA sequences that contains within it the information needed to determine their stability within the cells Interestingly, Kondo et al have identified, in the 3¢-untranslated ... and/or the efficiency of their immunodetection with antibodies against the epitope peptide tagged to these proteins Nonetheless, the effective expression of these proteins in the transfected cells ... (B–D) Inhibitory profiles of the pharmacological inhibitors BIM, Pd98053 and worthmanin Cells were incubated with the indicated inhibitors as described in (A) and further incubated with either...

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Báo cáo sinh học: "Wnt signaling and the developmental fate of lung cells" ppsx

Ngày tải lên : 06/08/2014, 18:21

... lack definitive markers for stem cells.” The findings also reveal something of the delicate interplay between the timing and nature of signaling in determining cell fate For example, the absolute ... example, the endodermal lineage derives from the innermost of the three layers of cells in the very early embryo, and cells within the endodermal lineage can have various fates, including becoming ... local injury and inflammation there is local up-regulation of Wnt signaling and the activity of ␤-catenin, and that this is then switching some of the cells to become progenitors of intestine.”...

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Báo cáo y học: "Eotaxin and FGF enhance signaling through an Extracellular signal-related kinase (ERK)-dependent pathway in the pathogenesis of Eosinophilic Esophagitis" doc

Ngày tải lên : 08/08/2014, 21:20

... found in a variety of tissues, including epithelial and mesenchymal tissue [20] bFGF increases the half-life of cells and could possibly increase the overall lifetime of the eosinophil in the esophagus ... eosinophils also express bFGF [28] The eosinophils may be operating in a positive feedback loop in which the expression bFGF is encouraging the increased activation of the eosinophil, which then ... were involved in enrolling and consenting patients JH drafted the manuscript All authors read and approved the final manuscript Competing interests The authors declare that they have no competing...

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Báo cáo y học: " Examination of effects of GSK3β phosphorylation, β-catenin phosphorylation, and β-catenin degradation on kinetics of Wnt signaling pathway using computational method" pdf

Ngày tải lên : 13/08/2014, 16:21

... twice the value obtained in the original Lee-Heinrich model This is similar to the case without wnt signaling (W = 0) This shows that the effect of constant wnt signaling in SS in the present modified ... β-catenin and axin with transient wnt signaling Solid line: the original Lee-Heinrich model Other lines: kG parameter was varied Long dashed line: kG = 0.1 min-1 Short dashed line: kG = 0.5 min-1 ... computationally, much of its role in cell signaling and the means by which it interacts with other pathways remain to be explored In the present study, in the light of the recent experimental studies...

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role of wnt signaling and glycogen synthase kinase-3 beta in adipocyte biology

Ngày tải lên : 14/11/2014, 09:42

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WNT signaling in the early development of zebrfish swimbladder and xenopus lung

Ngày tải lên : 11/09/2015, 09:07

... proteins also inhibit fibroblast growth factor (FGF) signaling by trapping FGF receptors in the ER Finally, insulin-like growthfactor (IGF) binding protein-4 (IGFBP-4) antagonizes Wnt signaling ... from Winata et al., 2009 1.7 The Wnt signaling 1.7.1 The discovery of Wnt signaling The first wnt gene, mouse wnt1, originally named Int-1, was identified in 1982 Int-1 encodes a secreted protein ... Shisa proteins are also considered Wnt antagonists because they trap Fz proteins in the ER Therefore, Fz proteins cannot reach the cell surface and thus Wnt signaling is inhibited cell autonomously...

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